- Damon Gupton - Bill Henderson
- Damon Gupton - Bill Henderson (voice)
- Nina Turner - Nina Turner
- Edwina Findley - Tori
- Michael King - Bernard
- Antonio Fargas - David Poe
- Terrence 'T.C.' Carson - Eldridge
- Derick Anthony - Darius
- Gregg Henry - Martin Proctor
- Charles Green - Teddy Evans
- Cory Scott Allen - Klovic
- Phillip DeVona - Dwayne Rogers
- Joshua Mikel - Steven Conners
- Alphonso A'Qen-Aten Jackson - Slim / Lieutenant
- Kendrick Cross - Kito Payne
- Catherine Dyer - Dr. Ashton Conley
- Chelsea Hayes - Woman
- Sara Torres - Private Chef
- Nick DeKay - Driver
- Bill Murphey - Administrator
- Kayte Giralt - Tobias' Lady 2
- Tonia Jackson - Yvette
- Jared Simon - Inspector Thomas
- Joseph Roark - Sânge Warrior #1
- Matt LaBorde - Sânge Warrior #2
- Nick Stanner - Sânge Warrior #3
- Charmin Lee - Batina
- Leydi Morales - Nurse
- Toshi Toda - Hiroshi
- Robert Walker Branchaud - Sheriff Clark
- Skye P. Marshall - Kara Fowdy
- Salli Richardson-Whitfield - Rebecca Montez
- Milli M. - Reporter #2
- Derek Evans - Patrolman Roman Hicks
- Shacai O'Neal - Woman
- Amy Parrish - Doctor
- Thom Williams - Cop #1
- Reginald Robinson - Romel
- Andy Allo - Zoe B.
- Shein Mompremier - Chenoa
- Ralph Wilcox - Marsellus
- John M. Johnson - Earnest Williams
- Mark Rowe - Det. Summers
- Teresa L. Graves - Ms. Brown
- Vanessa Aranegui - Ms. Gordon
- Karina Delbeau-Charles - Laticia
- Benjamin Crump - Benjamin Crump
- Monique Yvette Grant - Issa's Mother
- Vivia E. Armstrong - Freeland Resident #3
- Reggie Currelley - Freeland Resident #4
- Henry Bazemore Jr. - ASA Official
- David Alexander - Walter Rutledge
- Charlbi Dean - Syonide
- Morgan Brown - Thomas Hidalgo
- Richard Marrero - Dwayne
- Jay Harmon III - Jonate
- Josh Henry - Man in Lab Coat
- Faron Salisbury - Detective Glennon
- Polly Craig - Senior Citizen
- Patrick Lamont Jr. - Resident #1
- Mark Hicks - ASA Agent
- Shomari Love - Lieutenant
- Benedetto Robinson - Caleb Scott
- Jonathan D. Williams - Chemist
- Joey Thurmond - Business Man
- Mike Forbs - Citizen #3
- Marion Guyot - Mrs. Johnson
- Darryl W. Handy - Citizen #1
- Rachael Thompson - Plasmacorp Clerk
- Carlos Javier Rivera - Rafa
- Lucia Scarano - Older Latina Woman
- George Lott - Big
- Roger K. Moore - Lab Tech
- Matt Mercurio - Kam Yuen
- Eric Goins - Dr. Henry Mayfield
- Parisa Johnston - Dr. Sophia Cruz
- Bayland Rippenkroeger - Burglar #1
- Jessica Fontaine - Mama
- Patrick L. Reyes - Cashier
- Mark Thompson - Randy
- Rayne Caldwell - Young Tori
- Adam Cronan - Conspiracy Theorist
- Leah Monet - Teala
- Brandon Sauve - Ben
- Anisa Nyell Johnson - Taproom Goer #2
- Anisa Nyell Johnson - Waitress
- Eric Mendenhall - Joey Toledo
- Al-Jaleel Knox - LaShawn
- Derrick LeMont - Mr. Lewis
- Estes Tarver - Leonard
- Jennifer Van Horn - Rose
- Michael Finn - Man
- Darone Okolie - Bam
- Christopher Márquez - Latin Male Reporter
- Christopher Márquez - Nick
- Alex Phipps - Block
- Jennifer A. Martin - Nurse #2
- Aaron Quick Nelson - Security Officer
- Chan Ta Rivers - Nurse #1
- Holly Firfer - Reporter
- Nakia Dillard - Terrence Long
- Nakia Dillard - Terrence
- Kyanna Simone Simpson - Kiesha
- Anthony Reynolds - Deputy Chief Cayman
- Cedric Greenway - Father
- Crystal Lee Brown - Desk Sergeant
- Crystal Lee Brown - Sergeant King
- Crystal Lee Brown - Detective
- Swift Rice - Elevator Operator
- Linda Boston - Freeland Resident
- Billy Bussey - Gunman
- Caleb T. Thomas - Malik
- Donny Carrington - Youngster #2
- Leon Lamar - Store Owner
- Hal Whiteside - Officer #1
- Hector Banos - Officer #2
- Scott Hunter - Officer #3
- Kwajalyn Brown - Wife
- RJ Cyler - Todd Green
- Rachelle Neal - Monique
- Kausar Mohammed - Nurse Patel
- Robert Townsend - Dr. Napier Frank
- Justin Randell Brooke - Rodney
- Tracey Bonner - Lawanda White
- Eric C. Lynch - Councilman Kwame Parker
- Zsané Jhé - Tiffany Williams
- Zoë Renee - Maryam Luqman
- Kiah Alexandria Clingman - Young Woman
- Tosin Morohunfola - Instant
- Tosin Morohunfola - Assassin
- Milton Saul - Wealthy Donor (uncredited)
- Stella Smith - Teenage Grace Choi
- Katy O'Brian - Major Sara Grey
- Regina Ting Chen - Chandler Tong
- Zele Avradopoulos - Lab Director
- Jasun Jabbar Wardlaw Jr. - Tavon Singley
- Jasun Jabbar Wardlaw Jr. - Tavon
- Bruce Shepperson - Creep #1
- Michael Endoso - Officer Mancini
- Nick Pulos - Behemoth
- Kelvin Hair - Lydell Jackson
- Tre Stokes - Terry Andrews
- David Vaughn - Maitre D'
- Brad Sanders - Store Owner
- Reggie Hayes - Mayor Billy Black
- Troy Faruk - Dep. Chief Wesley Robinson
- Ruan Martins - ASA Agent
- Jermaine Holt - FPD Officer
- Tim Sitarz - Shaved Head Opponent
- Kristen Torrianni - News Anchor
- Karen Ceesay - Veretta Henderson
- Karen Ceesay - Veretta
- Denisha Gillespie - Girlfriend
- Warren Snipe - Thierry
- Warren Snipe - Anaya's Father
- Jessica Nicole Brown - Shy Teenager
- Kennedi Lindsey - Twenty-Something
- Nadia Lorencz - Lieutenant
- Cal Johnson - Officer #1
- James Roch - Cousin Donald
- Sibongile Mlambo - Maya Odell
- Yootha Wong-Loi-Sing - Wo Man
- Kaja Brielle - Imani
- Jef Holbrook - Party Pic Guy
- Bruce Blackshear - Guard
- Kedrick Brown - Marcel Payton
- Morgan Alexandria - Kiki Davidson
- Paden Fallis - Marshall Bates
- DJames Jones - Michael
- Marcenae Lynette - Female Officer
- Shannon Thomas - Policeman #1
- John David Bulla - Anarchist
- Mimi Fletcher - Woman Delivery Driver
- Thom Scott II - Agent
- Robert Yatta - Funeral Director Wallace
- Yolanda T. Ross - Nichelle Payne
- Yolanda T. Ross - Khalil's Mother
- Whitney Christopher - Rose Lawson
- Jeremy Rivette - ASA Agent
- Dabier - Will
- Kaden Washington Lewis - Young Jefferson
- Kaden Washington Lewis - Teen Jefferson
- Michele Jang - ASA Technician
- Michael Wright - Lazarus Prime
- Clifton Powell - Reverend Jeremiah Holt
- Myles Truitt - Issa Williams
- Erika Alexander - Perenna
- Kearran Giovanni - Giselle Cutter
- Madison Bailey - Wendy Hernandez
- Hosea Chanchez - Marcus Bishop
- Wayne Brady - Tyson Sykes / Gravedigger
- Wayne Brady - Gravedigger
- Brooke Ence - Rebecca Jones
- Derrick Lewis - Darryl Robinson
- Esteban Cueto - Joe
- Chase Anderson - Cyclotronic
- Kristyl Dawn Tift - Betty
- Derek Russo - Guard Captain
- Derek Russo - Guard
- Nevaina Graves Rhodes - Ms. Reeks
- Renell Gibbs - Kyrie
- Renell Gibbs - Young Dad
- Cindy L. Jefferson - Freeland Resident 3
- Libby Blake - Bartender
- Michael Anthony - Stone Killer
- Kelvin Witherspoon - Rayvon
- Antwan Mills - Herbert King
- Joseph Steven Yang - Older Asian Man
- Joseph Steven Yang - Old Man
- Joan Q. Scott - Older Woman
- Anthony Belevtsov - Markovian Soldier 1
- Pavel Kozlov - Markovian Soldier 2
- Neal Kodinsky - Markovian Soldier 3
- P.J. Byrne - Principal Mike Lowry
- Mac Wells - Sinzell Johnson
- Joshua Lamboy - Officer 2
- Gordon Danniels - Richard
- Dani Deetté - ASA Commando
- Matt McVay - Commando Bill
- Tyler Buckingham - Commando Ted
- Bethann Hardison - Dr. Bowlan
- Bethann Hardison - Dr. Bowlan (voice)
- Melissa Kunnap - Dying Female Meta
- Taylor Polidore - Lisa
- Glenn Magee - Mr. Singley
- Bonita Brisker - Mrs. Singley
- Tommy Kane - John Webb
- Tommy Kane - Reporter
- Christian Brunetti - ASA Captain
- Tony J. Scott - Amos Tucker (uncredited)
- Justin Livingston - Cloaked Gambi
- Edward Michael Scott - Harvey
- Charles Black - Elderly Man
- Andrea Frye - Mary Louise Shepard
- Darrell Snedeger - Officer
- Orelon Sidney - Female Anchor
- Vanessa Cater - ASA Guard
- Garrett Hines - Specialist Travis
- Diego Ward - ASA Commando 1
- Birgundi Baker - Anaya
- Thomas Belgrey - Colonel Yuri Mosin
- Bolton Marsh - American Doctor
- Martin Harris - Markovian Doctor
- Jill Scott - Lady Eve
- Jason Louder - Frank '2-Bits' Tanner
- Bill Duke - Agent Percy Odell
- Jennifer Riker - Dr. Helga Jace
- Gabriella Garcia - Erica Moran
- Boone Platt - Sergeant Gardner Grayle
- Adetinpo Thomas - Jamillah Olsen
- Brandon Hirsch - Dr. Matthew Blair
- Brianna Butler - Charlotte
- Tony Isabella - Judge Isabella
- Trevor Von Eeden - Judge von Eeden
- Vernika Rowe - Auntie Gina
- Rafael Castillo - Devonte Jones
- Jennifer Christa Palmer - Representative Nagar
- Christopher Ammanuel - TC
- Christopher Ammanuel - Baron / TC
- Christopher Ammanuel - Baron
- Christopher Ammanuel - TC (voice)
- T. Ryan Mooney - Markovian Captain
- Christopher B. Duncan - Commander Carson Williams (uncredited)
- Teesha Renee - Destiny
- Todd Anthony - Dr. Darius Morgan
- Sh'Kia Augustin - Shonda (voice)
- Alexander Hodge - Philky
- Jemarcus Kilgore - Montel
- James Logan - Redneck
- Kenneth Trujillo - Jesse Gentilucci
- Stephen David Calhoun - Lead Board Member
- Stephen David Calhoun - Lead Committee Member
- Sofia Vassilieva - Looker
- Amanda Baker - Rebecca Larsen
- Elena Varela - Lauren Caruso
- Matt Roszak - Red
- Rico Ball - Ishmael
- Will Blagrove - Keith Michaels
- Amanda Tavarez - Specialist Cabrera
- Amanda Tavarez - Specialist Cabera
- George Contini - Smug Committee Member
- Pacey Liz Walker - Board Member #4
- Stella Doyle - Woman Committee Member
- Stella Doyle - Female Board Member
- Vince Canlas - Board Member #5
- William Catlett - Latavious 'Lala' Johnson
- Keith Arthur Bolden - Alvin Pierce
- Jahking Guillory - Brandon
- Melissa De Sousa - Chief Ana Lopez
- Helen Joo Lee - Val Seong
- Laura Kariuki - Jennifer 'JJ' Pierce / Lightning
- Wallace Smith - Detective Hassan Shakur
- Savage Houston - Soldier Passenger
- Isabelle Ramer - Waitress (uncredited)
- Aaron Goodson - Local Artist
- Tony Isabella
- Trevor Von Eeden
- Adam Giaudrone
- Salim Akil
- Victoria Thomas
- Carl Ogawa
- Chase Paris
- Jennifer Lence
- Kurt Farquhar
Bill Duke interpreta a Agent Percy Odell en la serie.
Michael Wright interpreta a Lazarus Prime en la serie.
Gregg Henry interpreta a Martin Proctor en la serie.
Cress Williams hace el papel de Jefferson Pierce / Black Lightning.
Nafessa Williams hace el papel de Anissa Pierce / Thunder / Blackbird.
Christine Adams interpreta a Lynn Pierce en la serie.
Marvin 'Krondon' Jones III interpreta a Tobias Whale en la serie.
James Remar hace el papel de Peter Gambi.
Chantal Thuy interpreta a Grace Choi en la serie.
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