- Michael Strong - Johnny Troy
- Frank Silvera - Andrew Garcia
- Philip Sterling - Sergeant Basilio
- Frank Maxwell - Detective Jergen
- Mason Adams - Bill Wendover
- George Mitchell - Torrino
- Robert McQueeney - O'Brien
- Eleanor Phelps - Miss Deene
- Martin E. Brooks - Larry Babson
- Suzanne Pleshette - Wendy Jenkins
- Lenka Peterson - Dorothy Boyer
- John Kellogg - Lieutenant Davis
- Colleen Dewhurst - Taffy Connor
- Al Lewis - Chi Chi
- Edith Atwater - Lily Flagler
- Betty Garde - Landlady
- Madeleine Sherwood - Mary Waleski
- William Hickey - Billy
- Leo Penn - Lt. Larry Hayes
- Jean Alexander - Gertrude Brewer
- Miriam Colon - Maria Tristeza
- Don Hastings - Dave Carter
- Mike Kellin - Harry Keenan
- Bernard Kates - Victor Bernard
- Peter Falk - Fred Dana
- Clifford David - Joe
- Irene Dailey - Millie Baker
- Joshua Shelley - Willie Graff
- Richard Davalos - Danny Dombrowsky
- Alfred Ryder - Lester Ringle
- Mel Ruick - Dr. Richmond
- Fred Sadoff - Paul Williams
- Martin Balsam - Nick Santos
- Frank Overton - Bergen
- Bill Quinn - Magraw
- Phyllis Newman - Joanne Kittredge
- Phyllis Newman - Elsa Kramer
- James Mitchell - Frank
- Barbara Barrie - Mrs. Foley
- Barbara Barrie - Anne
- Vincent Gardenia - Bull
- Bert Freed - Lieutenant Rosenberg
- Don Saroyan - Salesman
- Frank Sutton - The Phoner
- Frank Sutton - Hecky
- Albert Dekker - Otto Flagler
- Ludwig Donath - 'Knish' Levin
- Ludwig Donath - Fred
- Henry Beckman - Frank Bandiner
- Clifton James - Patrolman Raymond
- Chris Gampel - Lieutenant Rice
- Frank Marth - Lieutenant Crown
- David Bauer - Lieutenant Fletcher
- Joseph Campanella - Sergeant
- Bill Hayes - Gordon Troy
- Joseph Bernard - Detective Seidel
- Bruce Gordon - Lt. Andy Andrews
- Diane Ladd - Selma Richmond
- Norman Rose - Rico
- Lois Nettleton - Lois Bergen
- Lois Nettleton - Lois Gray
- Tomas Milian - Juan Ortega
- Joanne Linville - Molly Orchid
- Peggy Feury - Paula Shayne
- Louis Guss - Hotel Manager
- Louis Guss - Augie, Henchman
- Ruth McDevitt - Mrs. Graff
- Lilia Skala - Anna Dombrowsky
- Arthur Batanides - Herbert Carson
- Michael Tolan - Mike Bergen
- Richard Ward - Alex
- Kay Medford - Georgia
- Milton Selzer - 1st Officer Denning
- Zohra Lampert - Anne
- Zohra Lampert - Norma Hart
- Ed Asner - Sergeant
- Joe Silver - Bennie, Carnival Worker
- Simon Oakland - Lieutenant
- Simon Oakland - Sgt. Steve Necclo
- Larry Hagman - Kenneth Davidson
- Ray Reinhardt - Jack Wilson
- Leonard Stone - 2nd Cop
- Curt Conway - Ransome
- Curt Conway - Lt. Harding
- Thomas A. Carlin - John Osler
- John McLiam - Mike Foley
- Frank Campanella - Lieutenant Harris
- Frank Campanella - Lieutenant Torri
- Frank Campanella - Lieutenant Cella
- Mary Michael - Mrs. O'Connell
- Mary Michael - Mrs. Frost
- John McGovern - Mr. Whittaker
- Arch Johnson - Det. Sam Donovan
Peter Falk interpreta a Fred Dana en la serie.
Madeleine Sherwood hace el papel de Mary Waleski.
Miriam Colon interpreta a Maria Tristeza en la serie.
Leonard Stone interpreta a 2nd Cop en la serie.
Martin Balsam hace el papel de Nick Santos.
Richard Davalos interpreta a Danny Dombrowsky en la serie.
Albert Dekker interpreta a Otto Flagler en la serie.
Beverly Garland interpreta a Casey Jones en la serie.
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