- Brigid Brannagh - Donna
- Robin Strasser - Teensy Manhart
- Yeardley Smith - Marlene
- T.J. Thyne - Vaughn
- Bodhi Elfman - Terry
- Laurie Metcalf - Spyder
- Linda Porter - Becky
- Camille Anderson - Pete's Girl
- Bill Brochtrup - Steve
- Floyd 'Red Crow' Westerman - George Littlefox
- Jane Seymour - Jane Seymour
- Vincent Schiavelli - Mr. Cutler
- Steve Young - Self
- Karen Lorre - Stephanie
- Devon Alan - Taylor
- Mark Christopher Lawrence - Arnold
- William Sanderson - Mike
- Paul Sand - Salazar
- Ron Fassler - Frank
- Ryan Stiles - Abraham Lincoln (uncredited)
- Anne Ramsay - Nancy
- Hilary Angelo - Dakota
- Erick Avari - Lalit
- Nancy Lenehan - Karen Love
- Robert Mailhouse - Adam
- Vernee Watson-Johnson - Ms. Valko
- Bobbie Phillips - Anna
- Joel Brooks - Arthur
- Ian Ogilvy - Geoffrey
- Kevin Sorbo - Charlie
- Octavia Spencer - Gloria
- Corbin Allred - Rick Sanderson
- Eric Allan Kramer - Officer Davis
- Heidi Mark - Allison
- Matthew Ashford - Trey
- Ed Begley Jr. - Self
- David Lee Smith - Sid (uncredited)
- Teller - Mr. Boots
- Ed Quinn - Stavros
- Julia Vera - Maria
- Ned Romero - John Running Bear
- Gary Collins - Self
- Christopher Darga - Mr. Marsh
- Earl Billings - Fred
- Jenna Leigh Green - Kelly Kincaid
- Rosalind Chao - Patricia
- Darcas Macopson - Kevin
- Michael Kostroff - Lou
- Brian Dunkleman - Salesperson
- Miriam Margolyes - Chloe
- Peter MacKenzie - Matthew
- Meredith Eaton - Kate
- Florence Stanley - Rose Hoffman
- John Byner - Reverend James
- James Eckhouse - Andy
- Christine Estabrook - Lindsay
- Robert Loggia - General Kirby
- Andrew Dice Clay - Self
- Rosemary Forsyth - Merrill
- Kevin Christy - Stan
- Paula Newsome - Charlene
- Juliette Lewis - September
- Michelle Shocked - Self
- Jessica Lundy - Patty
- Jim Turner - Chapman
- Holly Gagnier - Tina (voice)
- Todd Stashwick - Gunther
- Jon Cryer - Brian (uncredited)
- Joel McKinnon Miller - Hooper
- Allen Garfield - Stan Gottlieb
- Chick Hearn - Basketball Announcer (voice)
- Walter Olkewicz - Howie
- Nicholas Gonzalez - Young Juan
- Clyde Kusatsu - Al
- Diane Delano - Lina
- Bruce French - Doctor
- Catherine Dent - Cynthia
- Robert Wisdom - Prospero
- Liz Vassey - Kim
- John Mariano - Man (uncredited)
- T Bone Burnett - Self
- Suanne Spoke - Wanda
- Kirstie Alley - Dr. Trish (uncredited)
- Kevin Cooney - Archbishop Livingston
- Kathryn Joosten - Claire
- Bob Morrisey - Dr. Coleman
- Claudia Schiffer - Gretchen
- k.d. lang - Self
- Victor Raider-Wexler - Marty Hoffman
- Grace Zabriskie - Naomi
- John Harrington Bland - Umpire
- Leslie Charleson - Katherine
- Leslie Jordan - Kenny
- Brian Phelps - Guy #3
- Scott Thompson - David
- Mitzi McCall - Florence
- Pat Benatar - Self
- Miriam Flynn - Jasmine
- Billy West - Captain (voice)
- Jennifer Lyons - Brittany
- Rolando Molina - Hector
- Tommy Chong - Carl
- Patrick Fabian - Doug
- Julio Oscar Mechoso - Father Rodriguez
- Jeff Austin - Arthur
- Dan Desmond - Mr. Wylie
- Raphael Sbarge - Agent Gerson
- Dave Florek - Officer Mel
- Dick O'Neill - Mr. Waring
- Gloria LeRoy - Jeannette
- Carlos Lacámara - Fernando
- Bob Dylan - Self
- Travis Wester - Brandon Gullicksen
- Radmar Agana Jao - Ian
- Rebecca Staab - Judy
- Casey Sander - Abby's Father (uncredited)
- Patrick Thomas O'Brien - Roger
- Robert Donner - Joe
- Victor Campos - Hector
- Nina Foch - Beatrice
- Michael Winters - Rodney
- Tom Poston - Dr. Gillespie
- Chris Durand - Robber
- Angelo Pagán - Laundry Man
- P.J. Marino - Joe
- Anne-Marie Johnson - Laura
- Steve Hytner - William
- James Sie - Man on Line
- John Aylward - Kevin Kincaid
- Lucille Soong - Mrs. Wong
- Tom Virtue - Mr. Miller
- George Wyner - Herb
- Marissa Jaret Winokur - Anita
- Daphnée Duplaix Samuel - Laura (uncredited)
- Jodi Lyn O'Keefe - Simone
- Kevin Nealon - Mr. Clayborn
- Jennifer Darling - Suzanne
- Alice Ghostley - Mrs. Binns
- Paul Dooley - Judge Harper
- Maree Cheatham - Senator
- Lindsay Sloane - Jennifer
- Maria Bamford - Sandy
- Danielle Bisutti - Joy
- Cristine Rose - Autumn
- Stuart Pankin - Mr. Gottlieb
- Steve Valentine - Roger
- Joel Polis - Colonel Glickman
- Rosemary Alexander - Rosemary
- Paul Johansson - Leonard
- Bernard Fox - Henry
- Penn Jillette - Vincent (uncredited)
- Lyle Lovett - Self
- Stacey Travis - Lois
- Jesse D. Goins - Cop
- Drew Carey - Dharma's Fantasy Man
- Dot-Marie Jones - Hey-19
- Jason Beghe - Scott Kelley
- Kurt Fuller - David Saunders
- Scott Adsit - Howard
- Jim Meskimen - Fire Inspector
- Holmes Osborne - Reverend Blanchard
- Anne Haney - Mrs. Kirby
- Masi Oka - Nien-Jin
- Tracey Ellis - Sandy
- Bill Maher - Bill Maher
- Jane Lynch - Sheryl
- Joyce Guy - Nurse
- Dick Clark - Self
- Mary Gross - Mary
- Julie Pinson - Cici
- Jane Carr - Lorraine
- Nigel Gibbs - John
- Frank Roman - Jorge
- Kathleen Noone - Kathy Kincaid
- Torsten Voges - Hey-20
- Phill Lewis - Mr. Walden
- Tim Bagley - Nelson
- Terri Hoyos - Alba
- Michael Fairman - Porter
- Ed Asner - Earl Tucker
- Kristin Bauer - Stephanie
- Andy Milder - Russell Gotleib
- Romy Rosemont - Martha
- Jeanne Chinn - Wei-Hui
- Morgan Fairchild - Jackie
- Sarah Lancaster - Wendy
- Kevin Skousen - Stuart
- Harvey J. Alperin - Rabbi
- Terry Rhoads - Howard
- Debra Christofferson - Marilyn Peters
- Kenny Loggins - Self
- Peggy Doyle - Bingo Caller
- Peter Choi - Doctor
- Jacqueline Steiger - Tiffany
- Chuck Lorre
- Don Foster
Kirstie Alley interpreta a Dr. Trish (uncredited) en la serie.
Holmes Osborne hace el papel de Reverend Blanchard.
William Sanderson interpreta a Mike en la serie.
Vincent Schiavelli interpreta a Mr. Cutler en la serie.
Juliette Lewis interpreta a September en la serie.
Robert Loggia hace el papel de General Kirby.
Allen Garfield hace el papel de Stan Gottlieb.
Clyde Kusatsu interpreta a Al en la serie.
Bob Dylan interpreta a Self en la serie.
Torsten Voges interpreta a Hey-20 en la serie.
Capítulo disponible en las siguientes plataformas:
