- Ian McShane - Esteban Montoya
- Michael Des Barres - Power Station Vocalist
- G. Gordon Liddy - Capt. William 'Mr. Real Estate' Maynard
- Brion James - Edward Reese
- Liam Neeson - Sean Carroon
- Kevin Conway - Commander Fox
- Wesley Snipes - Silk
- Viggo Mortensen - Detective Eddie Trumbull
- Sam McMurray - Jimmy 'Jimbo' Walters
- Vincent Schiavelli - Lawrence Fowler
- Antonio Fargas - Alejandro Gutierrez
- Jsu Garcia - Colon (as Nick Corri)
- Barry Lynch - Barry Bloom
- Bruce Willis - Tony Amato
- John Spencer - Lt. Lee Atkins
- Reni Santoni - Lt. Arturo Dominguez
- Ed Lauter - Capt. Cahill
- Julia Roberts - Polly Wheeler
- William Gray Espy - Louis McCarthy
- Rosalind Chao - Mai Ying
- Moultrie Patten - Grover Watkins
- Samm-Art Williams - Lead DEA Agent
- Joe Dallesandro - DeMarco
- Sheena Easton - Caitlin Davies
- Walter Gotell - Max Klizer
- Eartha Kitt - Priestess Chata
- Annette Bening - Vicky
- Paul Gleason - Bunny Berrigan
- Lucinda Jenney - Annie Pierce
- Anne Carlisle - Lydia Sugarman
- Richard Belzer - Captain Hook
- Brian Dennehy - Reverend Billy Bob Proverb
- Jonathan Hadary - Hank Frazier
- Dean Stockwell - Jack Gretsky
- Arielle Dombasle - Callie Basset
- Daniel Gerroll - Richard Cross
- Jimmy Smits - Eddie Rivera
- Elizabeth Ashley - Linda Colby
- Bill Paxton - Vic Romano
- James Saito - Howie Wong
- John Cunningham - Miles Cowan
- John Leguizamo - Orlando Calderone
- Jeff Fahey - Eddie Kaye
- Peter Allen - Man in Gallery
- Belinda Montgomery - Caroline Crockett
- Bill Smitrovich - Lt. Scott Wheeler
- Michael Carmine - Snake
- Michael DeLorenzo - Salvatore Lombard
- Danitra Vance - Annette McAllister
- Gregory Sierra - Lt. Lou Rodriguez
- Ed O'Neill - Arthur Lawson / Artie Rollins
- Suzy Amis - Penny McGraw
- Lionel Pina - Detective Jake Estaban
- Mary Fanaro - Waitress
- Mary Fanaro - Julia Adams
- Julio Oscar Mechoso - Lester Kosko
- Julio Oscar Mechoso - Escobar
- Julio Oscar Mechoso - Lester
- Miguel Piñero - Esteban Calderone
- Giancarlo Esposito - Ricky
- Giancarlo Esposito - Luther
- Michael Santoro - Corky Fowler
- Jossie DeGuzman - Maria Rivera
- Darcy Shean - Donna Wheeler
- Harold Bergman - Judge Sumner D. Rupp
- Brian C. Smith - DA Gordon Avery
- Bud Hoey - Manager
- Paul Hecht - Sam Kovics
- Cheryl Giannini - Mrs. Lawson
- Julian Byrd - Captain Rodney
- Julian Byrd - Doyle
- Ving Rhames - Georges
- Tony Plana - Cinco
- Gary Richardson - Russo
- Mal Jones - Clayburn
- Larry Riley - Detective Bobby Price
- Jerry Mayer - Detective Alessi
- Mario Ernesto Sánchez - Jimmy
- Mario Ernesto Sánchez - Diplomat Roberto
- Cynthia Caquelin - Patty
- Afemo Omilami - Desmond Maxwell
- Dana Mark - Girl
- Melonee Rodgers - Bobby's Wife
- Jim Zubiena - Ludovici Armstrong
- Ron Taylor - Linus Oliver
- Tara King - Susan Castronova
- Raymond Forchion - Don
- Will Knickerbocker - Fields
- Ken Little - Monahan
- José Angel Santana - Guillermo Pino
- Tito Goya - Carlos Mendez
- Phanie Napoli - Angelina Medera
- Benjamin R. Rixson - Police Chief Albury
- Pepe Serna - Zabado
- George Kyle - Russo
- Norman Parker - FBI Agent Nick Pappas
- Coati Mundi - Tucker Smith
- Coati Mundi - Ramone
- Tom Mardirosian - FBI Agent McIntyre
- Katherine Borowitz - Rita
- Al Garrison - Gentle
- Dan Hedaya - Ben Schroeder
- Bill Cwikowski - Gun Dealer
- Vinnie Curto - Tony's Bodyguard
- Maria McDonald - Vanessa
- Charles McCaughan - Dale Gifford
- John Santucci - Dale Menton
- John Santucci - Charlie Fusco
- Margaret Whitton - Cassie Bramlette
- Jay Patterson - Billie Joe Higgins
- Keith Szarabajka - Joey Bramlette
- Esai Morales - Pete Romano
- John Pankow - Floyd Higgins
- Tom Bishop - Bobby
- William Kerwin - Paul
- Ray Nikolaison - Hank
- Michael Sandler - Pa Ryan
- Lenny Von Dohlen - Bob Rickert
- Michael Madsen - Sally Alvarado
- Terry O'Quinn - Richard Cain
- Mykelti Williamson - Leon Jefferson
- Jacqueline Brookes - Judge Cohen
- Jorge Gil - Ramon
- Jorge Gil - Royco
- Annie O'Neill - Mrs. Rickert
- Henry G. Sanders - Trick Baby
- Donna Rosae - Cain's Secretary
- Paul Roebling - Mark Jorgenson
- Maryann Plunkett - Mary McDermott
- Mitchell Lichtenstein - Mark Jr.
- Brent Jennings - Sgt. Hugh Heraty
- Brent Jennings - Jiveman
- Evan Handler - Louis Martinez
- Al Shannon - Eddie Rivers
- John Kapelos - Andy Sloan
- Rainbow Harvest - Angela
- Eric Bogosian - Zeke
- Alexis Arguello - Pepe Moya
- Shawn Elliott - Moya's Cousin
- John Snyder - Albert Szarbo
- Robin Johnson - Candy James
- Paul Austin - Det. Herb Ross
- Paul Tenn - Thai Assassin
- C. Andrew Davis - Doper
- Keye Luke - Lao Li
- Joan Chen - May Ying
- Garcelle Beauvais - Waitress
- Garcelle Beauvais - Gabriella
- Glenn Kubota - Ma Sek
- Peter Kwong - Grandson
- Kevin Gray - Grandson
- Richard Jenkins - DEA Agent Ed Waters
- Richard Edson - Wavey Davey
- Glenn Frey - Jimmy Cole
- John Garcia - Lieutenant Todo
- Raúl Martínez - Roberto Morales
- Nelson Oramas - Sam
- David Thornton - Lile
- Tery Ferman - Diane Gordon
- John Turturro - David Traynor
- Joe Morton - Lt. Jack Davis
- Jay O. Sanders - Det. Tim Duryea
- Eddie Castrodad - Jaime Escobar
- Alex Paez - Elio Escobar
- Julian Reyes - Raul Escobar
- Pedro De Pool - Jose Ruiz
- Claudia Robinson - Alisha Carrieres
- Adolfo Quinones - Pepe
- Danny Stone - Bostwick
- Jimmie Ray Weeks - Chuck Colby
- Jimmie Ray Weeks - Jerry Carrow
- Michael Hernandez - Xavier
- Mark Linn-Baker - 'Bonzo' Barry Gold
- Nicholas Woodeson - Artie Cross
- Johnny Vatos Hernandez - John Costelada
- Karla Tamburrelli - Ample Annie
- Ellen Greene - Darlene
- Jack Kehoe - Lt. John Malone
- Sylvia Miles - Muriel Goldman
- Pam Grier - Valerie Gordon
- David Patrick Kelly - Jerry
- Paul Calderon - Nicky
- Shawn McAllister - Edison (uncredited)
- Shawn McAllister - Wendall
- Frank Pesce - Benny
- Mai-Lis Kuniholm - Sha Sha
- Nancy Valen - Lana
- Peter Friedman - Morgan
- Frank Military - Ace
- Kim Greist - Brenda
- Gusmano Cesaretti - Paulie
- William Russ - Evan Freed
- Christopher Murney - ATF Agent Wilson
- Al Israel - Guzman
- Dennis Farina - Albert Lombard
- Vyto Ruginis - Process Server
- Iman - Lois Blyth
- Charlie Barnett - Noogie Lamont
- Michele Shay - Det. Montana Stone
- Kevin Corrigan - Jamison
- Jon Bauman - Augie
- Burt Young - Lupo Ramirez
- Chris Cooper - Jimmy Yagovitch
- Martin Ferrero - Izzy DeSoto
- Martin Ferrero - Izzy Moreno
- Alonna Shaw - Hitwoman
- Alonna Shaw - Detective Mills (uncredited)
- Carrell Myers - Dealer
- Mike Muir - Mike Muir - Singer at Club
- Barry Grayson - Father Gaffney
- Bill Russell - Judge Roger Ferguson
- Peter Nelson - Dan Shaw
- Ned Eisenberg - Frederico Librizzi
- Ned Eisenberg - Charlie Glide
- Ned Eisenberg - Sal Castelli
- Larry Pine - Tom Pierce
- Anthony Holland - Chance, the Editor
- Bradley White - David Macklin
- John Archie - Walter Mills
- Chuck Seubert - IAD Agent #1
- Elpidia Carrillo - Maria Pedroza
- Elpidia Carrillo - Sister Felicia
- Alice Adair - Carla Cappoletti
- Joe Santos - Oscar Carrera
- Jon Polito - El Gato
- Matt Frewer - Cliff King
- James Dybas - IAB Detective Stroh
- Stefen Laurantz - DEA Agent #3
- Robert Small - Greenspan
- Tony Vila Jr. - DEA Agent #2
- Austin Pendleton - Max Rogo
- Clayton Rohner - Timmy Davis
- Audrey Matson - Sarah Davis
- Marilyn Dodds Frank - Dr. Bergin
- Lou Colombo - Weber
- T.R. Durphy - Murder Suspect
- Ishah Laurah Wright - Girl in Restaurant (uncredited)
- James Tolkan - Mason Mather
- Brandon Tartikoff - Bartender (uncredited)
- Mel Swope
- Liam O'Brien
- John Nicolella
- Michael Mann
- Richard Brams
- George E. Crosby
Bill Paxton hace el papel de Vic Romano.
Liam Neeson hace el papel de Sean Carroon.
William Russ interpreta a Evan Freed en la serie.
Bruce Willis interpreta a Tony Amato en la serie.
Paul Calderon interpreta a Nicky en la serie.
Iman interpreta a Lois Blyth en la serie.
Elpidia Carrillo interpreta a Maria Pedroza en la serie.
John Diehl hace el papel de Larry Zito.
Brion James interpreta a Edward Reese en la serie.
Vincent Schiavelli hace el papel de Lawrence Fowler.
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