- Kirsten Alter - Commodore Tarvas
- Karl Ang - Hiro
- James Binkley - Rebel #2
- Robin Brûlé - Mother
- George Chiang - Sergeant of the Guards
- Christopher Dyson - Cell Commander
- Ish Morris - Rebel #1
- Gage Munroe - TJ
- Moti Yona - Caleb
- Russell Yuen - Akita
- Natalie Brown - Sarah
- Ruby Rose - Wendy
- Andrew Jackson - The General
- Dan Jeannotte - Derrick Moss
- Jeff Teravainen - Lieutenant Anders
- Jessica Huras - Catherine Moss
- Natalia Payne - Transfer Tech
- Bridget Wareham - Tech Shop Owner
- Jennifer Mote - Callie
- Wil Wheaton - Alexander Rook
- David Hewlett - Talbor Calchek
- Torri Higginson - Commander Truffault
- Michael Boisvert - Ferrous Officer
- James Gilbert - Commander Tarkanian
- Julien Hyacinthe - Sergeant Morse
- Paolo Mancini - Arn
- Ali Milner - Anya
- Sean Cullen - Professor Brophey
- Brendan Murray - Victor
- David Richmond-Peck - Commander Nieman
- Eugene A. Clark - Sheriff Vargas
- Tomaso Sanelli - Jake
- Peter DaCunha - Ethan
- Adrianna Di Liello - Madison
- Jim Annan - Miles Connor
- Katie Griffin - Debra Connor
- Laura Cilevitz - Guest #1
- Christine Cleary - Law Inforcement Officer #1
- Paul Rutledge - Law Inforcement Officer #2
- Nicolas Van Burek - Law Inforcement Officer #4
- Stephanie Belding - Quill
- Keethan Krish - Ishida Officer
- Ian Matthews - Wren
- Rhys Wyn Trenhaile - Colonel Strom
- Dylan Trowbridge - Corvik
- Genelle Williams - Wife of Kal Varrik (Six)
- Brian Hamman - Kumal
- Amos Crawley - Marak
- Andrew Moodie - Teku Fonsei
- Ayisha Issa - Solara Shockley
- Mishka Thébaud - Adrian Maro
- Amber Goldfarb - Drea
- Ennis Esmer - Wexler
- Jessica Sipos - Tash
- Amy Matysio - Lieutenant Vara
- Michael Rhoades - Giedon
- Michael Dufays - Sergeant Halsek
- David Collins - General Ueda
- Moses Nyarko - Ishida Cruiser Soldier #1
- Alexander Mandra - Ishida Cruiser Soldier #2
- Adrian Persad - Ishida Cruiser Soldier #3
- Cosette Derome - Ishida Cruiser Soldier #5
- Louis Paquette - Ishida Cruiser Soldier #6
- Andrew Priestman - Ishida Cruiser Soldier #7
- Ellen Wong - Misaki Han-Shireikan
- Michael Bisping - Goren
- Anna Hopkins - Ambrosia
- Sean Bell - Nemec
- Daniel Fanaberia - Ellis
- Michael Ayres - Security Android
- Wei Jen Lee - Ishida Female Cadet
- Michael Reventar - Ash
- Blair Williams - Mysterious Man
- Thomas Mitchell - Zem
- Rachael Ancheril - Della
- Dennis Andres - Turrence
- Mac Fyfe - Captain Darrow
- Gordon Hecht - Corporal Hendricks
- Steve Gagne - Traugott Garrison Guard #2
- Cam Fergus - Traugott Garrison Guard #3
- Paul Sun-Hyung Lee - Dr. Borsin
- Jean Yoon - Dr. Hajek
- Aldrin Bundoc - Ryo's Aide
- Richard Fitzpatrick - Baines
- Kiana Madeira - Lyra
- Anita Nittoly - Research Station Guard #1
- Dillon Jagersky - Research Station Guard #2
- Nick Stead - Research Station Guard #3
- Hiro Kanagawa - Emperor Ishida Tetsuda
- Regan Moore - Prisoner Instigator #1
- Miguel Anthony - Bruno
- Megan Murphy - Deputy Inman
- Simu Liu - Technician
- Ross Hull - News Anchor
- Nigel Bennett - Larcan Tanner
- Daniel Kash - Casino Boss
- Rob Stewart - Nassan
- Marty Adams - Elliott
- Billy MacLellan - Temal Danker
- Amanda Brugel - Keeley
- Inga Cadranel - Alicia Reynaud
- Daniel Fathers - Hansmeed
- Kristen Holden-Ried - Galactic Authority Inspector Kierken
- Joseph Mallozzi
- Paul Mullie
- Jay Firestone
Wil Wheaton interpreta a Alexander Rook en la serie.
Melissa O'Neil hace el papel de Two.
Anthony Lemke hace el papel de Three.
Alex Mallari Jr. hace el papel de Four.
Jodelle Ferland hace el papel de Five.
Roger Cross hace el papel de Six.
Zoie Palmer interpreta a The Android en la serie.
Capítulo disponible en las siguientes plataformas:
