- Sebastian Cabot - Dr. Carl Hyatt
- Doug McClure - Jed Sills
- Keir Dullea - Eddie Phillips
- Anne Baxter - Beatrice Martin Kipp
- Angie Dickinson - Karen Vale
- Sid Caesar - Johnny Wilder
- Dianne Foster - Phyllis Wood
- Jimmy Lydon - Ben Roberts
- Norman Burton - Lou Lewis
- Lloyd Bridges - Howard Robert Gentry
- Audrey Dalton - Ann Miles
- Paul Langton - The Architect
- Barney Phillips - Capt. Jack Howard
- Dennis Patrick - Nick Culley
- Diana Van der Vlis - Hope Reardon
- Laraine Day - Amnesiac Woman
- Charles Drake - Mack Weston
- Helen Brown - Miss Treadwell
- Jack Benny - Jack Bowen
- Tina Louise - Joanne Dunn
- Otto Kruger - George Emery
- Edward Mallory - Arthur Cole
- Diana Lynn - Jodi Lynn
- Henry Jones - Ed Thurston, D.A.
- Vladimir Sokoloff - Pedro Moreno
- Philip Ober - Marshall Winslow
- Claire Bloom - Gina Burton
- William Windom - Peter Morell
- Katherine Squire - Mrs. Vorlund
- Les Tremayne - Simon Oelrich
- Jeffrey Hunter - Edward "Jocko" Townsend
- Dorothy Malone - Lorna Shay
- John Dehner - George Shay
- Tony Randall - Luther Gage
- William Bramley - Burke
- Ralph Bellamy - Governor Tom Barker
- Chester Morris - Albert DeWitt
- Patricia Huston - Anne
- Elizabeth Montgomery - Vicki Page
- Jack Lord - Ernie Chapin
- Émile Genest - Felix Landauer
- Eleanor Parker - Marion Bannion/Gussie Hill
- Herschel Bernardi - Ned Hazly
- Harriet MacGibbon - The Countess
- Sam Hearn - Max
- Dina Merrill - Laura Hammond
- Robert Ellenstein - Rudy Pasada
- Louise Lorimer - Judge Singer
- Patricia Neal - Fran Davis
- Julie Adams - Jean Damion
- John Baragrey - Mitch Kane
- John Astin - Jim Poole
- Walter Pidgeon - John Baker
- Kent Smith - Ainslee
- Margaret Phillips - Beatrice Lawlor
- George Sanders - Richard Gilmore
- John Emery - Lawrence Price
- Ross Elliott - Jerry Bronson
- Richard Conte - Victor Ragar/Romak
- Signe Hasso - Marta Ragar
- Werner Klemperer - Franz Leder
- Noah Keen - Paul Delorio
- John Alderman - Andreas
- Anne Seymour - Mrs. Creighton
- Joyce Van Patten - Marcia James
- Warren Stevens - Eric Williams
- Myron McCormick - Phillip "Doc "Walters
- Charles Seel - The Electrician
- Charles Seel - Georgie Prince
- Sean McClory - Stamper
- Dabbs Greer - Hokey
- Jay Adler - Baines
- Mary Astor - Esther Brack
- Scott Marlowe - Daniel Brack
- Frank Overton - Martin Brack
- Olive Sturgess - Felice O'Neill
- Ford Rainey - Paul O'Neill
- Nick Adams - Weiler ("Kid")
- James Coburn - Gresch
- Alan Napier - Father Dunne, the Abbot
- Ed Nelson - Gil Stoneham
- Ed Nelson - Chuck Palmer
- Brendan Dillon - Father Thomas
- Dana Andrews - Judge Leland McIntyre
- Philip Abbott - Lawrence Dresher
- Lori March - Evelyn McIntyre
- Carolyn Craig - Joanna Leigh
- Tom Reese - Bucky Tate
- David Janssen - Len Kobalsky
- Robert Colbert - Phil Lowell
- Ed Peck - Ernie
- Don 'Red' Barry - Kyle Horgan
- Celeste Holm - Loraine Whitman
- Susan Oliver - Hope Anthony
- Doris Singleton - Mavis Long
- Phillip Pine - Harry Clark
- Lee Philips - Joe Meade
- William Phipps - John Lee
- Nobu McCarthy - Helen Low
- Tod Andrews - Dr. James Low
- James Hong - Louis Quong
- Teru Shimada - Ling Chow
- Dan O'Herlihy - Stephen Jordan
- Bethel Leslie - Cynthia Jordan
- Dorothy Green - Mildred Cowl
- Frank Maxwell - Alex Wismer
- Don Hanmer - Barney Cowl
- Don Taylor - Chip Damion
- Ron Randell - Ron Randell
- George Petrie - Jack Pennell
- Joseph Hoover - Tommy Bigelow
- Macdonald Carey - Frederick Haley
- Kathleen Crowley - Pauline Spencer
- Maxine Stuart - Dianne Cartwright
- William Allyn - Joel Drake
- Peter Helm - Ted Haley
- Ellen Burstyn - Margo as Ellen McRae
- Harry Carey, Jr. - Phil Cassidy
- Earl Holliman - Jack Quentin
- Edward Binns - Harl Stoner
- Stanley Adams - Cholly Luke
- Ilka Windish - Maria Richards
- Stefan Schnabel - Anton Szorny
- Milton Selzer - Wladyslaw Szorny
- Oscar Beregi Jr. - The Conductor
- Susan Kohner - Victoria Angelo
- Ilka Chase - Mary Milburn Reed
- Joe De Santis - Joe Angelo
- Warren Parker - Arthur Harper
- Buddy Ebsen - Pete O'Mara
- Paul Carr - Johnny Kay
- Judith Braun - Barbara O'Mara
- Tom Allen - Second Reporter
- Mary LaRoche - Martha
- Sheila Bromley - Mrs. Welch
- Myron Healey - Charlie Barron
- James Bell - Old Ben
- Kenneth MacDonald - Elmer
- Frankie Darro - Sonny
- Bart Patton - The Young Man
- William A. Graham
- Jules Munshin
- Paul Stewart
- Douglas Heyes
- Alexander Singer
- Don Medford
- Jameson Brewer
- Mark Rodgers
- Max Ehrlich
- Richard De Roy
- James Gunn
- Juarez Roberts
- Richard Berg
- Jon Kubichan
Jay Adler interpreta a Baines en la serie.
Richard Conte interpreta a Victor Ragar/Romak en la serie.
George Sanders interpreta a Richard Gilmore en la serie.
Philip Ober interpreta a Marshall Winslow en la serie.
Robert Ellenstein hace el papel de Rudy Pasada.
Les Tremayne hace el papel de Simon Oelrich.
Edward Binns hace el papel de Harl Stoner.
Lloyd Bridges interpreta a Howard Robert Gentry en la serie.
Patricia Neal hace el papel de Fran Davis.
Buddy Ebsen interpreta a Pete O'Mara en la serie.
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