- Amy Poehler - Self - Illustrious Guest
- Vince Staples - Self - Illustrious Guest
- Ben Stiller - Self - Illustrious Guest
- 2 Chainz - Self - Illustrious Guest
- Lupita Nyong'o - Self - Illustrious Guest
- Winston Duke - Self - Illustrious Guest
- Kirsten Gillibrand - Self - Illustrious Guest
- Carmelo Anthony - Self - Illustrious Guest
- Jordan Peele - Self - Illustrious Guest
- Anna Kendrick - Self - Illustrious Guest
- Cory Booker - Self - Illustrious Guest
- Lil Nas X - Self - Illustrious Guest
- Paul Scheer - Self - Special Appearance
- Charlize Theron - Self - Illustrious Guest
- Bill Hader - Self - Illustrious Guest
- Ava DuVernay - Self - Illustrious Guest
- Spike Lee - Self - Illustrious Guest
- Matt Walsh - Self - Illustrious Guest
- David Letterman - Self - Illustrious Guest
- Penn Badgley - Self - Illustrious Guest
- LaKeith Stanfield - Self - Illustrious Guest
- Kamala Harris - Self - Illustrious Guest
- Maxine Waters - Self - Illustrious Guest
- John Mulaney - Self - Illustrious Guest
- Barack Obama - Self - Illustrious Guest
- Killer Mike - Self - Illustrious Guest
- Missy Elliott - Self - Illustrious Guest
- Busta Rhymes - Self
- Diplo - Self
- Sheila E. - Self
- A$AP Ferg - Self
- Chris Rock - Self - Illustrious Guest
- RZA - Self - Illustrious Guest
- Sarah Cooper - Self - Illustrious Guest
- Yahya Abdul-Mateen II - Self - Illustrious Guest
- Ethan Hawke - Self - Illustrious Guest
- Jason Derulo - Self - Illustrious Guest
- Swizz Beatz - Self - Illustrious Guest
- Timbaland - Self - Illustrious Guest
- LL Cool J - Self - Illustrious Guest
- Tony Hawk - Self - Illustrious Guest
- Big Sean - Self - Illustrious Guest
- Janelle Monáe - Self - Illustrious Guest
- Jaden Smith - Self - Illustrious Guest
- Sue Bird - Self - Illustrious Guest
- Cori Bush - Self - Illustrious Guest
- Usain Bolt - Self - Illustrious Guest
- Stephen A. Smith - Self - Illustrious Guest
- Andy Samberg - Self - Illustrious Guest
- Eric André - Self - Illustrious Guest
- Judd Apatow - Self - Illustrious Guest
- Bubba Wallace - Self - Illustrious Guest
- Jon Stewart - Self - Illustrious Guest
- Jesse Williams - Self - Illustrious Guest
- Dwyane Wade - Self - Illustrious Guest
- Katie Porter - Self - Illustrious Guest
- Billy Porter - Self - Illustrious Guest
- Spike Jonze - Self - Illustrious Guest
- Rashida Jones - Self - Illustrious Guest
- Jay Ellis - Self - Illustrious Guest
- Alicia Keys - Self - Illustrious Guest
- Joe Biden - Self - Illustrious Guest
- Mark Cuban - Self - Illustrious Guest
- Tracee Ellis Ross - Self - Illustrious Guest
- Gabrielle Union - Self - Illustrious Guest
- Malcolm Gladwell - Self - Illustrious Guest
- Stacey Abrams - Self - Illustrious Guest
- John David Washington - Self - Illustrious Guest
- John David Washington - Self
- Seth Rogen - Self - Illustrious Guest
- Anthony Fauci - Self - Illustrious Guest
- Issa Rae - Self - Illustrious Guest
- Issa Rae - Self
- Demi Lovato - Self
- Don Cheadle - Self - Illustrious Guest
- Seth Meyers - Self - Illustrious Guest
- John Legend - Self - Illustrious Guest
- Nick Kroll - Self - Illustrious Guest
- J Balvin - Self
- Andra Day - Self
- Glenn Close - Self
- Kenan Thompson - Self
- Eddie Murphy - Self
- Phoebe Bridgers - Self
- Eddie Huang - Self
- Delroy Lindo - Self
- Ramy Youssef - Self
- Travis "Taco" Bennett - Self
- Kelly Rowland - Self
- Ludacris - Self
- Anthony Mackie - Self
- Zendaya - Self
- Whoopi Goldberg - Self
- Jazmine Sullivan - Self
- Freddie Gibbs - Self
- Travon Free - Self
- Julian Edelman - Self
- Taylour Paige - Self
- Yo-Yo Ma - Self
- Ziwe Fumudoh - Self
- Rashida Tlaib - Self
- Alexandria Ocasio-Cortez - Self
- Bobby Shmurda - Self
Glenn Close interpreta a Self en la serie.
Eddie Murphy hace el papel de Self.
Ethan Hawke interpreta a Self - Illustrious Guest en la serie.
Chris Rock interpreta a Self - Illustrious Guest en la serie.
Whoopi Goldberg interpreta a Self en la serie.
Don Cheadle hace el papel de Self - Illustrious Guest.
Desus Nice interpreta a Self - Host en la serie.
The Kid Mero interpreta a Self - Host en la serie.
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