- Elmarie Wendel - Mamie Dubcek
- Elmarie Wendel - Mrs. Dubcek
- John Mahoney - Dr. Leonard Hamlin
- Ian Lithgow - Leon
- Marnette Patterson - Volleyball Girl
- Susan Leslie - Kissing Woman
- Marla Sokoloff - Dina
- Pat Lach - Mother
- Lauren Graham - Laurie Harris
- Danielle Nicolet - Caryn
- Chris Hogan - Aubrey Pitman
- Benjamin King - Man In Bar
- Robert Lynch - Doug
- Whitney Rydbeck - Mr. Kersey
- Elayn J. Taylor - Teacher #1
- Linda Cardellini - Lorna
- Martha Stewart - Herself
- Jane Lynch - Ms. Koppel
- David Dunard - Mechanic
- Eddie Allen - Dr. Bankson
- Laurel Green - Moviegoer
- Kathryn Joosten - Cafeteria Lady
- Shay Astar - August
- Jake Thomas - Kid
- David DeLuise - Bug Pollone
- Larisa Oleynik - Alissa Strudwick
- Christine Baranski - Sonja Umdahl
- Rochelle Robinson - Waitress
- Roseanne Barr - Janet (as Roseanne)
- Lindsey Haun - Lisa
- Brynn Hartman - Venusian #1
- Cindy Crawford - Mascha
- Dennis Rodman - Himself
- Bryan Cranston - Neil Diamond impersonator
- William Shatner - Big Giant Head
- Bob Odenkirk - Gary
- David Hasselhoff - Doctor Lasker
- Dee Freeman - Waitress
- Dee Freeman - DMV Clerk
- Miguel Ferrer - Jack McManus
- Enrico Colantoni - Frankie
- Megan Mullally - Renata Albright
- Richard Belzer - Richard Belzer
- Tracy Morgan - Tracy Morgan
- Bob Clendenin - Man #1
- John Cleese - Dr. Liam Neesam
- Elvis Costello - Elvis Costello
- Laurie Metcalf - Jennifer Ravelli
- Ed Begley Jr. - Jeff
- Katherine LaNasa - Kate
- Richard Gilbert-Hill - Jeff's Brother
- Katie Layman - Muriel
- Darlene Kardon - Old Woman
- Eric Saiet - Pleasant Man
- Steve Viall - Male Necker
- Coleman McClary - Bookish Patron (uncredited)
- Maria Cina - Onya
- Karen Constantine - Woman
- William Bogert - Dean Sumner
- Jennifer Rhodes - Mrs. Sumner
- Anna Slotky - Cheryl
- Bruce Ed Morrow - Father Rice
- Harry S. Murphy - Professor
- Steven R. Barnett - Cable Man
- Elizabeth Carder - Homeless Women (uncredited)
- Bronson Pinchot - Roy Albright
- Michael Milhoan - Coach Strickland
- Michael Milhoan - Coach
- Richard Roat - Dr. Byron
- Andrew Hill Newman - DMV Agent
- Mailon Rivera - Campus Cop
- Charlotte Booker - Grace
- Kimberly Scott - Emily
- Lorna Scott - Mrs. Walters
- Heather McPhaul - Mrs. Duvall
- Robert Knott - Ellis
- Patrick Thomas - Customer #1
- Tami Tappan Damiano - Barbara
- Gigi Bermingham - Singing Trucker
- Martin Hilton - Singing Trucker
- Karl Hamann - Singing Trucker
- Linda Dangcil - Singing Trucker
- John Raitt - Trucker Gil
- Mike Starr - Frank Muller
- Lois Foraker - Patty Muller
- Ileen Getz - Judith
- Jane Galloway - Dr. Blumfeld
- John D'Aquino - Mr. Randell
- Ray Proscia - Mugger
- Lance E. Nichols - Security Salesman
- Robert Arce - Nutty Guy
- Lisa Kaminir - Margueritte
- Ken Magee - Policeman Joe
- J.J. Cohen - Frank
- Adam Consolo - Classmate
- Naomi Judd - Frances Randell
- Tom Jourden - Doctor
- Tom Simmons - Peter
- Steven M. Porter - Roger
- D. Elliot Woods - Doctor Ladypart
- Jan Claire - Nurse Wounds
- Lily Knight - Nurse Turner
- Harry Morgan - Professor Suter
- George Takei - George Takei
- Tim Bagley - Frank
- Tim Pulice - Guy in Line
- David Goetsch - Leaflet Guy
- Jim Meskimen - Alan
- Jean St. James - Waitress
- Steven M. Gagnon - Cop
- Wendy Schenker - Reporter
- Angela Robinson Witherspoon - Voter #2
- Michael Adler - Handler
- John Henry Kurtz - Commercial Voice (voice)
- Al Franken - Frank Gansmiller
- Neill Calabro - Gansmiller's Photographer (uncredited)
- Mike Ditka - Coach Mafferty
- Matthew Mahaney - Fan #1
- Bart McCarthy - Grouch
- Bart McCarthy - Hamlet VO (voice)
- James Grace - Fan #3
- Tatum Shank - Football Player
- Laraine Newman - Candace
- Burke Moses - Glenn
- Paxton Whitehead - Dr. Menard
- Danny Strong - Aramis
- Trevor Bullock - Porthos
- John Patrick White - Victor
- Craig Olsen - Drag Queen
- J. Patrick McCormack - Victor's Dad
- Riley Weston - Brianna
- Greg Bronson - Dinner Guest (uncredited)
- Greg Bronson - Wedding Guest (uncredited)
- Tara Strong - Exercise Lady (voice)
- Victor Raider-Wexler - Janitor
- Tom Towles - Dale
- Jim O'Heir - Walt
- Mark Christopher Lawrence - Bartender
- Jan Hooks - Vicki
- Mark Pitta - Joe Baggadonuts
- Lance Davis - Clerk #2
- Don Dowe - Drunk
- Dick Martin - Ben Littmeyer
- Jay Leno - Jay Leno (uncredited)
- Nikki Tyler-Flynn - Christine
- Peggy Mannix - Charity Women
- Michael McCarty - Santa Claus
- Jack Lindine - Santa #3
- Ed Evanko - Homeowner
- Jason Horst - Jason
- George Hertzberg - David
- Marvin Braverman - Izzy
- George Adams - Mall Shopper (uncredited)
- David Banuelos - Sally's Customer (uncredited)
- Bodhi Elfman - Orderly
- Bodhi Elfman - Clerk
- Philip Baker Hall - President Dewey
- Bill Lee Brown - Customer #1
- John Maynard - Customer #2
- Rex Linn - Webber
- Rex Linn - Chuck
- Robert Lyon Rasner - Timothy
- Mary-Pat Green - Diane
- Richard Karron - Jimmy
- Ryan O'Quinn - Tybalt (uncredited)
- Raye Birk - Jeweler
- Lise Simms - Gabby
- David Kirkwood - Yellin' Joe Slocum
- Frank Kopyc - Charlie
- Patricia Bethune - Teacher
- Marcy Goldman - Woman
- Nicki Aycox - Alyson
- Barry Casey II - Travis (uncredited)
- J.J. Rodgers - Bambi
- India Dupré - Christina
- Darlene Levin - Darlene
- Maureen Sue Levin - Maureen
- Ron West - Dr. Strudwick
- Henry Woronicz - Mr. St. Clair
- Brenda Strong - Miss Frost
- Brenda Strong - Mrs. Frost
- Nancy Lenehan - Mrs. St. Clair
- Jim Pirri - Michel
- Jim Pirri - Antonio
- Richard McGonagle - Dr. Howard
- Richard McGonagle - Head Doctor
- Richard McGonagle - Doctor
- Phil Hartman - Phillip
- Phil Hartman - Randy
- Justin Urich - Romano
- James Ingersoll - Mr. Patterson
- Sam Chew Jr. - Man
- John Craig - Kid
- Greg Proops - Yasmine
- Winifred Freedman - Suzette
- Layne Beamer - Jace
- Kyle Colerider-Krugh - Elroy
- Sydney Berry - Melanie
- Whitney Dupree - Girl #2
- Richard Fancy - Judge Debelko
- Richard Fancy - Judge DeBelko
- Jim Childs - Highschool Kid
- Linda Kash - Margie
- Rif Hutton - Bookstore Guy
- Christopher Holloway - Stage Manager
- Mark Hamill - Mark Hamill
- Alex Nevil - Delivery Guy (uncredited)
- Kevin Scannell - Dr. Goldberg
- James Wellington - Borskey
- Kevin Farley - Jehovah's Witness (uncredited)
- Randy Newman - Randy Newman
- Rebecca Grant - Harry's Dream Date (uncredited)
- Dan Gilvezan - Disc Jockey (voice)
- Dan Gilvezan - News Anchor
- Dan Gilvezan - Radio DJ (voice)
- Matt Sergott - Window Cleaning Dancer (uncredited)
- Lee Ryan - Minister
- David Bickford - Professor #1
- Don Gettinger - Professor #4 (uncredited)
- Spencer Vrooman - Dukes
- Leigh McCloskey - Matthew
- Gary Carlos Cervantes - Mechanic
- Elaine Stritch - Martha Albright
- George Grizzard - George Albright
- Emile Hirsch - Punk
- Linde Gibb - Nurse
- Julia Sweeney - Patty
- Jacee Jule - Instructor
- Jim O'Doherty - Clem
- Jim O'Doherty - Bailiff
- Jim O'Doherty - Guy
- Jason Carter - Seth
- Jack Hallett - Jury Foreman
- Patrick Kerr - Irving
- Joyce Guy - Claire
- Joe Bays - Foster
- Damon Chandler - Attorney #1
- Ana Gasteyer - Ana Gasteyer
- Ana Gasteyer - Dr. Brand
- Mary Portser - Attorney #6
- Peter Krause - Peter Connelly
- Steve Larson - Larry
- Susanne Wright - Woman
- Lauren Tuerk - Ms. Piazza
- Nancy Yee - Mrs. DeGuzman
- Brian Jacobs - Handler #1
- Sean Moran - Ernie
- Cathrine Grace - Veronica
- Chad Einbinder - Rico
- Chad Einbinder - Police Officer
- Sam Lloyd - Eddie
- Tom Ayers - Clerk
- Mark Burnham - Cooper
- Larry De Russy - Schiffy
- Joseph G. Medalis - Chancellor
- John Benjamin Hickey - Rick
- Suanne Spoke - Bibi
- Kathleen Garrett - Celia
- Lesley Fera - Woman #2
- George Oliver Hale - Guy #1
- Shireen Crutchfield - Kirsta
- Diana Castle - Saleswoman
- Roger Hewlett - Security Guard #1
- Al Foster - Security Guard #2
- Greg Gumbel - Greg Gumbel
- Beverly Johnson - Prell
- Irina Pantaeva - Gabriella
- Angie Everhart - Chloe
- Jennifer Lee Keyes - Venutian Girl
- Sonya Eddy - Ticket Taker
- Frank Clem - Waiter
- Alex Kubik - Counterman
- Shonda Whipple - Perky Idiot #2
- Marla Frees - Computer
- Scott Klace - Mark
- Mike Schiff - Dance Judge #1
- Mike Schiff - Guy Who Chokes on a Shrimp (uncredited)
- Denise Poirier - Judy
- Barbara Lee Bragg - Karen
- Cynthia Gravinese - Cindy
- Bill Irwin - Pickles
- Marguerite Moreau - Tina Emory
- Michael DeLuise - Paulie
- Peter DeLuise - Frank
- Dom DeLuise - Mr. Polone
- Everett Greenbaum - Norman
- Fred Pinkard - Louis
- Ken Thorley - Artie
- Charles C. Stevenson Jr. - Lester
- Gloria LeRoy - Dolores
- Christine Zander - Christine Zander
- Christine Zander - Voter #1
- Christine Zander - Margaret Williams
- Christine Zander - Woman
- Eugene Elman - Stan
- Miriam Flynn - Suzie Martin
- Jerry Lambert - Shop Owner
- Sam Arnold - Restaurant Patron (Stephen)
- Jordan Brower - Steve
- Dublin James Wahlberg - Vinny
- John Aylward - Registrar
- John Aylward - Chancellor
- Jim Beaver - Happy Doug
- Wayne Pére - Jonesy
- Jeff Doucette - Chet
- Andrew Patrick Ralston - Dr. Solomon's Student
- Amanda Carlin - Flora
- John Hillner - Steve
- Carey Eidel - Jeff
- Christopher Liam Moore - Waiter
- Bob Glouberman - Neighbor
- Tangie Ambrose - Lisa
- Lori Hall - Voice in Audience (voice)
- Lori Hall - Assistant
- Marianne Muellerleile - Lucy
- Marcus T. Paulk - Jimmy
- Miles Marsico - Freddy
- Jack Salvatore, Jr. - Roy
- Andrew Ducote - Todd
- Taylor Emerson - Ronnie
- Chip Chinery - Maintenance Guy
- Chip Chinery - Workman
- Chip Chinery - Guy
- Chip Chinery - Janitor
- Andrea Walters - Mom
- Larry Miller - Garvin
- Ed Gale - Oscar
- Arturo Gil - Lars
- John Valdetero - Giganticus
- Alex Alexander - Tiffany
- Rakefet Abergel - Carnival Guest
- Sid Newman - Phelps
- Jorge Luis Abreu - Ron
- Jim Jackman - Venetta
- Lawrence Mandley - Carlos
- Nicolas Coster - Chancellor Stevens
- Elizabeth Anne Smith - Tina
- Carol Mansell - Mrs. Smith
- Susan Bjurman - Mrs. Guthridge
- Ruth de Sosa - Laura
- Andrea Harper - Saleswoman
- Peter Jurasik - Principal Greschner
- Peggy Miley - The Columbian
- J.P. Manoux - Clerk
- Erika Christensen - Brianna
- Dorian Frankel - Customer
- Danilo Mancinelli - Basketball Player
- Obi Ndefo - Eric
- William Mesnik - Maitre d'
- Tim Haldeman - Mr. Kraft
- Dave Allen - Arthur
- Mike Grief - Riff
- Jim Maniaci - Raff
- Douglas Robert Jackson - Douglas
- Kurtwood Smith - Jacob
- Elsa Raven - Aunt Florence
- Jack Carter - Uncle Abe
- Christine Lakin - Michelle
- Courtney Peldon - Janine
- Jeanine Jackson - Claire
- Julie Claire - Jenny
- Cynthia Frost - Aunt Sylvia
- Jim Jansen - Mr. Gindek
- Susan Ilene Johnson - Linda
- Sally Brooks - Verna
- Bill Chott - Cable Guy
- Bill Chott - Fred
- Diane Delano - Lorraine
- Sara Ballantine - Mrs. Wheeler
- Matt McKenzie - Mr. Wheeler
- Sean Masterson - Justin
- Rick Cramer - Stenstrom
- John Eric Bentley - Todd
- Mimi Cozzens - Hamilton
- Michael Ensign - Fordham
- Van Epperson - Bill
- Lindsey Fields - Louise
- Kim Robillard - Howard
- Sean Christopher - Shopper
- Ron Roggé - Shopper
- Christopher Neiman - Caleb
- Kevin Nealon - Dennis Caslow
- Pat Finn - Chaz Montana
- Pat Finn - Paul
- Anthony Tyler Quinn - Sam 'The Butcher' Marchetti
- Donna Ponterotto - Waitress
- Jonathan Nichols - Bartender
- Susan Ruttan - Cathy
- Eric Jungmann - Jerry
- Dorian Gregory - Byron
- Chuck Roy - Ned
- Kathy Bates - Charlotte Everly
- John Bennett Perry - Hamilton Bell
- Kim Johnston Ulrich - Dorothy Strudwick
- William Bassett - Bernard
- Gil Christner - Carl
- Bernard Kates - Ronald
- Max Baker - Johann
- David Youse - Stage Manager
- E.J. Callahan - Sid
- Jack Kutcher - Chester
- Jill Matson - Ginger
- Jill Matson - Jill
- Jill Matson - Waitress
- Alexander Folk - Jack
- Terry Rhoads - Salesman
- Terry Rhoads - Bill
- Laura Wernette - Tasha
- Rick Hall - Limo Driver
- Aaron Paul - Student
- Amy Smallman - Nurse
- Curtis Armstrong - Ken Fretts
- Jeff Austin - Doctor
- Cesar Herrera - Manolito
- Jacqueline Torres - Mrs. Manolito
- Joel McCrary - George
- Steve Witting - Ted
- Janet Carroll - Mrs. Runquist
- Dennis Cockrum - Colonel Pinkham
- Madison Mason - Mr. Jack Wallencott
- Andrea C. Robinson - Mrs. Milly Wallencott
- John Balma - Eames
- David Chisum - Chip Caswell
- Melissa Greenspan - The Maid
- Billy Connolly - Inspector Macaffery
- Jane Morris - Mrs. Goltra
- Larry Dorf - Waiter
- Emily Osment - Dahlia
- Aaron Lustig - Dr. Severson
- Phil Reeves - Mr. Mora
- Victoria Garcia-Kelleher - Waitress
- Brian Dunkleman - Pizza Guy
- Ron Fassler - Auctioneer
- Bob Bancroft - Father Matthew
- Philip Bolden - Ben
- Mendi Segal - Man's Voice (voice)
- Bob Morrisey - Mr. Malone
- Lisa K. Wyatt - Hannah
- Theresa Mulligan - Triple A Lady
- Genie Francis - Gwen
- Kevin Ruf - New Father
- Kevin Ruf - T.V. Reporter #2
- Jonathan Frakes - Larry
- Heidi Mark - Miranda
- Steve Bean - Man
- Tom Kiesche - Large Man
- Jeanette O'Connor - Housewife
- Jeff Lewis - Young Man
- Lindsey McKeon - Tiffany
- Richard Livingston - Dr. Hallstrom
- Louan Gideon - Saleswoman
- Chyna - Janice
- Francis X. McCarthy - President
- David A. Kimball - Vice President
- Michelle Anne Johnson - Receptionist
- Pat Crawford Brown - Mrs. Larson
- Lane Davies - Chancellor Duncan
- Regan Burns - Security Guard
- Chris Moss - Dancer
- Bill Martin - Dance Judge #2
- Chekesha Van Putten - Dancer
- Alan Cumming - Angus 'The Hole' McDuff
- Jonathan Palmer - Herve
- Jonathan Palmer - Guest #1
- Trisha Simmons - T.V. Reporter #1
- Jim Hanna - Tourist #1
- Bonita Friedericy - Tourist #2
- Irene White - Tourist #3
- Michael Dempsey - Security Guard
- Larry Cox - Taylor
- Brad Bartlett - Mrs. Dubcek's Dance Partner
- Olivia d'Abo - Andrea
- Jerry Hauck - Frank
- Scott Torrence - Student #1
- Shiloh Strong - Student #2
- Paul Connor - Student #3
- Angell Conwell - Girl #1
- John M. Duncan - Audience member
- Jade Harlow - Student #4
- R. Brandon Johnson - LJ
- Paul Kim Jr. - Kwan
- Christopher Carroll - Justice of the Peace
- Alex Kalognomos - Greek Waiter
- Tammy Dahlstrom - Waitress
- Michael McShane - Phil
- Brian Palermo - Steve (voice)
- Brian Palermo - Mr. Barnes
- Brent Sexton - Duke
- Renee Raudman - Amber
- Shanee Edwards - Waitress
- Cheryl Carter - Customer
- Maggie Lacey - Christina
- Larry Udy - Bailiff
- Shane Powers - Mugger
- Shane Powers - Man
- Shane Powers - Video Pirate
- Anthony Holiday - Bodyguard
- Darrell Hammond - Darrell Hammond
- Ray Baker - Mr. Demarmel
- Ashlynn Rose - Kid
- Matt Battaglia - Bryce Canyon
- Andrea Hutchman - Christie
- Jilana Stewart - Cindy
- Alastair Surprise - Joel
- Armand Reiser - Spectator
- Harry Groener - Dr. Breen
- Stephanie Erb - Ellen
- Stan Cahill - Michael
- Steve Paymer - Mr. Spurndle
- Charles Rocket - Gary Hemmings
- Amy Hill - Rita
- Marc Goldsmith - Bartender
- Darcas Macopson - Biff
- Joshua Minnick - Guy
- Maurice Godin - Marty
- Ever Carradine - Cheryl
- Sean Gunn - Attendant
- Mark McKinney - Guy
- Carlos Jacott - Dr. Schulman
- Franc Ross - Man #2
- Sharon Madden - Guest #2
- Jeffrey Asch - Client #1
- Will Friedle - Stan
- Shad Hart - Bucky
- Derk Cheetwood - Junior
- Francis Guinan - Jedediah
- Meagen Fay - Annabet
- Danielle Weeks - Prudence
- Daniel Kountz - Jimmy
- Jamie Kaler - Delivery Man
- Paul Hayes - King
- Mindy Spence - Sam
- Wayne Thomas Yorke - Best Man
- Carole Davis - Aviana
- Curtis Andersen - Dougy
- David Chandler - Mr. Wexler
- Karen Austin - Anita
- Scott Cranford - Bodyguard
- James Earl Jones - Narrator (voice) (uncredited)
- Tom Werner
- Marcy Carsey
- Caryn Mandabach
- Mark Brazill
- Bonnie Turner
- Terry Turner
Mark Hamill interpreta a Mark Hamill en la serie.
Linda Cardellini hace el papel de Lorna.
Marianne Muellerleile hace el papel de Lucy.
Kurtwood Smith interpreta a Jacob en la serie.
Bronson Pinchot interpreta a Roy Albright en la serie.
Jonathan Frakes interpreta a Larry en la serie.
Philip Baker Hall hace el papel de President Dewey.
John Mahoney interpreta a Dr. Leonard Hamlin en la serie.
Larry Miller interpreta a Garvin en la serie.
Ed Gale interpreta a Oscar en la serie.
Capítulo disponible en las siguientes plataformas: