- Katy Mixon - April Buchanon
- Katy Mixon - April Buchanon (voice)
- Rhoda Griffis - The Teacher
- Raiko Bowman - Woman On Boardwalk
- Chandler Massey - Pliny Caldwell
- Simon Rhee - Sensei
- Marlene Forte - Soledad
- Joaquín Cosío - Hector
- Jody Hill - Andrew, Pat Anderson's Sponsor
- Deep Roy - Aaron
- Eddie 'Piolin' Sotelo - Announcer
- Efren Ramirez - Catuey
- Marco Rodríguez - Roger Hernandez
- Michael Peña - Mr. Cisneros
- Joe Buck - Joe Buck
- Gina Gershon - Realtor
- Adam Scott - Pat Anderson
- Sylvia Jefferies - Tracy
- Shannon Eubanks - Donna Schaeffer
- Jill Jane Clements - Shane's Mom
- Megan Hayes - Gloria
- Tim Ware - Shane's Dad
- Alisa Harris - Brenda
- Robin Mullins - Bobbi
- Craig Robinson - Reg Mackworthy
- Will Ferrell - Ashley Schaeffer
- Jason Sudeikis - Shane Gerald
- Jason Sudeikis - Cole Gerald
- Jason Sudeikis - Shane Gerald / Cole Gerald
- Don Johnson - Eduardo Sanchez
- Erick Chavarria - Casper
- Matthew McConaughey - Roy McDaniel
- Seth Rogen - Texas Pitcher
- Alex ter Avest - Andrea
- Amber Wallace - Kate
- John Cothran - Baseball Coach
- Diva Tyler - Mamie
- Justin Miles - Jacques
- Lily Tomlin - Tammy Powers
- Cat Cora - Self
- Marilyn Manson - Roller Rink Server
- Jerry Minor - Jamie Laing
- Michael Beasley - Jimmy Clay
- Jillian Bell - Dixie
- Samantha Beaulieu - Candy Cox
- Sacha Baron Cohen - Ronnie Thelman
- Bo Mitchell - Wayne
- Elizabeth De Razzo - Maria
- Ethan Alexander McGee - Dustin Jr.
- Omar J. Dorsey - Dontel Benjamin
- Tim Heidecker - Gene
- Ken Marino - Guy Young
- Jon Reep - Jed Forney
- Mariano Mendoza - Rodney 'Hammer' Garcia
- Alexander Skarsgård - Adult Toby Powers
- Lindsay Lohan - Adult Shayna Powers
- Collette Wolfe - Home Buyer
- Chris Henchy
- Will Ferrell
- Danny McBride
- Adam McKay
- Jody Hill
Deep Roy interpreta a Aaron en la serie.
Danny McBride interpreta a Kenny Powers en la serie.
Michael Peña interpreta a Mr. Cisneros en la serie.
Steve Little hace el papel de Stevie Janowski.
Katy Mixon interpreta a April Buchanon en la serie.
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