- Anderson Cooper - Self - Host
- Abby Phillip - Self - Reporter
- Donie O'Sullivan - Self - Correspondent
- Chloe Melas - Self - Host
- Britney Spears - Self - Archive Footage
- Ronan Farrow - Self
- Lori Majewski - Self
- Rosie O'Donnell - Self
- Van Jones - Self - Host
- Karen Bass - Self
- Henry “Kiki” Watson - Self
- Milton Grimes - Self
- Steve Lerman - Self
- Christina Rogers - Self
- Thomas Elfmont - Self
- Alex Jones - Self
- Madeleine Albright - Self
- Anne Applebaum - Self
- Benjamin Ginsberg - Self
- Benjamin Carter Hett - Self
- Robert Kagan - Self
- Steven Levitsky - Self
- Jon Meacham - Self
- Lisa Pine - Self
- Daniel Ziblatt - Self
- Elle Reeve - Self - Host
- Richard Spencer - Self
- Matthew Heimbach - Self
- Jeff Schoep - Self
- Matt Parrott - Self
- Ian Bremmer - Self
- Elizabeth Economy - Self
- Thomas L. Friedman - Self
- Victor Gao - Self
- Wolf Blitzer - Self - Anchor
- Evan Osnos - Self
- David Shambaugh - Self
- Lingling Wei - Self
- Dana Bash - Self - Host
- Peter Daszak - Self
- Danielle Anderson - Self
- Francis Collins - Self
- Maria Van Kerkhove - Self
- David Relman - Self
- Kristian Andersen - Self
- Alina Chan - Self
- Karl Eikenberry - Self
- Victor Blackwell - Self - Host
- Drew Griffin - Self - Host
- Deborah Birx - Self
- Stephen Hahn - Self
- Robert Redfield - Self
- Doris Kearns Goodwin - Self
- Kamala Harris - Self
- Doug Emhoff - Self
- Cory Booker - Self
- Catherine Cortez Masto - Self
- Maya Harris - Self
- Randi Kaye - Self - Host
- Anthony Fauci - Self
- Gloria Borger - Self - Host
- Bill Weir - Self - Host
- Al Gore - Self
- Greta Thunberg - Self
- Gavin Newsom - Self
- Miguel Marquez - Self - Host
- Fareed Zakaria - Self - Host
- John Berman - Self
- Tom Foreman - Self - Host
- Gilbert Gottfried - Self
- Judy Gold - Self
- Helen Hong - Self
- Owen Smith - Self
- Kamie Crawford - Self
- Billy West - Self
- Jake Tapper - Self - Host
- Carrie Sheffield - Self
- Soledad O'Brien - Self - Host
- Alisyn Camerota - Self - Host
- Sanjay Gupta - Self - Host
- Ed Lavandera - Self - Host
- Kate Bennett - Self - Host
- Laurie Segall - Self - Host
- Poppy Harlow - Self - Host
- Erin Burnett - Self - Host
- Anderson Cooper
Anderson Cooper interpreta a Self - Host en la serie.
Abby Phillip interpreta a Self - Reporter en la serie.
Donie O'Sullivan hace el papel de Self - Correspondent.
Chloe Melas hace el papel de Self - Host.
Britney Spears interpreta a Self - Archive Footage en la serie.
Ronan Farrow interpreta a Self en la serie.
Lori Majewski hace el papel de Self.
Rosie O'Donnell interpreta a Self en la serie.
Van Jones interpreta a Self - Host en la serie.
Karen Bass interpreta a Self en la serie.
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