- Mark Christopher Lawrence - Big Mike
- Ryan McPartlin - Devon Woodcomb
- Rachel Bilson - Lou Palone
- Bianca Roe - Agent
- C.S. Lee - Harry Tang
- Robert Picardo - Perseus
- James Hong - Ben Lo Pan
- Kristin Kreuk - Hannah
- Lorena Bernal - La Ciudad-Malena
- John Larroquette - Roan Montgomery
- Brooklyn Decker - Job applicant
- Jordana Brewster - Dr. Jill Roberts
- Diedrich Bader - Del
- Chevy Chase - Ted Roark
- Michael Clarke Duncan - Colt
- Tony Hale - Emmett Milbarge
- Anthony Azizi - Sheik Rajiv Amad
- Tricia Helfer - Agent Alex Forrest
- Brandon Routh - Daniel Shaw
- Mini Anden - Carina Miller
- Linda Hamilton - Mary Elizabeth Bartowski
- Clare Carey - Kathleen McHugh
- Nicole Richie - Heather Chandler
- Clyde Kusatsu - Morimoto
- Michael Strahan - Mitt
- Tony Todd - CIA Director Graham
- Gary Cole - Jack Burton
- Mitzi McCall - Blanche
- Kevin Weisman - Reardon Paine
- Robert Patrick - Col. James Keller
- Kyle Bornheimer - Hunter Perry
- Gwendoline Yeo - Mei-Ling Cho
- Melinda Clarke - Sasha Banacheck
- Tony Sirico - Matty
- Jerome Bettis - Jimmy Butterman
- Ben Savage - Mark Ratner
- Andrew Connolly - Jack Artman
- Ken Davitian - Uncle Bernie
- Angie Harmon - Sydney Prince
- Steve Austin - Hugo Panzer
- Michael Rooker - Mauser
- Adoni Maropis - Javier Cruz
- Matt Roth - Buy More Employee
- Pasha D. Lychnikoff - Victor Federov
- Timothy Dalton - Alexei Volkoff
- John Kapelos - Yari Demitrios
- Steve Valentine - Von Hayes
- Wendy Makkena - National Intelligence Director
- Cedric Yarbrough - Neil
- Carl Lumbly - Ty Bennett
- Lori Alan - Bill Bergey
- Jim Piddock - Curator of Classical Art
- Ivana Miličević - Ilsa Trinchina
- Mark Derwin - Detective Conway
- Anthony Ruivivar - Tommy
- Jed Rees - Nathan Edward 'Ned' Rhyerson
- Johnny Messner - Rafe Gruber
- Iqbal Theba - Peyman Alahi
- Henri Lubatti - Vasillis
- Christopher Cousins - Bill Bergey
- Josie Davis - Serena
- Dale Dye - General Stanfield
- John Fleck - Dr. Jonas Zarnow
- Louis Lombardi - Scotty
- Noureen DeWulf - Lizzie
- Matt Bomer - Bryce Larkin
- Peter Onorati - Wally Roberts
- Bruce Boxleitner - Dr. Woody Woodcomb
- Jim Pirri - Father
- Tom Waite - Bill
- Steve DeCastro - Guard #1
- Lyn Alicia Henderson - Large Mart Associate
- Nicolas Pajon - Ominous Customer
- David Burke - Mr. Mercer
- David Burke - HR Manager
- Bruno Amato - Security Agent
- Jordan Potter - Stoner
- Max Prado - Teenage Boy
- Grant Thompson - Allan Watterman
- Keli Daniels - Hotel Employee
- Neil Dickson - MI-6 Agent
- Adrian Kali Turner - Ray
- Philip Shahbaz - Art Dealer
- Brandon Molale - Ivan
- Chris Dotson - Scooter
- Ewan Chung - Lee Cho
- Ilyse Mimoun - Cashier
- Creagen Dow - Teenage Boy
- Jesse Heiman - Fernando
- Jonathan Sadowski - Laszlo Mahnovski
- Rick Hoffman - Agent Scary
- Darlene Kardon - Sweet Old Lady
- Michael Perl - Mark Price
- Scott Alan Smith - Professor Fleming
- Phil Abrams - Stanford Librarian
- Jill Czarnowski - Glenda Mitchell
- Shawn Huang - Kid
- James Lowe - Meathead
- Vinny Chhibber - Meathead #2
- Brandon Lim - Fraternity Brother #2
- Rosemary Gore - Natalia
- Lauren Mary Kim - Naomi Walker
- Kevin Patrick Burke - Magnus
- Emy Coligado - Poppy Tang
- Sanjay Chandani - Mason Whitney
- Theo Alexander - Stavros Demitrios
- Merritt Yohnka - Bomb Squad Captain
- John Bobek - Nerdy Technician
- David E. Brown - Thug
- Mo Anouti - Bodyguard #1
- Dmitri S. Boudrine - Bodyguard #2
- Craig Dabbs - Yari's Bodyguard
- Lauran Doverspike - Maddie
- Carolyn Power - Nurse
- Gary Weeks - Fireman
- Michael Wiseman - Lon Kirk
- David Paluck - Ship's Manager
- Ping Wu - Mr. Wu
- Kelvin Han Yee - Rashan Chen
- Aisha Kabia - Green Shirt Gal
- Casey Adams - Guard
- Scott Burn - Agent #3
- Igor Korosec - Russian Creep
- Vahe Bejan - Fat Drunk Russian
- Loren Avedon - Russian guard
- Alan Mueting - Russian Mobster
- Timothy Brennen - Agent Granzow
- Mark Brandon - World Send Driver
- Alex Parlar - Thug
- Matthew Jayson Cwern - Handsome Cool Guy
- Adam Sauter - Employee
- Manny M. Hernandez - Messenger
- Sarah Poynter - Stewardess
- Nathan Sutton - Agent Epstein
- Jason Collett - Buy More Employee
- Mark Kubr - Thug #1
- Sven Garrett - Hans
- Marcy Goldman - Nurse
- Gino Anthony Pesi - Bad Guy #1
- Tim Chiou - Mighty Jock
- Roberto 'Sanz' Sanchez - Columbian
- Brandon Ford Green - Conscientious Customer
- Hope Shapiro - Bunny
- Patrik Stanek - Andrei
- Jeff Wolfe - Ivan Fyodorov
- Faran Tahir - Farrokh Bulsara
- Bill Lewis - Stu Brewster
- Martin Yu - Engineer #2
- Mitchell Fink - Airman
- Amy Shelton-White - Local News Anchor
- William Abadie - Guy Lafleur
- Zach Hanks - Rommell
- Elaine Loh - Shari
- Aaron Ramzi - Lonnie
- Tom Sean Foley - FBI Guy
- Jason E. Kelley - Piano Player
- Sinqua Walls - Student
- Phillipe Simon - Opera Director
- Brandon Brendel - Bellboy #1
- Jim Pacitti - FBI Agent #1
- Patrick Kilpatrick - Leader
- John Knox - Swat Leader
- Dwayne Standridge - Town Car Driver
- Dominic Comperatore - Translator
- Debbie Campbell - Porter
- Gil Glasgow - Guard #1
- Alexander Fazel - Thug #1
- Stefanie Scott - Sarah at 12 years old
- Craig Susser - DeLorean Owner
- Tina Huang - Maureen Mitsubishi
- Matt Riedy - Swat Captain
- Lony'e Perrine - Buy More Employee
- Dominic Monaghan - Tyler Martin
- Harry Van Gorkum - Gavin
- Nina Fehren - Vixen #2
- Treisa Gary - Wife
- Andy Richter - Brad White
- Patricia Rae - Bolonia Grimes
- Jenny McCarthy-Wahlberg - Sylvia Arculin
- Brian Thompson - Cliff
- Alison Simpson - Vanessa
- Jennifer Jalene - Smooth Lau
- Jack Yang - Jason Wang
- James Kiriyama-Lem - Ambassador Mei Sheng
- Andrew C. Lim - Joe Lucky
- Wesley John - Needles
- Mel Fair - Newscaster
- Mel Fair - TV Reporter
- Mel Fair - News Anchor
- Andy Pessoa - Young Morgan
- Alexis Raich - Suzy O'Keefe
- Americus Abesamis - Security Guard
- Christopher Nightingale - Buy More Shopper
- Jonathan Cake - Cole Barker
- Katrina Law - Alexis
- Jessica Gomes - S.I. Model #1
- Jarah Mariano - S.I. Model #2
- Kaliko Kauahi - Customer
- Kaliko Kauahi - Angry Woman
- Artie O'Daly - Bell Man
- Stephen O'Mahoney - Fulcrum Agent
- Tim Coyne - Fulcrum Agent #2
- Mohammad Kavianpour - Fan
- Mohammad Kavianpour - Orderly
- Mohammad Kavianpour - Fulcrum Agent
- Vincent Duvall - Duncan
- Anthony Palermo - Paolo
- Melvin Abston - Attendant
- Matt Winston - Barclay
- Tyler Vincent - Courier
- Tyrone Howard - Agent #1
- Shaun Toub - Dr. Mohammed Zamir
- Pam Trotter - Rachel the Nurse
- Sala Baker - Terrorist Bodyguard
- Brian Kubach - Drew
- Lauren Cohan - Vivian Volkoff
- Lauren Cohan - Vivian McArthur
- Jeff Chase - Burly Russian
- Jeff Chase - Thug
- Pablo Espinosa - Javier Diaz
- Meggan Anderson - Translator
- John Jason Bailey - Roark Security
- Shaun Russell - Guard
- Tammy Dugen - Applicable female in electronics
- Tammy Dugen - Roane Girl
- Carrick O'Quinn - Guard #2
- Tug Coker - Miles
- Yolanda Snowball - Justice of the peace
- April Betts - Bridesmaid
- Matthew Willig - Yuri the Gobbler
- Matthew Willig - Uri
- Antonio D. Charity - Army Commando
- Jeremy Clark - Army Commando (uncredited)
- Evan Shafran - Buy More Customer
- Ángela Meyer - Military Convention Girl
- Ángela Meyer - Weapcon Convention Soldier
- Labrandon Shead - Groom
- Christian Svensson - Yuri / Frank
- Mario Di Donato - Gilles
- Victoria Oscar - Stage Manager
- Griffin Kohout - Agent
- Rogelio T. Ramos - Piano Player
- Joe Bucaro III - Mitch
- Tony Flores - Guard
- Vinnie Jones - Karl Stromberg
- Brian Oerly - Andy
- Eduardo Antonio Garcia - Head of Security
- Herbert Siguenza - Scared Revolutionary
- Weston Blakesley - Professor
- Andrew Constantini - Soldier
- Steve Hernandez - Salsa Band Musician
- Tom Kiesche - Captain Miles Galbraith
- Karen Huie - Old Thai Woman
- Fahim Anwar - Manoosh Depak
- Bob McCracken - Ring Manager
- Henry Clarke - Tour Guide
- Leslie-Anne Panaligan - Bartender
- Greg Derelian - Ring Agent
- Ian Gregory - Ring Boss
- Erik Betts - Del's Bodyguard
- Timothy Thomas Brown - Inspector
- Star Calvet - Kissing Girl
- Bill Cleavelin - Kirk
- Derek Graf - Technician #2
- Marilyn Monrovia - Resort Guest
- Greg Roman - Stanley Fitzroy
- Sterling Jones - Alex Coburn
- Mekenna Melvin - Alex McHugh
- D. David Morin - Major
- Frank Krueger - CIA Agent
- Stephen Oyoung - Ring Agent
- Andrew Kirsanov - Anatoli Zevlovski
- Michael Silva - Spa Host
- Heather Olt - CIA Operative
- Kat Rogers - Lisa
- Roger Cross - Ring Agent
- Kelly Thiebaud - Lady Agent
- Kelly Thiebaud - Evelyn Shaw
- Mary Pat Gleason - Morgue Clerk
- Greg Collins - General Bauer
- Paul Lacovara - Guard #1
- Paul Lacovara - Guard #2
- Pepper Binkley - Sally
- Asher Glaser - Waiter
- Timothy Eulich - Ring Thug
- Denney Pierce - Thug #2
- Kim Swennen - Denise
- Chris Lusti - Repairman
- Mario Perez - Shoplifter
- Jean Claude Leuyer - French Soldier
- Jean Claude Leuyer - Mob Guy
- Carlos Lacámara - Juan Diego Arnaldo
- Mark Pellegrino - Fulcrum agent
- Mark Pellegrino - Hector
- Lela Loren - Elia
- Ian Patrick Williams - Mustache Man
- Jack Guzman - Drugged Interpol Agent #1
- Nico Cortez - Interpol Agent #1
- Tim Loden - Polish Rocker
- Chino Binamo - Interpol Agent #2
- Anthony DiRocco - Arnaldo's Man #2
- Ron Provencal - Conductor
- Jackie Zane - Woman with Baby
- Fred Willard - Craig Turner
- Swoosie Kurtz - Laura Turner
- Scott Holroyd - Justin Sullivan
- Udo Kier - Otto Van Vogel
- Nadia Lanfranconi - Cassandra Meadows
- Lawrence Hilton-Jacobs - President of Zamibia
- Allan Louis - Dr. Martin Kwambe
- Kevin West - Merlin
- Christopher Lloyd - Dr. Leo Dreyfus
- Loretta Fox - Nurse
- Trevor Torseth - Ring Operative
- Peter Jason - General Merriweather
- Joshua Rush - Young Chuck
- Jadin Gould - Young Ellie
- Eddie Davenport - Agent Rosenbaum
- Eddie Davenport - French Soldier
- David Rickabaugh - Buy More Shopper
- Olivia Munn - Greta
- Larry Cedar - Interviewer
- Katie Cleary - Laura
- Harry Dean Stanton - Harry
- Dolph Lundgren - Marco
- Christopher Chen - HR Interviewer
- Sean Tomazin - Burly Guard
- Karolína Kurková - Sofia Stepanova
- Bronson Pinchot - Victor
- Lou Ferrigno - Sofia's Bodyguard
- Thierre Di Castro Garrito - Male Model / Bartender
- Chris Payne - CIA Nerd Herder
- Giovanni V. Giusti - Giovanni Milano
- Tia Texada - Hortensia Goya
- Alex Fernandez - Commandante Juan Pablo Turrini
- Todd Sherry - Dr. Fred Hornblower
- Eric Roberts - Packard
- Dave Bautista - T.I.
- Joel David Moore - Mackintosh
- Koby Azarly - Iranian sgt
- Mariano Mendoza - David Bautista PD
- Omid Zader - Iranian soldier #2
- Roland Kickinger - Security Guard
- Robert Englund - Dr. Stanley Wheelwright
- John Griffin - Pierce
- William Patrick Brown - Restaurant Patron
- Ana Gasteyer - Dasha
- Michelle N. Carter - Bank Teller
- David Goryl - Bank Guard
- Rob Riggle - Jim Rye
- Branton Box - Mercenary Guard
- Branton Box - Guard #409
- Summer Glau - Greta
- Richard Chamberlain - Adelbert De Smet
- Lance Aaron - International Spy
- James Lew - Anad Chenerad
- Arnold Chon - Sanouk
- Kaidy Kuna - Native Villager
- John Tamaki - Thai Dwarf
- Toshi Toda - Thai Bossman
- Torsten Voges - Dr. Mueller
- David J. Wright - The Scarred Man
- Monet Mazur - Barbara
- Mercy Malick - Instructor
- Isaiah Mustafa - Rick Noble
- Isaiah Mustafa - Greta #2
- Pooja Kumar - Jinsana
- Jean-Christophe Febbrari - Pierre Melville
- Joe Howard - Elderly Man
- Braeden Marcott - Wine Enthusiast
- Stacy Keibler - Victoria Dunwoody
- Stacy Keibler - Greta #3
- Mars Crain - Inmate
- Josh Harp - Inmate
- Kevin T. McCarthy - Creepy Prisoner
- Darin Toonder - Steve
- Maurice Whitfield - Terrence McBride
- Sam Zeller - Two-fingered inmate
- Sonita Henry - Dr. Ayub
- Игорь Жижикин - Armaund
- Fred Cross - Roni Eimacher
- Kevin Fabian - Barry Greenfield
- Paul Haitkin - Volkoff's Driver
- Stephanie Jackson - Nurse Young
- Russell Reynolds - Gentleman
- Jon Tognacci - Lieutenant
- Roman Mitichyan - Russian
- Roman Mitichyan - Hungarian
- Lesley-Ann Brandt - Fatima Tazi
- Ayelet Ben-Shahar - Yaida
- Kyle Derek - Body Guard#1
- Kimberly Estrada - Amina
- Donna Feldman - Salina
- Kellie Hamilton - Bellydancer
- Maz Siam - Saud Al Habi
- Issam Tahan - Darbouka Player
- Lou Diamond Phillips - Gaez
- Mircea Monroe - Amy
- Mercedes Mason - Zondra
- Damien Bray - Body Guard
- Brianna Nicole - Samba Dancer
- David S. Lee - Boris
- Kym Jackson - Charlize Grant
- Sonya Macari - Antonia
- Tudor Petruț - Jurek
- David Reynolds - Christoph
- Paul Witten - Masked Doorman
- François Chau - Guillermo Chan
- Ray Wise - Riley
- Tom Choi - Skinny guard
- Nicole Hawkyard - Leather Woman
- John O'Brien - Older CIA Tech
- Woon Young Park - Menacing Guard
- Michael J. Sielaff - Younger Technician
- James Kwong - Vault Guard
- Timur Kocak - Necati 'The Turk' Acar
- Jon Sklaroff - Dragan Pichushkin
- Nick Gracer - Head Thug
- James Francis Ginty - Lewis
- Karissa Vacker - Josie
- Mousa Kraish - Damian
- David H. Lawrence XVII - Marvin
- Anthony Molinari - Soldier
- Anthony Molinari - Bellhop
- Kevin Daniels - Ellyas Abshir
- Robert Okumu - Casino Guard
- Sahlima - Samira
- Cedric L. Williams - Somalia pirate
- Lisa LoCicero - Daphne Peralta
- Pamela Roylance - Sarah's Grandmother
- Timothy V. Murphy - Father of the Bride
- Lisa Fredrickson - Teenager's Mom
- George Ketsios - Paulie Klug
- Mandy Levin - Woman
- Kevin Makely - Bruno Klug
- Phoebe Neidhardt - Obnoxious Girl
- Alexa Blair Robertson - Young Sarah
- Mark Roman - Wedding Guest
- Nate Shelkey - Driver
- Gianna Simone - Ms Gehrlich The Bride
- Thom Williams - Franz Klug
- Kenny Kelleher - Hotel Employee
- India de Beaufort - Jasmine
- Millicent Martin - Mrs. Winterborne
- Michael Lespinasse - Armed Guard
- Christopher Bradley - Henchman Number 3
- Michael Bailey Smith - Vlad
- Christopher DeMaci - Scientist
- Rubén Garfias - Juan
- Zoran Korach - Guard #2
- Benjamin Byron Davis - Villain
- Graham Clarke - Englishman Sebastian Carlisle
- Timothy 'TJ' James Driscoll - Villain #3
- Marcus Natividad - Villain
- C.W. Pyun - Delivery Guy
- Richard Burgi - Clyde Decker
- Julia Milova - Volkoff's Receptionist
- Michael Duisenberg - CIA Agent Anderson
- Michael Hagiwara - The Therapist
- Craig Kilborn - Roger Bale
- Mark Hamill - Jean-Claude
- Ethan Phillips - Woodley
- Ben Cain - Stark
- Carrie-Anne Moss - Gertrude Verbanski
- Justin Hartley - Wesley Sneijder
- Jeff Fahey - Karl Sneijder
- Katie Locke O'Brien - Groovy Lady
- Charlet Chung - Susie Chin
- Joseph Ferrante - Gruff Guard
- David L. King - Executive
- Daniel Cummings - Verbanski's Assistant
- Bjorn Johnson - Mats Zorn
- David Koechner - Crazy Bob
- Catherine Dent - Jane
- Adam Bartley - Stu
- Judith Benezra - Linda
- Steve Monroe - Irv
- Matt Rasku - Waiter
- Michael Shaun Sandy - Cop
- Jefferson Cox - Javier
- Beau Garrett - Cult Leader
- Eric Lange - Colin Davis
- Freddie Wong - Freddie
- Jack Dimich - Timur
- Danny Pudi - Vali Chandrasekaren
- Yvette Nicole Brown - Buy More Employee
- Cesar Garcia - Shifty Inmate
- Derek Mears - Lance
- Sergio Kardenas - Hacker
- Lee Reherman - Simms
- Rebecca Romijn - Robin Cunnings
- Alex Boling - Sommelier
- Alex Marshall-Brown - Hostess
- Mikal Vega - Large Agent
- Joseph Gatt - Agent Hawk
- Mo Collins - Colonel Caroline Haim
- Stan Lee - Stan Lee
- David Batiste - CIA Security Guard
- Cher Calvin - Reporter
- Bryan Friday - Ted
- Cheryl Ladd - Emma
- Tim DeKay - Kieran Ryker
- Johnny Kostrey - Hungarian Waiter
- Rachel Eggleston - Molly
- Khristian Lupo - Hungarian #9
- Ray Lykins - Hungarian #8
- Tracy Pfau - Hungarian Woman
- John H. Tobin - Hungarian Villager
- Omar J. Dorsey - St. Germaine
- Marco Rodríguez - Rocky Falcone
- Jim Tavaré - Torturer
- Maya Butler - Rachel Williams
- Patrick Cohen - Bartender
- Angus Macfadyen - Nicholas Quinn
- Bo Derek - Bo Derek
- Jonny Jay - Snowboarder Employee
- Sandra Benton - Big Michelle
- Kiren - Indian Woman
- Roger Rignack - Jim
- Erin Cahill - Bobbi
- Ben Browder - Thug
- Robin Givens - Jane Bentley
- Yutaka Takeuchi - Business Man
- Scott Bakula - Steve Bartowski
- Vladimir Kulich - Renny Deutch
- Ilka Urbach - German Woman
- Robert Duncan McNeill - Operative
- Alexander von Roon - Lutz
- Morgan Fairchild - Honey Woodcomb
- Arnold Vosloo - Vincent Smith
- Hélène Cardona - German Secretary
- Armand Assante - Premier Alejandro Fulgencio Goya
- Stephen Holland - Barry Nyes
- Mark Sheppard - Ring Director
- Eric Corbin - Russian Party Guest
- Roman Arabia - Juan
- Mark Di Maria - Man in Suit
- Mara Lane - Thai Waitress
- McG
- Robert Duncan McNeill
- Josh Schwartz
- Patrick Rush
- Ali Adler
- Chris Fedak
- Tim Jones
Mark Hamill interpreta a Jean-Claude en la serie.
Carrie-Anne Moss hace el papel de Gertrude Verbanski.
Christopher Lloyd interpreta a Dr. Leo Dreyfus en la serie.
Dominic Monaghan interpreta a Tyler Martin en la serie.
Sala Baker hace el papel de Terrorist Bodyguard.
Scott Bakula interpreta a Steve Bartowski en la serie.
Udo Kier interpreta a Otto Van Vogel en la serie.
Dale Dye interpreta a General Stanfield en la serie.
Louis Lombardi hace el papel de Scotty.
Linda Hamilton interpreta a Mary Elizabeth Bartowski en la serie.
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