- Kid Cudi - Self - Co-Host
- Kid Cudi - Self
- 'Weird Al' Yankovic - Self - Co-Host
- 'Weird Al' Yankovic - Self
- 'Weird Al' Yankovic - Mike Cankers
- Mary Holland - Creepy Couple
- Mary Holland - Bathroom Patron
- Mary Holland - Magpie
- Mary Holland - Julie
- Joseph Gordon-Levitt - Self
- Allison Tolman - Ellen
- Kevin Bacon - Self
- Tegan Quin - Self
- Sara Quin - Self
- T-Pain - Self
- Aubrey Plaza - Self
- Joe Jonas - Self
- Nathan Fielder - Self
- Chris Wood - Perry Daffodil
- Lou Wilson - Cashier
- Mike Colter - Self
- Davis Desmond - Gordy Darcy
- Katherine McKalip - Aunt Eleanor
- Ian Nelson - Craig Wilson
- Paul Butcher - Tyler Cunningham
- Grant Palmer - Leland
- Rowan Smyth - Young Boy
- Jordan Lee - Future Scott
- Eva Anderson - Bridesmaid
- Cyrus Arnold - Terry Jetski
- Bil Dwyer - Captain Brock
- Jenna Fischer - Self
- Mary Elizabeth Winstead - Self
- Anna Kendrick - Self
- Cobie Smulders - Self
- Kaley Cuoco - Self
- Krysten Ritter - Self
- Jon Hamm - Self
- Seth Rogen - Self
- Paul Rudd - Self
- Elizabeth Banks - Self
- Zoe Saldaña - Self
- Rainn Wilson - Self
- Jessica Alba - Self
- Rashida Jones - Self
- Patton Oswalt - Self
- Ellie Kemper - Self
- Jake Johnson - Self
- Robert Kirkman - Self
- Carly Rae Jepsen - Self
- Karen Gillan - Self
- James Marsden - Self
- Brie Larson - Self
- Stephen Merchant - Self
- Amy Poehler - Self
- Zach Galifianakis - Self
- Michael Cera - Self
- Tim Heidecker - Phil Gorsley
- Jonathan Tysor - Young Donald
- Anthony Turpel - Dylan Darcy
- Mary Sohn - Mary
- Noah Staggs - Prison Inmate
- Dhruv Uday Singh - Pranked Guy
- Will Forte - Chet Barnsider
- David Koechner - Mr. Doublebutt
- Tom Fitzpatrick - Carl Langer
- Brian Huskey - Dr. Klinky von Tankerman
- Leo Allen - Francis Domingo
- Will Arnett - Dale
- Tony Hale - King of Cards
- Tony Hale - Self
- Ed Helms - Self
- Gillian Jacobs - Self
- Gillian Jacobs - Post-Apocalypse Woman
- Kristen Schaal - Gina Guppies
- Kristen Schaal - Self
- Jack Black - Self
- Andy Samberg - Self
- Jordan Peele - Tan Fu
- Aziz Ansari - Self
- Casey Wilson - Self
- Casey Wilson - Eugenia Clemente
- Ben Schwartz - Rodney Wayber
- David Cross - Self
- Andy Richter - Self
- Sarah Silverman - Self
- Joe Lo Truglio - Stan Couples
- Adam Devine - Nick
- Bill Hader - Self
- Bobby Moynihan - Fourvel
- Paul Reubens - Pee-Wee Herman
- Jim Gaffigan - Self
- Andy Dick - Self
- Clark Gregg - Self
- Andy Daly - Don Dimello
- Andy Daly - Chip Gardner
- Andy Daly - Danny Mahoney
- Jason Schwartzman - Self
- Jason Mantzoukas - Chef Luigi Lugosi
- Jason Mantzoukas - Self
- Craig Robinson - Self
- Fred Armisen - Self
- Nick Offerman - Self
- Lizzy Caplan - Self
- Tony Hawk - Self
- Alison Brie - Self
- Josh Groban - Self
- Steven Yeun - Self
- Wayne Coyne - Self
- Dane Cook - Self
- Chris Hardwick - Self
- Amber Tamblyn - Self
- Rob Corddry - Self
- Eric André - Self
- Jorma Taccone - Self
- Akiva Schaffer - Self
- Ty Burrell - Self
- Maya Rudolph - Self
- Eddie George - Self
- Simon Helberg - Self
- Mark Duplass - Self
- Brett Gelman - Dog Lawyer
- Brett Gelman - Self
- Brett Gelman - Mr. Celebrity
- Jesse Tyler Ferguson - Self
- Topher Grace - Cameraman
- Topher Grace - Self
- Dax Shepard - Self
- Joel McHale - Self
- Lil' Jon - Self
- Colin Hanks - Self
- Bob Odenkirk - Tommy Shalders
- Bob Odenkirk - Ofendorf
- Skylar Astin - Self
- Michael Sheen - Self
- Thomas Middleditch - Self
- Judd Apatow - Self
- Ken Marino - Self
- Paul Rust - Jack Blade
- Paul Rust - Self
- Paul Rust - Various
- Randall Park - Self
- A$AP Rocky - Self
- Uzo Aduba - Self
- Colton Dunn - Auto Mechanic
- Colton Dunn - Terry Lopez-Carmichael
- Judy Greer - Self
- David Krumholtz - Self
- Michelle Monaghan - Self
- Kathryn Hahn - Self
- Allison Janney - Self
- Ben Folds - Self
- Nat Faxon - Earl or Crathmore
- Pam Murphy - Marcy
- Tig Notaro - Police Officer
- Jim Rash - Sir Zanifer
- Joe Wengert - Jim
- Wyatt Griswold - Trick or Treater
- Eugene Cordero - Officer Daniels
- Jack McBrayer - Chad
- Kulap Vilaysack - Janice Manilow
- Seth Morris - Bob Ducca
- Seth Morris - Nells Hebber
- Fran Gillespie - Voyeurs Host
- Dave Foley - The Bomber
- David Theune - Victor Manilow
- D'Arcy Carden - Barbara Fleen
- Chris Parnell - Stephendorff
- Chris Parnell - Poseidon
- Adam Scott - Plumber Pierre
- Adam Scott - Self
- Brandon Johnson - Marvin McFerrin
- Adam Pally - Self
- Adam Pally - Robert DeBiro
- Matt Walsh - L. Jefe Manincharge
- John Gemberling - Andrew Jacks Playdough
- Paul F. Tompkins - Lord Andrew Lloyd Webber
- Paul F. Tompkins - Sir Andrew Lloyd Webber
- Paul F. Tompkins - J.W. Stillwater
- Paul F. Tompkins - Werner Herzog
- Paul F. Tompkins - Garry Marshall
- Paul F. Tompkins - The Cake Boss
- Paul F. Tompkins - Alan Thicke (voice) (uncredited)
- Andrew Rannells - Quinn Abernathy
- Andree Vermeulen - Reggie's Dream Girl
- Nick Kroll - Fabrice Fabrice
- Nick Kroll - El Chupacabra
- Stephanie Allynne - Stephanie
- Tim Kalpakis - Various
- Tim Kalpakis - Lloyd Fleen
- Zach Woods - The Remarkable Greg
- Phil LaMarr - Ricky Nichols
- Aidy Bryant - Segment Producer
- Vanessa Bayer - Susan Armhold
- Horatio Sanz - Victor Ramos
- Horatio Sanz - Darryl Drummond
- Tim Robinson - Al Sorbinstein
- Charlene deGuzman - Cassandra
- Kevin McDonald - Galactic Commander of the Planet Pylon
- Catherine Reitman - Lisa Wertz
- Paul Brittain - Jones Calvins
- Taran Killam - Smith Calvins
- Jerry Minor - Mailman Manny
- Jerry Minor - Fred Dumphrey
- Jason Alexander - Inspector Gantlet
- Gil Ozeri - Alfie Gaye
- Gil Ozeri - Billy Big Mouth Guy
- Thomas Lennon - The Phantom
- Thomas Lennon - Self
- Lynne Marie Stewart - Barbara Aukerman
- Kate McKinnon - Effie Villalopolus
- Robin Bartlett - Hot Dog Lady
- Kyle Mooney - Monty
- Matt Besser - Hooch the Mooch
- Matt Besser - Sheriff
- Matt Besser - Richard Uptill
- Paul Scheer - Jerry Donovan
- Derek Mears - Irate Fan
- Matthew Cardarople - D-Money
- Michael Daniel Cassady - Stagehand
- James Adomian - Jesse Ventura
- James Adomian - Giles Duggard
- Josh Fadem - Marty Sheesh
- Kirby - Boom Operator
- Kirby - Decaf Dame
- Rhys Darby - Uncle Deckard
- Samuel T. Herring - Self
- Whitney Cummings - Self
- Anthony Jeselnik - Self
- Neil Campbell - Sir Couchley (voice)
- Neil Campbell - Various
- Lauren Lapkus - Whitney Peeps
- Kevin Smith - Self
- Michael Blaiklock - Tustin Limbersnake
- Creed Bratton - Grandfather
- Maria Bamford - Claire Coulter
- Cameron Esposito - Server
- David Alan Grier - Network President
- Schoolboy Q - Self
- Nathan Barnatt - Flea
- Kyle Bornheimer - Pat Dantrick
- Jennette McCurdy - Allie Dawson
- Jack Antonoff - Jack the Crew Guy
- Jon Daly - Bill Cosby-Bukowski
- Jon Daly - Self
- Ronnie Adrian - Wally Casinos
- Ronnie Adrian - Ronnie
- Howard Kremer - Howard the Cameraman
- Todd Barry - Kid Cudi's Manager
- Noël Well - Aiden Tomasetto
- Henry Winkler - Leonard Rascal
- Beth Dover - Barbara Aukerman
- Jack Dylan Grazer - Kayden Aukerman
- Jon Gabrus - Crew Guy
- Jon Gabrus - Ronnie 'Brew Dude' Haynes
- George Wendt - Self
- Lennon Parham - Forsythia
- Lennon Parham - Gabby
- Kevin Allison - Bertram Jollymore
- Natasha Lyonne - Katie
- Brent Spiner - The Sandman
- Caroline Anderson - Madame Thenardier
- Kathryn Burns - Dancer
- Kris McGaha - Vocalist
- Rachel Montez Collins - Dancer
- Armen Weitzman - Thenardier
- Malin Åkerman - Self
- Regan Burns - Wilford
- Laraine Newman - Melrose Ballrod
- Laraine Newman - Mandy
- Timothy Casto - Denny
- Ingrid Haas - Propmaster Diana
- Ashleigh Crystal Hairston - Ashleigh
- Joel Jensen - Self
- Haley Joel Osment - Slow Joey
- Bryan Safi - Freddy
- Vince Gilligan - The Commissioner
- Tom Green - The Quizzler
- Claudia O'Doherty - Shandy Williams
- Bob Einstein - Harvey Wrinkleman
- Andrea Savage - Samantha
- Blake Anderson - Screggie
- Catherine Papadopoulos - Ahoop
- Pete Levin
- Danny Jelinek
- Stoney Sharp
- Ben Berman
- Neil Campbell
- Leo Allen
- David Ferguson
- Eva Anderson
- Michael Blaiklock
- Mike Hanford
Allison Janney hace el papel de Self.
Thomas Lennon interpreta a The Phantom en la serie.
Scott Aukerman interpreta a Self - Host en la serie.
Kevin Bacon interpreta a Self en la serie.
Michael Sheen interpreta a Self en la serie.
Colin Hanks interpreta a Self en la serie.
Jason Alexander interpreta a Inspector Gantlet en la serie.
Mike Colter hace el papel de Self.
David Cross interpreta a Self en la serie.
'Weird Al' Yankovic hace el papel de Self - Co-Host.
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