- Jill Ireland - Angela Lackland
- Gary Conway - Billy Carver
- Robert Wolders - Almaviva
- Andrew Prine - Amos Fargo
- Henry Darrow - Gideon
- Lori Saunders - Mary Pickett
- Ken Gampu - Kamba
- Jeffrey Hunter - Roark Logan
- Woodrow Parfrey - Quartermaster Owens
- Cam Clarke - Pasco, Jr.
- Burl Ives - Prater Beaseley
- Linda Marsh - Amy
- Arthur Batanides - Chief Tekwatana
- Burr DeBenning - Tom Lincoln
- Lois Nettleton - Sulie
- Kenneth Tobey - Taggart
- Sidney Blackmer - Jasper Ledbedder
- Bo Svenson - Warren Haskins
- Don Pedro Colley - Gideon
- Connie Gilchrist - Keziah Tench
- Floyd Patterson - George Hill
- Kathleen Freeman - Berthe
- Michael Dante - Akari
- Neville Brand - Tanner
- John Larch - Sam Hawken
- Jim Backus - Will Scataway
- Wilfrid Hyde-White - George Perkins
- Jon Walmsley - Pudge Farmingham
- Clint Ritchie - Two Feathers
- Barbara Bel Geddes - Molly Malone
- Warren Munson - Cpl. Tompkins
- Katherine Walsh - Elizabeth Corbett
- Richard Kiel - Lemouche
- Barbara Hershey - Dinah Hubbard
- Michael Witney - Orville
- Roger Miller - Jonny Appleseed
- Jack Albertson - Shem Sweet
- Greg Mullavey - Latham Green
- Luana Patten - Lucy MacFarland
- Isabel Sanford - Maybelle
- Harry Bellaver - Teduskan
- John McIntire - Timothy Patrick Bryan
- Keith Andes - Ben Moore
- Philip Carey - Gordon Lang
- Ron Howard - Luke
- David Brian - Maj. Horton
- Jerome Cowan - Jeremiah Loomis
- Mala Powers - Polly Cooper
- Severn Darden - Sir Hubert Spencer
- Alejandro Rey - The Sergeant
- Lloyd Nolan - Ben Hanks
- Frank Silvera - Marcel Bouvier
- Sam Jaffe - Jed Tolson
- Émile Genest - Lac Duquesne
- Anna Lee - Clara Merivale
- Macdonald Carey - Henry Pitcairn
- Michael Conrad - Sharben
- Bruce Cabot - Simon Bullard
- Robert Lansing - Capt. Robert Ives
- Henry Corden - Peter Mornay
- Brenda Benet - Princess Little Fawn
- Ruth Warrick - Wise Woman
- Geraldine Brooks - Esther Craig
- Henry Silva - Zapotec
- Fay Spain - Kathleen O'Hannrahan
- Peggy Stewart - Ida Morgan
- Maxwell Reed - Thomas Cromwell
- Val Avery - Watowah
- Morgan Brittany - Naomi Fluellen
- John Russell - Amos McAleer
- Pat Hingle - Will Carey
- Peter Duryea - Andrew Perigore
- Peter Whitney - Caleb Calhoun
- Robert Middleton - Simon Brasher
- Arthur Space - Sawyer
- Robert DoQui - Tom
- Dick Wessel - Moses Hennepin
- Brooke Bundy - Sarah
- Victoria Vetri - Susan Pepper
- Arthur Hunnicutt - Gabe
- Diane Ladd - Ronda Cameron
- Henry Wilcoxon - William Blunt
- Aldo Ray - Benton
- George Savalas - The Warden
- Edna Skinner - Sadie Clayburn
- Steve Ihnat - Tyler
- Otis Young - Adam
- Anne Seymour - Corn Woman
- David McLean - Smith
- Forrest Tucker - Joe Snag
- J. Pat O'Malley - Uncle Brian
- Joseph Hoover - Chad Oliver
- George D. Wallace - Philippe Gamet
- Kent Smith - General Hugh Scott
- Joan Hackett - Theodora
- Harlan Warde - Nicholas Burns
- Jacques Bergerac - Le Grande
- Mike Farrell - Johnson
- Ian Wolfe - Judge
- Ji-Tu Cumbuka - Lucas Hunter
- Robie Porter - Tom Chapin
- Maurice Evans - Beaumarchais
- Strother Martin - Solomon Tarbot
- Jack Kruschen - Herman
- Joel Fluellen - Joselito
- Alex Karras - Moose Williams
- Virginia Gregg - Nettie Pike
- Jeff Donnell - Varna Montgomery
- James Anderson - Watkins
- Julie Harris - Faith
- Leon Askin - Roquelin
- Ethel Waters - Rachael
- Mike Henry - Creole Jim
- John Ireland - Hiram Manville
- Herbert Anderson - Wyman
- JoAnna Cameron - Kellie
- Gloria Grahame - Molly Hogan
- Tim O'Connor - James Secord
- Peter Mark Richman - Hawk
- James Gregory - Captain Asa Webb
- Michael Burns - Cal Trevor
- James Best - Jethro Wyatt
- George Lindsey - Wigeon
- Jack Oakie - Otis Cobb
- Henry Brandon - Lije Moody
- Barbara Pepper - Mrs. Shanks
- Robert Random - Stephen
- John Lupton - Chadwick
- George Kennedy - Zach Morgan
- Joanna Moore - Lacey Lowe
- Nestor Paiva - Menewa
- Adam Williams - Mose
- Madlyn Rhue - Ester Moncour
- Edward Binns - Seth Jennings
- Walter Pidgeon - Lord Dunsmore
- Rafer Johnson - Rawls
- Alvy Moore - Amos Truro
- Anne Helm - Sumah
- Leslie Nielsen - William Russell
- Aliza Gur - Tawna
- Douglas Henderson - Gerald Ainsley
- Lynn Loring - Tekawitha McLeod
- Jeff York - Big Zack
- Claude Akins - Toka
- Murray MacLeod - Edgar
- Corey Fischer - Freddie Ledbedder
- Ricardo Montalban - Count Alfonso De Borba
- Sig Ruman - Van Coot
- Barry Kelley - Mr. Butters
- Dan Duryea - Simon Perigore
- Abraham Sofaer - Tamend
- Abraham Sofaer - Grey Cloud
- Milton Selzer - Isaac Delf
- Lilyan Chauvin - Madame Simon
- John Carradine - Zack Pike
- Michael Blodgett - Sam Linn
- Vincent Price - Dr. Thaddeus Morton
- Gregory Walcott - Tom Jimson
- Jodie Foster - Rachel Pickett
- Corinna Tsopei - White Wing
- Christopher Connelly - Jamie Blue
- Marianna Hill - Nancy Hanks
- James Westerfield - Hand
- James Westerfield - Simon Girty
- Tyler McVey - Preacher Potter
- Pamelyn Ferdin - Little Girl
- James McCallion - Hostler
- Michael Pate - Raccuwan
- Michael Pate - Pushta
- Leif Erickson - Aaron Burr
- Leif Erickson - Bill Sedley
- Richard Anderson - Sergeant Rafferty
- Shelley Fabares - Charity Brown
- Rhodes Reason - Dr. Jedrick
- Rhodes Reason - Captain William Butler
- Ted Cassidy - Gentle Sam
- Vic Tayback - American Soldier
- Vic Tayback - Hongas Hongas - Huron Indian Chief
- Hampton Fancher - Lieutenant Noland
- Hampton Fancher - Tad Arlen
- Steve Brodie - Darby
- Ramon Bieri - Hanker
- Dick Sargent - Andrew Cooper
- Dick Sargent - Reuben Stone
- Harold Gould - Major John Richardson
- Robin Mattson - Brae Secord
- Victor Buono - Mr. Quaife
- Jeff Morrow - Major Neville Hughes
- Jeff Morrow - Jody Brown
- Peter Jason - Clint Bickford
- Michael Forest - Canuda
- Michael Forest - Long Feather
- Will Geer - Adam Jarrett
- Bill Williams - Caleb Trevor
- Russ Conway - Tom Mayberry
- Lesley Woods - Elizabeth Creighton
- Hans Conried - Orlando, The Prophet
- Yaphet Kotto - Jonah
- Yaphet Kotto - Luke
- William Traylor - Tom Stoneman
- Jeff Pomerantz - David Hubbard
- Marvin Brody - Tom Bradley (uncredited)
- Marvin Brody - Cross
- Marj Dusay - Eugenie Journet
- Dick Foran - Jeremiah
- Dick Foran - Simon Doggett
- Burgess Meredith - Alex Hemming
- Frank De Kova - Talakum
- Frank De Kova - Saugus
- Lester Matthews - Major
- Charles Dierkop - Dumas
- Charles Dierkop - Dokker
- Carmen D'Antonio - Cherokee Woman (uncredited)
- Alan Baxter - John Ruth
- Alexander Scourby - Eli Bothwell
- Jon Lormer - Eli Jimson
- Jon Lormer - Yellow Knife
- Jack Elam - Petch
- Warren Stevens - Mathew Eliot / Edward Eliot
- Warren Stevens - Capt. Robert George
- Dina Merrill - Madeline Lorne
- Rodolfo Acosta - Gabriel
- Rodolfo Acosta - Running Fox
- Fabian - David Ellis
- Ellen Corby - Hilda Brock
- Timothy Scott - Phelps
- Zalman King - Evans
- Zalman King - Meshach Tarbot
- Patrick Whyte - Governor
- Rick Vallin - Sentry
- Leo Gordon - Silas Morgan
- Bethel Leslie - Zerelda Fluellen
- John Davidson - Sam Weaver
- John Davidson - Jimmy McGill
- Judson Pratt - Amos Wythe
- Judson Pratt - John Bridger
- Brock Peters - Pompey
- Paul Mantee - Atawa
- Jimmy Dean - Jeremiah
- Jimmy Dean - Delo Jones
- Jay Silverheels - Sashona
- Jay Silverheels - Chenrogan
- Jay Silverheels - Latawa
- John Vivyan - Major Halpen
- Nicholas Georgiade - Chief White Wolf
- Michael Ansara - Red Sky
- Michael Ansara - Sebastian Drake
- Doodles Weaver - Horseman
- Doodles Weaver - Bartender
- Richard Reeves - Bartender
- Timothy Carey - Lute Purdy
- Timothy Carey - Wibberly
- Chick Chandler - Ira Higgens
- Joe De Santis - Jigossassee
- Carlos Romero - Francisco
- Maudie Prickett - Flavia Tillridge (uncredited)
- Mario Alcalde - Russ Kresson
- Cameron Mitchell - James Dorsey
- Cameron Mitchell - George Rogers Clark
- Myrna Fahey - Sara
- Stanley Clements - Timbo
- David Opatoshu - Philip Cobb
- David Opatoshu - Tamenund
- Ronne Troup - Ellie
- Berry Kroeger - William Creighton
- Berry Kroeger - Governor of Virginia
- Malcolm Atterbury - Thaddeus Hill
- Mariette Hartley - Millie Boyd
- Mariette Hartley - Sister Cecilia
- Walter Burke - Hamel
- John Milford - Jud Baker
- Royal Dano - Matty Brenner
- Royal Dano - John Maddox
- Raymond Guth - Tatum
- Richard X. Slattery - Simon Foss
- Harry Lauter - Corbin
- Olan Soule - Silversmith
- Don 'Red' Barry - Amos Brown
- Henry Jones - Landers
- Henry Jones - Jonas Morgan
- Harry Basch - The Stranger
- Harry Basch - Jesse Watts
- Foster Brooks - Stranger
- Vito Scotti - Priest
- Cesare Danova - Michelet
- Cesare Danova - Henri Le Gaux
- Albert Carrier - Charles Penet
- Albert Carrier - Marquis De Lafayette
- Ken Mayer - Flint
- Charles Drake - Simon Jarvis
- Charles Drake - Andy Wharton
- Orville Sherman - Tupper
- Orville Sherman - Will Camfield
- Sid Haig - Typhoon
- Michael Rennie - Maj. Peter Wellington
- Michael Rennie - Edgar Newton
- Ed Flanders - Col. Richard Lackland
- Percy Helton - Mr. Stubbs
- Percy Helton - Jud
- Dennis Cross - Warrior (uncredited)
- Dennis Cross - Chief Red Hand
- Morgan Woodward - Tom Sutton
- Morgan Woodward - Elisha Tully
- Skip Ward - Davey
- Fran Ryan - Mrs. Jones
- Bernard Fox - Carruthers
- Chuck Roberson - Dutch
- Chuck Roberson - Shawnee Leader
- Chuck Roberson - Lige Henry
- Chuck Roberson - Dark Panther
- Alan Carney - Stagecoach Driver
- Mary Jane Saunders - Amantha
- Hal Baylor - Cyrus Ballard
- Christopher Dark - Kashita
- George Gobel - Francis Clover
- John Hoyt - Colonel James Lamport
- John Hoyt - Patrick Henry
- Chris Alcaide - Flathead Joseph
- Chris Alcaide - Noah Pierce
- George Sanders - Col. Roger Barr
- Leonard Nimoy - Oontah
- Ed Peck - John Hawkins
- Ed Peck - Smedley
- Charles Bateman - Maj. John Lorne
- Peter Graves - Logan Harris
- Douglas Fowley - Rufus C. Hoops
- Slim Pickens - Cletus Mott
- Slim Pickens - Simon Harman
- Shug Fisher - Jake Tench
- Shug Fisher - Blacksmith
- Shug Fisher - Tolliver
- Shug Fisher - Second Man
- Virginia Capers - Elsie
- William Fawcett - Gunsmith
- William Fawcett - Ben Pickens
- William Fawcett - Salem Innkeeper
- Whit Bissell - Stogie the Trapper
- Louise Sorel - Susanna
- Jack Lambert - Alexander McAfee
- Jack Lambert - Rafe Todd
- Jack Lambert - Stronk
- Aram Katcher - Thibaud
- Eddie Little Sky - Grey Eagle
- Eddie Little Sky - Naytuk
- Eddie Little Sky - Eagle
- Willis Bouchey - Rowley
- Paul Brinegar - Gurney
- Russ McCubbin - Sergeant
- Russ McCubbin - Armand
- Russ McCubbin - Slade
- Russ McCubbin - Jubal Markham
- Jeanne Cooper - Addie Ogilvie
- Jeanne Cooper - Amy Barr
- John Zaremba - Chaumet
- Sheldon Allman - Bill Scott
- Mike Mazurki - El Toro
- Mike Mazurki - Akasheta (uncredited)
- Butch Patrick - Black Cat Jack
- R. G. Armstrong - Jarvis
- R. G. Armstrong - Joseph Garth
- Torin Thatcher - President John Adams
- Torin Thatcher - Cyrus Blake / Enoch Blake
- Edward Mulhare - Col. Marcus Worthing
- Edward Mulhare - Adm. Lord Clydesdale
- Edward Mulhare - Col. Burton
- Nita Talbot - Sylvie Du Marais
- Raymond St. Jacques - Nimrod
- Rudy Robbins - Josh Cutler
- Channing Pollock - Fletcher Cameron
- Alan Napier - Col. Sir Hubert Crater
- Alan Napier - Lord Brisbane
- Patricia Huston - Amanda Dobson
- Richard Webb - Murdock
- Richard Webb - Bryant
- Richard Webb - Capt. Riley
- Robert Donner - Pike
- Glenn R. Wilder - Hawks
- Mort Mills - Gen. Grosscup
- Mort Mills - Andrew Hubbard
- MaKee K. Blaisdell - Eagle Feather
- Ric Roman - Theyandaga (uncredited)
- Lyle Bettger - Lehman Henderson
- Lyle Bettger - Joseph Montgomery
- Gordon Jump - Marcus Clements
- Buck Young - Henry Foxx
- Nan Leslie - Ada Mayberry
- Bryan O'Byrne - Mr. Portman
- John Crawford - Tolliver
- John Crawford - Press Boker
- John Crawford - Jeremy Cain
- Mabel Albertson - Mrs. Abigail Adams
- Elena Verdugo - Violet Morton
- Dick Peabody - Samuel Stone
- Dick Peabody - Dawson
- George J. Lewis - Menewa (uncredited)
- George J. Lewis - Indian Chief
- Jock Mahoney - O'Connor
- Belle Mitchell - Old Indian Woman (uncredited)
- Sue England - Nanteen
- Simon Oakland - Dull Knife
- Simon Oakland - Bickford
- Simon Oakland - General James Wilkerson
- Robert McCord - Jones (uncredited)
- Lloyd Bochner - Roger Morgan
- Lloyd Bochner - Churchill James
- Lloyd Bochner - Maksoana
- Lloyd Bochner - Colonel Chalmers
- Mary Fickett - Hannah Wilkes
- Lawrence Montaigne - Hayes Fuller
- Lawrence Montaigne - Mawson
- Myron Healey - Lynch
- Myron Healey - Mike Kravic
- Myron Healey - James Burns
- Tom Lowell - Davy Gist
- Cesar Romero - Adm. Alejandro Buenaventura
- Cesar Romero - Esteban de Vaca
- Cesar Romero - Colonel Carlos Navarro
- Robert Sorrells - Luke Girty
- Robert Sorrells - Hogan
- Kevin O'Neal - Adam Webster
- John Pickard - Telly
- John Pickard - Beckitt
- Charles Macaulay - Col. Arthur Merivale
- Charles Macaulay - Colonel Gates
- Hank Worden - Blue Belly (uncredited)
- Hank Worden - Hansom Cab Driver
- Booth Colman - Whitmore
- Booth Colman - High Pvt. A. Slimpsey
- Booth Colman - Gov. Patrick Henry
- Kevin Hagen - John Dobson
- Kevin Hagen - Alex Stokes
- Kevin Hagen - Bart Wallace
- James Griffith - Coll
- James Griffith - Feathers
- Harry Dean Stanton - Jeb Girty
- Harry Dean Stanton - Crane
- Lane Bradford - Sam
- Lane Bradford - John Beachum
- Vaughn Taylor - Judge Qualey
- Vaughn Taylor - Justice Homer Godwin
- Jim Davis - Rafe Carson
- Jim Davis - Carpenter
- Jim Davis - Sam Ralston
- Virginia Christine - Martha
- Virginia Christine - Mrs. Brewster
- Hank Patterson - Jed Harper (uncredited)
- Hank Patterson - Fiddler
- Hank Patterson - Gray
- Tom McFadden - Livery Man
- Tom McFadden - Sentry
- Kurt Russell - Jed
- Kurt Russell - Paul Bickford
- Kurt Russell - William Craig
- Kurt Russell - Nathan Jarrett
- Kurt Russell - Mathew
- Valentin de Vargas - Rio
- Valentin de Vargas - Oneha
- Robert J. Wilke - Toff
- Robert J. Wilke - Jake Manning
- Robert J. Wilke - Fryman
- Victor French - Ess
- Victor French - Blue Belly Sangster
- Joseph V. Perry - Kinch
- Joseph V. Perry - Tabuka
- Joseph V. Perry - Gardner
- Joseph V. Perry - Tolliver
- Paul Fix - Quonab
- Paul Fix - Chief Great Bear
- William Phipps - Dink
- William Phipps - Horn
- Roy Jenson - Cash Doyle
- Roy Jenson - Luke
- Roy Jenson - Jensen
- Roy Jenson - Crane Hawkins
- Gene Evans - Joshua Craig
- Gene Evans - Stark
- William Smith - Catoga
- William Smith - Amos Martin
- William Smith - Amos (uncredited)
- William Smith - Campuits
- Ivor Barry - Commodore Morrison
- Ivor Barry - Hamilton
- Ivor Barry - British Commandant
- Ivor Barry - President Washington
- Sean McClory - Liam O'Hara
- Sean McClory - Bartender
- Sean McClory - Ephron Marsh
- Harold Goodwin - Grover Hanks
- Harold Goodwin - Loomis
- Harold Goodwin - Harper
- Harold Goodwin - Evans
- Harold Goodwin - David
- Ted White - Rider
- Ted White - First Trapper
- Ted White - Carata (uncredited)
- Ted White - Sgt. Judd Blake
- Ted White - Morse
- Ted White - Middleton
- Ted White - Aweetok (uncredited)
- Ted White - Pushta
- Ted White - Captain Harper
- Ted White - Hawks
- Ted White - Coach Driver
- Alan Caillou - Sergeant Ridley
- Alan Caillou - British Major
- Alan Caillou - British Captain
- Alan Caillou - Sergeant McIntosh
- Alan Caillou - Sgt. Harry Pickens
- Armando Silvestre - Jim Santee
- Armando Silvestre - Captain Torres
- Armando Silvestre - Gabriel
- Liam Sullivan - Patrick Henry
- Liam Sullivan - Colonel Trevelyan
- James Doohan - Bruce MacFarland
- James Doohan - Fletcher
- Ford Rainey - Jonas Wilkes
- Ford Rainey - Matawa
- Ford Rainey - John Gist
- Eddie Quillan - Ephraim Smith (uncredited)
- Eddie Quillan - Mr. Stokey
- Eddie Quillan - Proprietor
- Eddie Quillan - Inn Landlord
- David Watson - David Scott
- David Watson - Prince Louis
- Frank Orsatti - Emathala
- Frank Orsatti - Sentry
- Frank Orsatti - Tupi (uncredited)
- Ted Eccles - Jason
- Ted Eccles - First Boy
- Ted Eccles - Hal Gist
- John Orchard - Stone
- John Orchard - Sergeant Malcolm
- John Orchard - British Corporal
- John Orchard - British Sergeant
- John Orchard - Sgt. Braddock
- John Orchard - Sergeant Perkins
- William Corcoran - Joe Higbee
- William Corcoran - Third Boy
- Jack Bannon - Lieutenant Poole
- Jack Bannon - Corporal
- Jack Bannon - Lieutenant Parker
- Jack Bannon - Larkin
- Jack Bannon - Officer
- Jack Bannon - Corporal Smythe
- Jack Bannon - British Guard
- Med Flory - Bingen
- Med Flory - Joker
- Med Flory - Jubal
- Med Flory - Dobbs
- Med Flory - Luke
- Sheldon Collins - Stinky Brown
- Sheldon Collins - Hoot Owl Tom
- Bill Walker - Ephraim
- Bill Walker - Mr. Horner
- Bill Walker - Perrault
- William 'Shorty' Young - Blacksmith (uncredited)
- Harry Harvey - Luther Michaels
- Harry Harvey - Justice of the Peace (uncredited)
- Frank Hagney - Indian Chief
- Frank Hagney - Settler
- Abel Fernandez - Warrior
- Cyril Delevanti - Nitashanta
- Robert Logan - Jericho Jones
- Sol Gorss - Ruffian
- Carole Cook - Annie Boyd
- Bill Fletcher - Major John Andre
- Michael St. Clair - Leamas O'Leary
- Len Wayland - Simon
- Norman Leavitt - Starkie
- Harold J. Stone - Greenbriar
- Charles Seel - Trapper Stitching Furs (uncredited)
- Rosey Grier - Gabe Cooper
- Phil Proctor - Bernard
- Elizabeth Baur - Virginia Brewster
- Barbra Fuller - Woman
- John Daheim - Scalp Hunter (uncredited)
- Barney Rosenzweig
- George Sherman
- Ted Schilz
- Aaron Rosenberg
- Cliff Bole
Ricardo Montalban interpreta a Count Alfonso De Borba en la serie.
Cesar Romero hace el papel de Adm. Alejandro Buenaventura.
Jodie Foster interpreta a Rachel Pickett en la serie.
James Griffith interpreta a Coll en la serie.
George Sanders interpreta a Col. Roger Barr en la serie.
Robert J. Wilke hace el papel de Fryman.
Percy Helton hace el papel de Mr. Stubbs.
Vaughn Taylor interpreta a Judge Qualey en la serie.
Brock Peters interpreta a Pompey en la serie.
R. G. Armstrong hace el papel de Joseph Garth.
Capítulo disponible en las siguientes plataformas:
