- Giancarlo Esposito - Doc
- Adrienne Barbeau - Dixie Parmelee
- Tobin Bell - Chief Connors
- Jesse C. Boyd - Richie Grenadine
- Cailey Fleming - Evie
- Ravi Naidu - Man in the suitcase
- Will Kindrachuk - Justin
- Madison Bailey - Carla
- Ian Gregg - Alex
- Logan Allen - Harold
- Dylan Gage - Smitty
- Afemo Omilami - Brenner
- Tricia Helfer - Lydia Layne
- Michael Scialabba - Tom Harding
- Danielle Lyn - Celia
- Bruce Davison - Avery Whitlock
- Susannah Devereux - Marjorie Whitlock
- Dane Rhodes - Lester M. Barclay
- Karen Strassman - Leslianne Dowd
- David Arquette - Sheriff Deke
- Tommy Kane - Don Pomade
- Kermit Rolison - Pastor Mitchell Ryan
- Callan Wilson - Private Rivers
- Kid Cudi - Doc Kessler
- Nelson Bonilla - Sgt. Quist
- Jeffrey Combs - Obersturmfuhrer Reinhard Schmelzgerat
- Kate Freund - Woman in White
- DJ Qualls - Clark Wilson
- Antwan Mills - Detective Moseley
- Melissa Saint-Amand - Debbie
- Chad Michael Collins - Dr. Herbert Sloan
- Dana Gould - Henry Quayle
- Hina Khan - Kelly
- Beth Keener - Suzy Spry
- Jason Graham - Randy Witten
- Darin Toonder - Professor Jim Scott
- Sydney Wease - Rose Phillips
- David Alexander Kaplan - Joseph Phillips
- James Devoti - Chet
- Gena Shaw - Leigh Phillips
- Christopher Nathan - Timmy Grenadine
- Diane D. Carter - Cashier
- Michael May - Eddie Hathaway
- Madison Thompson - Jill
- Tom Olson - Mr. Boatner
- Jasun Jabbar Wardlaw Jr. - Binky Bradwell
- Connor Christie - Pete
- Andrew Eakle - Bobby Reevestein
- Erica Frene - Mrs. Hathaway
- Julia Denton - Mrs. Collins
- Big Boi - Pawnbroker
- Nasim Bowlus - Greeter
- Carey Jones - The Scarecrow
- Addison Hershey - Susie
- Voltaire Colin Council - Billy
- David Wise - First Responder #2
- Jordan Patrick - Kevin
- Dennis Bouldin - First Responder #1
- Grace Toso - Zombie Marjorie
- Ryan Clay Gwaltney - Angela's Husband
- Connor Hammond - Ezra
- Dave MacDonald - Captain Lawrence Talby
- Brock Duncan - Joe Aurora
- Tyner Rushing - June
- Jana Allen - Barb
- Kevin Dillon - Kevin
- Chris Schmidt Jr. - Billy Niles
- Mark Ashworth - Norm Roberts
- Marissa Chanel Hampton - Claudia Aberlan
- Coley Campany - Mrs. Bookberry
- Ted Raimi - Ted Raimi
- Todd Allen Durkin - George
- Peter Leake - Goodman Tapert
- Iman Benson - Morgue
- Keith David - Murdoch
- Dominique Harris - Morgue Actress
- C. Thomas Howell - Sam Spinster
- Starr Lajoie - Pam Actress
- Ali Larter - Pam Spinster
- Ashley Laurence - Brenda
- Josh McDermitt - Harlan
- Pamela Ricardo - Family Member
- Ryan Kwanten - Alex (segment "The Right Snuff")
- Breckin Meyer - Ted (segment "The Right Snuff")
- Selena Anduze - Janet (Segment "Pipe Screams")
- Brooke Butler - Mallory (Segment "Within The Walls of Madness")
- Barbara Crampton - Victoria (Segment "Pipe Screams")
- Eric Edelstein - Linus (Segment "Pipe Screams")
- Gabrielle Byndloss - Sandra (segment "The Right Snuff")
- Ethan Embry - Hank
- Molly Ringwald - Mrs. Porter (segment "Sibling Rivalry")
- Brayden Benson - Jack
- Maddie Nichols - Lola (segment "Sibling Rivalry")
- Erin Beute - Bloom
- Andrew Brodeur - Andrew (segment "Sibling Rivalry")
- Malone Thomas - Beth
- Ja'ness Tate - Grace (segment "Sibling Rivalry")
- Lowrey Brown - Conner
- Jerri Tubbs - Mom (segment "Sibling Rivalry")
- Kaelynn Harris - Regina
- Alayna Bernard - Lyla (uncredited) (Segment "Pipe Screams")
- Hannah Kepple - Debra
- Justin Long - Simon
- Olivia Hawthorne - Trenice
- Nico Gomez - Carlos
- D'Arcy Carden - Renee Sherman
- Monica Louwerens - Mom
- Drew Matthews - Zeller (Segment "Within The Walls of Madness")
- Bruce Shepperson - Security Guard
- Denise Crosby - Trollenberg (Segment "Within The Walls of Madness")
- James Remar - Bateman
- Brittany L. Smith - Tara Cartwright (Segment "Within The Walls of Madness")
- Hannah Fierman - Countess Patrovska
- Andrew Bachelor - Jack
- Victor Rivera - Lampini
- Nicholas Logan - Carson (segment "Within the Walls of Madness")
- Connor Jones - Thomas (segment "By the Silver Water of Lake Champlain")
- Valerie LeBlanc - Danielle
- Leonard R. Butler - Warden (Segment "Within The Walls of Madness")
- Keith Arthur Bolden - Mr. Boone
- Brandon Quinn - Wade Cruise
- Jade Fernandez - Geesa
- Gina Hiraizumi - Dr. Mai Sato
- Kenny Alfonso - Mitch Duclon
- Joe Ando-Hirsh - Bobby Tanaka
- Nate Andrade - Tsuburaya Monster
- Nicholas Massouh - Elmer Strick
- Nic Starr - Director Poppler
- Deborah Bowman - Estelle Flinty
- Jackson Beals - Officer Bunk Dill
- Tony DeMil - Polish Frank
- Glenn Magee - Officer Willis
- Suehyla El-Attar - Sara
- Chris Mayers - Barry
- Johnathon Schaech - Dalton
- Abigail Dolan - Theresa
- Cynthia Evans - Maria
- Boston Pierce - Michael
- Samantha Worthen - Mrs. Jones
- Reagan Higgins - Mercy
- Matt Skollar - Incinerator Worker
- Omer Mughal - Podcaster #1
- Hannah Aslesen - Podcaster #2
- John Crow - News Anchor
- Matthew Barnes - Tim
- Devon Hales - Lauren
- Jibre Hordges - Saul
- Lauren Richards - Mia
- Kamran Shaikh - Bob
- Shannon Eubanks - Catherine
- Grant Feely - Timmy
- Emerson Bennett - 5-year-old Henry
- David Alexander Kaplan - 9-year-old Henry
- Garrett Zehner - Oldest Tim
- Jody Whitehurst - Doctor
- Jabari Marshall - Mover
- Mark Hamill - Mayor Wrightson (voice)
- Danielle Harris - Marnie Wrightson (voice)
- Ron Livingston - Mac Kamen (voice)
- Fayna Sanchez - Serese/Carmella/Harried Mom (voice)
- Kate Thulin - Kids (voice)
- Andy Daly - Clark "Murph" Murphy/Deputy Anton/Old Fella /Local Yokel (voice)
- Reid Scott - Congressman
- Michael Rooker - Beau
- Sarah Jon - Mai
- Cristian Gonzalez - Police Chief Evan Foster
- Joshua Mikel - Cliven Ridgeway
- J.R. Rodriguez - Truck Driver Carl
- Bryan Brendle - Joe Donovan
- Rey Hernandez - Farmer Jeremy
- Karlton Davis - Young Man
- Mai Delapa - Mother
- Aodhan Lane - Skeeter
- Kadianne Whyte - Miranda
- Ruth Codd - Cassandra (segment "20 Minutes with Cassandra")
- Samantha Sloyan - Lorna (segment "20 Minutes with Cassandra")
- Franckie Francois - Okwe (segment "20 Minutes with Cassandra")
- Nick Heffelfinger - Delivery Person (segment "20 Minutes with Cassandra")
- Matthew James Dowden - James Harris (segment "Smile")
- Lucie Guest - Sarah Harris (segment "Smile")
- Max Archibald - Max (segment "Smile")
- Roberto Lanzas - Photographer (segment "Smile")
- Daniel Ian Joeck - Maitre D' (segment "Smile")
- Claire Friesen - Waitress (segment "Smile")
- Aleksandra Cross - Excited Young Woman (segment "Smile")
- Mateo Deuma - Gabriel (segment "Smile")
- Ryan Beil - Jay (Segment: The Hat)
- Sara Canning - Astrid (Segment: The Hat)
- Marlee Walchuk - Nicole (Segment: The Hat)
- Kelly Metzger - May (Segment: The Hat)
- David Beairsto - Bachman (Segment: The Hat)
- Sachin Sahel - Richard (Segment: Grieving Process)
- Rachel Drance - April (Segment: Grieving Process)
- Maemae Renfrow - Jean (Segment: Grieving Process)
- Kingston Chan - Daisy (Segment: Grieving Process)
- Elfina Luk - Detective Kiernan (Segment: Grieving Process)
- Rebecca Davis - Dr. Spence (Segment: Grieving Process)
- Dylan Sloane - Lyle (segment "Parent Death Trap")
- Shaughnessy Redden - Archiba (segment "Parent Death Trap")
- Chloe Babcook - Violet (segment "Parent Death Trap")
- Andrea Drepaul - Special Agent Ella (segment "Parent Death Trap")
- Ed Chow - Special Agent Mann (segment "Parent Death Trap")
- Julie Howgate - Vivianne Meyers (segment "Parent Death Trap")
- Tariq Leslie - Chester Meyers (segment "Parent Death Trap")
- Talia Mathers - Woman (segment "Parent Death Trap")
- Cooper Bibaud - Police Officer #1 (segment "Parent Death Trap")
- Loretta Walsh - Gloria (segment "Parent Death Trap")
- Keegan Connor Tracy - Marcia (segment "To Grandmother's House We Go")
- Emma Oliver - Ruby (segment "To Grandmother's House We Go")
- Jason Bell - Werewolf (segment "To Grandmother's House We Go")
- Jason McKinnon - Benny (segment "To Grandmother's House We Go")
- Marion Eisman - Belinda (segment "To Grandmother's House We Go")
- Teana-Marie Smith - Preacher (segment "To Grandmother's House We Go")
- Amanda Huxtable - Carla (segment "To Grandmother's House We Go")
- David Avadon - David (segment "To Grandmother's House We Go")
- Devyn Dalton - Ruby Werewolf (segment "To Grandmother's House We Go")
- Karis Cameron - Anna (segment "Meet the Belaskos")
- Matthew Nelson-Mahood - Alex (segment "Meet the Belaskos")
- Brendan Taylor - Chuck (segment "Meet the Belaskos")
- Donavon Stinson - Doug (segment "Meet the Belaskos")
- Lisa Durupt - Helena (segment "Meet the Belaskos")
- Andrew Long - Hunter 1 (segment "Meet the Belaskos")
- Andrew Nadanyi - Hunter 2 (segment "Meet the Belaskos")
- Jonathan Vellner - Hunter 3 (segment "Meet the Belaskos")
- Sari Mercer - Mother Roach (segment "Meet the Belaskos")
- Connor Wong - Dave (segment "Cheat Code")
- Lochlyn Munro - Jeff (segment "Cheat Code")
- Nikolas Filipovic - Spencer (segment "Cheat Code")
- Kelly Ann Woods - Spencer's Mom (segment "Cheat Code")
- Kyle Strauts - Alien (segment "Cheat Code")
- Curtis Lum - Ryan (segment "Something Burrowed, Something Blue")
- Tom Atkins - Frank (segment "Something Burrowed, Something Blue")
- Kristy Dawn Dinsmore - Allison (segment "Something Burrowed, Something Blue")
- Bernie Yao - Daryl (segment "Something Burrowed, Something Blue")
- Anja Savcic - Angela (segment "Doodles")
- Tina Grant - Sonja (segment "Doodles")
- Tyler McClendon - Roger Barton (segment "Doodles")
- David Clennon - Calvin (segment "Doodles")
- Kenny Wood-Schatz - Bartender (segment "Doodles")
- Kevin Amestoy - Cartoonist (segment "Doodles")
- Kyra Zagorsky - Sarah (segment "George Romero in 3D")
- Graham Verchere - Martin (segment "George Romero in 3D")
- Megan Charpentier - Dawn (segment "George Romero in 3D")
- Sebastian Kroon - George Romero (segment "George Romero in 3D")
- Peter New - Cooper (segment "George Romero in 3D")
- Roberto Alejandro Sandoval Santana - Zombie #2 (segment "George Romero in 3D")
- Rochelle Greenwood - Miranda (segment "Baby Teeth")
- Alison Thornton - Shelby (segment "Baby Teeth")
- Micaela Nyland - Kaitlyn (segment "Baby Teeth")
- Maya Ford - Nurse (segment "Baby Teeth")
- Greg Nicotero
Giancarlo Esposito interpreta a Doc en la serie.
Adrienne Barbeau interpreta a Dixie Parmelee en la serie.
Tobin Bell interpreta a Chief Connors en la serie.
Jesse C. Boyd hace el papel de Richie Grenadine.
Cailey Fleming hace el papel de Evie.
Ravi Naidu interpreta a Man in the suitcase en la serie.
Will Kindrachuk interpreta a Justin en la serie.
Madison Bailey interpreta a Carla en la serie.
Ian Gregg hace el papel de Alex.
Logan Allen interpreta a Harold en la serie.
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