- Rick Gomez - Detective Daniel Ramos
- Chase Ellison - Willie Stevens
- Rino Romano - Paul Turcotte in 1976
- J.C. Brandy - Chandler
- Wendy Schaal - Darlene Beechem
- Derek Hamilton - Jimmy Black
- Alia Shawkat - Denise Stein
- LeVar Burton - Marvin Lloyd
- John Kapelos - Hugo Pinkston
- Kathleen Wilhoite - Sally McBride
- Daniel Zacapa - Carlos Ramirez
- Stacy Keach - Jack 'Mac' McNorris
- Nathan West - Zack Berman
- Bob Clendenin - Doofus
- Virginia Madsen - Erika Ashland
- Cody Kasch - Trevor 'T.J.' Jankowski Jr.
- Shannon Sturges - Cherie Hechler
- Chris Gartin - Jonny Rand
- Peter Trencher - Coroner
- Kelly Hu - Rachel Durrel
- Matt Craven - Dr. Michael Hirsch
- Beau Billingslea - Police Academy Commandant
- Tyler Christopher - Holden McKay
- Alimi Ballard - Young Marvin Lloyd
- Jennifer Sky - Vanessa Griggs / Laura
- Sheeri Rappaport - Janice Edwards
- Arlen Escarpeta - Cantrel LaFontaine
- Alexander Gould - Tom at 8
- Christian Camargo - Bradley Dawson
- Kate Flannery - Tracey
- Larry Joshua - Chet
- Miguel A. Núñez Jr. - Freaktown
- Raja Fenske - Puppet
- Rick Ravanello - Sean Dornan
- Trent Cameron - Bernie Leonard
- Howard Hesseman - Mel Castle
- Kevin Dunn - Ron Berman
- Erin Daniels - Officer Karen Crane
- Kim Murphy - Susan
- Stephen Macht - John Donadoni
- Megan Henning - Emily
- Wade Williams - Paul Barnes
- Joe Penny - Les Van Buren
- Kelly Rowan - Marian McNorris
- Ken Davitian - Jewelry Store Owner
- Alex Meneses - Vicki Pineda
- Tracey Walter - Dwayne
- Michael Muhney - Chris Griggs
- Katee Sackhoff - Holly
- Ernie Grunwald - Charlie Graham
- Jessica Lundy - Vivian Colson
- Mimi Paley - Rachel Stein
- Robert Wisdom - Chronic (Daryl C. Norcott)
- Fran Bennett - Beatrice Rahming
- Mark Moses - Don Schneider
- Megan Ward - Kelly Stevens
- Marquise Wilson - Friend #3
- Gina Hecht - Doreen Stein
- Michael Paul Chan - Lobo Chan
- Dan Byrd - Eddie Colson
- Ramón Franco - Luis Valdoriso
- Rebecca Lowman - Lisa
- Dayo Ade - Banger
- Tommy Hinkley - Mr. Flannery
- Jason George - Thomas Paltrow
- Doug Hutchison - Wally Pollard
- Christopher Gorham - Gordon Sinclair
- Robert LaSardo - Pope
- Nigel Gibbs - Alex Leonard
- Ali Hillis - Melanie Stone
- Loren Lester - Homeowner
- Paige Hurd - Grace Adams
- Vanessa Williams - Detective Katherine Pierce
- Fredric Lehne - Reggie Flood
- April Grace - Cynthia
- Silas Weir Mitchell - Erik Sorenson
- Kirk Trutner - Homeless Man
- David Proval - Paul Turcotte
- Dempsey Pappion - Young Greg Haymer
- Dorian Harewood - Captain Ronald Hicks
- Lombardo Boyar - Eddie
- Kristin Bauer - Prostitute
- Joe Spano - Henry Stein
- Paul Moyer - Paul Moyer
- Neil Patrick Harris - Peter Corman
- David Dunard - Irate Grandfather
- Frank John Hughes - Officer Vincent Manzani
- Patricia Wettig - Nora Jean Flannery
- Beth Grant - Landlady
- Gregg Henry - Robert Colson
- Garikayi Mutambirwa - Friend #2
- Michael Dempsey - Recovering drunk
- Bobby Hosea - Greg Haymer
- Anthony Montgomery - Recruit Dwight Baker
- Richard Erdman - Kevin's Dad
- Christoph Krisea - Warden Frank Collins
- David Burke - Jay Colson
- Chris Mulkey - Kevin Van Horn
- Cullen Douglas - Arnold Rabjohn
- Ray Laska - Edward Nelson
- Mark Totty - Chip Pollard
- Henry G. Sanders - Police Sergeant Miller
- Annika Peterson - Katrina
- Brian Sites - Taylor Gates
- Salvator Xuereb - John McBride
- Ryan Stockstad - Paramedic (uncredited)
- Kim Rhodes - Julia Sloane
- Gregory White - Judge Harold Denby
- Javier Grillo-Marxuach
- Jon Avnet
- Fred Golan
- Stephen Sassen
- Graham Yost
- Philip Giffin
Alexander Gould interpreta a Tom at 8 en la serie.
Stacy Keach interpreta a Jack 'Mac' McNorris en la serie.
LeVar Burton interpreta a Marvin Lloyd en la serie.
Gregg Henry interpreta a Robert Colson en la serie.
Tracey Walter interpreta a Dwayne en la serie.
David Proval interpreta a Paul Turcotte en la serie.
Donnie Wahlberg interpreta a Detective Joel Stevens en la serie.
Neal McDonough hace el papel de Assistant District Attorney David McNorris.
Mykelti Williamson interpreta a Police Department Detective II Bobby 'Fearless' Smith en la serie.
Gary Basaraba hace el papel de Police Department Police Officer III Ray Hechler.
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