- Kelly Hu - Detective Veronica Jin
- Jerel Xavier Alston - Kevin Bryant
- La La Anthony - Markisha Taylor
- La La Anthony - Markaisha Taylor
- Kylee D. Allen - Zoe
- Rayan Lawrence - K-9
- Rodney Rowland - ER Doctor
- Marc Collins - Kwame's Buddy
- Cocoa Brown - Deborah Griffin
- Ticarus Bunch - Older Roland
- Christian Gabriel Anderson - Kwame
- Markice Moore - Filmel
- Bolton Marsh - Captain Ward
- Steven G. Turner - Broad Shoulder Man
- Brii Renee' - Poundcake
- Nasir Rahim - Factory Worker
- James Logan - Security Guard
- Johnnie Gordon - Young Meech
- Antwan Mills - Rock
- Ammar Nemo - Sam
- Tristin Fazekas - Detective Wallace
- Michael Ellison - Maître D'
- Patrice Fisher - Edna
- Kennedy Chanel - Simone
- Jaylon Gordon - Young Terry
- Wood Harris - Pat
- Laila Pruitt - Nicole
- Laila Pruitt - Nicole Flenory
- Dana Abercrombie - Jada
- Angelo Reyes - Leander
- Lee Osorio - Male Lawyer
- Darryl L. Dillard - Neighbor
- Jermel Howard - Que
- Myles Bullock - Slick
- Raymond Seay - Darius
- Stacy Hall - Sweep
- Josh Covitt - Mr. Tolbert
- Yani Simone - Anita
- Nijah Brenea - Lookie Loo #1
- Dorothy Sanders - Lookie Loo #2
- Kai Malik - High Roller
- Kash Doll - Monique
- Sean Michael Gloria - Detective Jonathan Lopez
- Christian Robinson - Tiny
- Jemal McNeil - David 'Three-D' Dublin
- Jemal McNeil - David 'Three D' Dublin
- Snoop Dogg - Pastor Swift
- Eminem - White Boy Rick
- Stormy Merriwether - Zoe
- Angela Davis - Melissa Grills
- Thom Scott II - Surgeon
- Rafael Castillo - Nedo
- Jon Chaffin - Older Meech (uncredited)
- Jon Chaffin - Older Meech
- Peyton Alex Smith - Boom
- Walnette Marie Santiago - Big L
- Serayah - Lori
- D.C. Young Fly - Saint
- Dawn Halfkenny - Tracy
- Michael H. Cole - Mr. Ryan
- Sydney Mitchell - LaWanda
- Donnell Rawlings - Alvin
- Tyshon Freeman - Hoop
- Lil' Zane - Sockie
- Jasun Jabbar Wardlaw Jr. - Dink
- Felisha Terrell - Commander Mars
- Felisha Terrell - Commander Marceline "Mars" Beckwith
- Shondalia White - Karen
- Jay Amir - Curly
- Edwin Walker - Duke / Crew Member
- Vincent van Hinte - Drano Detective
- Kendrick Smith - Craps Player
- Leslie Jones - SAC Tracy Chambers
- Mustafa Harris - Older Terry
- Christine Horn - Mabel
- Lauren Halperin - Denise
- Zuri Parker - Park Goer Kid (uncredited)
- Matthew Jose Vasquez - Carlos 'Los' Huera
- Tasha Smith
- Terri Kopp
- Rose McAleese
- Tariq Simmons
- Patrick Moss
- Kirkland Morris
- Randy Huggins
- Lil Meech
- Randy Huggins
- 50 Cent
- Frank Renzulli
- Jennifer Wyatt-Beasley
Eminem interpreta a White Boy Rick en la serie.
Steve Harris interpreta a Detective Bryant en la serie.
Jerel Xavier Alston hace el papel de Kevin Bryant.
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