- Valerie Jones - Judy Winslow
- Jaleel White - Steve Urkel
- Rosetta LeNoire - Estelle Winslow
- Rosetta LeNoire - Estelle 'Mother' Winslow
- Kristoff St. John - D'Andre
- Tracey Cherelle Jones - Toni
- Marley Shelton - Becky Sue
- Fred Willard - Vice Principal Mallet
- James Lew - Man in Bar
- Terri J. Vaughn - Girl #1 at Party
- Peter Dennis - Captain Hightower
- Amy Hunter - Agnes Pritzker
- Eddie Mekka - Mr. Nutting
- Rachel True - Sue
- Dennis Burkley - Repairman
- T.K. Carter - Ty
- Lamont Bentley - Andre
- Mindy Sterling - Coach
- Sondra Currie - Sharon
- Richard Kline - Mr. Fleming
- Walter Jones - Kissel
- Sherman Hemsley - Captain Savage
- Gerrit Graham - Landlord
- Kyla Pratt - Kelsey Webster
- George Wyner - Mr. Tolbert
- Donna Summer - Aunt Oona
- Lark Voorhies - Dream Girl
- Olivia Brown - Vanessa
- Lynn Swann - Greg Johnston
- Larry Csonka - Larry Csonka
- Jarrad Paul - Kevin
- Sanaa Lathan - Allison
- Jaime Cardriche - Osgood
- Barry Jenner - Lt. Lieu Murtaugh
- Cherie Johnson - Maxine Johnson
- Michael McDonald - Manager
- Ken Foree - High Top
- Ryan Bollman - Gun Salesman
- David Graf - Sergeant Shishka
- Stoney Jackson - Lee
- Jason David Frank - Skull
- Rif Hutton - Reverend Fuller
- Keone Young - Fred Yamano
- Hana Hatae - Steve Urkel #3
- David St. James - Joey
- Mike Adamle - Mike Adamle
- Dick O'Neill - Commissioner Geiss
- Whitman Mayo - Fletcher
- Julius Carry - Oscar
- Michael Bailey Smith - Snap
- Tony Longo - Butterball
- Kimberly Russell - Darlene
- Spencer Garrett - Larry Johnson
- Kelly Perine - Petey
- Tom Poston - Mr. Looney
- Craig Kirkwood - Gary Menteer
- Christopher Darga - Jenkins
- Bumper Robinson - Daniel Wallace
- Kim Valentine - Cassie Lynn
- Iqbal Theba - Zoohair Bhutto
- Ron Orbach - Nick Neidermeyer
- Tammy Townsend - Greta McClure
- Johnny Brown - Pastor Fuller
- Monique Lanier - Monica
- Michole Briana White - Melissa
- Kathryn Joosten - Grocery Checker
- Ted Lange - Frank Winslow
- Robert Axelrod - Paul McCartney Look Alike
- Essence Atkins - Becky
- Danielle Nicolet - Vonda Mahoney
- Clyde Kusatsu - Principal Edgar Shimata
- John Mariano - Ring Announcer
- Greg Collins - Officer Miller
- Mari Morrow - Oneisha
- Susan Krebs - Ms. Steuben
- Trina McGee - Josi
- Judyann Elder - Harriette Winslow
- Judyann Elder - Sister Bernadette
- Dave Koz - Himself
- Derek McGrath - Pat
- Derek McGrath - Conductor
- Lou B. Washington - Darnell Clark (as Ludie Washington)
- Venus DeMilo Thomas - K.C.
- Julius Wright - Richie Crawford
- Garcelle Beauvais - Lulu
- Bob Delegall - George Randolph
- Daniel Faraldo - Ramon
- Thom Curley - The Coach
- Nicholas Hormann - Mr. Walbrook
- Cal Gibson - Al
- Loretta Jean - Gloria
- Robert Noble - Bernie
- Jesse Stock - Kid with Snowball
- Rugg Williams - Laura's Study Partner
- Judette Warren - Tanya
- Lynn 'Red' Williams - Sabre
- Larry Thompson - The Referee
- Mike Genovese - Coach Westfield
- Pamela Holt - Homecoming Princess
- Annie Gagen - Charlene
- Annie Gagen - Customer
- Mary Deese - Disgruntled Passenger
- Gregory Garcia - High Scool Student Gregory
- Gregory Garcia - Army Soldier Lopez
- Shavar Ross - Weasel
- Donna Lynn Leavy - Mrs. Tannen
- Diane Hsu - Mrs. Wong
- Patrick J. Dancy - Ted
- Patrick J. Dancy - Ted Curran
- Stacy Arnell - Stephanie
- Keri Johnson - Jim
- Naya Rivera - Gwendolyn
- Kenny Johnson - Gorgeous Waiter
- Juan Pope - Chain
- Juan Pope - Orderly
- Juan Pope - Curtis Williams
- Juan Pope - Recruit
- Thom Sharp - Dr. Miller
- Thom Sharp - Bob
- Eric Jerome Kirkland - Himself
- Judith Drake - Complaining Customer
- Angus Duncan - Martin
- Gary LeRoi Gray - Little G
- Chris Villa - DJ
- Carl Ciarfalio - Arm Wrestler
- David Lea - Jack
- Robert Wall - Self
- Benny Luciano - Student
- Terence Mathews - Roscoe
- Andrea White - Volunteer
- Kyndra Joy Casper - Tough Girl #2
- Raushan Hammond - Latin Club Member
- Sonya Haynes - Tough Girl #1
- Channing Chase - Beth
- Lewis Dauber - Minister Barnes
- Matt Landers - Robber
- Matt Landers - Flint
- Heather Morgan - Marilyn
- Orlando Brown - 3J
- Richard Vidan - Ricky
- Bob Glouberman - Bellhop
- JD Roberto - Beliboy
- David Spates - Audience Member
- David L. Lander - Oliver
- Russell Sanderlin Sr. - Wedding Guest
- Cerita Monet Bickelmann - Elizabeth
- Montae Russell - DJ
- Tim Padilla - Poetry Student
- Eric Poppick - Mr. Ludke
- Renee Tenison - Tawny
- John Patrick White - Robbins
- Ron Canada - Dave McClure
- Tasha Taylor - Ariana
- Tasha Taylor - Girl at Party
- Sanetta Y. Gipson - Audience Member
- Sanetta Y. Gipson - Audience Member #1
- Cedella Marley - Herself
- Ziggy Marley - Himself
- Steve Vinovich - Simon Kincaid
- Lamont Johnson - Bone Crusher
- Julie Uribe - Audience Member #2
- Julie Uribe - Audience Member
- Steven Rozic - P.J.
- Lira Angel - Audience Member #3
- Martin Grey - Delivery Man
- Martin Grey - Joe
- F. William Parker - Mr. Waxman
- Ed Cambridge - Fletcher Thomas
- Patrick Malone - Jeff
- Lorna Scott - Homeroom Teacher
- Michelle Thomas - Myra Monkhouse
- Shawn Harrison - Waldo Geraldo Faldo
- Oscar Dillon - Sidekick
- Brooke Marie Procida - Donna Santangelo
- Philip Tan - Snap's Gang Member
- Carmen Carter - Singer
- Brian J. Williams - Man in Tires
- Brian Blondell - Chef
- Thomas Rosales Jr. - Pirate
- Michael Caldwell - James
- John Del Regno - Boxing Announcer
- Tanika Ray - Waitress
- Raf Mauro - Referee
- Cody Dorkin - Steve Urkel #2
- Heidi Fecht - Helga
- Mary Pat Gleason - Berta
- Milton James - Oskar
- Bill Moynihan - German Man
- Joel Anderson - Charlie Sullivan
- Marlon Young - Willie
- Benjamin Lum - Delivery Man
- Jennie Kwan - Kimberly
- Gregg Binkley - Lionel
- Rich Correll - Stevil (voice)
- Gregory White - Al
- LaWanda Page - Elmerita Puckerwood
- Raymond D. Turner - Chauffeur
- Pamela Eells
David St. James hace el papel de Joey.
Philip Tan interpreta a Snap's Gang Member en la serie.
Clyde Kusatsu interpreta a Principal Edgar Shimata en la serie.
Reginald VelJohnson interpreta a Carl Winslow en la serie.
Darius McCrary interpreta a Eddie Winslow en la serie.
Kellie Shanygne Williams hace el papel de Laura Winslow.
Jaleel White hace el papel de Steve Urkel.
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