- Gwen Stefani - Self
- Bobak Ferdowsi - Self
- Chadwick Boseman - Self
- Chris Evans - Self
- Tony Hale - Self
- Gwyneth Paltrow - Self
- Drew Barrymore - Self
- Wanda Sykes - Self
- Jon Favreau - Self
- Barbara Boxer - Self
- Ashton Kutcher - Self
- Rachel Bloom - Self
- Kate Hudson - Self
- Bill Nye - Self
- Lizzy Caplan - Self
- David Spade - Self
- Will Arnett - Self
- Megan Fox - Self
- Christina Aguilera - Self
- Wagner Moura - Self
- Wiz Khalifa - Self
- Norman Reedus - Self
- Michael Strahan - Self
- Sarah Paulson - Self
- Jason Biggs - Self
- Jenny Mollen - Self
- Nancy Pelosi - Self
- Keith Olbermann - Self
- Allison Janney - Self
- Anna Faris - Self
- Elliot Page - Self
- Florence Henderson - Self
- Von Miller - Self
- Eric André - Self
- Joel Kinnaman - Self
- Kate Upton - Self
- David Cross - Self
- Aaron Eckhart - Self
- Neil deGrasse Tyson - Self
- Michael Sheen - Self
- Sarah Silverman - Self
- Diane Guerrero - Self
- Craig Ferguson - Self
- Mike Colter - Self
- Amy Schumer - Self
- Mark Cuban - Self
- Chris Pratt - Self
- Lea Michele - Self
- Reggie Miller - Self
- T.J. Miller - Self
- Edgar Ramírez - Self
- Jessica Alba - Self
- Gavin Newsom - Self
- Kristen Bell - Self
- Don Cheadle - Self
- Joshua Jackson - Self
- Ed Begley Jr. - Self
- Rob Lowe - Self
- John Mulaney - Self
- Nick Kroll - Self
- Russell Peters - Self
- Krysten Ritter - Self
- Rumer Willis - Self
- Taylor Lautner - Self
- Jennifer Connelly - Self
- Kevin Hart - Self
- Jesse Ventura - Self
- Larry King - Self
- Connie Britton - Self
- Hilary Swank - Self
- Ava DuVernay - Self
- Tyler Perry - Self
- Cobie Smulders - Self
- Isla Fisher - Self
- Thomas Lennon - Self
- Meghan Trainor - Self
- Priyanka Chopra Jonas - Self
- Ron Howard - Self
- Felicity Jones - Self
- Norah Jones - Self
- Shannen Doherty - Self
- Nicole Richie - Self
- Trevante Rhodes - Self
- Rose McGowan - Self
- Chelsea Clinton - Self
- Mary McCartney - Self
- Stella McCartney - Self
- Colleen Ballinger - Self
- Carol Burnett - Self
- Rob Corddry - Self
- Mary McCormack - Self
- Nikki Glaser - Self
- Jake Tapper - Self
- Maria Shriver - Self
- Matt LeBlanc - Self
- Sarah Jessica Parker - Self
- Morgan Spurlock - Self
- Trevor Noah - Self
- Julianna Margulies - Self
- Emmy Rossum - Self
- Valerie Jarrett - Self
- Milo Ventimiglia - Self
- Kyra Sedgwick - Self
- Sally Field - Self
- Jessica Chastain - Self
- Dale Earnhardt Jr. - Self
- Van Jones - Self
- Taylor Schilling - Self
- Dascha Polanco - Self
- Lea DeLaria - Self
- Uzo Aduba - Self
- Susan Sarandon - Self
- Gael García Bernal - Self
- Eric Garcetti - Self
- Cameron Dallas - Self
- Common - Self
- Maren Morris - Self
- Jennifer Lawrence - Self
- Chris Hardwick - Self
- Melissa McCarthy - Self
- Hugh Davidson - Self
- Larry Dorf - Self
- Rachel Ramras - Self
- Charlize Theron - Self
- Kumail Nanjiani - Self
- Jim Parsons - Self
- Rashida Jones - Self
- Gaby Hoffmann - Self
- Goldie Hawn - Self
- Tracee Ellis Ross - Self
- Aisha Tyler - Self
- Rosario Dawson - Self
- Cory Booker - Self
- Leah Remini - Self
- Geoffrey Rush - Self
- Danny McBride - Self
- Anthony Anderson - Self
- Elizabeth Warren - Self
- Al Franken - Self
- Thomas Middleditch - Self
- Eddie Izzard - Self
- Salma Hayek Pinault - Self
- Don Lemon - Self
- Jerrod Carmichael - Self
- Alison Brie - Self
- Betty Gilpin - Self
- Elisabeth Moss - Self
- Janet Mock - Self
- Russell Wilson - Self
- Kurt Warner - Self
- Aly Raisman - Self
- Laila Ali - Self
- Cara Delevingne - Self
- Garbiñe Muguruza - Self
- Harry Styles - Self
- Rita Ora - Self
- John Bradley - Self
- Kate Beckinsale - Self
- Joey Soloway - Self
- Niecy Nash-Betts - Self
- Ted Lieu - Self
- Eric Swalwell - Self
- Freida Pinto - Self
- Reese Witherspoon - Self
- Kathy Bates - Self
- Dan Rather - Self
- Flula Borg - Self
- Fortune Feimster - Self
- Jessica Biel - Self
- Abbi Jacobson - Self
- Ilana Glazer - Self
- Andrea Savage - Self
- James Corden - Self
- Bella Thorne - Self
- Kirsten Gillibrand - Self
- Emma Stone - Self
- Billie Jean King - Self
- Maggie Gyllenhaal - Self
- Macklemore - Self
- Diego Luna - Self
- DeRay Mckesson - Self
- Jackie Chan - Self
- Tom Steyer - Self
- Vikas Khanna - Self
- Mallika Sherawat - Self
- Shilpa Shetty Kundra - Self
- Ethan Jones - Stephen Miller and General John Kelly
- David Farrier - Self
- Darrell Issa - Self (archive footage)
- Matthew Berry - Self - Guest
- Max Greenfield - Self - Guest
- Jeff Ross - Self - Guest
- Rik Reinholdtsen
- Bryan Paulk
- Mason Steinberg
- Sue Murphy
- Chelsea Handler
Gael García Bernal hace el papel de Self.
Sarah Jessica Parker interpreta a Self en la serie.
Allison Janney interpreta a Self en la serie.
Norman Reedus interpreta a Self en la serie.
Thomas Lennon hace el papel de Self.
Sally Field interpreta a Self en la serie.
Maggie Gyllenhaal interpreta a Self en la serie.
Rob Lowe hace el papel de Self.
Salma Hayek Pinault hace el papel de Self.
Jesse Ventura interpreta a Self en la serie.
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