- Emily Kinney - Emily
- Michael Chernus - Pastor Rick
- Judy Gold - Rabbi
- Rebecca Watson - Blonde Woman (uncredited)
- Liz Holtan - Amber
- E.J. Bonilla - Scott
- Angela Lewis - Day Nurse
- Cynthia Nixon - Rebecca
- Reid Scott - Todd Mauer
- Ned Eisenberg - Dr. Volimer
- Ann Harada - Brenda
- Jessica Cummings - Second Receptionist
- John Hillner - Doctor
- Brian Dennehy - Dad
- Isaac Mizrahi - Self
- Kathy Najimy - Cathy's Therapist
- Connie Ray - Connie Schuler
- Darlene Hunt - Hospice Administrator
- Michael Ray Escamilla - Angel
- Bianca Amato - Susan Rand
- Marceline Hugot - Ina
- David Aaron Baker - Priest
- David Wilson Barnes - Wesley
- Marin Mazzie - Janelle Milson
- Jen Sese - Florist
- Rosemary Howard - Hospice Visitor (uncredited)
- Marisa R. Silver - Fashion Show Guest (uncredited)
- Darlene Hunt
- Vivian Cannon
- Laura Linney
- Neal H. Moritz
- Michael Engler
- Jenny Bicks
Laura Linney interpreta a Cathy Jamison en la serie.
John Benjamin Hickey hace el papel de Sean Tolkey.
Oliver Platt interpreta a Paul Jamison en la serie.
Gabourey Sidibe hace el papel de Andrea Jackson.
Gabriel Basso interpreta a Adam Jamison en la serie.
Capítulo disponible en las siguientes plataformas:
