- Rainn Wilson - Phil Lebensmal
- Derek Cecil - Dr. Robert Donatti
- Kevin Sussman - Walter Pine
- Thomas Mann - Alfred Boryweitz
- Andy Daly - Dr. Richard Price
- Adam Bartley - Scientist
- Joshua Hoover - Anthony Powers
- Brandon Gibson - Tom Clemens
- Robert Alan Beuth - Frank Marsten
- Ali Kinkade - Jenny Marie Kay
- Sigi Ravet - Laurel Moore
- Debbie Pollack - Louise
- John Alton - Stage Manager
- Eileen Álvarez - Hair Stylist
- Isaac Jay - Harry the PA
- Caroline Cole - Charlene Ogilvy
- Amentii Sledge - Linda Sloane
- Tate Ellington - Dr. Bates
- James Gleason - Chairman of the Board
- Michael James Bell - Highway Suit
- Troy Vincent - UCLA Professor
- B.J. Novak - Six-Thirty (voice)
- Beau Bridges - Harry Wilson
- Jake Short - Ralph Bailey
- Marc Evan Jackson - Dr. Leland Mason
- Nicolas Coster - Paul Astor
- Barry Livingston - Pastor
- Alex Boling - Oocyte Chemist
- Lee Eisenberg - Funeral Director
- Brian Leckner - Businessman
- Aaron Coleman - Harriet's Colleague
- Paul James - Charlie Sloane
- Caryn West - Mrs. Mudford
- Phoebe Kuhlman - Nurse
- Kandis Fay - New Mother
- Jonney Ahmanson - Baseball Fan
- Steven Pritchard - Whiskey Guy
- Sherry Larson - Gerta Borgnino
- Constance Ejuma - Agnes
- Keena Ferguson - Rhoda
- Danny Brown - Jodie
- Jeff Marlow - Bank Manager
- Casey Feigh - Moving Supervisor
- Hero Hunter - James 'Junior' Sloane
- Lola Kelly - Housewife
- Amanda Walsh - Waitress
- Todd Aaron Brotze - Consultant
- Joy Jacobson - Shari
- Alex Staggs - Sound Mixer
- Julianne Buescher - Secretary
- Daniele O'Loughlin - Harried Mother
- Nathan Caywood - Male Audience Member #1
- Jonathan Fishman - Male Audience Member #2
- Herbert Russell - Male Audience Member #3
- James Vincent - Male Audience Member #4
- Tammy Caplan - Female Audience Member #1
- Jessy Greer - Female Audience Member #2
- Jackson Kelly - John Zott
- Jon Fletcher - Ezra Zott
- Danielle Hoetmer - Iris Zott
- Tunisia Hardison - Marge
- Annie O'Donnell - Mrs. Eugenia Waterhouse
- Chanté Bowser - Suz
- Carson Zone - Mayor's Son
- Meredith Jackson - Mayor's Wife
- Vaughndio Forbes - Sanford
- Dan Sachoff - Reporter
- Hannah Horton - Walter's Secretary / Walter's Secretary - Joan
- David Lee Hess - Rheumy Eyes
- Lon Gowan - Head Cop Stunt #1
- Kim D'Armond - Audience Member #1
- Christina Childress - Stunt Protestor #1
- Adam O'Byrne - Bishop
- Caden Dragomer - Young Calvin Evans
- Myles Cranford - Clarence Wakely
- Mara Hernandez - Jesse
- Taylor Foster - Jewelry Store Employee
- Vincent Stalba - Scientific American Photographer
- Natalie Wetta - Sister Mary Lou
- Emily Happe - Sister Beth Ann
- Ashley Monique Clark - Martha Wakely
- Alyssa Preston - Wilson's Secretary
- Griffen Campbell - Lester
- Rosemarie DeWitt - Avery Parker
- Ronin Lee - Paralegal
- Greg Benson - Kenneth
- Darin Toonder - Committee Chair
- David Bickford - Councilman Sommers
- Sam Bixby - Valet
- Maddie Levy - Young Avery
- Sarah Glassman - Student #2
- Mfoniso Udofia
- Hannah Fidell
- Boo Killebrew
- Natalie Sandy
- John Papsidera
- Rosa Handelman
- John Bauman
- Carlos Rafael Rivera
Beau Bridges interpreta a Harry Wilson en la serie.
Lewis Pullman interpreta a Calvin Evans en la serie.
Aja Naomi King interpreta a Harriet Sloane en la serie.
Stephanie Koenig interpreta a Fran Frask en la serie.
Patrick Walker interpreta a Curtis Wakely en la serie.
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