- Paul Eiding - Emcee
- Jennifer Runyon - Karen
- Lynne Thigpen - Sarah Donnelly
- Betsy Randle - Fay
- William Sadler - Ken
- Lee Weaver - Snookie Reams
- Michael E. Knight - Freddy
- Henry Holden - Patient
- Richard Portnow - Harry
- Cristine Rose - Gloria
- Brent Jennings - Frank
- Daniel Zacapa - Brian
- Stan Rodarte - Support Group Member
- Carlene Watkins - Wendy
- Ben Savage - Matthew Lacey
- Sam McMurray - Mike
- Jennifer Bassey - Eleanor Guthrie
- Bob Snead - Steven Guthrie
- Catherine MacNeal - The Party Guest
- Lee Arenberg - Caroler
- Dakin Matthews - David Hennessey
- Dakin Matthews - David
- Sylvia Sidney - Mrs. Lumenski
- William Glover - Father Gorman
- Angela Paton - Mother Superior
- Trevor Eve - Ricky Fortune
- Freddie Garrity - Freddie Garrity
- Mary Anne Schafer - Helen
- Keone Young - Mr. Yoshimura
- Patricia Ayame Thomson - Sashiko
- Yuri Ogawa - Mrs. Yoshimura
- Cleavon Little - Tony Larkin
- Doug Carfrae - The Waiter
- Woody Harrelson - Richard
- Gerrit Graham - Gary
- Nancy Lane - Carol
- Gwen Verdon - Yvonne
- Barbara Rhoades - Marie
- Elizabeth Maclellan - Barbara
- Wendy Schaal - Lisa
- Tiiu Leek - The Anchorwoman
- Larry McCormick - The Reporter
- Annie Golden - Sylvia
- Shannon Tweed - Margo
- Morgan Brittany - Liz
- Nancy Linari - Dr. Osbourne
- Elizabeth Savage - Wanda
- Pat Crawford Brown - Kirk's Mom
- Mark Arnott - Ray
- Alan Blumenfeld - Joe
- Miriam Flynn - Penny
- Peter Jurasik - Brad
- Lee Wilkof - Roy
- Kevin Michael Doyle - Stan
- Susan Kellermann - Blomlika
- Jan Hooks - Suzanne
- Mary Carver - Mom
- John Lavachielli - Orlando
- Oliver Clark - Arthur Prescott
- Rod McCary - T. Pat Conner
- Mary Pat Gleason - Secretary
- Clive Revill - Louise's Dad
- Jenny Agutter - Sarah
- Lila Kaye - Audrey
- Tony Mandarich - Rudy
- Stephen Elliott - Phil Lacey
- Elizabeth Franz - Emma
- Janice Lynde - Dr. Davenport
- Ellen Ratner - Molly
- Cu Ba Nguyen - Chow Ling
- Jeffrey DeMunn - Neil Cramer
- Jeff Garlin - Deliveryman
- Jeanette Nolan - Clara
- George Petrie - Lester
- Paul Barselou - Lloyd
- Nedra Volz - Dotty
- Jane Daly - Gail
- Juliet Sorci - Melissa
- Timothy Jones - Waiter
- Gordon Clapp - Dave Travis
- Lisa Aliff - Ski Bunny
- Patrick Collins - Lionel
- Murphy Cross - Female Piano Player
- Denise Gallup - Twin Girlfriend
- Dian Gallup - Twin Girlfriend
- Victoria Haas - Nun
- Ruben Santiago-Hudson - Orlando
- Ruben Santiago-Hudson - Curtis
- Ruben Santiago-Hudson - Larry
- Kay Perry - Woman
- Jeff Lester - Cliff
- Matt Landers - Father
- Nick Rutherford - Joey
- Wayne Federman - Paul
- Zane Lasky - Sheldon
- Raye Birk - Dr. Hendricks
- Michele Pawk - Barbara Denison
- Pat Reilly - Stretch Hendricks
- Adam Carl - Mladen
- Gino De Mauro - Bobby Meyer
- Nancy Lenehan - Mrs. Williams
- Perry Anzilotti - Mr. Babyface
- Alex Zuckerman - Jason
- Nicky Katt - Amorous Male Student
- Mike Hagerty - Al
- Donald Gibb - Frenchie
- Bill Henderson - Pete
- Don Frankel - Arnie
- Gina Belafonte - Sudha
- Jennifer Flackett - Smoke-Ender
- David Pasquesi - Smoke-Ender
- Gwendolyn Shepherd - Smoke-Ender
- Tony Hayes - Smoke-Ender
- Judd Trichter - Danny
- Valorie Armstrong - Blair
- Cliff Norton - Pilot
- Kenny McMurphy - Clerk
- Eda Reiss Merin - Mrs. Spencer
- Eda Reiss Merin - Patient
- Deborah Harmon - Wendy Lacey
- Billy Corben - Matthew Lacey
- Patty Toy - Young Mother
- Nita Whitaker - Female Officer
- Nathan Jung - Husband
- Gracie Harrison - Erin
- Kevin Dunn - Bob Morris
- Ele Keats - Sandy
- Ele Keats - Amorous Female Student
- Brynn Thayer - Terry
- Patrick Puccinelli - Officer Biggs
- Patrick Puccinelli - Dave
- Patrick Puccinelli - Policeman
- Patrick Puccinelli - Male Officer
- Bo Sharon - Boy
- Doug Sheehan - Jason Fowler
- John O'Leary - Minister
- Kyle Scott Jackson - Desk Sergeant
- Richard Blum - The Bartender
- Richard Blum - Harry The Waiter
- Richard Blum - Barman
- Richard Blum - Man
- Richard Blum - Bailiff
- Sab Shimono - Charlie Moura
- Milton James - Cab Driver
- Megan McGinnis - Girl
- Sandra Wild - Lorraine
- Tim Haldeman - Tim
- Tim Haldeman - Husband
- Corbin Bernsen - Blake McCarron
- Helen Page Camp - Aunt Trudy
- Leslie Bevis - Jessica Stone
- Paige Pengra - Jessica at 17 & 22
- Erika Flores - Jessica at 12
- Ed Evanko - Mr. Beasley
- Jason Strickland - Jimmy
- Lori A. Fox - Nurse
- Jodie Mann - Patron
- Robin Greer - Woman
- Robin Greer - Robin
- Olivia Brown - Denise
- Kathryn Danielle - Stacy
- Nina Foch - Mrs. Lacey
- John Ingle - Senator
- John Ingle - Judge Bradford
- Miguel A. Núñez Jr. - Henry
- Meg Wyllie - Millie Hanson
- Peter Smith - Young John Lacey
- Peter Smith - John at 17 & 22
- Robin Strasser - Brooke Collins
- Larry Spinak - Male Student
- Patrick Day - Male Student
- Megan Mullally - Molly
- Lorenzo Lamas - Alejandro Braceros
- Grace Albertson - Prim Woman
- Grace Albertson - Mourner
- Mindy Seeger - Jackie
- Laura Julian - Receptionist
- Robin Cahall - Patient
- Delane Matthews - Dr. Janet Benjamin
- Lane Davies - Walter Harrison
- Glen Mauro - Danny
- Jack Manning - Funeral Director
- Jack Manning - Minister
- Gary Mauro - Donny
- Lela Ivey - Betsy
- William Boyett - Officer
- Christine Cattell - Jennifer
- Christine Cattell - Alexis
- Clyde Kusatsu - Officer
- George Hearn - Frank Hollander
- Irina Davidoff - Natasha
- Mihaly 'Michu' Meszaros - Mishka
- Chambers Stevens - Fraternity Member
- Alice Hirson - Mrs. Morris
- Dan Gilvezan - Pete
- John David Conti - Leo
- Elizabeth Morehead - Donna
- Marlene Mancini - Florence Kellem
- Marlene Mancini - Secretary
- Melissa Berger - Wife
- Kate McNeil - Carol
- Lisa Long - Woman
- Lisa Long - Mourner
- Gregory Salata - Mitch
- Elsa Raven - Barbara Olafson
- Nicholas Cascone - Robber
- Tim Jones - Calvin
- Tim Jones - Waiter
- Wayne Tippit - Everett Sutton
- Diana Barrows - Tina
- Marietta DePrima - Annie
- Anita Barone - Connie
- Jerome Courtland - Frank
- Tristan Tait - Kenny
- Kevin Scannell - Rocco
- Peter Iacangelo - Mort
- Mario Machado - Male Newscaster
- Dale Harimoto - Female Newscaster
- Stephanie Blake - Ramona
- Van Epperson - Robber
- John Carter - Judge Humphrey
- Micah Rowe - Kid
- Arthur Reggie III - Kid
- Cherie Michan - Heather
- Heather Elizabeth Parkhurst - Nancy
- Heather Elizabeth Parkhurst - Cindy
- Cleto Augusto - Max
- Ned Eisenberg - C.J.
- Nick Tate - Brian Courtney
- Diana Castle - Felicia Courtney
- Cliff Bemis - Marvin
- Kristen Cloke - Annette
- Suzanne LaRusch - Nurse
- Sharon Conley - Woman
- David Pressman - Larry
- David Pressman - Robb
- Donald Grant - Matt
- John Calvin - Richard
- Martin Cassidy - Man
- Bonnie Pemberton - Reporter
- Peter Jason - Bill Conners
- Kristine Blackburn - Sarah
- Michael McManus - Bruce
- Jeremy Stevens - Dick
- Melora Walters - Maria
- Harold Gould - William Shakespeare
- Deborah Shelton - John's Fantasy Woman
- Scott Bryce - Mary Beth's Fantasy Man
- Dale Gonyea - Piano Player
- Karl David-Djerf - Young Kirk
- Marisa Theodore - Jenny
- Elayne Boosler - Joanne
- Ed. Weinberger
Angela Paton interpreta a Mother Superior en la serie.
Sylvia Sidney hace el papel de Mrs. Lumenski.
Stephen Elliott interpreta a Phil Lacey en la serie.
Patrick Collins interpreta a Lionel en la serie.
Melora Walters interpreta a Maria en la serie.
Richard Portnow hace el papel de Harry.
Lee Arenberg hace el papel de Caroler.
Lee Weaver interpreta a Snookie Reams en la serie.
Clyde Kusatsu interpreta a Officer en la serie.
Judd Hirsch hace el papel de John Lacey.
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