- Anthony Hammer - Adrian Orlowski
- Fiona Corke - Judith Welling
- Martin Blum - Steve Rickards
- Chelsea Blake - Holly Bannister
- Jude Beaumont - Michaela Kaplan
- Scott Major - Graeme Combes
- Ella Scott Lynch - Narelle O'Brien
- Mark Raffety - Steven Akkerman
- Julie Eckersley - Rita Solomon
- Grant Piro - Craig Pierce
- Wendy Hughes - Victoria Semple
- Geoff Paine - Jim Conway
- Tony Rickards - Mike Davies
- Paul Mercurio - D'Arcy Carlton
- Louise Siversen - Janice Quinn
- Alison Whyte - Petra Milde
- Simon Lyndon - Josh Braddock
- Alyce Platt - Lorraine Sparkes
- Daniela Farinacci - Marion Palmer
- Greg Stone - Dean Palmer
- Ian Bliss - Toby Hendricks
- Kat Stewart - Claire Jackson
- Andrew S. Gilbert - Jumbo Watson
- Petra Yared - Michelle Johnson
- Caroline Brazier - Frances Deerborne
- John McTernan - Asst. Commissioner Bill Mulholland
- Nicole Chamoun - Selma Al Basri
- Nicholas Bell - Mark Silver
- Vince Colosimo - Ernie Calabrese
- David Whiteley - Reg Brown
- Simon Maiden - Troy Lucas
- Annie Jones - Kelly Pilsbury
- Kim Gyngell - Adam Boldt
- Rhys McConnochie - Callum Ryan
- Carolyn Bock - Linda Wolfe
- Dennis Coard - Kevin Callaghan
- Andrew Curry - Liam Callaghan
- Tasma Walton - Claudia Leigh
- Jane Allsop - Jo Andrews
- Andrew Lees - Constable Jake Lockwood
- Lucy Bell - Deborah Van Der Lind
- Alexandra Schepisi - Alexandra Misto
- Brett Climo - Victor Carling
- Genevieve Morris - Rhonda 'Ronnie' Lafferty
- Hamish Michael - Marcus Linton
- John Brumpton - Scott Hurley
- Jeff Truman - Maxwell Craven
- Alex Papps - Superintendant Campbell Harland
- Sachin Joab - Raj
- Gil Tucker - Sam McIntyre
- John Flaus - Dusty Beckinsdale
- Debra Byrne - Marijke Sharman
- Craig McLachlan - Leon Grasby
- Blair McDonough - Cameron Gunning
- Cassandra Magrath - Bree Lynch
- Bruce Spence - Maurice Biederman
- Nicole Nabout - Rachel Markham
- Peter O'Brien - Warren Endicot
- Danielle Cormack - Shirley Steadman
- Peta Brady - Kim Charlton
- Rodney Afif - Assad Mansour
- Marshall Napier - Wilton Sparkes
- Louise Crawford - Karen Hatzic
- Matthew Quartermaine - Hamish Gilchrist
- Jacqueline Brennan - Bonnie Roper
- Rod Mullinar - Oliver Braxton
- Elspeth Ballantyne - Miss Evelyn Purcell
- Jesse Rowles - John Karlsen
- Joelene Crnogorac - Lila Sharman
- Cameron Nugent - Paul Winston
- Lara Robinson - Louise Patterson
- Margot Robbie - Caitlin Brentford
- Rebel Wilson - Sarah Gilbert
- David James - Ian Chalmers
- Katy Brinson - Carly Stayner
- Pino Amenta
- Jet Wilkinson
- Paul Moloney
- Kevin Carlin
- Tony Tilse
- Steve Mann
David Field interpreta a Terry Jarvis en la serie.
Shane Bourne hace el papel de Detective Senior Sergeant Stanley Wolfe.
Noni Hazlehurst interpreta a Commander Bernice Waverley en la serie.
Nadine Garner interpreta a Detective Senior Constable Jennifer Mapplethorpe en la serie.
Damien Richardson hace el papel de Detective Sergeant Matt Ryan.
Aaron Pedersen interpreta a Detective Senior Constable Duncan Freeman en la serie.
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