- Rick Gomez - Detective Daniel Ramos
- Chase Ellison - Willie Stevens
- Rino Romano - Paul Turcotte in 1976
- J.C. Brandy - Chandler
- Wendy Schaal - Darlene Beechem
- Derek Hamilton - Jimmy Black
- Alia Shawkat - Denise Stein
- LeVar Burton - Marvin Lloyd
- John Kapelos - Hugo Pinkston
- Kathleen Wilhoite - Sally McBride
- Daniel Zacapa - Carlos Ramirez
- Stacy Keach - Jack 'Mac' McNorris
- Nathan West - Zack Berman
- Bob Clendenin - Doofus
- Virginia Madsen - Erika Ashland
- Cody Kasch - Trevor 'T.J.' Jankowski Jr.
- Shannon Sturges - Cherie Hechler
- Chris Gartin - Jonny Rand
- Peter Trencher - Coroner
- Kelly Hu - Rachel Durrel
- Matt Craven - Dr. Michael Hirsch
- Beau Billingslea - Police Academy Commandant
- Tyler Christopher - Holden McKay
- Alimi Ballard - Young Marvin Lloyd
- Jennifer Sky - Vanessa Griggs / Laura
- Sheeri Rappaport - Janice Edwards
- Arlen Escarpeta - Cantrel LaFontaine
- Alexander Gould - Tom at 8
- Christian Camargo - Bradley Dawson
- Kate Flannery - Tracey
- Larry Joshua - Chet
- Miguel A. Núñez Jr. - Freaktown
- Raja Fenske - Puppet
- Rick Ravanello - Sean Dornan
- Trent Cameron - Bernie Leonard
- Howard Hesseman - Mel Castle
- Kevin Dunn - Ron Berman
- Erin Daniels - Officer Karen Crane
- Kim Murphy - Susan
- Stephen Macht - John Donadoni
- Megan Henning - Emily
- Wade Williams - Paul Barnes
- Joe Penny - Les Van Buren
- Kelly Rowan - Marian McNorris
- Ken Davitian - Jewelry Store Owner
- Alex Meneses - Vicki Pineda
- Tracey Walter - Dwayne
- Michael Muhney - Chris Griggs
- Katee Sackhoff - Holly
- Ernie Grunwald - Charlie Graham
- Jessica Lundy - Vivian Colson
- Mimi Paley - Rachel Stein
- Robert Wisdom - Chronic (Daryl C. Norcott)
- Fran Bennett - Beatrice Rahming
- Mark Moses - Don Schneider
- Megan Ward - Kelly Stevens
- Marquise Wilson - Friend #3
- Gina Hecht - Doreen Stein
- Michael Paul Chan - Lobo Chan
- Dan Byrd - Eddie Colson
- Ramón Franco - Luis Valdoriso
- Rebecca Lowman - Lisa
- Dayo Ade - Banger
- Tommy Hinkley - Mr. Flannery
- Jason George - Thomas Paltrow
- Doug Hutchison - Wally Pollard
- Christopher Gorham - Gordon Sinclair
- Robert LaSardo - Pope
- Nigel Gibbs - Alex Leonard
- Ali Hillis - Melanie Stone
- Loren Lester - Homeowner
- Paige Hurd - Grace Adams
- Vanessa Williams - Detective Katherine Pierce
- Fredric Lehne - Reggie Flood
- April Grace - Cynthia
- Silas Weir Mitchell - Erik Sorenson
- Kirk Trutner - Homeless Man
- David Proval - Paul Turcotte
- Dempsey Pappion - Young Greg Haymer
- Dorian Harewood - Captain Ronald Hicks
- Lombardo Boyar - Eddie
- Kristin Bauer - Prostitute
- Joe Spano - Henry Stein
- Paul Moyer - Paul Moyer
- Neil Patrick Harris - Peter Corman
- David Dunard - Irate Grandfather
- Frank John Hughes - Officer Vincent Manzani
- Patricia Wettig - Nora Jean Flannery
- Beth Grant - Landlady
- Gregg Henry - Robert Colson
- Garikayi Mutambirwa - Friend #2
- Michael Dempsey - Recovering drunk
- Bobby Hosea - Greg Haymer
- Anthony Montgomery - Recruit Dwight Baker
- Richard Erdman - Kevin's Dad
- Christoph Krisea - Warden Frank Collins
- David Burke - Jay Colson
- Chris Mulkey - Kevin Van Horn
- Cullen Douglas - Arnold Rabjohn
- Ray Laska - Edward Nelson
- Mark Totty - Chip Pollard
- Henry G. Sanders - Police Sergeant Miller
- Annika Peterson - Katrina
- Brian Sites - Taylor Gates
- Salvator Xuereb - John McBride
- Ryan Stockstad - Paramedic (uncredited)
- Kim Rhodes - Julia Sloane
- Gregory White - Judge Harold Denby
- Javier Grillo-Marxuach
- Jon Avnet
- Fred Golan
- Stephen Sassen
- Graham Yost
- Philip Giffin
Alexander Gould hace el papel de Tom at 8.
Stacy Keach hace el papel de Jack 'Mac' McNorris.
LeVar Burton interpreta a Marvin Lloyd en la serie.
Gregg Henry interpreta a Robert Colson en la serie.
Tracey Walter hace el papel de Dwayne.
David Proval hace el papel de Paul Turcotte.
Donnie Wahlberg hace el papel de Detective Joel Stevens.
Neal McDonough hace el papel de Assistant District Attorney David McNorris.
Mykelti Williamson interpreta a Police Department Detective II Bobby 'Fearless' Smith en la serie.
Gary Basaraba interpreta a Police Department Police Officer III Ray Hechler en la serie.
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