- Alisha Newton - Isla Vandeberg
- Julia Benson - Mary Vandeberg
- Michael Eklund - Black Market Dealer
- Kendra Westwood - Dr. Sharon Bhandari
- Benjamin Goas - The Boy / Kieran
- June B. Wilde - Woman From Restaurant
- Amanda Marier - Amy Morrison
- Klarc Jerome Wilson - Maddox's Aide
- Scott Pocha - Wichita Cop
- Aaron Paul Stewart - Store Clerk
- Jaren Moore - Man at Gas Pump
- Andrei Kovski - Eastern European
- Amanda Wong - Front Desk Clerk
- Jayce Barreiro - Hotel Manager
- Yoshie Bancroft - Agent McGuire
- King Lau - Situation Team Agent
- Adam Abrams - Woman's Husband
- Nesta Chapman - Floating Woman #2
- David Alpay - Eric King
- Jeanie Cloutier - Agent Kazemi
- Tom Lim - Scientist Ortiz
- Kelly Metzger - Orbital Doctor
- J.P. Padda - Orbital Doctor
- Stephen Adekolu - Hazmat Agent #1
- Matthew MacCaull - Muntz
- Sarah Desjardins - Nicole Hegmann
- Christopher Shyer - Richard Hegmann
- Raf Rogers - Agent Huerta
- Leo Chiang - Special Ops Captain
- Donia Kash - Katie
- Corina Akeson - Orbital Doctor
- Miguel Castillo - Tech Keller
- Leana Yu - Jean Chen
- Saskia Wedding - Hazmat Agent #1
- Derek Kwan - Hazmat Agent #2
- AJ Crivello-Jones - Hazmat Agent #3
- Gus Khosrowkhani - Medical Examiner
- Greer Whillans - Shadowy Figure #1
- Kevin Li - Shadowy Figure #3
- Andres Soto - Efrain Muñoz
- Humberly González - Sofia
- Steve Bacic - Beck
- Kwesi Ameyaw - Agent Reed
- Calix Miguel - Arturo Muñoz
- Javier Lacroix - Farmer
- Hamza Fouad - M.E. John
- Montserrat Hernandez - Worker #2
- Sofia Hodsoni - Maria Muñoz
- Jay Zhang - Orbital Scientist
- Moon Hee Suk - Orbital Doctor
- Bret Correll - Scientist Taking Readings
- Christine Lee - Agent Mallory
- Donald Sales - Agent Mackie
- Adam Kirschner - Eickmann
- Isabel Birch - Young Dee Dee
- Amro Majzoub - Agent Melho
- Philip Prajoux - Man on the Bus
- Myrasol Martinez - Woman on the Bus
- Synthia Yusuf - Orbital Field Agent #1
- Johnson Phan - TAC Team Agent #1
- Rhys Williams - TAC Team Agent #3
- Leif Havdale - TAC Team Agent #4
- Matt Reimer - TAC Team Agent #6
- Gerald Paetz - Bus Driver
- Jared Payne - INFLUX Operative #1
- Jason Bell - INFLUX Operative #3
- Paloma Kwiatkowski - Clara Cox
- Siddhartha Minhas - Young Subash
- Daniel Bacon - Dr. Masakela
- Cardi Wong - Caspian Cole
- Devinder Dillon - Subash
- Saul Camargo - Jose Manza
- Adrian Petriw - Orbital Tech
- Tarun Keram - Kearn
- Eric Yue - Old Caspian Cole
- Alexandra Siouras - Maddox's Assistant
- Alexandra Siouras - Maddox's Assistanat
- Benjamin Hollingsworth - Luke Packard
- Evelyn Burke - Caroline Packard
- Kate Dion-Richard - Gloria Hernandez
- Dmitry Chepovetsky - Tarkolov
- Rowan Schlosberg - Holloway
- Todd Thomson - Harris Grohl
- Sean Poague - Bill Curtis
- Andy Canete - Sam Hernandez
- Jeremiah Oh - Agent Li
- Dalias Blake - Interrogation Agent #1
- Chris Webb - Interrogation Agent #2
- Lauro David Chartrand-DelValle - MP #1
- Jovan Nenadic - MP #2
- Gabrielle Ryan - Dee Dee Jones
- Anjali Jay - Priya Ferris
- Megan Danso - Young Woman
- Darren E. Scott - Agent Sha
- Charles Jarman - Agent Phelps
- Jorgito Vargas Jr. - Agent Gomez
- Nevin Burkholder - Worker
- Ian Ronningen - MI-6 Operative
- Darcy Hinds - Tech Man #2
- Tracey Roath - Tired Motel Clerk
- Phillip Mitchell - INFLUX Operative #4
- Nickolas Baric - INFLUX Operative #6
- Zak Santiago - Gary Garcia
- Brady Droulis - Steven
- Adrian Neblett - Vincent
- Jennifer Mawhinney - Maddox's Assistant
- Ryan Mah - Justin
- Paula Burrows - Cheryl
- Navid Charkhi - Jafar
- Anna Barker - Clare
- Carlo Yu - Alvin
- Aliyah O'Brien - Grace
- Keenan Tracey - Shelby
- Jess McLeod - Kathleen
- Garfield Wilson - Gibson
- Byron Noble - Niels
- Azriel Dalman - Mac
- Scott Nicholson - Stunt Driver #2
- Jeffery Aro - Stunt Driver #3
- Josh Blacker - Colonel Kellogg
- Max Montesi - Jensen
- Shaquan Lewis - Leblanc
- Kyal Scott - Nelson
- Mark Gash - Doctor Goldman
- Christopher Pearce - Agent Russell
- Ryo Hayashida - Kasuga
- Iris Paluly - Doctor #2
- Hunter Golden - Gas Station Clerk
- Daniel Jacobsen - Base Guard
- Ana Mahmoodi - Afghan Woman
- Eddie Canelea - Hazmat #1
- Renée Taylor - Hazmat #4
- Colby Chartrand - Taliban #2
- Sam Yunussov - Taliban #4
- Howie Lai - Agent Chin
- Erin Karpluk - Mariel Caldwell
- Evan Rein - Zimmer
- Zarina Sterling - Asalah
- Michelle Choi-Lee - April Han
- Thomas Cadrot - Agent Tom
- Kheon Clarke - Tech Kelso
- Amy McInnes - Doctor #2
- Leah Hennessey - Medic #1
- Brian McCaig - New Prison Guard
- J.J. Makaro - Stunt Medic #1
- Aaron Au - Stunt Medic #2
- Rob 'Sluggo' Boyce - Stunt Medic #3
- Andrea Stefancikova - Irina
- Ben Cotton - Loeb
- Jennifer Copping - Julia Maddox
- Sebastian Roché - Brill
- John Noble - Otto
- Jennifer Juniper Angeli - Linda
- Christian Rose - Dario Maddox
- Amanda McEwan - Woman
- Julian Black Antelope - Dahkeya Nakai
- Ron Wear - Man
- Ava Leemet - Another Woman
- Richard O'Sullivan - Particle Man
- Claire Friesen - Chess Board Person #1
- Phil Trasolini - Chess Board Person #5
- Fatuma Namatovu - Chess Board Person #7
- Tim Zhang - Chess Board Person #9
- Samantha Corbin-Miller
- Padraic McKinley
- Katie O'Hara
- John Papsidera
- Bonnie Benwick
- Corinne Clark
- J.H. Wyman
John Noble hace el papel de Otto.
Jonathan Tucker interpreta a Bryan Beneventi en la serie.
Riann Steele interpreta a Finola Jones en la serie.
Norbert Leo Butz interpreta a Craig Maddox en la serie.
Scroobius Pip hace el papel de Anson Ash.
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