- Stacy Keach, Sr. - Warren Andrews
- Teru Shimada - Kotaro Suto
- John Craven - Mr. Hathaway
- Russ Conway - Coach O'Brien
- Ruth Warrick - Lydia Darragh
- Richard Denning - Col. Patterson
- Herb Vigran - Bernie
- Tom Tully - John Honeyman
- Jack Kelly - James E. West
- Frank Lovejoy - Inspector Ed McCook
- John Fraser - Tom Giddings
- Leo G. Carroll - William Penn
- Chuck Connors - Harry
- William Forrest - Dr. Sam Halleck
- Ruth Donnelly - Ma Dolan
- Beverly Washburn - Elizabeth
- Otto Graham - Self
- Maureen O'Sullivan - Sister Mary Benedict
- Bruce Bennett - Abe Lincoln
- Cynthia Stone - Pat Connors
- Robert Horton - Ranger Norm Keller
- Murvyn Vye - Ruiz
- Dan Tobin - Graffan
- Liam Sullivan - George Washington
- William Campbell - Officer Clyde Bannon
- Noel Toy - Mrs. Nomura
- Henry Kulky - Ernie
- Christopher Dark - Richard West
- Maidie Norman - Aunt Nellie
- Charles Bronson - John Stanizewski
- Howard St. John - Benjamin Franklin
- Gordon Jones - Lt. Treusch
- Ron Hagerthy - Billy Brandon (as a man)
- Nestor Paiva - Senor Alverez
- Ed Kemmer - Maj. S. V. Bingham, Jr.
- Perry Lopez - Pete Salavedo
- Melinda Casey - Vi as a teenager
- Madge Blake - Mrs. Morrissey
- Jane Darwell - Minna
- Brian Aherne - John Kirk
- Ann Harding - Mrs. Milgrim
- Oskar Homolka - Jeno Reinitz
- Herbert Rudley - Lt. Folson
- Lew Ayres - Matt Needham
- Robert Sterling - Charles Jerrold
- Joe Quinn - Policeman
- Lorna Thayer - Miss Holmes
- Esther Dale - Aunt Tabitha
- Lloyd Corrigan - Bowling Green
- John Lupton - Rembrandt Peale
- Gertrude Michael - Major Pauline Cushman
- John Litel - Dr. Silkworth
- James Gleason - Noah Larkin
- Rhys Williams - William Armstrong
- Amanda Blake - Nancy Hart
- Will Wright - George's Father
- Susan Seaforth Hayes - Sarah
- Forrest Taylor - Mark Hopkins
- Ben Johnson - Cal Bennett
- William Talman - Wes Hardin
- Harry Bartell - Ben Davis
- Jeff Morrow - Chief Justice John Marshall
- Robert Karnes - Pilot
- Phyllis Coates - Barbara Leland
- Eduard Franz - Samuel Morse
- Cecil Kellaway - Sam Mulford
- Strother Martin - Wilkins
- John Hamilton - Porter
- John Hamilton - Colonel Norton
- Dan O'Herlihy - Nathaniel Hawthorne
- Dan O'Herlihy - Benedict Arnold
- Harry Morgan - Homer Byington
- Johnny Crawford - Billy Brandon (as a boy)
- Peter Graves - Maj. Tom Howie
- Michael Fox - George Wooley
- Robin Hughes - Lt. Col. Carleton
- Don Taylor - Bob Lawrence
- Mary Murphy - Rowena
- Fred Clark - Ollendorf
- Frances Bavier - Mrs. Hayes
- Charles McGraw - Wilkie Bowman
- Rachel Ames - Carol
- Steven Geray - Bela Hovarth
- Harry Shannon - Samuel Morse
- Percy Helton - Mr. Fuller
- Paul Fix - Mr. Barton
- Anne Jeffreys - Lucinda Teffy
- Vladimir Sokoloff - Jake Bartosh
- Roy Thinnes - Mickey Hubbard
- James Griffith - Abraham Lincoln
- James Griffith - Clay Doggett
- Pierre Watkin - Allan Pinkerton
- Scott Forbes - Agent Gorson Willis
- Elizabeth Patterson - Mrs. Couche
- Chick Chandler - Mrs. Couche
- Stafford Repp - Thompson
- Edward Platt - Dr. Banner
- Doris Lloyd - Lady Montagu
- Philip Van Zandt - Mario
- Sean McClory - Andrew Johnson
- Jeff Donnell - Ann Rutledge
- John McIntire - John Chapman aka Johnny Appleseed
- John McIntire - Newspaper editor
- Malcolm Atterbury - Conductor
- Onslow Stevens - Sam Houston
- Ward Bond - M / Sgt. Lou Diamond
- Ward Bond - Harvey Kendall
- Barry Kelley - Reporter
- Paul Picerni - Principal John Norton
- Paul Picerni - James Ohio Pattie
- Joi Lansing - Florence
- Barbara Woodell - Miss Bronson
- Ray Teal - Howard
- Robert Strauss - Baron Henry William Von Stiegel
- Frances Rafferty - Anna Judah
- Kathleen Crowley - Abigail Paddock
- Paul Langton - Captain Joshua Patten
- Robert Middleton - William Harper
- Edgar Dearing - Fitz
- Anthony Eustrel - Cochrane
- Constance Ford - Mrs. Bannon
- Lon Chaney Jr. - Zeke Wells
- Lon Chaney Jr. - Old Jeff Harris
- Hans Conried - General Francis Marion
- James Daly - Bill
- John Bryant - Fred
- George Chandler - Proprietor
- Nick Dennis - Sgt. Chiaco
- John Beradino - Julio Gonzales
- Robert Warwick - Alexander Majors
- Robert Warwick - Harper
- Raymond Bailey - Dr. Scott
- Harry Lauter - Harry Grant
- Harry Lauter - Ray Marshall
- Francis McDonald - Calaveras Kid
- Kevin McCarthy - Frank O'Keefe
- Reginald Denny - Gen. Prescott
- Reginald Denny - Col. Patterson
- Arthur Franz - Casimir Pulaski
- Arthur Franz - Dr. William Gorgas
- Russell Johnson - Dan Marshall
- Russell Johnson - Karl Nader
- Sheila Bromley - Mrs. Watson
- Don Kennedy - Jack Jouett
- Barbara Billingsley - Dorothea Meadows
- Barbara Billingsley - Harriet Kohler
- Willis Bouchey - Tom Carver
- Ray Collins - Daniel Webster
- John Wengraf - Von Schwarz
- John Wengraf - German Colonel
- Robert Easton - George Merchant
- Patrick O'Neal - James King
- Tom Brown - Theodore Roosevelt
- Lee Van Cleef - 1st Mate Hawl Finch
- John Abbott - Col. Barton
- Gary Gray - Apple Knocker
- Gary Gray - John Sargent
- Gary Gray - Jackie Jensen (age 16)
- Howard Freeman - William M. 'Boss' Tweed
- Walter Reed - Capt. Marsh
- John Hoyt - Hessian officer
- John Hoyt - Com. Smedley
- Lurene Tuttle - Betsy Peale
- Margaret Field - Mrs. King
- Carl Benton Reid - Cmdr. Ingraham
- Carl Benton Reid - Manning
- Joseph V. Perry - William Dircks
- Hal Baylor - Lumberjack
- Aline Towne - Marion Minot
- Paul Harvey - Mayor
- Jim Davis - J.L. Armstrong
- Roy Barcroft - Herbert Wheelock
- Trevor Bardette - Senator Gwinn
- Stuart Whitman - Capt. W. H. Puntenney
- Marjorie Lord - Mrs. Field
- Marjorie Lord - Lee Powell Coleman
- Rebecca Welles - Joan
- Louis Jean Heydt - James Madison
- Walter Brennan - Link Morley
- Richard Loo - Ho Chung
- Dan Duryea - Joe Kohler
- James Best - Slate Morley
- James Best - Harry
- Ann Doran - Caroline
- Ann Doran - Mrs. Honeyman
- Virginia Gregg - Mrs. Sherman
- Virginia Gregg - Aunt Agnes
- James Seay - Lt. Wells
- James Seay - Mr. Watson
- James Seay - Theodore Dreiser
- James Seay - William Joslin
- George Nader - Eliphalet Remington II
- Fiona Hale - Mrs. Betty Jackson
- Richard Eyer - Tony Lucas
- Richard Eyer - Tim Kendall
- Richard Eyer - Brian Beck
- Frank Ferguson - Dr. Green
- Steve Pendleton - Beecher
- Edgar Buchanan - Horace Greeley
- Edgar Buchanan - Doc Mathew
- Hugh Beaumont - Lewis Graham
- Hugh Beaumont - Coach Jack Cody
- Hugh Beaumont - Father Werr
- Virginia Christine - Mrs. Sargent
- Richard Garrick - Benjamin Franklin
- Douglass Dumbrille - Lord Rawdon
- Richard Erdman - Harry Jordan
- Guy Williams - Player
- Dayton Lummis - Lee
- Leo Britt - Lord Cornwallis
- Paula Raymond - Polly Key
- Paula Raymond - Dr. Elizabeth Blackwell
- Gloria Talbott - Mary Scott
- Gloria Talbott - Nancy Merki
- Gloria Talbott - Mary
- Dabbs Greer - Johann
- Dabbs Greer - John Adams
- Betty Lynn - Beth Shearer
- Walter Kingsford - General Carleton
- Russell Simpson - Quatermaster
- Russell Simpson - Judge Grant
- Robert Osterloh - Simpson
- Robert Osterloh - Sam Houghton
- Lamont Johnson - Lt. Col. Coleman
- Lamont Johnson - Lt. Matt Maury
- Lamont Johnson - Paul Shearer
- Brad Morrow - Jerry
- Dan White - Stan
- Ross Elliott - Zack Garson
- Ross Elliott - Theodore Judah
- Ross Elliott - James Otis
- Ross Elliott - Ralph Kerchum
- John Ericson - Leon Patterson
- John Ericson - Joe Loring
- Milton Frome - Mr. Reynolds
- Hal Stalmaster - Bob - age 14
- Lisa Montell - Frederica McLane
James Griffith interpreta a Clay Doggett en la serie.
Reginald Denny hace el papel de Gen. Prescott.
Percy Helton interpreta a Mr. Fuller en la serie.
Leo G. Carroll hace el papel de William Penn.
Charles Bronson hace el papel de John Stanizewski.
Nick Dennis interpreta a Sgt. Chiaco en la serie.
Walter Brennan interpreta a Link Morley en la serie.
Ward Bond interpreta a Harvey Kendall en la serie.
Lew Ayres interpreta a Matt Needham en la serie.
Lon Chaney Jr. interpreta a Zeke Wells en la serie.
Capítulo disponible en las siguientes plataformas:
