- Zandy Hartig - Nurse Dori
- Zandy Hartig - Nicky's Mom
- Dannah Feinglass Phirman - Appalled Mom
- Dominic Monaghan - Oren Maestro
- Jason Sudeikis - Dr. Robert 'Bobby' Fiscus
- Jesse Plemons - Jesse
- Skyler Brigmann - Noah
- Gilli Nissim - Script Supervisor
- Joshua Rush - Seth
- Noah Urrea - Trevor
- Bil Dwyer - Alan Stack
- Michael Grant - Richard Jarvis
- Dhruv Uday Singh - Doctor
- Lisa Edelstein - Lisa Edelstein
- Rich Fulcher - Greg
- Sarah Silverman - Britches
- Matthew Perry - Matthew Perry
- Marlon Wayans - Dr. Black
- Sarah Hyland - Famous Person
- Rob Riggle - Dr. Brock Stryker
- Michael McKean - Death
- Alicia Silverstone - Kelly
- Paul Scheer - Sir Tinkle Button
- Jordan Peele - Dr. Brian
- Ryan Hansen - Kyle Bradway
- Stephen Root - Hank Maestro
- Brian Huskey - Chet
- Brian Huskey - Hobo Clown
- Ed Helms - Dr. Ed Helms
- Ed Helms - TV Announcer (voice)
- Martin Starr - Roman DeBeers
- Ike Barinholtz - Peter Principato
- Jason Mantzoukas - Mole Man
- Mather Zickel - Louis La Fonda
- Nick Kroll - Nicky
- Nick Kroll - Little Nicky
- Nick Kroll - Dr. Geza
- Nick Kroll - Nicky (uncredited)
- David Ferguson - Reporter 2
- Logan Arens - Dizzy Boy
- Joe Lo Truglio - Shane
- Joe Lo Truglio - The Voice of Antonio Zavala (voice)
- Kathryn Hahn - Lamaze Teacher
- Tom Virtue - Dr. Random
- Anne-Marie Johnson - Dr. Parker
- Taylor Lipman - Young Cancer Patient
- Brooke Dillman - Blake's Mom
- Cutter Garcia - Dr. Antonio Zavala
- John Ross Bowie - Dr. Max von Sydow
- John Ross Bowie - Dr. Max Von Sydow
- Carly Craig - Catlike Doctor
- Carly Craig - Blake's TV Wife
- Ethan Stone - Handsome Janitor (uncredited)
- A.D. Miles - Ribbon Cutter
- A.D. Miles - Administrator - Ribbon Cutter
- Eva Longoria - The New Chef
- Allison Smith - Nurse Allison
- Annalise Basso - Morgan
- Grant Collins - Blake's TV Son
- Laura Marano - Haley
- Laura Marano - Haley (uncredited)
- Renée Victor - Gladys
- Beth Dover - Nurse Beth
- Eva Amurri Martino - Lovely Nurse
- Toby Huss - Old Timey Psychiatrist
- Lei'lah Star - Sick Girl in Creches (uncredited)
- Lei'lah Star - Girl in the Wheelchair (uncredited)
- Marion Ross - Elderly Nurse
- Lizzy Caplan - Casey Klein
- Lizzy Caplan - Harmony
- Sita Young - Black & White Nurse
- Eddie Pepitone - Shady Mobster
- Kevin Sussman - Daffy Giraffy
- Matt Ballard - Cop
- Angela Sarafyan - Olga
- Suzanne Turner - Parent
- Curtis Gwinn - Trustafarian
- Garrett Ryan - Kid
- Cameron Sanders - Kid
- Ariana Guido - Girl with Broken Arm (uncredited)
- Julie Brister - Nurse
- Clark Duke - Captain Stern
- Ernie Hudson - Hubert McGraw
- Jeff Ross - Self
- Adam Scott - Lt. D'Ghor Koru
- Mark L. Young - Raye LePlante
- Jenny O'Hara - Georgene Lefkowits
- Jason Sklar - Self
- Randy Sklar - Self
- Joe Filippone - Breakdancer
- Ashley McGullam - Patient
- Rasha Goel - Indian Chief
- Matt Walsh - Cameraman
- Matt Walsh - Dr. Trotter
- Nate Corddry - Dr. Jason Mantzoukas
- Nate Corddry - Prosecuting Attorney
- Nate Corddry - Dr. Nate Corddry
- John Cho - Park
- Armen Weitzman - Dr. Fantastic
- Armen Weitzman - Dr. Frantastic
- Kurtwood Smith - Ben Hayflick
- Caroline Aaron - Glenn's Mom
- Mike Ivy - Boss
- Rasika Mathur - Nidhi
- Peter Cameron - David Wain's PA
- Peter Cameron - Pranked Nurse (uncredited)
- Terrell Ransom Jr. - Patient
- Kulap Vilaysack - Nurse Kulap
- Kulap Vilaysack - Nurse Sandy
- Dean Misch - Cool German Kid
- José Zúñiga - Gang Boss
- Missy Yager - Mom of the Kid
- Jackie Clarke - School Teacher
- Matt Besser - Dr. Adair
- Matt Besser - Circus Clown
- G.G. Townson - Blake's Daughter / Ajuku Girls
- Ed Begley Jr. - Senator Throman
- Dash Dobrofsky - Justin
- Rachael Harris - Mrs. Throman
- Mia Barron - Freckles
- Colin Bates - Daniel Throman
- Todd Stashwick - Officer
- Anjul Nigam - Sultan's Aide
- Faran Tahir - Malik
- Iqbal Theba - Sultan Abdul Aziz
- Ian Abercrombie - Butler
- Marcus Brown - LA Laker
- Becky Thyre - Voice Over Coach
- Zachary Gordon - Mike
- Christian Hutcherson - Grimace
- Aaron Sanders - Randall
- Nick Offerman - Lt. Chance Briggs
- Nick Offerman - Detective Chance Briggs
- Roz McHenry - Mean Nurse (uncredited)
- Brandon Johnson - Black Blake
- Kym Whitley - Black Administrator
- Kate Walsh - Self (uncredited)
- Kate Walsh - Self
- Harmon Jones - Sam
- Thomas Lennon - Pat
- Jamie Denbo - Nurse Robin
- Jamie Denbo - Jamie Denbo
- Jamie Denbo - Mother
- Jamie Denbo - Zipporah
- Elizabeth Ann Koshak - Dr. Izzy (uncredited)
- Jordan Black - Mr. Dunn
- Skylan Brooks - Boy
- David Wain - Rabbi Jewy McJewJew
- David Wain - David Wain
- David Wain - Self
- David Wain - Square Dance Caller
- Billy Merritt - Dirty Randy
- Charlie Sanders - White Man
- Fay Wolf - Mom
- Jon Hamm - Derrick Childrens
- Jon Hamm - Arthur Childrens
- Jon Hamm - Derrick Childrens / Arthur Childrens
- Mike Starr - Taxi Driver
- Morgan Walsh - Nurse Morgan
- Ryan Berg - Hospital Administrator
- Ryan Berg - Prop Master
- Raphael Bob-Waksberg - Reporter 3
- David Doty - Arthur Childrens
- Colton Dunn - 70's Dude
- Joshua Erenberg - Boy
- Brian Gallivan - Reporter 1
- Whitney Teubner - Whitney
- Whitney Teubner - Whitney (uncredited)
- Paul Ben-Victor - Spiros
- Richard Brooks - Robert
- S.E. Perry - Warden
- Amro Salama - Logan's Dad
- Sarah Thyre - Mother
- Scott Aukerman - Desperate Dad
- Lennon Parham - Pharmacist
- Jack Coghlan - Young Child
- Bruce Davison - Narrator
- Lauren Beach - Screaming Child
- Kathryn Burns - Dancer #3
- Luke Davis - Kid
- Katie Russell - Dancer #4
- Devon Woods - Child #1
- Abigail Spencer - Young Cheif
- Abigail Spencer - Chief in Her 20s
- Abigail Spencer - Maxine Spratt
- Holley Fain - Intern
- Emily Maya Mills - Nurse
- Seth Morris - Dr. Nate Schachter
- Seth Morris - Tug Spano
- Seth Morris - (uncredited)
- Seth Morris - Butch
- Christopher Chen - Doctor (uncredited)
- Kate Freund - Delivery Woman
- Ian Roberts - Dr. Antoine
- Ian Roberts - Hoss O'Brien
- Ian Roberts - Soldier 1
- Jerry Lambert - Doctor
- Brody Stevens - Father
- Lauren Weedman - Angry Mother
- Logan Shea - Micha Spiegelman
- Kaitlin Doubleday - Female Intern
- Avery Phillips - Orphan
- Steve Agee - Lollipop Salesman
- Steve Agee - Terry
- Michael Shepperd - Transvestite
- Jean St. James - Distraught Woman
- Wayne Bastrup - Swedish Glenn (uncredited)
- Kerri Kenney - Dutch Tourist
- Kerri Kenney - Kerri Kenney-Silver
- John Gemberling - Trustafarian
- John Gemberling - Private Corcoran
- Jason Ellis - Burly Tattood Man
- Sean Conroy - Drunk Daddy
- Sean Conroy - Dad of the Kid
- Erich Bergen - Male Nurse / Dancer
- Ali Marsh - Midwife
- Lauri Johnson - Rosa
- Gabriel Aslan - Rosa's Son (uncredited)
- Timothy Busfield - Dr. Bloomfield
- Marston Fobbs - Male Set PA
- Délé Ogundiran - Female Set PA
- Josh Sussman - Jake
- François Chau - Mr. Lee
- François Chau - Kaiju
- Jennifer Westfeldt - Jessica Meetcher
- Nikki Hahn - Carrie
- Michaela Watkins - Lacey Briggs
- Jovan Armand - Mexican Boy
- Tucker Albrizzi - Kid
- Tucker Albrizzi - Terry
- Keegan-Michael Key - Captain Tripper
- Keegan-Michael Key - Cop
- Phillipe Simon - Father
- Carlos C. Torres - Pinata Kid
- Lauren Cohan - Lulu Pratt
- Frank Ferrante - Braedon Downs
- Frances Fisher - Headmistress
- Sasha Jackson - Valerie Flume
- Jaime Murray - Kitty Black
- Jim Piddock - Cyrus Mittleman
- Dileep Rao - Glenn Richard
- Rosalind Ayres - The Duchess
- Jamie Donovan - Bartender
- Mae Hi - Owen's Mom
- Mae Hi - Writer #2
- Jessica Oyelowo - Mother
- Rebecca Reid - Nurse Dorothy
- Aubrey Wakeling - Man
- Peter Serafinowicz - Michael Caine (voice)
- Christina Pickles - Glenn's Mom
- Kelly Ryan - Another Mom
- Leslie Thurston - Wife
- Janet Varney - Stacy
- Anna Vocino - Mom
- Tara Macken - Samantha
- Philip Baker Hall - Dr. Joseph Mengele
- Tina Huang - Tourist Mom
- Katherine Kendall - Flight Attendant 1
- Jake Martin - Parent
- Lindsay Sloane - Pat
- Lindsay Sloane - Roxanne
- Bob Rumnock - Businessman
- James Sharpe - Tourist
- Will Sasso - Office Bailnt
- Will Sasso - Tucker
- Frederick Weller - Elliot
- Jenny Robertson - Kid's Mom
- Andrew Stock - Young Sal
- Darren Dupree Washington - Cop
- Darren Dupree Washington - Police Officer (uncredited)
- Reginald VelJohnson - Judge Lester Harrison
- Major Curda - Kid Patient
- Joey Diaz - Vito
- David Krumholtz - Dookie
- Eddie Mekka - Frankie
- Rick Overton - Chairman
- Rick Pasqualone - Italian
- Miriam Tolan - Wife
- Sarah Hoffmeister - Choking Girl (uncredited)
- Aidan Miner - Young Kid
- Kevin Pollak - Kevin Pollak
- Jozella Reed - Writer #1
- Nami Paix - Yoko Ono (uncredited)
- James Adomian - Madonna
- James Adomian - Louis C.K. / Madonna / Freddie Mercury / Rihanna / Kate Upton
- James Adomian - Reporter / Madonna
- Jake Huang - Victim
- Yoshio Iizuka - Gojira
- James Lew - Mosura
- Jayden Maddux - Willy
- Hiroshi Watanabe - Japanese Detective
- James Wellington - Captain
- Jaleel White - Chuck Engall
- Christina Kirk - Marnie Weiss
- Erica Oyama - Flight Attendant 3
- Erica Oyama - Fairy
- Alice Lo - Trumpet Teacher
- Logan Miller - Chase McKeever
- Judah Friedlander - 'Weird Al' Yankovic
- Carla Gallo - Denise
- Richard Kind - Marvin
- Justin Kirk - Michael
- Annie O'Donnell - Betty
- Brian Doyle-Murray - Dr. Santa Claus
- Alexa Havins - Susan
- Jay Johnston - Captain Beach-House
- Andrew Pifko - Steve Perry
- Cole Sand - Dylan
- Andrew Santino - Jasper-Pants
- Aaron Brumfield - Strong Man
- Nina Franoszek - Party Host
- Wolf Muser - NATO Chairman
- Laura Chinn - Patient #1
- Carter Hastings - Kid
- Cassidy May Benullo - Baby Chief (voice)
- Cassidy May Benullo - Mainframe (voice)
- James Urbaniak - Future Doctor
- Steven Weber - John Tandy
- Brian Linsley - General Gates
- Michael Winslow - Self
- William Atherton - Levon Bainter
- Joshua Leary - David
- Owen Burke - Mailman
- Jessica Chaffin - Hypnotist
- Mason Davis - Kid
- Mark Kelly - Audience Guy #2
- Pasha D. Lychnikoff - Bad Guy #1
- Amanda Troop - Audience Lady
- Vladimir Tevlovski - Gunman
- Alex Berg - Audience Guy #1
- Alan Smyth - Briggs
- Alan Smyth - Father O'Boylan
- Michael Blieden - Assistant Director
- 'Weird Al' Yankovic - Young Michael
- 'Weird Al' Yankovic - 'Weird Al' Yankovic
- Jayne Taini - Older Woman
- Sam Trammell - Denizen Stoop
- Robert Craighead - Captain Berg
- Jack McBrayer - Ballard
- Brooklyn Rae Silzer - Doctor Little Girl
- Mary Votava - Mallika
- Diane Sellers - Judge
- Chris Parnell - Ron Pippin
- Lilan Bowden - Sauna Staffer
- Daniel Riordan - Russian General
- Paul Welsh - Worker
- Karl T. Wright - African Diplomat
- Ronny Cox - Tooter Daniels
- Julie Bowen - First Lady
- Joshua Malina - Gene
- Liz Cackowski - Carol Torton
- Richard Benjamin - Dan Richards
- Max Charles - Billy
- Fred Melamed - Leonard Hillman
- Christina Chang - Duenna
- Shaifali Ratti - Nidhi
- Karthik Srinivasan - Dev
- Cheryl Tiegs - Cheryl Tiegs
- Madeline Walter - Waitress
- Michael McCafferty - Mark Matt
- Ravi Patel - Dr. Sunnit Bharta
- Constance Wu - Pepsi Lamarr
- David Mattey - Cyborg
- Vico Ortiz - Female Warrior
- Ty Parker - Kip
- Amber Friendly - Female Doctor
- Amber Friendly - Dr. Martha Kriete
- Nathan Fielder - Matthew Hauser
- Michael Showalter - Nils Vildervaan
- Stephnie Weir - Rhonda
- Tony Hale - Brad Lendricks
- Jonathan R. Freeman - Bike Clerk
- Robert Forster - Donald
- Ben Feldman - Leo Richie
- Mimi Kennedy - Ma Richie
- Lindsey Kraft - Esther
- Michael Lerner - Pop
- Tamara Mello - Melanie
- Rachel Blanchard - Missy
- Betsy Brandt - Dr. Kids
- Hannibal Buress - Hannibal Buress
- Irene Roseen - Old Woman
- Kaleti Williams - Khan
- Ben Zelevansky - Cop
- Bart McCarthy - Todd the Vagrant
- Marla Gibbs - Flossie
- Brenda Koo - Janet
- Samm Levine - Chuggy Simple
- Nathan Caywood - Concession Clerk
- Wayne Federman - Dr. Reed
- Clint Jung - Mailman
- JoBeth Williams - Linda
- Ethan Dizon - Braden
- Kayla Madison - Sarah
- George Wendt - Governor Jasper Ruth
- Brandin Stennis - Patient
- Ronnie Clark - Biker
- Valerie Harper - Mamma Fiorucci
- Lee Garlington - Geraldine Peters
- Molly Shannon - Paula Reilly
- Barry Bostwick - Grandpa Richie
- Paul Dooley - Grandpa Ben
- Judith Drake - Grandma Richie
- Hayley Huntley - Nurse
- Shirley Jones - Grandma Shirley
- Linda Porter - Grandma Betty
- Denell Johnson - Mover
- Con Schell - Dr. Parker's Guard
- John-Clay Scott - Big Guard
- Jason Antoon - Imam Islam
- Tom Arnold - Tom Arnold
- Dick Cavett - Dick Cavett
- Randall Park - Jamyang
- D.J. Bonebrake - X
- Exene Cervenka - X
- John Doe - X
- Raven Alexis - Porno Nurse
- Joanna Angel - Porno Patient
Rick Overton interpreta a Chairman en la serie.
Ronny Cox interpreta a Tooter Daniels en la serie.
Thomas Lennon interpreta a Pat en la serie.
Dominic Monaghan hace el papel de Oren Maestro.
Kurtwood Smith interpreta a Ben Hayflick en la serie.
Caroline Aaron hace el papel de Glenn's Mom.
Jenny O'Hara interpreta a Georgene Lefkowits en la serie.
Frances Fisher interpreta a Headmistress en la serie.
Philip Baker Hall hace el papel de Dr. Joseph Mengele.
Michael Lerner interpreta a Pop en la serie.
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