- Ricardo Montalban - Luis Montoya
- Rod Steiger - Vincenzo Fortelli
- John Ashton - Calvin MacGruder
- Peter Falk - Columbo
- Stephen Elliott - General Padget
- Laurence Luckinbill - Mark McAndrews
- Marianne Muellerleile - Nurse Hilda
- Madeleine Sherwood - Ms. Brady
- Kim Cattrall - Joanne Nicholls
- Jessie Royce Landis - Mrs. Chadwick
- Martin Landau - Dexter Paris / Norman Paris
- Robert Ellenstein - Stein
- Nehemiah Persoff - Jesse Jerome
- Joan Shawlee - Mitilda
- Avner Garbi - Kardarsian
- Michael V. Gazzo - Vittorio Rossi
- G. D. Spradlin - Martin Hammond
- Alma Beltran - Mrs. Fernandez
- Vincent Price - David Lang
- Edie McClurg - Mrs. Lerby
- Anthony James - Tommy
- Robert Loggia - Harry Blandford
- Paul Shenar - Sergeant Young
- Robert Foxworth - Frankie Brailie
- Mark Margolis - Cosner
- Dean Stockwell - Eric Wagner
- Patrick McGoohan - Oscar Finch
- Burt Young - Mo Weinberg
- Mel Ferrer - Jerry Parks
- Lee Arenberg - Paramilitary Man #3
- Jeff Goldblum - Protester (uncredited)
- Hector Elizondo - Hassan Salah
- Julie Harris - Karen Fielding
- Gena Rowlands - Elizabeth Van Wick
- George Hamilton - Mark Collier
- Nick Dennis - Guard
- Timothy Carey - Tony
- Val Avery - Artie Jessup
- Frank McRae - Lt. Robertson
- Rick Marzan - Police Officer
- David Huddleston - Mayor
- George Buck - George Thornwood
- Sal Mineo - Rahmin Habib
- William Shatner - Fielding Chase
- Anthony Zerbe - Max Dyson
- Leonard Nimoy - Barry Mayfield
- Lew Ayres - Howard Nicholson
- Majel Barrett - Hospital Announcer (voice) (uncredited)
- Bruce Kirby - Phil Brindle
- Aubrey Morris - Fred
- Jack Kruschen - Tomlin Dudek
- Jimmy Ortega - Reporter
- Peter Falk
- Everett Chambers
- Roland Kibbee
- Dean Hargrove
- Richard Alan Simmons
- Edward K. Dodds
Ricardo Montalban interpreta a Luis Montoya en la serie.
Rod Steiger hace el papel de Vincenzo Fortelli.
John Ashton interpreta a Calvin MacGruder en la serie.
Peter Falk interpreta a Columbo en la serie.
Stephen Elliott interpreta a General Padget en la serie.
Laurence Luckinbill interpreta a Mark McAndrews en la serie.
Marianne Muellerleile hace el papel de Nurse Hilda.
Madeleine Sherwood interpreta a Ms. Brady en la serie.
Kim Cattrall hace el papel de Joanne Nicholls.
Jessie Royce Landis interpreta a Mrs. Chadwick en la serie.
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