- Catherine McLeod - Secretary
- David Brian - Frank Andreotis
- Herschel Bernardi - Louis Strode
- Joby Baker - Larry Delby
- Jim Backus - Karl Bigger
- Don Beddoe - Clem Burgess
- Jeannie Carson - The Blonde
- Patricia Medina - Jenny Stapleton
- Frank McHugh - Wilbur Morton
- John Marley - Lt. Gene Marcus
- John Alvin - Norman Reno
- Zina Bethune - Lucinda Jackson
- Pat Crowley - Holly Baker
- John Larch - Benjamin Riker
- Pamela Duncan - Frances
- Kent Smith - Charles Dennis
- George Voskovec - Willy Brower
- Susan Oliver - Kitty Bester
- Keir Dullea - Alec Benson
- Henry Silva - Ray Riley
- Jack Lord - Wilt Farrell
- Simon Oakland - Walter Hayes
- Larry Blyden - Jay Adams
- Geraldine Brooks - Joanne Douglas
- Perry Lopez - Nico Berengeri
- Judson Pratt - Leonard Mead
- Sandy Kenyon - Waldo
- Paul Birch - Sheriff Rainey
- Paul Carr - Eddie Novak
- Ian Wolfe - Pop Parkson
- Bert Freed - Dave Reed
- George Mitchell - David Michaels
- Carl Benton Reid - John Stapleton
- Robert Blake - Rick Carter
- Byron Morrow - Meyers
- Everett Sloane - Sam Palmer
- Alex Nicol - Peter Fleming
- Dick Whittinghill - John Tellford
- Michael Dante - Danny Speckter
- Fay Spain - Enid Lazzo
- George Macready - James Harrison
- Madlyn Rhue - Margarita Safa
- Anne Helm - Rita Vulner
- James Coburn - Arthur Troy
- Walter Slezak - Arnie Grote
- Marsha Hunt - Gloria Bonner
- Jacqueline Scott - Helen
- Pat Hingle - Sam Cortner
- Terry Becker - Julius Lenke
- Gloria Talbott - Bobbie
- Bernie Hamilton - Willie Carter
- Barbara Baxley - Clara Combes
- Richard Kiley - Doug Crawford
- Ross Elliott - Lieutenant Spencer
- Phyllis Love - Cele Orlatti
- Ludwig Donath - Hans Saltzman
- Bernard Kates - James Shepple
- Donna Douglas - Edie
- Fritz Weaver - Martin Weir
- Joe Mantell - Maury Troy
- Jesse White - Rudy
- Sheila Bromley - Helen Marstow
- Paul Stewart - Alexander Marish
- Charles Bronson - Hank Conrad
- Neville Brand - Milton E. Bonner
- David Janssen - Dan Mullin
- Anthony Caruso - Ned Falco
- Charles McGraw - Earl Klegg
- Bruce Gordon - Marcus Jackson
- Stanley Clements - Bellboy
- Roger Mobley - Cort Cortner
- Barbara Eden - Terri Emson
- John Anderson - Kenneth Drake
- Jack Klugman - Mike Colonni
- Anne Seymour - Viola Ashlow
- Phillip Pine - Phil Krajac
- Alex Cord - Larry Rome
- Carl Milletaire - Police Chief Mondial
- Clifton James - Tom Larch
- Paul Richards - William Norman
- Robert Duvall - Tom Nugent
- Stuart Nisbet - Detective
- Eduardo Ciannelli - Vincent Orlatti
- Robert Ellenstein - James Condon
- Robert Vaughn - Phillip Colerane
- Ivan Dixon - Willie Williams
- Ivan Dixon - Joe Sherman
- Gene Roth - Syndicate Board Member (uncredited)
- Telly Savalas - Frank Meehan
- Telly Savalas - Harry Remick
- Juanita Moore - Beatrice George
- Chris Robinson - Jack Hayes
- David Lewis - Martin Allard
- Bethel Leslie - Frances Olney
- Arlene Martel - Anna Vargaray
- Sammy Davis Jr. - Sammy Davis Jr.
- Dorothy Dandridge - Norma Sherman
- Ned Glass - Eddie
- Majel Barrett - Grace Newberg
- Cloris Leachman - Katie Cortner
- Ricardo Montalban - Vincent Pavanne
- Sam Jaffe - Louis Speckter
- Philip Abbott - Lt. Martin Cahurn
- Philip Abbott - Howard Douglas
- Denver Pyle - Chief Amos Trask
- Philip Ober - Herman Hausner
- J. Pat O'Malley - Joe Hagen
- Ford Rainey - Capt. Martin Amherst
- Edward Andrews - Herman Combes
- Harold Gould - Bookkeeper
- Philip Bourneuf - Gilbert Caxley
- Kevin Hagen - Charlie Chinn
- Maura McGiveney - Secretary
- Martin Balsam - Jack Garsell
- James Flavin - Arnie Kellwin
- Tyler McVey - Eaton
- Herbert Rudley - Howard Arneg
- H.M. Wynant - Joe Anneau
- Marion Ross - Laura Harding
- David White - Howard Judlow
- DeForest Kelley - Bob Tully
- Regis Toomey - Judge Thomas Otto
- Beverly Garland - Janette
- Don Rickles - Dave Malloy
- Ed Asner - Dave Keller
- Edward Binns - Capt. Ernest Lemoyne
- Bernard Fein - Ben Kilrea
- Eugene Iglesias - Pete Garcia
- Jack Ging - Steve Strohm
- Ed Begley - Edward Hoagley
- Ed Begley - Tully Johnson
- Leo Penn - Larry Cram
- Henry Beckman - Sgt. Kaline
- John Beradino - Al Krajac
- Michael Constantine - Herbert Lorgan
- Joanna Barnes - Carol Tredman
- Norman Alden - Fred Jackson
- Jack Hogan - Gil Grand
- Harlan Warde - Jerome Von
- Lawrence Dobkin - Dale Statesman
- Jack Kruschen - Bill Ziegler
- Sidney Blackmer - Joseph Callan
- Lloyd Bochner - William Hillier
- Kathie Browne - Connie Agnew
- Lin McCarthy - Peter Long
- Bartlett Robinson - Foster Fallon
- Alex Gerry - Oscar Perrin
- Harry Guardino - John Maychin
- Dan Seymour - Milano
- Ed Nelson - Peter Stull
- Leonard Nimoy - Ralph Tomek
- Joseph Ruskin - Hirsh (uncredited)
- Jan Shepard - Karen
- Jerry Paris - Harry White
- Milton Selzer - George Forbes
- Milton Selzer - Lou Metzger
- Henry Wills - Henny
- Dabbs Greer - Willie Beal
- John Bryant - Ronnie
- Frank Maxwell - Walter Trenson
- Charles Aidman - Mike Ballantine
- Larry Gates - Zales Yoder
- Alexander Scourby - Judge Philip Hallson
- Robert Karnes - John Hurlie
- Robert Osterloh - Capt. Frank Leslie
- Vaughn Taylor - Harry Marstow
- Evans Evans - Lynne Roberts
- Gerald Hiken - Vic Fell
- Carol Eve Rossen - Stella Caulfield
- Paul Lambert - Al Coston
- Noah Keen - Sidney Shallet
- Noah Keen - John Bernard
- Dee J. Thompson - Maggie Sommers
- Norman Fell - Frank Driscoll
- Bruce Dern - Joe Krajac
- Bruce Dern - Eddie Light
- Al Ruscio - Vic
- Robert Culp - Hank Shannon
- Robert Culp - Kurt Yoder
- Harry Dean Stanton - Hood
- Ted Knight - Joe Bowen
- Ted Knight - Detective
- Berkeley Harris - John Lincoln
- Harold J. Stone - Dave Braddock
- Alan Dexter - Arthur Williams
- Paul Monash
Ricardo Montalban hace el papel de Vincent Pavanne.
Robert Duvall hace el papel de Tom Nugent.
Larry Gates hace el papel de Zales Yoder.
Vaughn Taylor hace el papel de Harry Marstow.
John Marley interpreta a Lt. Gene Marcus en la serie.
Philip Ober interpreta a Herman Hausner en la serie.
Robert Ellenstein interpreta a James Condon en la serie.
Edward Binns interpreta a Capt. Ernest Lemoyne en la serie.
Charles Bronson interpreta a Hank Conrad en la serie.
Martin Balsam interpreta a Jack Garsell en la serie.
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