- Pat Morita - Master Udon
- Dimebag Darrell - Musical guest
- Phil Anselmo - Musical guest
- Vinnie Paul Abbott - Musical guest
- Rex Brown - Musical guest
- Dee Bradley Baker - Squilliam Fancyson (voice)
- John Rhys-Davies - Man Ray (voice)
- Ricky Gervais - Narrator
- Ernest Borgnine - Mermaid Man (voice)
- Tim Conway - Barnacle Boy (voice)
- Bob Joles - Man Ray (voice)
- Mike Bell - Santa Claus
- John Goodman - Santa Claus (voice)
- Lewis Black - Santa Claus (voice)
- Amy Poehler - Grandma (voice)
- Christopher Guest - Stanley S. Squarepants (voice)
- Johnny Depp - Jack Kahuna Laguna (voice)
- Michael McKean - Captain Frostymug (voice)
- Adam West - Mermaid Man (voice)
- Burt Ward - Barnacle Boy (voice)
- Brian Doyle-Murray - Flying Dutchman (voice)
- Brian Doyle-Murray - Flying Duchman (voice)
- Brian Doyle-Murray - Flying Dutchman / Dutchbomb / Atomic Dutchman (voice)
- John O'Hurley - King Neptune (voice)
- Victoria Beckham - Queen Amphitrite (voice)
- Sebastian Bach - Triton (voice)
- Sirena Irwin - Margaret SquarePants (voice)
- Sara Paxton - The Witch, Mummy (voice)
- Camryn Walling - Kid/Boy Fish (voice)
- Camryn Walling - Kid, Pumpkin (voice)
- Johnny Knoxville - Johnny Krill (voice)
- Mark Fite - Not Dead Fred (voice)
- Charles Nelson Reilly - The Dirty Bubble (voice)
- Jim Jarmusch - Special Guest Appearance
- John Lurie - Special Guest Appearance
- Marion Ross - Grandma SquarePants (voice)
- Max Schreck - Nosferatu (archive footage)
- Alexander Ward - Nosferatu
- Alton Brown - Nicholas Withers (voice)
- Andy Samberg - Colonel Carper
- Laraine Newman - Granny Plankton / Nurse (voice)
- Laraine Newman - Granny Plankton (voice)
- Laraine Newman - Additional Voices (voice)
- Aubrey Plaza - Nocturna (voice)
- C.H. Greenblatt - Carl (voice)
- Sherm Cohen
- Kent Osborne
- Steve Fonti
- Alex Gordon
- Tom King
- Jim Schumann
- Kyle McCulloch
- Mr. Lawrence
- Merriwether Williams
- Mike Bell
- David Fain
- Solomon Georgio
- Jennie Monica
- Andy Rheingold
- Larry Le Francis
- Dina Buteyn
- Stephen Hillenburg
- Aaron Freeman
- Cee Lo Green
- Dimebag Darrell
- Michael Melchiondo Jr.
Mr. Lawrence interpreta a Plankton / Larry the Lobster (voice) en la serie.
Johnny Depp hace el papel de Jack Kahuna Laguna (voice).
Mike Bell interpreta a Santa Claus en la serie.
John Rhys-Davies interpreta a Man Ray (voice) en la serie.
John Goodman hace el papel de Santa Claus (voice).
Brian Doyle-Murray interpreta a Flying Dutchman (voice) en la serie.
Tom Kenny interpreta a SpongeBob SquarePants (voice) en la serie.
Bill Fagerbakke hace el papel de Patrick Star (voice).
Rodger Bumpass interpreta a Squidward (voice) en la serie.
Clancy Brown hace el papel de Mr. Krabs (voice).
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