- Ed Asner - April's grandfather
- Abhi Sinha - Danny Gupta
- Miles Gaston Villanueva - Richie Miranda
- Vondie Curtis-Hall - Lawrence
- Jessica Meraz - Natalie Ortiz
- Steven Weber - Dr. George Carver
- Scott Michael Foster - Leo Hendrie
- Shi Ne Nielson - Raquel Avila
- Augusto Aguilera - Kieran
- Rob Kerkovich - Graham
- Dylan Gelula - Ford
- Jake Picking - Sean
- Todd Waring - Bruce Hendrie
- John Ross Bowie - Paul Peters
- Kelsey Crane - Mallory
- Gracie Dzienny - Greer Danville
- Maksim Chmerkovskiy - Dance Instructor
- Anne-Marie Johnson - Arianna
- Sam Anderson - Gerald Rayburn
- Livia Treviño - Cindy
- Randy Vasquez - Stephen Vonn
- Izzy Diaz - Stan
- Charles Van Eman - Ben
- Jamie Renée Smith - Dana
- Gwen Holloway - Julie
- Osmani Rodriguez - Mark
- Tamara Hickey - Tasha
- Caroline Portu - Larkin
- Swati Kapila - Tara
- Paula Plum - Sally
- Gita Reddy - Sanya Badal
- Gita Reddy - Sanya Bada
- Tom Irwin - Thomas Carver
- Andy Mientus - Jackson
- Susan Chuang - Vera
- Alycia Grant - Meg
- Gregg Perrie - Howard
- Thomas Fowler - Brian Connors
- Teresa Huang - Dr. Fong
- Allison Poccia - Leslie
- Merrin Dungey - Dr. Susan Hamburg
- Doug Simpson - Mr. Ostrowsky
- Bridgett Newton - Carrie Rosen
- Nathan Mohebbi - Adam
- Bryna Weiss - Gertie
- Reatha Grey - Dottie
- Terri Hoyos - Charlotte Morissey
- Chuti Tiu - Lailani Matapang
- Pamala Tyson - Martine Brouard
- John C. Moskoff - Sol Greenberg
- Erin Matthews - Pamela Danville
- Robert Merrill - Will Danville
- Ashley Argota - Kristina
- Rahnuma Panthaky - Joan Gregorian
- Beth Dover - Morgan
- Bob Gebert - Dr. Stibler
- Karl T. Wright - David Masters
- Kimrie Lewis - Madeline
- Kate Avallone - Helena Morris
- Stephen Schneider - Aaron
- Marion Ross - April's Granmother
- Laura Harring - Olivia Ortiz
- Pamela Shaddock - Janice
- David Douglas - Orin
- Scott Connors - Luc
- Alex Carter - Chef Quincy
- D.J. Blickenstaff - Kevin
- Kent Avenido - Pete
- Mary Fegreus - Jessica Smith
- Aasha Davis - Sophie
- Ross Butler - Hunter
- Patrick Carlyle - Doug
- John Grady - Brian
- Sean Persaud - Eli
- Nick Steele - Adam Platt
- Gregory Zarian - Max
- Chelsea Zhang - Shelby
- Maxim Knight - Julian
- Alice Amter - Aditi
- Gigi Bermingham - Blair
- Mary Beth Evans - Catherine
- Mary Beth Evans - Catherine Hendrie
- Catherine Kamei - Chloe
- Lynn Whitfield - Karen Callahan
- Nora Kirkpatrick - Jaclyn
- Illeana Douglas - Dominic's Mother
- Lindsey Kraft - Shawna
- Diana DeLaCruz - Dr. Linda Velasco
- Parker Mack - Finn Madill
- Mac Brandt - Vance Madill
- Keisuke Hoashi - Dr. Kei Takahashi
- Krysta Rodriguez - Vanessa
- Barry Livingston - Bob Reiser
- Ursula Taherian - Passe Nger
- Aurora Perrineau - Margo
- Christopher Mowod - Denver
- Annika Noelle - Abbi
- Tyler Sellers - Tripp
- Nathalia Castellon - Julia
- Ali Ghandour - Generous Partier
- Krista Kalmus - Layla
- Liam McKanna - Nicholas
- Ashlee Füss - Fiona
- Tamlyn Tomita - Molly
- Tamlyn Tomita - Mae
- Tyler Case - Jake Cohen
- John Billingsley - Edwin Shaw
- Leisha Hailey - Juliet
- Greg Germann - William
- Timothy Granaderos - Gabe
- Kaylee Bryant - Sydney
- Brian McGovern - Timothy Carson
- Christine Lekas - Rose Carson
- Reamy Hall - Nancy Carson
- Pat McNeely - Grandma Ida
- Vaz Andreas - Wedding Emcee
- Amber Stevens West - Frankie
- Walter Addison - Sam
- Dio Johnson - Bouncer
- Michael S. Chambers - Male Dancer #1
- Riley Baron - Jerry
- Evan Bittencourt - TJ
- Raney Branch - Ruthie
- Alexandra Grey - Kenya
- Grant Jordan - Andrew
- Ben Lewis - Josh
- Kylee Russell - Mariah
- Kimmy Shields - Ryan
- Sarayu Blue - Dr. Lin
- Colin Egglesfield - Dr. Barratt
- Ashley Dulaney - Newbie
- Rasha Goel - Weatherwoman
- Michael Hyland - Chris Charles
- Andra Petru - Charles Patron
- Nick Nicotera - Calvin Roth
- Ariel Llinas - Greeter
- Pam Murphy - Medic
- Kit Pongetti - Jill Jacobs
- Devon Spence - Eric
- Sara Amini - Clinic Doctor
- Tyler Johnson - Tiege
- David Chan - Host
- Anthony Garland - Mark
- Micah Tayloe Owens - Youngest Brother
- Alexa Najera - Lesbian
- Forrest Wheeler - Boy (uncredited)
- Adore Delano - Funeral Singer
- Matthew Cardarople - Teen Clerk
Tamlyn Tomita hace el papel de Molly.
Italia Ricci interpreta a April Carver en la serie.
Mary Page Keller interpreta a Sara Carver en la serie.
Haley Ramm interpreta a Brenna Carver en la serie.
Richard Brancatisano interpreta a Dominic Russo en la serie.
Aisha Dee hace el papel de Beth Kingston.
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