- Wendell Pierce - Conrad White
- Chelsea Field - Cassy Swann
- Charles Levin - Vinnie DiSalvo
- Richard Murphy - Richie Fineberg
- Kathryn Harrold - Mary Ward
- Scott Jaeck - Joey Donello
- Catherine Parks - Brooke Bros
- Lee Richardson - Alex Streeter
- James Avery - Mr. Fairchild
- Lisa Barnes - Andrea
- Benjamin Bratt - Carlos Torres
- John Capodice - Mel Zeiss
- Richard Foronjy - Arnie
- Lela Ivey - Angie
- Adam Jeffries - Robert Harwood
- Paul Linke - Raymond Chumley
- Steve Nevil - Cameraman
- Beah Richards - Etta Mays
- Wil Shriner - Doctor Jenning
- Christopher Carroll - Senator Durning
- Gary Carlos Cervantes - Busboy
- Malcolm Danare - B.D.
- Joe Dorsey - Lt. Colonel DuBois
- Gilbert Lewis - Fire Captain Hank
- Melanie MacQueen - Sue Danton
- Greg Miller - Hammerhead
- Paul Motley - Old Man
- Joel Polis - Vartan
- Trish Ramish - Lycra Girl
- Davis Roberts - Mr. Harrison
- Thomas Ryan - Ogden Yute
- Bryan Sapphire - Bike Messenger
- Eric Server - Jack Dutton
- Ben Wright - Guest star
- Robert Ackerman - Deputy Chief Kinch
- Leah Ayres - Stephanie Sellars
- John P. Connolly - Allan Rossiter
- Jackie Cooper - John C. Dodd
- John Davey - Cop
- James Eckhouse - Business Reporter
- Andrea Evans - Andrea Schaffer
- François Giroday - Bob Drexell
- Andreas Katsulas - Frankie Chapin
- Leigh C. Kim - Eddie Chambers
- Freeman King - Lamont Thomas
- Art K. Koustik - Officer Pauley
- Warren Munson - Ned Barber
- Ken Page - Captain Russell
- Rose Portillo - Officer Bates
- Oz Tortora - Tony Rago
- Aixa Clemente - Joyce
- Bryan Cranston - Congressman Marple
- William Glover - Prof. Dalrymple
- Dex Elliott Sanders - Ramos
- Christine Avila - Mrs. Rodriguez
- Ari Barak - Ephram Bohoud
- Richard G. Camphuis - Cop
- Gloria Cromwell - Peggy MacIlwaine
- Deborah Lacey - Lanie Phillips
- Jeff Skier - Jeff Pelletier
- George D. Wallace - Judge Bowker
- Peter Zapp - Elliot Steinfeld
- Don Amendolia - Bernie Amesol
- Carl Franklin - Cop
- Michael McNab - Bouncer
- Ron Pinkard - Vincent Weese
- Kitty Swink - Jane Hessig
- Bill Lee Brown - Rescue Worker
- Walter Addison - Vasily Rostochenko
- Lou Beatty Jr. - Larry Benning
- Ray Girardin - Arthur Baranco
- Allan Arkush
- David Milch
Lloyd Bridges interpreta a Jonathan Turner en la serie.
Michael Woods hace el papel de Clay Gibson.
Mark Blum hace el papel de Edison King.
William Russ interpreta a Redmond Dunne en la serie.
Helen Slater interpreta a Anne McKenna en la serie.
Daniel Roebuck hace el papel de Haskell Epstein.
Jenny Wright hace el papel de Doreen Duncan.
Christian Clemenson interpreta a Todd Lunden en la serie.
Kurt Fuller hace el papel de Miles Plato.
Wendell Pierce hace el papel de Conrad White.
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