- Kira Guloien - Hanna Peters
- André De Shields - Harold
- Gray Powell - Dr. Noah Wolf
- Simon Webster - Young Oliver
- Daniel Kash - Dr. Cohen
- Lanette Ware - Mrs. Chase
- Donna Murphy - Dr. Muriel Landon
- Tom Hulshof - Gus Peters
- David Kohlsmith - Ellis Peters
- Getenesh Berhe - The Bride
- Adrian Griffin - Mr. Chase
- Martha Girvin - Staff Nurse
- Will Corno - Doctor
- Andriah Bryan - Neuro Nurse
- Amy Stewart - Child Protective Agent
- Sarah Brooks - Nurse Manager
- Nedra Marie Taylor - Jessie Williams
- Jaden Waldman - Young Oliver Wolf
- Alex Ozerov-Meyer - John Doe
- David Klein - Pete
- Nabeel El Khafif - Mr. Felder
- Richard Walters - Jessie's Brother
- Nck Name - Anesthesiologist
- Adesola Adesina - Teammate #1
- Eamon Stocks - Pete's Roommate
- Steve Howey - Wyatt James
- Rainbow Sun Francks - Morris Allen
- Markeda McKay - Emily
- Nadine Whiteman - Emily's Mom
- Alex Spencer - Emily's Dad
- Kate Corbett - Rosie
- John Thomas Gauthier - Billy
- Robert Ifedi - Biker
- Dorrett White - Nurse Carter
- Jack Giffin - Screaming Patient
- Samantha Hanratty - Bridget
- Nisa Gunduz - Nurse Portia Flores
- Elias Edraki - Charlie
- Joshua Peace - Officer Stanley
- Kiki Hammill - Maya
- Jamie Robinson - Hospital Security
- Patricia C. Wright-Domingue - Elderly Woman
- Nadine Hyatt - Cop
- Elena Ouspenskaia - Mrs. Petrov
- Joshua Echebiri - Steve Hill
- Theo Vandergraaf - Aiden (Ghost)
- Sabryn Rock - Anna Hill
- Nicki Burke - Dr. Jordana Moore
- Stacy Smith - Mrs. Miller
- Tim Campbell - Mr. Miller
- Philip Yang - Head General
- Stephanie Moran - Beautiful Woman
- Shanna Armogan - Beautiful Woman 2
- Oliver Sacks
- Henrik Bastin
- DeMane Davis
- Andy Serkis
- Michael Grassi
- Will Tennant
- Greg Berlanti
Zachary Quinto interpreta a Dr. Oliver Wolf en la serie.
Teddy Sears interpreta a Dr. Josh Nichols en la serie.
Tamberla Perry hace el papel de Dr. Carol Pierce.
Alex MacNicoll interpreta a Dr. Van Markus en la serie.
Spence Moore II interpreta a Dr. Jacob Nash en la serie.
Aury Krebs interpreta a Dr. Dana Dang en la serie.
Ashleigh LaThrop interpreta a Dr. Ericka Kinney en la serie.
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