- George Hamilton - Ned's Father (uncredited)
- Grant Shaud - Steve Kaiser
- Jonathan Mangum - Bernard Slaybeck
- Jennifer Elise Cox - Elise Hofer
- Dana Davis - Barb
- Wilson Cruz - Sid Tango
- Eddie Shin - Wilfred Woodruff
- Michael Cornacchia - Burly Bruce Carter
- Barbara Barrie - Mamma Jacobs
- Alexander Gould - Elliot McQuoddy
- Daeg Faerch - Ingmar Todd
- Ed Brigadier - Minister
- Diana Scarwid - Mother Superior
- Tim Conlon - Chas Spielman
- Jayma Mays - Elsita / Elsa
- Mary Kay Place - Annabelle Vandersloop
- Ethan Phillips - Daniel Hill
- Paul F. Tompkins - Gunther Pinker
- Fred Williamson - Roland 'Rollie' Stingwell
- Patrick Fabian - Mark Chase
- Debra Mooney - Calista Cod
- Ivana Miličević - Hedda Lillihammer
- Lee Arenberg - Arnaud Bailey
- Patrick Breen - Leo Gaswint
- Carlos Alazraqui - Gordon McSmalls
- French Stewart - Woolsey Nicholls
- Mo Collins - Sister Larue
- Joel McHale - Harold Hundin
- Ron Yuan - Shrimpboy
- Christopher Sieber - Napoleon LeNez
- Paul Reubens - Oscar Vibenius
- Dash Mihok - Lemuel 'Lefty Lem' Weinger
- Josh Randall - Charles Charles
- Jessica Lundy - Hillary Hundin
- Michael Hitchcock - Father Eduardo Dedonde
- Gina Torres - Lila Robinson
- E.J. Callahan - Jackson Lucas
- Orlando Jones - Magnus Olsdatter
- Wendie Malick - Coral Ramora
- Shelley Berman - Gustav Hofer
- Peter Cambor - Dusty Fitz
- Julia Campbell - Emma Newsome
- David Koechner - Merle McQuoddy
- Hamish Linklater - John Joseph Jacobs
- George Segal - Roy 'Buster' Bustamante
- Rachael Harris - Georgeann Heaps
- Eric Stonestreet - Leo Burns
- Steve Hytner - Andrew Brown
- David Arquette - Randy Mann
- Raúl Esparza - Alfredo Aldarisio
- Christopher Neiman - Lucas Shoemaker
- Patrick Fischler - The Waffle Nazi
- Stephen Root - Dwight Dixon
- Jenny Wade - Hallie Hundin
- Missi Pyle - Betty Bee
- Joey Slotnick - Jimmy Neptune
- Constance Zimmer - Coco Juniper
- Danny Comden - Rob Wright
- Michael McDonald - Galveston Gus
- Tim Bagley - Colonel Likkin
- Mark Harelik - Ramsfeld Snuppy
- Beth Grant - Marianne Marie Beattle
- Brad Grunberg - Funeral Director
- Brad Grunberg - Lawrence Schatz / Louis Schatz
- Autumn Reeser - Kentucky Fitz
- Wayne Wilderson - Wendell Featherstone
- Lydia Look - Heather Hundin
- Josh Hopkins - Shane Trickle
- Perry Anzilotti - Augustus Papen
- Nora Dunn - Blanche Ramora
- Samantha Hanratty - Young Chuck
- Julie Wittner - Deedee Duffield
- Riki Lindhome - Jeanine
- Omar Avila - Manuel
- Sy Richardson - Coroner
- Artie O'Daly - Rocky Milano
- Ralph P. Martin - Pinky McCoy
- Christine Adams - Simone Hundin
- Sarah Jayne Jensen - Anita Gray
- Molly Shannon - Dilly Balsam
- Mike White - Billy Balsam
- Jeff Marlow - Victor Narramore
- Googy Gress - Bryce Von Deenis
- Hayley McFarland - Nikki Heaps
- Graham McTavish - Hansel Von Getz
- Marc Raducci - Olive's Dad
- Alexandra Barreto - Veronica Villanueva
- Hayes MacArthur - Buddy Amicus
- Phil Abrams - Dr. Eugene Halifax
- Colton Haynes - Ares Kostopolous
- Blake Kushi - Rubbie Wu
- Graham Miller - Ralston
- Alex Miller - Maurice
- Jamison Yang - Tam Phong
- Jordan Feldman - Willie Gerkin
- Richard Benjamin - Jerry Holmes
- Willie Garson - Dick Dicker
- Robert Picardo - Detective Puget
- Steven Wash Jr. - Young Emerson
- Ted Garcia - Newscaster
- Murray Gershenz - Rabbi
- Tina Gloss - Ned's Mother
- Leyna Nguyen - Newscaster
- Jeff Wolfe - Shiny Shoes Killer
- Matt Braunger - Rick
- Taji Coleman - Beth
- Terry Anzur - Newscaster
- Terry Anzur - Anchorwoman
- Victor Z. Isaac - Delivery Boy
- Howard Mann - Elderly Man
- Vince Cefalu - Bradan
- Dan Glenn - Young Jackson
- Raf Mauro - Old Dead Guy
- Karly Rothenberg - Becky
- Tammy Dahlstrom - Woman
- Colby Paul - Abner Newsome
- Audrey Wasilewski - Madeline McLean
- Allan Graf - Angry Neighbor
- Robin Gwynne - Customer
- Theo Alexander - Pierre
- Michael Christian Alexander - Customer
- Nicole Greenwood - Ms. Moss
- Loren Lazerine - Jackie Johnny
- Mark Povinelli - Simon / Human Cannonball
- Mary K. DeVault - Sister Maria Christina
- Heather Brooker - Missy Scrivner
- Joshua LeBar - Joe
- Carolyn McDermott - Brave-Faced Wife
- J.R. Nutt - Chris
- Andrea Lui - Mei Ting
- Ping Wu - Bao Ting
- Chao Li Chi - Hua Jaing
- Teddy Chen Culver - Busboy
- Mae Hi - La Di Ting
- Jolene Kim - Waitress / Dealer
- Charles Shen - Bodyguard
- Atticus Todd - Bodyguard
- Fred Willard - The Great Herrmann
- Kerri Kenney - Alexandria
- Connor Merkovich - 12 Yr Maurice
- Keenan Merkovich - 12 Yr Ralston
- Ethan Kogan - James-Andrew - Bellboy-Porter
- Hugh Holub - Judge
- Joleen Lutz - The Widow Likkin
- Kristen Olson - Nora McQuoddy
- Michael Weaver - Nils Nilsen
- Rachel Cannon - Erin Embry
- Sam Pancake - Denny Downs
- John Cantwell - Devotee
- Ellery Sprayberry - Young Olive
- Francesca P. Roberts - Amelia Stingwell
- Matt Winston - Michael Brunt
- Melinda Bennett - Principal Eleanor Swindle
- Nicky Endres - Tour Guide
- Andy Forrest - Mr. Booker
- Sam Ingraffia - Specialist
- Carol Mansell - Trish
- Stefan Marks - Mr. Abner
- Byrne Offutt - Mr. Cray
- Yolanda Snowball - Female Teacher
- Craig Tsuyumine - Red Faced Teacher
- Mackenzie Brooke Smith - Young Lily (5 yrs)
- Lawrence Trilling
- Bruce Cohen
- Dan Jinks
- Barry Sonnenfeld
- Bryan Fuller
- Rina Mimoun
Willie Garson interpreta a Dick Dicker en la serie.
Alexander Gould interpreta a Elliot McQuoddy en la serie.
Missi Pyle interpreta a Betty Bee en la serie.
Diana Scarwid interpreta a Mother Superior en la serie.
Lee Arenberg hace el papel de Arnaud Bailey.
George Hamilton interpreta a Ned's Father (uncredited) en la serie.
Riki Lindhome interpreta a Jeanine en la serie.
Lee Pace interpreta a Ned en la serie.
Anna Friel interpreta a Charlotte Charles en la serie.
Chi McBride hace el papel de Emerson Cod.
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