- Adam Rodriguez - Hector Villanueva
- Dylan Walsh - Jimmy Doyle
- Anthony Lee - Reverend Basil Matheson
- Douglas Spain - Carlos
- Jeremy Ratchford - Robert Stanley
- Robert David Hall - John Keough
- Kerry O'Malley - Sherry
- Channon Roe - Remy
- Erika Eleniak - Officer Christine Bannon
- Ron Roggé - Cop #1
- Theodore Bikel - Solomon Shuyler
- David Packer - Lanny Zeiter
- Jeff Coopwood - Second Bystander
- Tony Plana - Lt. Casisas
- Melora Walters - Carly
- Christopher Darga - Morty
- Richard Riehle - Donald Jarman
- Bryan Cranston - IAB Lt. Gordon Denton
- David Reivers - Cedric Mason
- Persia White - Cinnamon
- Joseph Whipp - B.C. Commander Stampp
- Michael Fairman - Dr. Vanderluke
- Manny Perez - Estefan
- Julie Caitlin Brown - Attorney Bonnie Tovavick
- Brigid Brannagh - Emmeline 'Emily' Flannagan
- Yvette Nipar - Undercover Officer
- George Wyner - John Hertzfeld
- Richard Gilliland - Neil Jessop
- Joel Stoffer - Chuck
- Barry Shabaka Henley - Mr. Anders
- John Bolger - Officer Tom Pittorino
- Kathryn Joosten - Mrs. Mariah Westbrook
- Tia Texada - Sylvia
- Cameron Dye - Bobby Quinn
- Michael D. Roberts - Lieutenant Dandridge
- Iqbal Theba - Omar Rashmid
- Jana Marie Hupp - Yvonne Lowery
- Tara Karsian - Violet Squalante
- Michael Raynor - Johnny Rodriguez
- Wanda De Jesus - Detective Marina McConnell
- Frank Medrano - Sal
- Carrie Hamilton - Gerrie Fallon-Scranton
- Danny Trejo - Louis - Hertz's Bodyguard
- Yasiin Bey - Darius
- Maurice Chasse - Stuart Saulsberry
- Mark Rolston - Detective Lou Conroy
- Lisa Boyle - 1st Female
- Joseph Ruskin - Chaim Rosenthal
- John F. O'Donohue - Detective Ed Murphy
- Cynthia Martells - Mavis Hopkins
- Jack Knight - Deputy Commissioner
- Kurt Fuller - Gerald Nader
- Scott Jaeck - FBI Boss
- John Cothran - Wendell Ford
- Louis Giambalvo - Sergeant Paul Cerutti
- Lizette Carrión - Luce
- A.J. Langer - Kathleen Doyle
- Michael Paul Chan - Detective Keith Chan
- John Finn - Officer Ray MacElwaine
- Kirk B.R. Woller - Russian Fence
- Flex Alexander - Buster
- Richard Schiff - Chris McIntrick
- Jennifer Hetrick - Miss Wilcox
- Pasha D. Lychnikoff - Dimitri Gort
- James Morrison - Paul Ingelmann
- Jack Blessing - Officer Anthony Fiano
- Stephen Lee - Leonard Gabrinitez
- Don Stark - George Hauer
- Paul Ben-Victor - Steve Richards
- Miriam Flynn - Dee / Alison Williams
- Karl Makinen - Tommy Lang
- Raymond O'Keefe - Detective Kasis
- Skipp Sudduth - Officer Stan Pritchard
- Jack McGee - Kevin O'Donnell
- Christopher Meloni - Joe
- Joseph Fuqua - Doug Eiler
- James Wellington - Chuck
- Richard McGonagle - William 'Woody' McKenzie
- Milo Ventimiglia - Johnny Mancuso
- LeAnna Croom - Penny O'Rourke
- Scott Burkholder - Neal Merton
- James Pickens Jr. - Detective Reggie Simpson
- Jack Conley - FBI Agent Mike Francis
- Anita Finlay - Therapist
- Michael Laskin - Heagan's Lawyer
- Harvey Silver - Maurice
- Joel Brooks - Aaron Geller
- Jessica Alba - Melissa Hauer
- Danielle Harris - Willow Mortner
- Del Zamora - Jesus
- Mo Gallini - Third Killer
- Michael Yama - Mr. Hayashi
- Jason Ross-Azikiwe - Trevor
- Robert Madrid - Cop
- Michael Bowen - Detective Paul Taglia
- Jeremy Roberts - Paul Scranton
- Steven Flynn - Patrick Westbrook
- Ramón Franco - Ronnie
- Geoffrey Rivas - Detective Louis Rodriguez
- Cyrus Farmer - Dashawn Hopkins
- Leonard Lightfoot - Det. Gavin Cox
- Patricia Belcher - Regina Hopkins
- Patricia Healy - Flavia Gravenites
- Elisa Gabrielli - Female Clown
- Ethel Ayler - Mabel Oakley
- George Buck Flower - Manus Bleeker
- Dylan Haggerty - Honeydew
- Christopher Stanley - Officer Matt Heagan
- John Michael Bolger - Officer Tom Pittorino
- Ralph Monaco - Nick
- Dennis Creaghan - Inspector Al Friedrich
- Joe Sabatino - Eddie
- Dwight Ewell - Bystander
- Mike Genovese - Charlie Rico
- Elena Maddalo - Elena
- Stephen Rappaport - Bobby Rubio
- Jordan Marder - Butchie
- Neal Matarazzo - Detective Hayes
- Angel Aviles - Ty
- Edward Blanchard - Brian
- Ryan Cutrona - Detective Bill Larkin
- Karla Tamburrelli - Vicky Santoro
- James MacDonald - Officer Marshal Bovier
- Levan Uchaneishvili - Boris Liepaja
- Ilia Volok - Landlord
- Adam Lieberman - Officer Murphy
- Marshall Manesh - Tenant
- Larry Brandenburg - Lt. Peter Fiorello
- Bob Koherr - Lloyd Rogers
- Rick Batalla - Esteban Cuerto
- Mariangela Pino - Deputy Commissioner Julliane Brooks
- Scott Allan Campbell - IAB Sgt. Jerry Martens
- Jerry O'Donnell - Nick Glenn
- Rene Rivera - Bud
- Carole Goldman - Antique Dealer
- Alex Wexo - ESU Cop
- Dewey Weber - Lonnie Sharpe
- Georgann Johnson - Ruth Williams
- McNally Sagal - Deputy District Attorney Zarloski
- Badja Djola - Clude Miller
- Michael Bofshever - Dr. Paul Sinsky
- Beau Starr - Lou Wolzak
- Ivelka Reyes - Ignas Hagainoz
- Karina Arroyave - Lola
- Leland Orser - ER Intern
- David Warshofsky - Barman
- Lillian Hurst - Aunt
- Harley Zumbrum - Choppy
- Mark Kiely - Officer Kevin Patrick
- Nada Despotovich - Jenny
- Larry Jenkins - Polo
- Star Jasper - Noreen Patrick
- Greg Wrangler - Tom Dillon
- Rainoldo Gooding - Skel #1
- Jessy Terrero - Skel #2
- Eugene Williams - Skel #3
- Peter Anthony Rocca - First Paramedic
- James Hanlon - Officer Mike Cavanaugh
- Jody Wood - Cop #1
- Alex Demir - Cop #2
- Ray Garvey - Cop #3
- Walt MacPherson - Joe Stivik
- Carlease Burke - Civilian Aide
- James Quattrochi - Paramedic #2
- Chris McGinn - Bystander
- Bill Clark - Captain Paul Clark
- Bradford English - Captain Lou Zerola
- Bill Morey - Mr. Stutt
- Rickey D'Shon Collins - Darnell Withers
- Adina Porter - Angela Withers
- Michael David Lally - Priest
- Dwayne L. Barnes - Kenny Nevins
- Josh Cruze - Eduard Vasquez
- Lennie Loftin - Dale
- Alpheus Merchant - Wilson
- Rai Tasco - First Bystander
- James Lorinz - Donald Westbrook
- Richard Cummings Jr. - Lloyd Pauling
- John Prosky - Mr. Bloomford
- June Christopher - P.A.A.
- Peter Birkenhead - A.D.A.
- Mik Scriba - Sgt. Al Hurley
- Andrew Walker - Det. Greco
- David Paul Needles - First Hasid
- William G. Schilling - Officer Gus Steiger
- David Kriegel - Assistant District Attorney
- Jack Shearer - Howard Beigel
- James Parks - Kevin O'Donnell
- George Gerdes - Defense Attorney Calloway
- David Selburg - Assistant District Attorney McGinty
- Andrew Sikking - Roll Call Officer
- Andrew Sikking - Lowery's Partner
- Andrew Sikking - Uniform Cop
- Andrew Sikking - Uniform Officer
- Richard Penn - Detective Larry Faderick
- Kevin Quigley - Civilian
- Elliot Goldwag - Judge Brennan
- Richard Whiten - Court Officer
- Arminae Austen - Det. Eldridge
- Vincent Guastaferro - Henry Mancuso
- Ray McKinnon - Gilbert Van Eggidy
- Ashley Gardner - Bonnie Van Eggidy
- Vinny Argiro - Dominic Varone
- Jose Soto - Danny Soto
- Glenn Taranto - Officer Gene Kantorski
- Glenn Taranto - Uniform #1
- Rosie Taravella - Nucci Mancuso
- Robby Robinson - Melvin Weeks
- Joe Flood - CSU Cop
- Jascha Washington - Theron Weeks
- Bill Bolender - Paddy Flannagan
- Karmin Murcelo - Cora Paraso
- Joanna Sanchez - Adela Palmiero
- Al D'Andrea - Lt. Wilkins
- Adrienne Wilde - Nurse #1
- Gerry Vichi - Witness
- Jimmy Ortega - First Killer
- Linda Klein - Nurse #2
- Guy Garner - Doctor #2
- Conor O'Farrell - Det. Stuart Morrissey
- Michael Ray Miller - Detective
- Michael Ray Miller - Det. Bullock
- Kristopher Logan - Danny Meehan
- Bill Ferrell - Cop #2
- Garrett M. Brown - Detective
- Henry DiGiovanni - Delivery Decoy
- Richard Minchenberg - Alvin Stern
- Jimmy Taenaka - First Hoodlum
- Adilah Barnes - Bettina Gladwin
- Lindsey Ginter - Det. Tim DiWalla
- Jason Blicker - Assistant District Attorney Allen Venable
- Steve Larson - Eddie
- Dean Rader Duval - Ben Chetwynd
- Howard Mungo - Art Gladky
- Beth Payne - Shannon
- Carlos Alvarado - Ortega
- Wayne Collins - Shannon
- Javier Grajeda - Officer Casillas
- Sandra Teres - Crying Mother
- Ralph P. Martin - The Bookie
- Brian George - Joe Sarkasian
- Gareth Williams - Officer Greg Tollins
- Courtney Gains - Joe Beldon
- Jose Yenque - Tomas
- Viola Kates Stimpson - Mrs. Carlyle
- Gabriel González - Ernesto
- Sonny Marinelli - Jenkins
- David Kirkwood - Jamison
- Sarah Trigger - Lorraine Matarazzo
- Barry Kivel - Barry Neely
- Rachel Davies - Widow Fuller
- Patricia Bethune - Waitress
- Steven Bochco
- Marc Buckland
- Doug Palau
- William M. Finkelstein
- David Milch
Adam Rodriguez interpreta a Off. Hector Villanueva en la serie.
Yancy Butler interpreta a Anne-Marie Kersey en la serie.
Capítulo disponible en las siguientes plataformas:
