- Richard Gunn - Calvin Theodore
- Jennifer Blanc - Kendra Maibaum
- Jensen Ackles - Alec McDowell
- Jensen Ackles - Ben
- Kevin Durand - Joshua
- Kevin Durand - Isaac
- Lawrence Pressman - Uncle Jonas Cale
- Abraham Benrubi - Break
- Stephen Lee - Dan Vogelsang
- Kim Hawthorne - Jacinda Katsuno
- Stanley Kamel - Edgar Sonrisa
- Kristin Bauer - Lydia Meyerson
- Paul Popowich - Darren McKennon
- Sebastian Spence - Charles Smith
- Douglas O'Keeffe - Bruno Anselmo
- Sarah-Jane Redmond - Lauren Braganza
- Lauren Lee Smith - Natalie
- Kyley Statham - Young Jondy
- Hiro Kanagawa - Theo
- Alessandro Juliani - Druid
- Eileen Pedde - Hannah
- Taylor Reid - Sophy
- Garry Chalk - Lt. Walter Eastep
- Fulvio Cecere - Sandoval
- Alexander Pervakov - Steroid Case Guard
- Kate Luyben - Blonde at Party
- Steve Makaj - Lead Thug
- Branden Williams - Eric
- Zinaid Memišević - Captain
- Emily Tennant - Language Student 1
- Brittany Moldowan - Language Student 2
- Christopher Attadia - Language Student 3
- Byron Mann - Det. Matt Sung
- A.C. Peterson - Warden Terrence Leeson
- Christine Chatelain - Max's Young Mother
- Michelle Goh - Michiko
- Kristie Marsden - Lucy
- John Sampson - Thug 1
- Derek Morrison - Thug 2
- Suleka Mathew - News Reporter
- Suleka Mathew - Reporter
- Colin Foo - Proprietor
- Jasmin Dring - Proprietor's Wife
- Richard Lett - Fence
- Andy Rukes - Orderly
- Michael Eklund - Officer Miller
- Reese McBeth - Young Man From Cell
- Peter Grasso - Guard
- Tony Perez - Nathan Herrero
- Lisa Rodríguez - Alina Herrero
- Murray Lowry - Drunk
- Duane Dickinson - Guard 2
- Bruce Pinard - Guard 3
- Brenda James - Valerie Cale
- Gavin Buhr - Henry
- Rodney Rowland - Mitch - Valerie's Husband
- Emy Aneke - Waiter
- Emy Aneke - Watch Captain
- Ralph Alderman - Impound Clerk
- Alex Green - Security Guard
- Nicole G. Leier - Phone Girl 1
- Warren Takeuchi - Coroner
- Taayla Markell - Mercy Chang
- Ron Blecker - TAC Leader
- Ron Blecker - Drill Sergeant
- Ron Blecker - Drill Instructor
- Ron Blecker - TAC Officer
- George Cheung - Dr. Tanaka
- Mark Houghton - Captain Exter
- Troy Ruptash - Jon Darius
- Mike Weinberg - Jude Thatcher
- Shannon Powell - Terrorist (Waitress)
- Wren Roberts - Terrorist 1
- Nicole Bilderback - Brin / X5-734
- Robert Gossett - James McGinnis
- John Dennis Johnston - Maj. Jake Sanders
- Harsh Nayyar - Mr. Sivapathasindaram
- Rick Dobran - Julio
- Gustavo Febres - Fico
- Chris Duggan - Brig Guard 2
- Joey Aresco - Captain Dale Swanstrom
- Brian Markinson - Dr. Sam Carr
- P.J. Johal - Technician
- D. Neil Mark - Checkpoint Cop 2
- Marcus Sim - Teenager 1
- Aaron Joseph - Teenager 2
- Scantone Jones - Cop
- Donny Lucas - Paramedic
- Rob Freeman - Sergeant
- Rob Freeman - TAC OP Kalins
- Rob Freeman - TAC Officer 1
- Rob Freeman - Lieutenant
- Lucia Walters - Nurse
- James Kidnie - Gerhardt Bronck
- Mack 10 - Tacoma Bleed
- José Vargas - Jorge
- Link Baker - Sven
- Thomas Hunt - D'Nardis
- Jim Shield - Bronck Goon
- Bethoe Shirkoff - Mrs. Moreno
- Patrick Kilpatrick - Red Five
- Alex Zahara - Johanssen
- Mark Gibbon - Red Six
- Kendall Saunders - Brittannica
- Peter Scoular - Bellman
- Jodelle Ferland - Annabelle
- Nancy Sivak - Mary Jo
- Catherine Lough Haggquist - News Anchor
- Catherine Lough Haggquist - Reporter
- Judith Maxie - Jeanne Breitel
- Dennis P. Kelli - Marshal Lionel Parsons
- Brett Le Bourveau - Cop 2
- Michael Benyaer - Onion Runyon
- Susan Hogan - Aunt Margo
- Samantha Smith - Daphne
- Bridget O'Sullivan - Matronly Woman
- Bob Wilde - Inspector
- Bob Wilde - Silhouetted Figure
- Michael Teigen - Bennett
- David Abbott - Minister
- Tyler Labine - Messenger #2
- Tyler Labine - Cyril
- Harry Rob Bruner - Angelo Biondello
- Gillian Carfra - Woman
- Michael-Ann Connor - Woman At Boarding House
- Carolyne Maraghi - Tia
- Taras Kostyuk - Red Seven
- James Tsai - Neighbor
- Julia Arkos - Tammy
- Rob LaBelle - Manticore Doctor
- Dean Aylesworth - Gas Station Attendant
- Chris Gauthier - Mechanic
- Brenda Bakke - Dr. Adriana Vertes
- Ashley Crow - Trudy
- Scott Heindl - Thug #2
- Scott Heindl - Jack
- Mark Rolston - Herman Colberg
- Kurt Max Runte - Clyde
- Ian Tracey - B.C.
- Salvator Xuereb - Dean
- James Ashcroft - Deputy Hallahan
- Daniel Boileau - Benny
- Alex Carter - Sidney Croal - Synthedyne CEO
- Tangelia Rouse - Diamond Latrell
- Winnie Hung - Maid
- Darrell Lee-Izeard - Bodyguard
- Dee Jay Jackson - Lamar
- Dee Jay Jackson - Gordie
- Robert Floyd - Father Destry
- Jason Diablo - Mr. Scott
- Antonio Cupo - Valet
- Antonio Cupo - Male X5
- Nana Visitor - Elizabeth Renfro
- James Kirk - Young Ben
- Jenn Forgie - Clerk at Coroner's Office
- Glenn Ennis - TAC Officer
- Glenn Ennis - TAC Officer 3
- Colin Lawrence - TAC Officer 2
- Colin Lawrence - TAC OP O'Neill
- Glen Gould - Prisoner
- G. Michael Gray - Dieter
- G. Michael Gray - Traidy
- Rainn Wilson - Phil
- Kevin McNulty - Gil
- Dexter Bell - Snuffy
- Jaren Brandt Bartlett - Kid
- Troy Turi - Thug
- Keith Dallas - O.G.
- Matthew Brevner - Baseball Kid
- Carson - Guy on the Cross
- Lorena Gale - Teacher
- Steve Bacic - Soldier 2
- Kris Pope - Rafer
- Nicki Aycox - Syl
- Brad Loree - Young Soldier
- Brad Loree - Sector Cop 1
- Sean Campbell - Special OP 1
- Daniel Bacon - Silo Technician
- Daniel Bacon - Technician
- Daniel Bacon - Control Room Tech 1
- Michasha Armstrong - Tuck
- Michasha Armstrong - Bodyguard 1
- Yee Jee Tso - Lanky Messenger
- Martin Budny - Tracking Van Tech
- Angela Moore - Nurse Betty
- Angela Moore - Female Beat Cop
- Greg Kean - Male Doctor
- Veena Sood - Female Doctor
- Jamie Bell - Zero
- Brian Drummond - TAC Officer 1
- Brian Drummond - Special OP 2
- Nicki Clyne - Fixit
- Sarah Jane Morris - Ralph
- Grace Park - Female Breeding X5
- Jesse Moss - X6 / Bullett
- Jennifer Jasey - Shelly
- Kevin Conway - Operative at Warehouse
- Chris Kramer - Mike
- Kaare Anderson - Cop 1 (Thug)
- Kaare Anderson - Sector Cop 2
- Colin Cunningham - Transhuman (DAC)
- Adam Henderson - Manticore Doctor
- Craig Veroni - Otto
- Craig Veroni - Airport Security Guard
- Craig Veroni - Soldier 1
- Alana Husband - Female X6
- Andrew Francis - Male X6
- Steve Archer - Tech
- Lisa Calder - Flo
- Claude Duhamel - Clerk
- Josh Byer - Gate Soldier
- Josh Byer - Zed
- Cameron McDonald - Cop
- Connor Widdows - Bugler
- Norman Armour - A Young Sandeman
- Norman Armour - Sleazy Clerk
- Janet Wright - Annie
- Rob deLeeuw - Man
- Rob deLeeuw - Supervisor
- Shawn Stewart - Bloody Fighter 1
- Ken Kirzinger - Bloody Fighter 2
- Michael Sunczyk - Rafe
- Michael Sunczyk - Pick Up Truck Driver
- Leanne Adachi - Computer Tech
- John DeSantis - The Mangler (Miller)
- Dalias Blake - Military Tech
- Brendan Beiser - Blue Collar Husband
- Jane Sowerby - Blue Collar Wife
- John Hainsworth - Skinny Homeless Guy
- Kimani Ray Smith - Bearded Homeless Guy
- Ron Selmour - Brig Guard 1
- Ron Selmour - Dan
- Angela Uyeda - Cop 2
- Oscar Goncalves - Sector Cop 1
- Oscar Goncalves - Sector Cop 3
- John Callander - Prisoner
- John Callander - Motel Clerk
- Ryan DeBoer - X6-252
- Michael David Simms - Police Captain
- Stephen Aberle - Professor Long
- Russell Ferrier - Desk Cop
- Russell Ferrier - Sonny
- Shaker Paleja - Trooper
- Greg Chan - Vendor 2
- Rick Tae - Proprietor
- Zen Lim - Young Chinese
- Raugi Yu - Ticket Taker
- Donald Fong - Dead Chinese 1
- Laara Ong - Dead Chinese 2
- Winston Brown - Bartender
- Darcy Laurie - Dix
- Darcy Laurie - KK
- Darcy Laurie - Ike
- Paul Becker - Male X-5
- Sarah Carter - Katarina
- Lance Gibson - Half Dead
- Lance Gibson - Man on the Street #3
- Todd Stashwick - Sally
- Emily Holmes - Wendy Olsen
- Emily Holmes - Saleswoman
- Emily Holmes - Wendy White
- Travis MacDonald - Bum
- Jillian Marie Hubert - Trina
- Deanne Henry - Serena (Rafer's Mom)
- Leslie Jones - Waitress
- Bobby Stewart - Checkpoint Cop 1
- Bobby Stewart - Sector Cop 1
- Bobby Stewart - Bald Cop
- Jana Ritter - Asha Look-A-Like
- Jaron Albertin - Logan Look-A-Like
- Darren Moore - Man on the Street
- Darren Moore - AA Man
- Darren Moore - Nomlie in Cell
- Darren Moore - Bystander
- French Tickner - Father McAllister
- John Cassini - Blond Cop
- John Mann - British Eddy
- Ryan Robbins - Arnie Haas
- Ryan Robbins - Arnie Haas (uncredited)
- Ian Marsh - Drill Sergeant
- Ian Marsh - Doorman 1
- David Parker - Officer Pearson
- Stephania Ciccone - Mrs. Le Pera
- Mike Dopud - Cop 3
- Garfield Wilson - Gun Happy Cop
- Patrick Gallagher - Hispanic Cop
- Seth Ranaweera - Shashi
- Fred Keating - Buddy Thompson
- Sonya Salomaa - Lux
- Anita Brown - Gill Girl
- Jesse Hutch - Gill Guy
- Jessica Amlee - Brittany
- Kendall Cross - Bitsy
- Darryl Quon - Bouncer
- Claudette Roche - Rita
- Michael Bower - Brain
- Terry Chen - S1W Member
- Noel Callahan - Vid Kid
- Mark Lukyn - Operative 1
- Mark Lukyn - White's Guy
- Mark Lukyn - Tech
- Mark Lukyn - Lieutenant
- Michael Kopsa - Robert Berrisford
- Meghan Ory - Rachel Berrisford
- Simon Longmore - Arcade Cop
- Eric Breker - Agent 1
- Tiffany Lyndall-Knight - TV Commercial
- Micah Gardener - Simon Lehane
- Darren E. Scott - SWAT Guy 2
- Suzanne Ristic - Maid
- Scott Bellis - Lab Tech
- Tony Alcantar - Irving
- Enuka Okuma - Dr. Colleen Harrington
- Sarah Strange - Elizabeth Blanchard
- Peter Williams - Hal
- Jerry Wasserman - Dr. George
- Fiona Hogan - Muriel
- Sarah Cole Burnett - Emma
- Alexander Farquharson - Boy at Gas Line-up
- Ryan Drescher - Tim
- Ben Cotton - Biker at Gas Line-up
- Sharon Heath - Nurse
- Fred Ewanuick - Luke
- Fred Ewanuick - Bird
- Brian Jensen - Mole
- Brian Jensen - Cop at Venue
- Alanis Peart - Second Nurse
- Kwesi Ameyaw - Lab Tech
- Laara Sadiq - Attending Nurse
- Rekha Sharma - Dr. Beverly Shankar
- Rekha Sharma - Beverly Hing (Coroner)
- Ari Solomon - CDC Tech
- Keegan Connor Tracy - Rain
- Sam Witwer - Marrow
- Matthew Currie Holmes - Push
- Donavon Stinson - Bill (Channel 3 News)
- Camille Sullivan - Lida
- Dagmar Midcap - Reporter
- Dagmar Midcap - Newswoman
- Dagmar Midcap - Newscaster
- Birkett Turton - Jonathan
- Juliet Dunn - Desk Nurse
- Carolyn Tweedle - Cat Woman
- Sean Amsing - Wallace
- Miles Meadows - Rollins
- Zak Santiago - Kurt
- Frankie J. Allison - Shakes
- Eliza Norbury - Janis
- Missy Peregrym - Hottie Blood
- David Gianopoulos - Tony Rinaldi
- Simon Burnett - Phalanx Warrior
- Simon Burnett - Purebred 1
- Christopher Gordon - Purebred 2
- Christopher Gordon - Phalanx Warrior
- Tracy Ryan - Mia
- Callum Keith Rennie - Sheriff Lamar
- Laurie Brunetti - Dougie Colantonio
- Gabrielle Rose - Moorehead
- John Juliani - The Boss
- Garwin Sanford - Head Priest
- Louis Chirillo - Bobby No Neck
- Peter Benson - Walter
- Malcolm Stewart - Director Paul Simms
- Devin Douglas Drewitz - Samuel
- Lee Jay Bamberry - Ringmaster
- Aaron Douglas - Clerk
- Jase Anthony Griffith - Operative 2
- Stephen Spender - Security Guard
- Dominika Juillet - Priestess
- Kandyse McClure - Annie Fisher
- Noah Beggs - Detective Krakow
- Gerry Durand - ND Cop
- Sadie Lawrence - Young Widow
- Jorgito Vargas Jr. - Bug
- Paul Moniz de Sa - Uniformed Cop
- L. Harvey Gold - Lawyer
- Mark Burgess - Rev. Caldwell
- David Berner - Host
- Mitchell Kosterman - Lieutenant
- Paul Perri - Senator McKinley
- Darryl Scheelar - Sector Cop 2
- Rick Worthy - Lieutenant Clemente
- Henri Lubatti - C.J.
- Erin Karpluk - Gem
- Amy Dumas - Thula
- Cameron Bright - Johnny
- Jim Thorburn - Steve
- David Haysom - Checkpoint Cop
- Jeffrey Ballard - Dalton
- Alison Matthews - Female Newscaster
- Dion Luther - Reporter
- Dion Luther - Bill Hailey
- Peter Shinkoda - Albino X
- Lori Stewart - Phalanx Warrior
- Steven McMichael - Phalanx Warrior
- Lorin Heath - Cece
- Tahmoh Penikett - ND Cop
- Christine Willes - Church Lady
- Gardiner Millar - Man on the Street #2
- Peter Kent - Security Guard Peter
- Jim Dunn - Intruder
- Natassia Malthe - Redhead at Party
- Sylvesta Stuart - TAC Leader
- Peter Bryant - Bling
- Rob Smith - Pinstriped Suit Man
- Desiree Zurowski - Squatter Mom (uncredited)
- Mike Mitchell - Mule
- Mike Mitchell - Transhuman
- Mike Mitchell - Guard 1
- Guyle Fraizer - Technician
- David Kaye - Sage / Sam Gilan
- Gus Lynch - Mack
- Susan Boyajian - (uncredited)
- Shawn Reis - Red Eight
- Adrian Glynn McMorran - Dylan
- Robert Lewis - Dochnovich
- Ty Olsson - Driver 2000 (uncredited) / Mario
- Angelika Libera - Pretty Redhead
- Danny Dworkis - Detective
- Nicholas Harrison - Cop 1
- John MacCarthy
- Gina Lamar
- Kenneth Biller
- Moira Kirland
- René Echevarria
- Rae Sanchini
- Michael Angeli
- Joel McNeely
Callum Keith Rennie hace el papel de Sheriff Lamar.
Jessica Alba interpreta a Max Guevara en la serie.
Michael Weatherly hace el papel de Logan Cale.
Valarie Rae Miller interpreta a Cynthia McEachin en la serie.
J.C. MacKenzie interpreta a Reagan Ronald en la serie.
Jensen Ackles hace el papel de Alec McDowell.
Kevin Durand hace el papel de Joshua.
Martin Cummins hace el papel de Ames White.
Richard Gunn interpreta a Calvin Theodore en la serie.
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