- Dion Johnstone - Jordan Cole
- Brit MacRae - Jessica Hicks
- Peter Mensah - Levi
- Cihang Ma - Michelle
- Sasha Roiz - Pavel Bartok
- Rebecca Liddiard - Madelyn
- Tyler Elliot Burke - Arlo Shank
- Eric McCormack - Cole Banks
- Shazad Latif - Ali
- Pamela Estrada - Lily
- Tamara Duarte - Nadia
- Alexandre Bourgeois - AJ Malley
- Allan Hawco - Captain Donovan
- Claire Forlani - Janet
- Emilio Doorgasingh - Hassan Esmaili
- Kelly McCormack - Charlotte
- Etienne Kellici - Lucas
- Charlie Carrick - Richard Bright
- Wendy Crewson - Diana Bright
- Donal Logue - Sheriff McCullough
- A.J. Simmons - Jacob
- Evan Buliung - Derek
- Peter Outerbridge - Captain Stephen Littlefield
- Kristian Bruun - Hoffman
- Paris Jefferson - Gillian
- Dougray Scott - Ethan Moreau
- Patrick Garrow - Walter Mack
- Ben Carlson - Jack Bazin
- Dylan Taylor - Brad (uncredited)
- Dylan Taylor - Brad
- Greg Bryk - Tyler Brick
- Lauren Lee Smith - Linda Halley
- Cara Ricketts - Dr. Lopez
- Ted Atherton - Commander Foster
- Stuart Hughes - Surgeon
- Lisa Berry - Tabatha
- Lisa Berry - Alexis Johnson
- Tyler Fayose - Co-Pilot Arthur Delaney
- Chantelle Han - Su-Lin Donovan
- Ai Barrett - Lucy Donovan
- Ryan Pierce - Hugh Kelehar
- Christopher Leveaux - Bob Lear
- Chloe Farnworth - Flight Attendant Sims
- Wanda Ventham - Wendy
- Rachel Bles - Inna
- Rachel Bles - Inna (uncredited)
- Helen King - Radio Operator
- Greg Campbell - Supervisor
- Kathryn Davis - Counter Rep
- Martin Ballantyne - Taxi Driver (uncredited)
- Daniel Eghan - Passenger Flight 716 (uncredited)
- Mark Gooden - Passenger Flight 716 (uncredited)
- Nicholle Hembra - Elizabeth Rogers (uncredited)
- Alexander Crowther - Lieutenant Peter Valery
- Akbar Kurtha - Ariel Levitan
- Raoul Bhaneja - Dr. Mackay
- Mark Lutz - Gavin Malley
- Mark Lutz - Gavin Malley (uncredited)
- Ryan Allen - Detective Gibbons
- Oliver Ford Davies - Amis
- Emmanuel Kabongo - Orderly
- Jamaal Grant - Uniformed Officer
- Neven Pajkic - Airport Security Guy (uncredited)
- Jamila Wingett - Reporter
- Nick Harris - Police Officer
- Dmitry Chepovetsky - Stefon Tark
- Patricia McKenzie - Dr. Lee
- Ali Badshah - Paramedic
- Daniela Vlaskalic - Interviewer
- Thamela Mpumlwana - Owen Carter
- Lee Byford - Police Protection Officer (uncredited)
- Jay Nifaoui - Mossad Agent (uncredited)
- Jason O'Mara - Max O'Neill
- Jennifer Podemski - Gail
- Marcus Nance - Keith
- Danny Waugh - Parker
- Libby Osler - Amy
- Sabryn Rock - Vivian
- Florence Ordesh - Rose Tate
- Sara Farb - Beth
- Nicco Lorenzo Garcia - Immigration Officer
- Curtis Caravaggio - Phillip Hogan
- Lindsey Connell - Mary Mack
- Mark Sparks - Devon
- Karl Campbell - Marshal Jones
- Matthew Bennett - Detroit News Anchor
- Antonio Ortega - Tattooed Man
- Kerry-Lee Finkle - Barbara
- Jon De Leon - FBI Agent (uncredited)
- Jon De Leon - FBI Agent
- Diana Bentley - Sioghan
- Conrad Pla - Carlos Orega
- Rogue Johnston - FBI Agent
- Chris Young - Hitman
- Rodrigo Fernandez-Stoll - Father Emilio
- Jack Murray - Connor Tate
- Laurie Murdoch - Grandpa Miller
- Jake Weber - Captain Joe Turner
- Susan Coyne - Susan
- Paula Boudreau - Margery Shank
- Cindy Sampson - Francine Quigley
- Jaeden Noel - Tyler Lupinski
- Wesley French - 1st Mate Dave Sullivan
- Shailyn Pierre-Dixon - Jada Collins
- Steve O'Connell - Gregg Walsh
- Renee Hackett - Debra
- Romaine Waite - Ziggy Reynard
- Sarah Swire - Alexa
- Jennifer Gibson - Elizabeth
- James Acton - Shipyard Foreperson
- Yasmine Majchrzak - Officer
- Basel Daoud - Turkish Guard
- O.C. Ukeje - Agent Manning
- Sydney Ozerov-Meyer - Sophia Giles
- Felipe Rodriguez
- T.J. Scott
- Jackie May
- Spencer Levine
- Tina Grewal
- Vincent Shiao
- Julie Lacey
- Scott Garvie
- Karine Martin
- Kathleen Meek
- Keith Power
Christopher Plummer hace el papel de Howard Lawson.
Claire Forlani interpreta a Janet en la serie.
Jake Weber interpreta a Captain Joe Turner en la serie.
Akbar Kurtha interpreta a Ariel Levitan en la serie.
Greg Bryk interpreta a Tyler Brick en la serie.
Archie Panjabi interpreta a Kendra O'Malley en la serie.
Mark Rendall interpreta a Theo Barker en la serie.
Kristen Holden-Ried interpreta a Dom Hayes en la serie.
Patrick Sabongui hace el papel de Shakir Urgessa.
Savonna Spracklin hace el papel de Annie Sullivan.
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