- Dan Woods - Principal Daniel Raditch
- Justin Kelly - Jake Martin
- Paula Brancati - Jane Vaughn
- Dylan Everett - Campbell 'Cam' Saunders
- Raymond Ablack - Sav Bhandari
- Nina Dobrev - Mia Jones
- Spencer Van Wyck - Wesley Betenkamp
- Cassie Steele - Manny Santos
- Landon Liboiron - Declan Coyne
- Chloe Rose - Katie Matlin
- Pat Mastroianni - Joey Jeremiah
- Stacie Mistysyn - Caitlin Ryan
- Sarah Barrable-Tishauer - Liberty Van Zandt
- Daniel Clark - Sean Cameron
- Jake Goldsbie - Toby Isaacs
- Amanda Stepto - Christine Nelson
- Shenae Grimes-Beech - Darcy Edwards
- Melissa DiMarco - Principal Daphne Hatzilakos
- Mike Lobel - Jay Hogart
- Mazin Elsadig - Damien Hayes
- Stacey Farber - Ellie Nash
- Evan Williams - Kelly Ashoona
- Adamo Ruggiero - Marco Del Rossi
- Natty Zavitz - Bruce the Moose
- Scott Paterson - Johnny DiMarco
- Jajube Mandiela - Chantay Black
- Aislinn Paul - Clare Edwards
- Samantha Munro - Anya MacPherson
- Annie Clark - Fiona Coyne
- Argiris Karras - Riley Stavros
- Shannon Kook - Zane Park
- Jahmil French - Dave Turner
- Jordan Todosey - Adam Torres
- Daniel Kelly - Owen Milligan
- A.J. Saudin - Connor DeLaurier
- Sam Earle - K.C. Guthrie
- Shanice Banton - Marisol Lewis
- Demetrius Joyette - Michael 'Mike' Dallas
- Cristine Prosperi - Imogen Moreno
- Luke Bilyk - Drew Torres
- Jessica Tyler - Jenna Middleton
- Sarah Fisher - Rebecca 'Becky' Baker
- Ana Golja - Zoë Rivas
- Lyle Lettau - Tristan Milligan
- Munro Chambers - Eli Goldsworthy
- Alicia Dea Josipovic - Bianca DeSousa
- Melinda Shankar - Alli Bhandari
- Nikki Gould - Grace Cardinal
- Craig Arnold - Lucas 'Luke' Baker
- Cory Lee - Ms. Oh
- Stefan Brogren - Archie Simpson
- Amanda Arcuri - Lola Pacini
- Reiya Downs - Shay Powers
- Ricardo Hoyos - Zig Novak
- André Dae Kim - Winston Chu
- Spencer MacPherson - Hunter Hollingsworth
- Eric Osborne - Miles Hollingsworth III
- Olivia Scriven - Maya Matlin
- Sara Waisglass - Frankie Hollingsworth
- Richard Walters - Tiny Bell
- Jacob Neayem - Mohammed 'Mo' Mashkour
- Jake Epstein - Craig Manning
- Dalmar Abuzeid - Danny Van Zandt
- Melissa McIntyre - Ashley Kerwin
- Marc Donato - Derek Haig
- Deanna Casaluce - Alex Nuñez
- Alex Steele - Tori Santamaria
- Alex Steele - Angela Jeremiah
- Anthony Christian Potenza - Cashier
- Barbara Mamabolo - Older Girl at Party
- Marc Minardi - Lucas Valieri
- Sean O'Neill - Robson
- Keke Palmer - Keke Palmer
- Ruth Marshall - Helen Edwards
- Devon Bostick - Nic
- Genelle Williams - Carla Carlisle
- Nathan Stephenson - Griffin
- Von Flores - Mr. Joseph Santos
- Kate Todd - Natasha
- Natasha Bedingfield - Herself
- Jason Mewes - Jason Mewes
- Maria Vacratsis - Sheila
- Linlyn Lue - Ms. Laura Kwan
- Terra Vnesa - Trina
- Kit Weyman - Sulley
- John Bregar - Dylan Michalchuk
- Michael Kinney - Darryl Armstrong
- Katie Lai - Kendra Mason
- Al Mukaddam - Mohammed
- Alanis Morissette - Self
- Benjamin Hollingsworth - Devon
- Morgan Kelly - Skinny
- Philip Nozuka - Chester Hosoda
- Joe Pingue - Tony
- Hugh Dillon - Albert Manning
- Billy Ray Cyrus - Duke
- Kevin Smith - Kevin Smith
- Shirley Douglas - Professor Dunwoody
- Ephraim Ellis - Rick Murray
- Roger Dunn - Mr. Morton
- Anais Granofsky - Lucy
- Jennifer Podemski - Ms. Chantel Sauvé
- David Orth - Christopher
- Neil Hope - Derek 'Wheels' Wheeler (Uncredited)
- Elisa Moolecherry - Sydney
- Rebecca Haines - Kathleen Mead (Uncredited)
- Maria Ricossa - Kate Kerwin
- Don McKellar - Keith
- Siluck Saysanasy - Yick Yu (Uncredited)
- Mark Wilson - The Landlord
- Stephen Amell - Doorman
- Kyle Mac - Frat Guy #2
- Ishan Davé - Linus
- Devyn Nekoda - Arlene Takahashi
- Paul Popowich - Asher Shostak
- Meghan Heffern - Summer
- Brooke Johnson - Professeur Janes
- Graham Abbey - Glenn Martin
- Vanessa Morgan - Vanessa
- Jordan Chan - Lily
- Jonas Chernick - Mr. Betenkamp
- Riley Gilchrist - Dr. Christopoulos
- Peter Tufford Kennedy - Bullfrog Goldsworthy
- Paul Sun-Hyung Lee - Juan Tong
- Greta Onieogou - Sirina
- Christopher Jacot - Matt Oleander
- Athena Karkanis - Rachel
- Joanne Vannicola - Chef Kaz
- Ted Atherton - Randall Edwards
- Daniel Kash - Mr. Stavros
- Kevin Hanchard - Pest Control Manager
- Lara Jean Chorostecki - Molly
- Shauna MacDonald - Mrs. Novak
- Zoie Palmer - Officer
- Nigel Hamer - Toby's father
- Ho Chow - Policeman
- Sara Holmes - Alison
- Darrin Brown - Dwayne Myers (Uncredited)
- Michael Carry - Simon Dexter (Uncredited)
- Irene Courakos - Alexa Pappadopolos (Uncredited)
- Lisa Berry - Theatre Manager
- Melanie Scrofano - Meredith Fox
- Debra McGrath - NYU interviewer (as Deb McGrath)
- Sydney Ozerov-Meyer - Paula
- Janet Porter - Dr. Sandler
- Kyra Azzopardi - Trish
- Sarah Mennell - Detective Robbins
- Chris Anton - Sammy
- Zach Smadu - Randy
- Claire Rankin - Mrs. Jones
- Tamina Pollack-Paris - Lucy
- Judy Marshak - Grandma Baker
- Rene Lemieux - Grand-Père de Leo
- Andrew Priestman - Greg
- Nico Racicot - Andre
- Marc-Anthony Sarria - Oliver
- Anthony Gerbrandt - Fiona's Attacker
- Louis Paquette - Thief
- Jill Frappier - Grand-Mère de Leo
- Samantha Helt - Christie
- Karen Andrew - Liz
- Tynomi Banks - Drag Queen
- Shaun Shetty - Steve Patel
- Susanne Sutchy - Juliana Santoro
- Kate Lynch - Dr. Frank
- Samantha Brown - Heidi
- Lamar Johnson - Niner
- Jessica Clement - Naomi
- Kathryn Kriitmaa - Lieutenant Stedman
- Grisha Pasternak - Ron-Ron
- Maggie Cassella - Counsellor
- Amanda Joy - Kayla
- Tony Craig - Lawyer
- Brenda Kamino - Judge
- Karl Campbell - Bodyguard
- Elias Edraki - Anson
- Will Bowes - Thomas
- Ellora Patnaik - Nurse
- Greg Ellwand - Eamonn Grundy
- Jason Gosbee - Roman
- Shay Mitchell - Model
- Marcia Johnson - Dr. Yablonsky
- A.K. Shand - Katie
- Landon Norris - Aron DiMarco
- Tracy Shreve - Mrs. Turner
- Malcolm Xerxes - Dr. MacKay
- Barbara Radecki - Mrs. Saunders
- Rishma Malik Scott - Mrs. Ameena Hassan
- Krysta Carter - TV Star Lo
- Tangara Jones - Julie
- Indiana Jagait - Mr. Hassan
- Fraser Young - Lederhöser
- Kim Bourne - Carolyn
- Laura Miyata - Lindsay
- Ursula Campbell - Missy
- Brian Bisson - Stripper Chef
- Mishu Vellani - Mrs. Bhandari
- Marvin Ishmael - Mr. Bhandari
- Joy Tanner - Mrs. Laura Coyne
- Ramona Milano - Audra Torres
- Niamh Wilson - Jack Jones
- Steve Belford - Jesse Stefanovic
- Valerie Buhagiar - Mrs. Stavros
- Flossie McKnight - LoveQueen16
- Tyler Stentiford - Liam Berish
- Jayne Heitmeyer - Toni Stark
- Chaz Bono - Chaz
- Debra Felstead - Officer
Aislinn Paul interpreta a Clare Edwards en la serie.
A.J. Saudin hace el papel de Connor DeLaurier.
Demetrius Joyette hace el papel de Michael 'Mike' Dallas.
Cristine Prosperi hace el papel de Imogen Moreno.
Luke Bilyk interpreta a Drew Torres en la serie.
Sarah Fisher interpreta a Rebecca 'Becky' Baker en la serie.
Ana Golja interpreta a Zoë Rivas en la serie.
Lyle Lettau interpreta a Tristan Milligan en la serie.
Munro Chambers hace el papel de Eli Goldsworthy.
Melinda Shankar interpreta a Alli Bhandari en la serie.
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