- Ronald Leigh-Hunt - Commander Ford
- Patrick Newell - Alex
- John Harrison - Daniels
- William Marshall - Saul Khano
- Robert Shaw - Tony Costello
- Peter Arne - Major Hassler
- Nadja Regin - Melina
- Peter Sallis - John Gordon
- Noel Howlett - Dr. McKenna
- Robert Cawdron - President Varnold
- Robert Raglan - Storch
- Robert Raglan - Dr. Stanifors
- John Phillips - Coyannis
- Paul Eddington - Captain Schulman
- Graham Ashley - Police Sergeant
- Lisa Daniely - Linda Janson
- Trisha Noble - Susan Wade
- John Tate - Fisherman
- Bernard Lee - Lord Ammanford
- Patricia Driscoll - Catherine Archer
- Patricia Driscoll - Lady Judith Lindsay
- Michael Collins - Police Sergeant
- Sylvia Syms - Paula Glover
- Eunice Gayson - Louise Bancroft
- Mervyn Johns - Armstrong
- Francesca Annis - Judy
- Michael Balfour - Gaston
- Larry Taylor - Henri
- Helen Cherry - Mrs. Joan Pearson
- Andrew Faulds - General Khan
- Andrew Faulds - Mullins
- John G. Heller - Manuel
- John G. Heller - Czech Policeman
- John G. Heller - Joseph
- Elizabeth Ashley - Lady Fielding
- Maurice Denham - Volos
- Earl Cameron - Chand
- Howard Marion-Crawford - Archer
- Howard Marion-Crawford - Gregori
- Lee Montague - Major Latour
- Alan Wheatley - Solicitor
- Erik Chitty - Butler
- Martine Beswick - Girl
- Chris Adcock - Cafe Patron (uncredited)
- Robert Ayres - Hamilton
- Harold Kasket - Moukta
- Jerome Willis - Second Pursuer
- Jerome Willis - Colonel Maturin
- Anton Rodgers - Attala
- Joan Hickson - Mrs. Curtis
- Nadim Sawalha - Nikolaou
- Donald Houston - Edmund Bierce
- Wanda Ventham - Penny
- Nicola Pagett - Nicola
- Alfred Burke - Craven
- Percy Herbert - Innkeeper
- Francis de Wolff - Paul Alexander
- Patsy Rowlands - Mrs. Elsie Farebrother
- Edward Underdown - Capt. Morgan
- Desmond Llewelyn - Charles - Doorman
- Ian Stuart Black
Earl Cameron hace el papel de Chand.
Patrick McGoohan interpreta a John Drake en la serie.
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