- Bobby Cannavale - Uncle Tommy
- Steve Buscemi - Father Mac
- Brad Garrett - Roy
- Jon Stewart - Jon Stewart
- Charlie Day - Glen Rossi
- Al Gore - Al Gore
- Philip Ettinger - Evan
- Chase Sui Wonders - Nikki
- Ray Romano - Ray Romano
- John Mulaney - John Mulaney
- Simon Rex - Crispy
- Kenan Thompson - Referee
- Sunita Mani - Monica
- Oona Roche - Casey
- Charlamagne Tha God - Priest
- Sebastian Stan - Sebastian Stan
- Teresa Avia Lim - Cathy
- Lynne Koplitz - Donna
- Derek Gaines - Derek
- Arielle Raycene - Skipper
- Annie Pisapia - Waitress (uncredited)
- Jane Curtin - Marie
- Marissa Jaret Winokur - Lori
- Nadia Dajani - Barbara
- Preston Brodrick - Young Pete
- Joshua Bitton - Scott Davidson
- Bob Roseman - Brian
- Danielle Dallacco - Mary
- Neko White - Wedding DJ
- Dave Sirus - Dave
- Barry Anderson - Rusty
- Abigail Donaghy - Luna
- Lenique Vincent - Iz
- Ralph Cashen - Hank
- Shane Gillis - Gilly
- NaTonia Monét - Kamilah
- Gabriel 'G-Rod' Rodriguez - Scary Man
- Chris O'Donnell - Pete's Agent (uncredited)
- Method Man - Carnival Worker
- Delaney Quinn - Anna
- Carly Aquilino - Carly
- Latrisha Talley - Judine
- Dave Attell - Park Guest
- Adam Cantor - Real Carnival Worker
- Rob O'Malley - Devon Leech
- Joan Almedilla - Customs Agent
- La La Anthony - Lisa
- Ryan O'Connor - Ryan
- Lindsay Burdge - Lizzie
- J.J. Abrams - J.J. Abrams
- Kevin Corrigan - Saloon Keeper
- Nathan Fillion - Ace Spade
- John Pollono - Michael
- Machine Gun Kelly - Colson
- Paul Walter Hauser - Hauser
- Jordan Rock - Jordan
- Ricky Velez - Ricky
- Paul Virzi - Donnie
- Joey Gay - Joey
- Big Wet - Nelson
- Giulio Gallarotti - Giulio
- Cam'ron - Cam'ron
- Andy Milonakis - Andy Milonakis
- Jadakiss - Jadakiss
- David Howard Thornton - Art the Clown
- Eli Manning - Eli Manning
- Judah Miller
- Dave Sirus
- Jason Orley
- Lorne Michaels
- Erin David
- Andrew Singer
Brad Garrett hace el papel de Roy.
Steve Buscemi interpreta a Father Mac en la serie.
Pete Davidson interpreta a Pete Davidson en la serie.
Edie Falco interpreta a Amy Davidson en la serie.
Joe Pesci hace el papel de Joe Larocca.
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