- Carolyn Hennesy - Barbara Coman
- Ryan Devlin - Smith Frank
- Sheryl Crow - Sara
- Alan Ruck - Frank Miller
- Scott Foley - Jeff
- Sarah Chalke - Angie
- Jennifer Aniston - Glenn
- Barry Bostwick - Roger Frank
- Spencer Locke - Kylie
- Beverly D'Angelo - Sheila Keller
- Nick Zano - Josh
- Rachael Harris - Shanna Miller
- Brennan Bailey - Kid
- Tyler Steelman - Robbie
- Lisa Kudrow - Dr. Amy Evans
- Peter Looney - Man
- Michelle Williams - Laurie's Foster Sister
- Michael J. Willett - Glee Club Member
- Cody Simpson - Pete
- David Clayton Rogers - Matt
- Murrugun the Mystic - Sword Guy
- Karen Y. McClain - Tina
- Leena Huff - College Girl
- Van Epperson - Dwayne
- Jennifer Cortese - Vivian
- Daryl Keith Roach - Tournament Official
- John Ruby - Barista
- Andrew Thacher - Doug
- Anne Leighton - Sam
- Austen Parros - Waiter
- Shaughn Buchholz - Young Guy
- Sam Laybourne - Steve
- Tava Smiley - Woman
- Martez Covington - Randall
- Vanita Harbour - Girl
- Michael McDonald - Wayne Gibbons
- Ryan Biegel - Doug
- Gloria Garayua - Rosa
- Bill Lee Brown - Starter
- Denny Kirkwood - Austen
- Wendi McLendon-Covey - Vice Principal
- Chet Grissom - Vendor
- Steve Valentine - Announcer #1 (voice)
- Ivan Allen - Announcer #2 (voice)
- Collette Wolfe - Kirsten
- Joe Toro - Lifeguard
- Crista Flanagan - Destiny
- Nia Vardalos - Angela Torres
- Marcus DeAnda - Nestor Torres
- Lou Diamond Phillips - Lou Diamond Phillips
- Lamarcus Tinker - Kevin
- Dusty Burwell - Creepy Kid #2
- Andrew DiPalma - Blake
- Sam Lloyd - Ted Buckland
- Sean Smith - Vet
- Jamie Lea Willett - Zeta Girl
- Bob Clendenin - Tom
- Jonathan McDaniel - Ryan
- Ken Jenkins - Chick
- Jake Martin - Beach Guy
- Chris Zylka - BJ
- Gregory Hinton - Bouncer
- Stacy Barnhisel - Robbie's Mom
- Thomas Crawford - Principal
- Samantha Cope - Girl
- Lou Mulford - Ms. Pritchett
- Kevin Gould - Young Man
- Jennifer Holland - Candee
- May Wang - Lisa
- Julia Emelin - Carol
- David Goryl - Man
- Tyra Colar - Girl
- Jim Hanna - Russ
- Alex Schemmer - Trent
- Alan Heitz - Jim / Guy
- Aja Bair - Lisa
- Heather Sims - Passerby #1
- Heather Sims - Customer
- Ahmed Best - Dwayne
- Katie O'Rourke - Mom
- Katie O'Rourke - Betsy
- Kristian Capalik - Alex
- Octavio Solorio - Gardener
- Charlotte Labadie - Girl
- Dot-Marie Jones - Woman
- Brenda Vivian - Beth
- Windell Middlebrooks - Gerald
- Michael Earl Reid - Carney Man
- Eddie Alfano - Robber
- Ben Kronen - Mr. Rockwell
- Keith Burke - Cop
- Angelica Pulido - Marina
- Whit Spurgeon - Car Dealer
- Travis Guba - Coach
- Dexter Darden - Glee Club Member
- Shelbie Bruce - Glee Club Member
- Adam Roque - Glee Club Member
- Kallie Flynn Childress - Glee Club Member
- Sawyer Ever - Stan
- Shawn Parikh - Sig
- Sean Persaud - Crying Student
- Damon Kohli - Doctor
- Alex Ball - Customer
- Alex Ball - Patient
- Brian Bradley - Park Ranger
- Robert Maschio - Pool Man (The Todd)
- George Miserlis - Crispin
- Philip McNiven - Roy
- Paul Rogan - Quebec Tourist
- Briga Heelan - Holly
- Nicole Sullivan - Lynn Mettler
- Zach Braff - Pizza Guy (uncredited)
- Susan Blakely - Betsy
- George Anthony Bell - Campus Cop
- Brett Barrett - Customer
- Elaine Loh - Hiker
- Clint Jordan - Park Ranger
- Al Carabello - Paramedic
- Edwin Hodge - Wade
- Brooke Baumer - Female Clerk
- Marcus Choi - Customer
- Maliabeth Johnson - Hot Chick
- Bob Harrigan - Weatherman
- Frank DeCaro - Restaurant Owner
- David Arquette - Daniel
- Duane R. Shepard Sr. - Boss
- Brad Morris - Jerry
- Whitney Hoy - Amanda
- Patrick Faucette - Cop
- Julia Cho - Barista
- Heather Moiseve - Woman
- Ali Wentworth - Jessica
- Griffin Kunitz - Stan
- Emily R. Wilson - Bonnie
- Timothy E. Goodwin - Officer
- Dylan Booth - Bearded Guy
- Andy St. Clair - Dan
- Kale Clauson - Guy
- Amy Phillips - Janet
- Camden Gray - Young Travis
- Shayne Anderson - Waiter
- Krista Marie Yu - Girl
- Kimberly Horner - Amanda
- Gillian Vigman - Mary
- David Jahn - Therapist
- Maria Christina Thayer - Riggs
- Jason Boggs - Referee
- Lexi Ainsworth - Young Girl
- Shirley Jones - Anne
- Steven Shaw - Norman
- Michael Patrick McGill - Richard Vernon
- Garry Clemmons - Jogging Twin
- Jason Clemmons - Jogging Twin
- Tippi Hedren - Tippi Hedren
- Ronnie Mund - Ronnie
- Jeffrey Damnit - Fire Eater
- Angel Oquendo - Concierge
- Rob Delaney - Guide
- Joshua Radin - One Man Band
- Tami Tappan Damiano - Passing French Girl
- Jim Lau - Passing Asian Tourist
- Matthew Perry - Sam
- Laya DeLeon Hayes - Cookie Seller
- Jonathan Spencer - Man with Puppies
- Lynn Adrianna - Hysterical Mother
- Phillip Jeanmarie - Director
- Robert Romanus - Director
- Brennan Murray - Ride Operator
- Christopher Shea - Man
- Shane Giedraitis - Young Travis
- Rachel Quaintance - Admissions Woman
- Brendan Jennings - Coffee Bucks Manager
- Keye Chen - Orion
- Everton Lawrence - Customer
- Jen D'Angelo - Azriel
- Julianna Guill - Haylee
- Margaret Emery - Attractive Woman
- Dominic Flores - Clerk
- David Heath - Big Daddy Payne
- Nils Allen Stewart - Captain Carnage
- Bruno Oliver - Doctor
- Hope Simpson - Director
- Karlito Cineas - Kid
- Carly Craig - Mother at Cake Shop
- Carly Craig - Kelly
- Heather Brooker - Female Cop
- Paul Keith - Soldier
- Brandon Larkins - Mr. T Impersonator
- Ron Funches - Marty
- Fred Ornstein - Old Man at Bar
- Jason Rogel - Change Customer
- Erik Van Wyck - Cold Beer Customer
- Danielle Weeks - Wine Woman
- Chris Mast - Perv Stache
- Lilah Richcreek Estrada - Hostess Kim
- Ray Laska - Boss
- Joe Lorenzo - Construction Worker
- Paula Newsome - Principal Shore
- Sam Pancake - Mr. Danner
- Monica Young - Lynn
- Andy Pessoa - Adam
- Jeremy Rowley - Male Chef
- Annie Sertich - Female Chef
- Mitch Silpa - Mobster
- Alex Lombard - Leah
- Judith McConnell - Diane
- Timothy Colangelo - Couple Member
- Cindy Crawford - Cindy Crawford
- Donna Pieroni - Promo Viking Woman
- Cynthia Ferrer - Betty
- Melanie Paxson - Mary
- Christa Miller
Michelle Williams interpreta a Laurie's Foster Sister en la serie.
Christa Miller interpreta a Ellie Torres en la serie.
Alan Ruck interpreta a Frank Miller en la serie.
Courteney Cox interpreta a Jules Cobb en la serie.
Busy Philipps interpreta a Laurie Keller en la serie.
Dan Byrd interpreta a Travis Cobb en la serie.
Josh Hopkins interpreta a Grayson Ellis en la serie.
Ian Gomez interpreta a Andy Torres en la serie.
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