- Jerry O'Connell - Woody Hoyt
- Jerry O'Connell - Detective Woody Hoyt
- Leslie Bibb - Tallulah Simmons
- Chris Gartin - Dr. Phillip Winter
- Tara Lynne Barr - Sally Yates
- John Kapelos - Halper
- Tom Virtue - Saunders
- Jessica Harper - Dorris Meisner
- Vanessa Marcil - Sam Marquez
- Richard Biggs - Dr. Russell Flynn
- Kevin Chamberlin - Neville
- Cayden Boyd - Kyle Moran
- Hector Luis Bustamante - Pete Delgado
- Charlie O'Connell - Calvin
- Heather McComb - Kate
- Chris Noth - FBI Special Agent Drew Haley
- Norma Maldonado - Carolyn Macelli
- Nicole Pulliam - Young Mrs. Avery
- Eddie Jones - Pete O'Malley
- Blake Lindsley - Prof. Katherine Danvers
- Brian Stokes Mitchell - Jay Myers
- Rachel Specter - Daniella
- Zack Ward - FBI Agent Blair
- David Andrews - Gerald Bayless
- Michael Rooker - Shawn Curaco
- Bradley Stryker - Jack
- Abby Brammell - Marcie Holloman
- Donna Pescow - Debbie's Mother
- Colin Ferguson - Brad Ferris
- David Naughton - DA Jenetta
- David Shatraw - Peter Cronin
- Mackenzie Phillips - Elaine Stahler
- Larry Drake - Tom
- Cole Petersen - Todd Reynolds
- Aimee Graham - Vicki Cross
- P.J. Byrne - Forensic Goofball
- Brendan Kelly - Gerry McCourt
- Elizabeth Rice - Sarah Browning
- Van Epperson - Clem
- John Towey - Delbert Zimmerman
- Francis Guinan - Dr. Alexander
- Ashley Greene - Ann Rappaport
- Stanley Anderson - Pat Donnelly
- Barry Shabaka Henley - Omar Maltese
- Lynne Marta - Celia Brackett
- Dan Butler - Arnold Hummer
- Eddie Mekka - James Talbot
- Ernie Lively - Sheriff Roper
- Mariel Hemingway - Lisa Fromer
- Francis Capra - Det. Jason Harris
- Gabrielle Carteris - Dawn McGuire
- Armin Shimerman - Dr. McCain
- Wallace Shawn - Howard Stiles
- Sara Botsford - Lauren Ryder
- Reginald VelJohnson - Kirk Holden
- Gina Gershon - Charlie Davis
- Aaron Meeks - Young Man
- Megan Gallagher - Rachel
- Alex Nesic - Harrison
- Neil Hopkins - Lester Corrigan
- Ivonne Coll - Mrs. Salazar
- Dale Midkiff - Jerry Miller
- Galyn Görg - Therapist
- Robert Duncan McNeill - Matt
- Douglas Smith - Steven Reynolds
- David Weidoff - Chad Buckley
- Keri Lynn Pratt - Lisa Price
- Derek Webster - Dave Rosso
- Sarah Joy Brown - Susan Mayo
- Stephen Snedden - Young Max Cavanaugh
- Judith Hoag - Alice Ross
- Graham Phillips - Kyle / Jonah Wheeler
- Kavi Raz - Dr. Singh
- Cyia Batten - Debra Scott
- Jim Metzler - Judge Clarence Gordon
- Karen Austin - Sarah Fulton
- John D'Aquino - Harold Fallon
- Tyler Christopher - Officer Fisher
- Edita Brychta - Dr. Mansell
- Jose Pablo Cantillo - Danny Artega
- Peter MacKenzie - Frank Ripton
- Kim Morgan Greene - Mrs. Jenkins
- Michael T. Weiss - James Horton
- Brynn Thayer - Gina Hurst
- Reed Diamond - Gordon Kimball
- James Caan - Ed Deline
- Randee Heller - Julie Harvey
- Lauren Stamile - Sarah Soble
- Ken Kercheval - Mr. Payton
- Mathew St. Patrick - William Avery
- Andrea Bogart - Nicole Wheeler
- Liliana Mumy - Lena
- Ned Vaughn - Paul Simpson
- Susan Gibney - Renee Walcott
- Jonathan Del Arco - Dr. Alex Cuevas
- Kitty Swink - Dr. Dupree
- Kiko Ellsworth - Detective Parnell
- Colleen Flynn - Katherine Fielding
- Clayton Rohner - Henry Ross
- Omari Hardwick - Ronald Pasco
- Gregory Jbara - Stan Benedict
- Erin Cahill - Tyler
- Megan Follows - Beth
- Tony Todd - Coach Jim Evans
- Carla Gallo - Marissa Owens
- Susan Haskell - Jane Newman
- Bill Mumy - Paper Shredder Operator
- K Callan - Penelope Zimmerman
- Patrick Kerr - Conrad O'Dell
- Aaron D. Spears - Seamus
- Ian Abercrombie - George
- Helen Slater - Elaine Tallridge
- John Badham - Marty
- Slade Pearce - Danny Alioto
- Barbara Tarbuck - Jennine Burke nee Gallow
- Kimberly McCullough - Isabelle
- Seamus Dever - Tom Murch
- Eyal Podell - Jason Hartzman
- Marcus Giamatti - Donald Hagen
- Philip Casnoff - Dr. Sanchez
- Eric Stonestreet - Steve Anderman
- Lucinda Jenney - Judy Strand
- Cliff DeYoung - Dr. Cassidy
- Julia Campbell - Maddy Whitford
- Judson Mills - Scott Weber
- Michelle Page - Natasha
- Charles Mesure - J.D. Pollack
- Robert Joy - Ethan Grady
- Matt Roth - Dave Gilbert
- Victor Raider-Wexler - Maury
- Jim Piddock - Norman Gibson
- Mia Korf - Dr. Grace Yakura
- Nan Martin - Lydia
- Carmen Argenziano - Diego Artega
- Angela Goethals - Deborah
- Indigo - Keisha Morton
- Brian Howe - Cosgrove
- Fredric Lehne - John Roberts
- Jonathan Scarfe - Ken Scott
- Jack Noseworthy - Detective Jack Hannah
- Larry Sullivan - George Winters
- Kate Norby - Kelly McDonald
- Neil Vipond - Priest
- Ed Quinn - Tyler
- Alyson Reed - Gail
- Dennis Boutsikaris - Dr. Bernard Krump
- Boris Kodjoe - Detective Elliot Chandler
- Jsu Garcia - Martin Cruz
- Richard Gilliland - Charles Monroe
- Janet Gunn - Martha Eldridge
- Eugene Byrd - Sidney
- Emy Coligado - Emmy
- Gregory Itzin - Andrew Helm
- Danielle C. Ryan - Amanda
- Henry Winkler - Dr. Jack Slocum
- Jeremy London - Louis Jeffries
- Michael Reilly Burke - FBI Agent Sullivan
- Lesley Ann Warren - Arlene Lebowski
- Leah Pipes - Melissa Ripton
- Patrick Fabian - Buddy Holly / Horned Rimmed Glasses
- Lisa Rotondi - Dianne Anthony
- Daphne Ashbrook - Mrs. Carter
- Clint Howard - Gil Runkis
- Rolando Molina - Hector Chirullo
- Spencer Garrett - Paramax Industries Official
- Glenn Morshower - Bill Strand
- Gary Graham - Ben Morgan
- Lisa Lackey - Claire Payton
- Edward Herrmann - Thomas Malden
- Cliff Emmich - Dr. Marlen
- Andrea Martin - Nora Kaminski
- Meredith Monroe - Rebecca
- Bairbre Dowling - Sister Mary Katherine
- Robert LuPone - Curt Schneider
- Hilary Shepard - Trudi
- Shailene Woodley - Young Jordan Cavanaugh
- Rudolf Martin - Albie Samson
- Jamie Elman - Jonathan
- Soren Fulton - Johnny Rocket
- Brian Poth - Greg Hewitt
- Bill Applebaum - Nate
- Scott William Winters - Ranger
- Kelly Cole - Mitch Platt
- Vanessa Lee Chester - Andrea
- Morgan Flynn - Lorrie
- Frederick Koehler - Matt
- Randy Oglesby - Chief Committee Interviewer
- Blake Robbins - Peter Ellison
- Christopher Cousins - Father Lynch
- Dey Young - Taylor Parker Kent
- Steven Culp - Rick Frazier
- Steffani Brass - Monroe's Daughter
- Tammy Lauren - Faye Vaughn
- Raphael Sbarge - Phil
- Adam Nelson - Frank Dawber
- Sean O'Bryan - Jake Gerloff
- Joshua Desroches - Lucas Agley
- Aaron Lustig - MRC Attorney
- James Gammon - Olin Price
- Michael DeLorenzo - Stranger
- Lauri Johnson - Saleswoman
- Zachary Quinto - Leo Fulton Jr
- Judith Scott - FBI Agent Annie Larrabee / Jenny
- Jesse Head - Brian Heeley
- Lee Garlington - Dixie
- Anne Marie Howard - Andrea Ripton
- Maury Sterling - Scott Marshall
- Susan Walters - Gail Horton
- Jonathan Murphy - Joey Campbell
- Jack McGee - Mickey Rowan
- Robin Riker - Frances Pritchard
- Fran Bennett - Judge
- Rodney Scott - Kieran Conroy
- Robyn Lively - Connie
- Mary Mara - Denise Tremaine
- Ted Shackelford - Emmett Parker
- Erik Palladino - Agent Gropius
- Jeff Kober - Daryl Wood
- Keith Szarabajka - Peter Nash
- Stacy Haiduk - Mrs. Cartland
- Marc Vann - Harold Goddard
- Jon Polito - Dick
- Kristen Wilson - Kim Watkins
- Brad William Henke - Andy Lebowski
- Rachel Boston - Geneva Todd
- Ski Carr - Security Officer
- Bruce French - Samuel Horton
- William Ragsdale - Bob
- John Livingston - Rebecca's Husband
- Shirley Knight - Frances Littleton
- Christine Estabrook - Anne Lauer
- Shawn Christian - Adam Flynn
- Lisa Thornhill - Melissa Tate
- Clementine Ford - Young Woman
- Erin Cardillo - Peta Longo
- William R. Moses - Terrance Duvall
- William R. Moses - Attorney
- Stephanie Zimbalist - Mrs. Sullivan
- Howard Hesseman - Barney Reynolds
- Kim Miyori - Mrs. Nagawa
- Johnny Pacar - Ben Kensith
- Lynne Moody - Helene Coleman
- Linda Purl - Joan
- Scott Michael Campbell - Off. John Hardwick
- James Pickens Jr. - Agent Hawkins
- William Russ - Jack Olson
- Carl Reiner - Harry Macy
- Robert Picardo - Bruno Casnelli
- Lusia Strus - Eddie Dawson's Girlfriend
- Anthony Starke - Brad Halford
- Kali Rocha - Felix Tate
- Jeff Perry - Kyle Everett
- Jeff Doucette - Mr. Nicholson
- Michelle Nolden - Dr. Amy Bowen
- Lindsay Frost - Maggie Macy
- Sandra Bernhard - Roz Framus
- Mercedes McNab - Natalie Carson
- Valerie Cruz - Madeline Pillsbury
- Denise Crosby - Carla Moran
- Brooke Smith - Dr. Kate Switzer
- Jennifer Finnigan - Devan Maguire
- Sara Foster - Tammi Eldridge
- David Monahan - Matt Seely
- Pamela Sinha - Anna Shah
- Amy Sloan - Natalie Goodson
- Joe Spano - Captain Innis
- Max Perlich - Chill
- J.P. Manoux - Sorenson
- Leighton Meester - Marie Strand
- Hira Ambrosino - Reporter
- John Lafayette - Norton
- Adina Porter - Vicki Moran
- William Mapother - Henry Bishop
- Alan Dale - Carl Logan
- Matthew John Armstrong - John Bailey
- Kyle Secor - Detective Collins
- Shashawnee Hall - Lester Marsh
- Carol Potter - Leslie Winton
- Barry Livingston - Ron Perkins
- Paul Wesley - Quentin Baker
- Cathryn de Prume - Annie Cartwright
- Meta Golding - Dr. Candace Mclntyre
- Dave Power - Det. Rogers
- Danica Stewart - Cindy Tallridge
- Tom Verica - Mitch Weyland
- Tovah Feldshuh - Mrs. Elaine Brandau
- Zilah Mendoza - Lori Dawson
- Leon Russom - Earl Lewis
- Robert Curtis Brown - Phil Granger
- David Denman - Cole Tanner
- Emily Deschanel - Michelle
- Lenny Wolpe - Ronald Cosgrove
- Aaron Norvell - Uniform
- Christine Ebersole - Mrs. Maguire
- Ashley Jones - Beth Flaherty
- Austen Parros - J.J. Keene
- Alicia Coppola - Meredith Stackhouse
- Richard Fancy - Judge Dixon
- Michael Dempsey - Power Company Guy
- Romy Rosemont - Allison Cohen
- Ernie Hudson - Colonel Wirth
- David Clennon - Charles Gibson
- Jenny Gago - Mrs. Vega
- Neill Barry - Jack Marshall
- Neal Jones - Russell Berman
- Bobby Hosea - David Blake
- David Burke - Michael Branch
- Jack Klugman - Leo Gelber
- Silas Weir Mitchell - Frank Jones / Alastair Dark
- Stephanie Venditto - Linda Kirsh
- Vic Chao - Tech Specialist
- Carlos Gómez - George Diaz
- Mageina Tovah - Laura Bennett
- Larry Poindexter - Mr. O'Riley
- Josh Duhamel - Danny McCoy
- Dendrie Taylor - Mrs. Oliver
- June Kyoto Lu - Mrs. Katsui
- Sprague Grayden - Clarissa Harrison
- Camille Guaty - Luisa Santana
- Rodney Eastman - Homeless Guy
- Greg Collins - Construction Worker
- Karim Prince - Arif Cuttahey
- Christian Clemenson - Fr. Edward Klausner
- Shawn Michael Patrick - Public Defender
- Jaime Ray Newman - Gwen Osbourne
- Yvette Nipar - Sandra Babcock
- Joe O'Connor - Alan Manning
- Daniel Quinn - Steven Browning
- Phil Abrams - Samuel Burnham
- Hart Bochner - Dr. Ben Hothorne
- Jeffrey Nordling - Tom Crane
- Jason Gedrick - Eli Graham
- Kasha Kropinski - Kimmy Moran
- Isabella Hofmann - Dr. Mara Pelone
- Paul Ben-Victor - Theo
- Colby French - Tony Baron
- Richard Cox - Clark Credle
- Michael Welch - Josh Winter
- Cody Arens - Mike Stackhouse
- James Read - Dean William Hargrave
- Brad Hawkins - Mortician
- Anthony Heald - Attorney McBride
- Andy Powers - Gavin Eldridge
- Ben Donovan - Grant Myers
- Bruce Boxleitner - Foster Eldridge
- Henry Dittman - Kyle Millhouse
- Nick Wechsler - Hopper
- Frank Renzulli - Frank Lioso
- Edward Conna - Nolan Babcock
- Brian Sites - Derrek Mobley
- Robert Noble - John J. McPhears - Age 55
- Colleen McDermott - Claudia Simpson
- Ronn Surels - Gas Mask #2
- Michelle Anne Johnson - TV Reporter
- María Celedonio - Nora
- Peter Onorati - Detective Benza
- Patricia Place - Mrs. Flynn
- Kiva Dawson - Jordan's Dancer
- Vilma Andico - Waitress
- Lois Nettleton - Evelyn
- Daniel Roebuck - George Falk
- John Posey - Dr. Cal Yarborough
- Andy Umberger - Dr. Leonard Bloom
- Tara Ochs - Stacey Ryder (uncredited)
- Lisa Long - Falk's Lawyer
- Amanda Carlin - Carol Logan
- Roxana Brusso - Nanny Officer
- Jane Fleiss - Krista Browning
- Jacqueline Schultz - Tamara Bishop
- David Hutchison - FBI Shooter
- Christopher Curry - Jimm Keller
- Isaac C. Singleton Jr. - Rudy Coombs
- Matthew Yang King - Dr. Yeung
- Tom McCleister - Charlie
- Tom McCleister - Security Officer
- Tom McCleister - Charlie the Guard
- Hollie Stenson - Caitlin
- Cynthia Lamontagne - Mary Jo Zimmerman
- Ethan Sandler - Jeffrey Brandau
- Ethan Sandler - Josh Barrow
- Ethan Sandler - Pakistani Man
- Paige Brooks - Reporter
- Diana Terranova - Bonnie Parazzo
- Joanna Canton - Dena Weyland
- Valeri Ross - Shrink
- James McAuley - Saint Francis of Assisi
- Paul Winfield - Phillip Sanders
- Tom Gallop - TV Executive
- Nicolas Surovy - Arthur Gramble
- Mary-Joan Negro - Alicia Gramble
- Gloria Dorson - Mrs. Pilarski
- Marcia Lynn - Dying Patient
- Alexandra Barreto - Anastasia
- Mark Pellegrino - Keith Walker
- J.J. Boone - Woman
- Cheryl McWilliams - Mrs. Hildebrant
- Steve Stapenhorst - Mr. Hildebrant
- Adria Tennor - Denice
- Darlena Tejeiro - Dahlia
- Rachael Crawford - Samantha Reid
- Cheryl Carter - Cassandra Murphy
- Meredith Zealy - Vicki Weber
- Francesco Quinn - Lead Cuban
- Sarah Denison - Teller
- Zeljko Ivanek - Elliot McCafferty
- Carol Avery - Nurse
- Sarah Brooke - Female Surgeon
- Katherine Disque - Nurse #2
- Debra Engle - ER Doctor
- Sharline Liu - ER Nurse
- Caryn West - Lawyer
- Diana Yanez - Uniform Officer
- Kecia Lewis - Intake Nurse
- Vic Polizos - Lou Harcourt
- Tamlyn Tomita - Grace Yakura
- Gabe Cohen - Funeral Director
- Nynno Ahli - Uniform Cop
- Shannon Woodward - Lucy (uncredited)
- Brian Tarantina - Devlin Inmate Martinson
- Clark Sanchez - Inmate #1
- Brian Cousins - Bobby Grayson
- Ilya Melnikoff - Foreman
- Alan F. Smith - Agent
- Alan Feinstein - Blackie Conroy
- Vince Grant - Denny Logan / Denise
- Greg Bronson - Coroner (uncredited)
- Dale E. Turner - Jumpsuit
- Ray Baker - FBI Agent / Major
- Marlene Forte - Gloria
- Dennis Bailey - Martin Bishop
- Jack Laufer - Herman Redding
- Christopher Boyer - Martin Griffith
- Frank Clem - The Man
- Marcy Goldman - Retirement Home Nurse
- Steven Flynn - The Killer
- William Morgan Sheppard - Clive Alpert
- Jack Stehlin - Dale Alpert
- Brian Palermo - Lewis Pate
- David Brisbin - Everett Sloane
- Scott Summitt - Store Customer
- John de Lancie - Thaxton
- Georgann Johnson - Jordan's Grandmother
- Kylee Cochran - Cynthia Montgomery
- Cynthia Ferrer - Mrs. Montgomery
- Greg Callahan - Mr. Montgomery
- Rick Hoffman - Phil Berman
- Susan Isaacs - Elizabeth Freed
- Nicole Marcks - Dana Flynn / Barrow
- Obi Ndefo - Joe Wheeler
- Vyto Ruginis - Stuart Fielding
- Jeff Yagher - Ross Larken
- Carl M. Craig - Calvin Wheeler
- Mario Prado Jr. - Fireman
- Matthew Glave - FBI Special Agent Aaron Miller
- Ron Canada - Mr. Brody
- Joseph Hodge - Mohammed Faraj
- Michael Harney - John Morrissey
- Wade Williams - FBI Criminologist Barker
- Scott Waara - Husband with Baby
- Steve Ryan - Boston Fire Chief
- Dennis Christopher - Charles Rutledge
- Chris Flanders - Fireman
- Sean Foley - Cop
- Patrick Tuttle - FBI Agent
- Nina Landey - Laura
- George Coe - Warren Lauer
- Scott Atkinson - Tom
- Hadley Eure - Reporter
- Ingrid Beer - Shirley McGinty / Luanne McGinty
- Dave Florek - Bob The Alien Hunter
- Casey Biggs - Film Producer
- Eli Jones - Camera Assistant
- Thom Scott II - Uniform Cop
- Lily Knight - Beth Pomerantz
- Nancy Linehan Charles - Court Judge
- Gregg Daniel - Sean Morgan
- Ivar Brogger - Michael Pascal
- Harold Surratt - Judge #1
- Kirk Trutner - Pizza Guy / Summons Deliverer
- Kathleen Nolan - Doris Horton
- Lee Weaver - Photo Shop Owner
- Morgan Nagler - Jena
- Stephanie Bradley - Emily Cavanaugh
- Rhes Low - Uniformed Cop
- Bree Michael Warner - Kay Marshall
- Daphne Bloomer - Nurse
- Adam Storke - John Soriano
- Lorraine Toussaint - Elaine Duchamps
- John Combs - Ted
- Patrick Stinson - Boston Anchorman
- Darwin Harris - Helicopter Pilot
- Anthony Crivello - Albert DiSalvo
- Robert Cicchini - Diner Owner
- Mike Sode - News Reporter
- Allison Barcott - Ruth Carter
- Joe Maruzzo - Eric Brazil
- Damien Leake - Otis
- Tom Towles - Bull Williamson
- Frankie J. Allison - Struther Matthews
- Clement Blake - Joe
- Christopher Joel Ives - Cameron O'Day
- Billy Mayo - Cop
- Khanya Mkhize - Teen Mother
- Bonnie Burroughs - Mom O'Day
- Maria Moreno - Rosa
- Roxana Zal - Mrs. Strahan
- David Figlioli - Wayne Bifford
- Carlos Alvarado - Guatemalan Man
- Bahni Turpin - Bonny
- Bahni Turpin - Bahni
- Matthew Jones - S.W.A.T. Officer
- Pamela Shaddock - Nurse
- David Purdham - Anthony Winton
- Darren Pettie - Det. Rohrbach
- James Avery - Dr. Erkhart
- Jack Conley - Prison Guard Shanahan
- Stephen Markle - Dr. Seymour Martin
- Shanee Edwards - Newscaster
- Mette Holt - Mrs. Crane
- Michael Paul Chan - Yoshi
- Kevin Alejandro - Connor Marshall
- Kenneth Choi - Garma
- Oris Erhuero - Fireman
- Mike Grief - Cabby
- Craig Jackson - Technician
- Zale Morris - Janitor
- Kim Delgado - Police Sergent
- Kim Delgado - Desk Cop
- James Handy - Mr. Bergstrom
- Steven Barr - Trawlerman
- Scott MacDonald - Hubbard
- Ned Schmidtke - Richard Daniels
- Patrick Huey - Detective
- Callan White - Mrs. Daniels
- Leon - Vicellous Owens
- Matt Carmody - Richard Barnes
- Chad Todhunter - Ryan Jeter
- K.C. Clyde - Bouncer
- Biff Wiff - Father Jake
- Brian Oerly - High Speed
- Allison Lange - Annie Cody
- Sarah Ann Morris - Margot
- Victoria Gabrielle Platt - Maxine
- Elle Alexander - Jolene
- Christine Toy Johnson - Cindy Zhou
- Joel Higgins - Mr. Oliver
- Bernard White - Martin Vezned / Mr. Jones
- Joel Brooks - Bank Manager
- Rocco Sisto - Restaurant Owner
- Christian Middelthon - Poolboy Lou
- Lisa Renee Pitts - Uniformed Officer
- Holly Gagnier - Jennifer Robinson
- Christopher Murray - Uniformed Officer
- Christian J. Meoli - Seth Pale
- Matt Koruba - Goth Kid
- Claudette Sutherland - Mrs. Logan
- Jesse Corti - Det. Al Morris
- Bertila Damas - Juror
- Starletta DuPois - Juror
- Graham Beckel - Juror
- Jonathan Adams - Juror
- Kim Evey - Simone Muang
- Bob Glouberman - Joe Rosenblatt
- Kareem J. Grimes - Pat Simmons
- Ken Jeong - Steve Choi
- Antonia Jones - Sylvia Thompson
- Bryce Lenon - Jake Logan
- Dean Nolen - Attorney Hagen
- David Ripley - Darryl Cole Ainsworth
- Meera Simhan - Zuleda Salman
- Anthony DeSando - Father Paul
- Tomas Arana - Father Casnelli
- Lenny Citrano - Leonard
- Baadja-Lyne Odums - Landlady
- Nicholas Shaffer - Tech
- David Ramsey - Agent Scannell
- Lin Shaye - Leather Lauren
- Cyd Strittmatter - Mrs. Brown
- Michael G. Canaan - Goon #1
- Chad Einbinder - Hotel Manager
- Paul Witten - Agent #1
- David Joyner - CSU Tech
- David Norona - Dr. Cabrera
- Jeff Fahey - Bounty Hunter
- Gary Carlos Cervantes - Cabby
- Josh Cruze - Florist
- Pamala Tyson - Althea Hurd
- Sydney Walsh - Lawyer Judith Madison
- Tanya Berezin - Judge
- Angela Elayne Gibbs - Margaret Houston
- Mark Christopher Lawrence - Rob Morton
- Steve Hofvendahl - Van Marshall
- Natalija Nogulich - Mrs. Novotna
- Michele Greene - Pam Oakley
- Patrick St. Esprit - Off. Dodd
- Morocco Omari - Ruckheiser
- Karl Wiedergott - Aaron Furney
- Chase Matthews - Bicyclist in Park
- Hans Raith - Bodyguard
- Robert Gossett - Jack Hayes
- John Scherer - Principal Vasco
- Don Harvey - Coach Vickers
- Chet Grissom - Sgt. Adam O'Hara
- Robyn Hyden - Female Cop
- Megan Henning - Waitress
- Benita Krista Nall - Receptionist
- Kimberly Dawn Guerrero - Amber
- Melissa Haizlip - Local Reporter
- Bradford English - Frank Givens
- T.E. Russell - Dave
- Kristoffer Ryan Winters - Baby Face Brian
- Louis Iacoviello - Officer Michaels
- Ruben Madera - Arthur
- Andy B. Dardaine - Police Officer
- Jim Beaver - Ranger Diggory
- Morgan Rusler - Amos Tibbs
- Matt Eyde - Mike
- Chad Darnell - Jeffrey Montgomery
- Richard Augustine - Uniformed Officer
- Richard Augustine - Steven
- Annabelle Milne - Elvira
- Marcus Chait - Alex Dwyer / Ernie Pitts
- Max Grodénchik - Maintenance Worker
- Elaine Hendrix - Julie Seaton
- Amy Stewart - Lois Hammond
- Cindy Pickett - Laura Corday
- April Grace - Ms. Hopper
- Patrick Cassidy - Dr. Scott Berger
- Dean Norris - Liam Moore
- Nick von Esmarch - Dan Meeks
- Michael Shannon - Philip Corday
- Jonathan Fraser - Richard Flynn
- Don McManus - Dr. Horace Banner
- Arija Bareikis - Detective Annie Capra
- Tom Bresnahan - A.J. Crawford
- Tom Bresnahan - Jimmy Donnelly
- Stoney Westmoreland - Frank Huss
- Perla Walter - Mrs. Abolita
- Dawn-Lyen Gardner - Leever
- Stacy Solodkin - Audrey
- Aisha Hinds - Asmina Chol
- Michael O'Neill - Chris Benz
- John J. Dalesandro - Davis Perry
- Hugh Davidson - FBI Suit #1
- Michael Bryan French - Daniel Harrison
- Kate Fuglei - Mrs. Monroe
- Amy Aquino - Lois Carver
- Jacob Bruce - Officer Jefferson
- Jacob Bruce - O'Brien
- Jacob Bruce - Jefferson
- Jacob Bruce - Uniform Cop
- Joshua Harto - Joshua Goodson
- Gregory Alan Williams - U.S. Army Chaplain
- Roberta Bassin - Mrs. McPhears
- Sally Champlin - Administrator
- Ben Murray - John J. McPhears - Age 15
- Jack Gwaltney - Judge Thad Halloran
- Tim DeZarn - Police Chief
- Michael McCarty - Dr. Anderson
- Paul Keeley - Galtieri
- Michael Rose - Sergeant
- Buddy Dolan - Cop #1
- Bennett Dunn - Young Olin Price
- Judith Moreland - Doctor
- Judith Moreland - Devlin Correctional Facility Official
- Patrice Pitman Quinn - Deena
- Bellina Logan - Mortician
- Cornelia Hayes O'Herlihy - Eva Stinson
- Daphne Maxwell Reid - Mrs. Avery
- Brian Catalano - Detective #1
- Steven Clawson - Delirious Man
- Kevin Kilner - Mr. Darnell
- Wolf Muser - Defense Attorney
- Rhonda Stubbins White - Florence Mills
- Zach Grenier - Norman Farrell
- Eric Pierpoint - Fireman
- Patti Yasutake - Mrs. Mika Yamamoto
- David Paul Francis - Motel Manager
- Anne Thomas - Darla Channing
- Michael Mantell - Roger Shyler
- Peter J. Lucas - Karl Marchenko
- Jerry Hardin - Vernon Abbott
- John P. Connolly - Neal Freely
- Jon Huertas - Manuel Rios
- Tim Weske - Fencing opponent
- Mark Aaron Wagner - Zach Bouchard
- Smith Cho - Female Fencer
- Brian Reed Garvin - Phil the Bartender
- Robin Karfo - Mrs. Chiemingo
- Lola Glaudini - Pamela Bragman / Samantha Rae
- Alexandra Krosney - Leann Dawber
- Corinne Reilly - Mrs. Yates
- Gill Gayle - Carl Yates
- Benjamin Burdick - Male Employee
- Scott DeFoe - Tactical Leader
- Ken Land - Scott Page
- Donn Swaby - Reggie Duplaix
- Jeff Newburg - Rich Kid #1
- Bradley Dodds - Rich Kid #2
- Nichelle Hines - Paramedic #1
- Nichelle Hines - Paramedic
- Elizabeth Sung - Su-Ying Zhang
- Greg Watanabe - Mr. Lee Zhang
- Eamonn Roche - Dr. Shaw
- Paul Keith - 'Vagrant' Lester Abbot
- Scott Rinker - Noel Abbot
- Fernando Chien - Quan Cheng
- Jim Abele - Owen Stanwood
- Jerry Kernion - Davis
- Nick Vlassopoulos - Robert Castelli
- Dee Freeman - Mrs. Jenkins
- Mark Margolis - Cahill
- William Marsh - Ian 'Sherlock' Begley
- Conni Marie Brazelton - Dr. Ford
- Danielle McKee - Homicide Victim
- Isa Jonay - Bouncer
- Jon Braver - Faller / Vilson Ahmeti
- Ellerine Harding - Clerk
- Stacey Carino - Marcy Strauss
- Anthony Molinari - Colin Walsh
- Anthony Molinari - Thief
- K.T. Thangavelu - Nurse
- Matthew Linhardt - Doctor
- Gideon Potter - Jennings
- Michael Adler - A.D.A. Willis
- Paul Darrigo - Security Guard
- P. David Miller - SWAT Team Leader
- Caleb Campbell - FBI Officer
- Jody Hart - Sniper #1
- Pat Destro - Ellen
- Christine Dunford - Nicole
- Brenda Wehle - Mother Superior
- Erica Sullivan - Sister Theresa
- Mark Tymchyshyn - Phillip Soble
- Joel Grey - Carl Meisner
- Thomas Lumberg Jr. - Cop
- Yeni Alvarez - Paramedic
- Brooke Hamlin - Madeline Soble
- Kaela Dobkin - Beth Siles
- David DeSantos - Nestor Sanchez
- Tyler Neitzel - Tommy Riggs
- Bryan McMullin - Hot Guy
- Stephen Monroe Taylor - Wayne Riggs
- Stephen Monroe Taylor - Wayne 'Danger' Riggs
- Abbey Skinner - Hot Girl
- Sung Yun Cho - OR Nurse
- Caryn Mower - Mrs. Titleman
- Michael Lawson - Lyle Titleman
- Brian Kimmet - Oliver Titleman
- Mark A. Nash - Massachusetts State Police
- Bruno Oliver - Cop #1
- Robert Rigamonti - Surgeon
- Billy Salvadore - Perp
- Christopher DerGregorian - Bicycle Cop
- Christopher Goodman - Gordon Tolliver
- Christopher Goodman - Deputy Joe Whatley
- Jeremy Roberts - Teddy Dubois
- Danielle Burgio - Maria Margosian
- Danielle Burgio - Andrea Goddard
- Keone Young - Jimmy Ning
- Raymond J. Barry - Mr. Nicholas
- Tim Ryan - Colby Marshall
- Tim Ryan - Plainclothes Officer
- Don Maloney - Officer Bussford
- John Allsopp - Vegas Detective
- David Mark Dean - Biker
- Robert Fabiani - Al
- Deji LaRay - Secret Sevice Agent
- Sarah Simmons - Mrs. Nicholas
- Amy Grabow - Bridgette Sparks
- John Paul Pitoc - Kirk Hammond
- Steven Koller - Mr. Reynolds
- Thomas Alexander - Uniform Cop 3
- Dig Wayne - Officer Frank
- Dig Wayne - Uniform Cop 2
- Dig Wayne - Uniform Cop #2
- Joseph Castanon - Brandon Holloman
- James Martin Kelly - Police Captain
- Alec Ledd - UPS Guy
- Kevin Makely - Assistant Attorney General
- Bruce Nozick - Overgard suit
- David Grant Wright - Assistant Warden
- Ruth Silveira - Judge Nancy Wright
- Mandy June Turpin - Annette Carson
- Stacey Moseley - Nurse
- Dominic Janes - Michael Graham
- Ed Aristone - Kevin Carter
- Al Whiting - Cop
- J. Robin Miller - Connie Winters
- Kristin Minter - Sara
- David Burtka - Craig Heeley
- Eddie Allen - Peter Holland
- Tyler Patrick Jones - Young Brian Heeley
- Francis Fallon - Uniform Cop
- Francis Fallon - Officer Moreno
- Christopher Michael - Ed Duvane
- Michael Owen - Mr. Stockton
- Craig Tsuyumine - Reporter
- Ryan Van de Kamp Buchanan - Police Officer
- Ryan Van de Kamp Buchanan - Paramedic
- Dee Wallace - Lorraine Heeley
- Amaris Dupree - Officer Perez
- Saxon Trainor - Robert Stockton's Fiancee
- Terry Nemeroff - Leon Meyers
- Dorenda Moore - Lisa Radlauer
- Charles Duckworth - Jesse Spaulding
- Andrew Borba - Abe Yaslow
- Barry Wiggins - Officer Spaulding
- Jamison Jones - Dan Radlauer
- Myndy Crist - Andrea Carruthers
- Jeffrey Pierce - Bill Patterson
- Ted Detwiler - Roger Carruthers
- Greg Fitzpatrick - Dexter Pontillo
- Greg Fitzpatrick - Suspect
- Eddie Mills - Sheriff Davey Correll
- Todd Stashwick - Bank Manager Raleigh
- Ken Garcia - Mr. Alvarez
- Jordan Garrett - Derrick Wyath
- Jeffrey Muller - Keith Kirkwood
- John Tague - Gordon
- Samantha Klein - Kara Kirkwood
- Annie Fitzgerald - Betty Wyath
- Annie Corley - Frances Murphy
- Yvonne Delarosa - Noemi Alvarez
- Marianne Muellerleile - Alice
- Dean Francois - Prosecuter
- James Eckhouse - Mr. Cartland
- Marvin Jordan - Suit
- Josh Wingate - Trent Willows
- Rick Cluchey - Mr. Hurst
- Vis Brown - Inmate #1
- Shawn McDonald - Cop
- J. Karen Thomas - Mrs. Gurney
- Cristine Rose - Dr. Wasserman
- Christian Monzon - Ernesto Sanchez
- T.W. Leshner - Chad Wasserman
- Scott Lincoln - The Captain
- Milos Milicevic - Big Man
- Ray Santiago - Omar 'Lil O' Rodriguez
- Kristin Bauer - Molly Greene
- Mario Orozco - Henchman
- April Eckfeld - Carrie Hartsman
- Alex McKenna - Abby Macy
- Tyler Nimmons - Director of Rehab
- David Ury - Arthur Hay
- Salli Saffioti - Charlene Davis
- Ja'net DuBois - Mrs. Jones
- Jeremiah Birkett - Agent Winter
- Shan Applegate - Robert Payton
- Mark Hicks - Don Travis
- Mike Caravella - Eddie Dawson
- D.J. Harner - Nurse Latham
- Russell Sams - Nate
- Todd Soley - Nicholas
- Jeanette Brox - Shannon Paige
- Rob Swanson - Peterson
- Sean R. Lake - Cafe Patron
- Rubén Garfias - Manny Hernandez
- Jeff Corbett - Tom Wheeler
- Lisa Kaminir - Attorney Stewart
- Dana MacDuff - Hitman
- Bob Rusch - Officer Sanders
- Ken Weiler - ADA Mathew Lasky
- Richard Wharton - Pawnbroker
- Lenore Thomas Douglas - Judge's Clerk
- Peter Birkenhead - Ted Hawthorne
- Craig Zimmerman - Bartender
- Chris Gann - U.S. Marshal
- James Huang - First Uni
- Kasey Mahaffy - Second Uni
- Kofi Natei - Cop #1
- Jamie Martz - Michael Elwing
- Cecelia Antoinette - Betty Pinsky
- Edward Carnevale - Driver 2
- Dihlon McManne - Tom
- Owen Smith - Andy
- Quinn Sullivan - Anne
- Wayne Thomas Yorke - Louis Blake
- Sterling Beaumon - Stewart Manning
- Cassandra Creech - Ms. Caullings
- Terri Hoyos - Panel Chair
- Tessa Ludwick - Huyen
- Ludo Vika - Zoila
- Petra Sprecher - Protester
- Alma Collins - Grandma Caullings
- Blake Shields - Off. Connor Greco
- James Earl - Man with Leg Wound
- Tony Perez - Man Rescued from Truck
- Ron Butler - Calvin Dobbs
- Ron Butler - Lawyer
- Jason Ross-Azikiwe - Lieutenant Johnson
- Larnell Stovall - Carjacker
- Hugh Daly - Boston SWAT
- James McMann - James the Videographer
- Shaun Weiss - Brian Osguld
- Jackson Wurth - Young Brian Osguld
- Anthony Jennings - Boxer
- Sarah Hudson - Susan Osguld
- Mireille Enos - Sandy Walsh
- Molly Sims - Delinda Deline
- Joe Childs - Harry Fleck
- Kunal Sharma - Park Employee
- Jeremy Craven - Jesse's Friend
- Denise Gentile - Judith Gelman
- Wendy L. Walsh - News Reporter
- Kim Estes - Judge Christopher Hanna
- Ron Silver - Shelly Levine
- William Walton - Jury Foreperson
- Kimberly Demarse - Theresa Getty
- Taira Soo - EMT
- Kevin Foster - Patrick Mahoney
- Anne Betancourt - Linda Gonzales
- Patricia De Leon - Magda Garcia
- Brian T. Delaney - Uni One
- Brian T. Delaney - Uniform #1
- Brian T. Delaney - Uni
- Carmen Corral - Isabel
- Alina Herrera - Elena Garcia
- Sophia Santi - Sick Woman
- Javier Montoya - Thomas Garcia
- David Andriole - David Tallridge
- Val Lauren - Eric Margosian
- Gina St. John - News Anchor
- Gina St. John - Reporter
- Gina St. John - Newscaster
- Parvesh Cheena - Groundskeeper
- Kayla Mae Maloney - Stephanie Federma
- Scott Michael Morgan - Officer Rooney
- Shahine Ezell - Charlie Baxley
- Aris Mendoza - Rosa
- Tim Lounibos - Jamie's Father
- Elizabeth Keener - Stacey
- Ariel Winter - Gwen
- John Prosky - Keene's Lawyer
- Chancellor Miller - Tyler
- Cullen G. Chambers - Bobby Wheeler
- Adam Jamal Craig - Officer Hansel
- Adam Jamal Craig - UNI
- B.J. Clinkscales - Beau Wallace
- Phillip Jeanmarie - Darryl Bellamy
- Britain Spellings - Delivery Guy
- Joyce Lee - Nurse
- Lawrence Pressman - Judge Harlan Marshall
- Rachel Nicks - Tracy Seaver
- Ted Garcia - Anchorman
- Susan Slome - Carly Peppino
- William Francis McGuire - Mr. Carson
- Andy Hnilo - Daniel Kensith
- Jenny Morgan - Sarah Pasternak
- Sarah Lafleur - Julie
- Jeffrey Donovan - William Ivers
- Tony Longo - Donald Gene
- Janine Venable - Anesthesiologist
- Janine Venable - Nurse Daniels
- Ashleigh Sumner - Debbie Baron
- Emma Bates - Emma Curaco / Carolyn Anderman
- Josette DiCarlo - Anna
- Paul McCarthy-Boyington - Danny Baker
- Sean Moran - Howard the Magnificent
- Tony Mouleart - Stan
- David Winston Barge - Police Officer
- Roxana Ortega - Special Agent Janie Rush
- John Mahon - Police Captain
- Steve Abbott - Dean Cody
- Jerry Trainor - Brian
- Lidet Viravong - Basit Bakar
- Tom Ohmer - Captain Seaver
- D.W. Moffett - Eddy Winslow
- Mike Lutz - FBI Agent
- Rick Parker - Biker (uncredited)
- Jermaine Jackson - Looter
- Monnae Michaell - Mrs. Jenner
- Greg Allen Johnson - Woodshop Supervisor
- Александр Кузнецов - Viktor
- Steve Gibbons - Rescue Team Member
- Thomas Mills - Caretaker
- Eric Ware - CMT Tech
- Richard Steinmetz - Daniel Gallow
- J.D. Hall - Carl
- Ken Magee - Power co. rep
- Mark Kiely - Ryan Wheeler
- Scott Allan Campbell - George Driscoll
- Charles Janasz - Lawyer
- Brett Wagner - Bartender
- José Zúñiga - George Cortinez
- Javier Grajeda - Louis Vega
- Rae Ritke - Patty Weyland
- Tom Beyer - Guy
- Jeremy Davidson - Daniel Brackett
- Jamie McShane - Hotel Manager
- Robert Joseph - Cop
- David Reynolds - Hans
- Curtis Armstrong - Herb / The Punisher
- John Walcutt - Mr. Little
- Paul Perri - Jerry
- Alex Nevil - Burt Lowe
- Daniel Kountz - Aaron Neil
- Kenneth Meseroll - Judge
- Gino Montesinos - Cuban
- Rick Fitts - Dick Robbins
- John Gowans - Mr. Levin
- Brandon Johnson - Male Resident
- Christopher John Fields - Mack Hacken
- Jeff Cahill - Davey
- David Andrew Nash - Orderly
- Ellen Greene - Mrs. Dunham
- Allan Arkush
Don Harvey interpreta a Coach Vickers en la serie.
James Caan interpreta a Ed Deline en la serie.
Paul Winfield hace el papel de Dr. Phillip Sanders.
Brian Tarantina interpreta a Devlin Inmate Martinson en la serie.
Marianne Muellerleile interpreta a Alice en la serie.
Josh Cruze interpreta a Florist en la serie.
William Russ interpreta a D.A. Jack Olson en la serie.
Tamlyn Tomita interpreta a Grace Yakura en la serie.
Michael Shannon hace el papel de Philip Corday.
Sandra Bernhard interpreta a Roz Framus en la serie.
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