- Jeff Meacham - Josh Oppenhol
- Katlyn Nichol - Olivia Lockhart
- Laurence Fishburne - Pops Johnson
- Ken Jenkins - Bernie
- Brandon Gibson - Adam
- Amber Rose - Dominique
- Aloe Blacc - Aloe Blacc
- Fonzworth Bentley - Fonzworth Bentley
- Trevor Jackson - Aaron
- Allen Maldonado - Curtis
- Harrison Holzer - Wes
- Issac Ryan Brown - Young Dre
- Prestyn Bates - Cole
- Beau Bridges - Paul
- Marla Gibbs - Mabel
- Leslie Grossman - Gwen
- Ted Allen - himself
- Daniel Lee Robertson III - Patron
- Christopher Jefferson - Student
- Kale Culley - Jar
- Hunter Wayne Pratt - Boy at Animal Kingdom Park
- Daveed Diggs - Johan Johnson
- Francia Raísa - Ana Torres
- Sean Combs - Elroy Savoy
- Kellee Stewart - Angela Strong
- Amanda Seales - Barbara
- Octavia Spencer - Octavia Spencer
- Laila Ali - Laila Ali
- Andy Daly - Dr. Evan Windsor
- Monique A. Green - Niecy
- Wanda Sykes - Daphne Lido
- Katt Williams - Perry
- Dara Reneé - Stunts
- Quvenzhané Wallis - Kyra
- Michael Strahan - June Bug
- Nelson Franklin - Connor Stevens
- Anna Deavere Smith - Alicia
- Brandon Routh - Banner Copeland
- Mandell Maughan - Amy Copeland
- Geffri Maya - Zion
- Christina Anthony - Denise
- Aiden Lewandowski - Raymond Bautista
- Golden Brooks - Aisha
- Jill Marie Jones - Lisa
- Persia White - Robin
- Scott Mosenson - Dr. Feinberg
- Joelle Better - Emily
- Baron Vaughn - Doug
- Loretta Devine - Lynette
- Jill Scott - Yaya
- Taylor Leigh Edwards - Marie
- Tyree Brown - Colin
- Nayah Damasen - Sasha
- Eric Davis - Mr. Williams
- Catherine Reitman - Lucy
- Alanna Fox - Rita
- Gillian White - Tanya
- Anthony Alabi - Lewis
- Madison Shamoun - Lily
- Arica Himmel - Young Rainbow
- Kelly Vrooman - Miranda
- Cleo Fraser - Sophie
- Joel McHale - Joel McHale
- Jennie Pierson - Ms. Davis
- Eric Garcetti - Eric Garcetti
- Emerson Min - Mason
- Michael Jai White - Vincent
- Liz Jenkins - Principal Biggs
- Keith David - Loose Craig
- Glynn Turman - Billy Blade
- Matt Braunger - Jeremy
- Chloe Bailey - Jazz Forster
- Judy Reyes - Dr. Laurie
- Raven-Symoné - Rhonda Johnson
- Parminder Nagra - Dr. Wen
- Danny Glover - Uncle Norman
- Nicole Sullivan - Janine
- Rob Huebel - Gary
- Nathan Morris - Nathan Morris
- Wanya Morris - Wanya Morris
- Shawn Stockman - Shawn Stockman
- Zendaya - Resheida
- Michelle Obama - Michelle Obama
- Sanai Victoria - Cousin Diamond
- Joshua Caleb Johnson - Jalen
- Gavin White - Quinn
- Notlim Taylor - Cousin Cha-Cha
- Paul F. Tompkins - Dr. Reagan
- Maui Kai Malone - Jedi Girl
- Rosalind Chao - Dr. Stone
- Michelle Meredith - Tour Guide
- David L. King - Mr. Boyer
- Leigh Bush - Mrs. Boyer
- Mike C. Nelson - Nurse Larry
- Jenna Osterlund - Employee
- Elizabeth June - Harriet Tubman
- Ursula Burton - Candace
- Morgan Bertsch - Student
- Sharon Muthu - Charani
- Grace Rowe - Tanya
- Nick Carson - Zach
- Harvey J. Alperin - Neighbor
- David Goldman - Bruce Greenstein
- Arden Belle - Kyra Kang-Nussbaum
- Michael Nanfria - Kevin
- Mandy Levin - Sydney Martin
- Kimberley Crossman - Tawny
- Jacob Kemp - Kris
- Ana Ortiz - Angelica
- Virginia Montero - Conchita
- Edi Patterson - Laura
- Senyo Amoaku - Guy
- Arianna Jaffier - Little Girl
- Jon Reep - Owner
- Shane Blades - Police Officer
- John Maholm - Bus Driver
- Amy Schloerb - Desk Clerk
- Alexandra Hoover - Female Snowboarder
- Michael Bailey Smith - Security Guard
- Nicole Day - Masseuse
- Belle Angel - Black Family
- Yolanda English - Guest
- Richard Riehle - Solomon
- Renee Dorian - Stacy
- Jesse Burch - Keith
- Matthew Rocheleau - Jason
- Raja Deka - Dr. Dilip Kotwala
- Joel Spence - Jonas
- Shannon McClung - Waiter
- Jeff Lewis - Pizza Guy
- Mari Weiss - Doctor
- Marc Fajardo - Fabiano Waiter
- A.J. Tannen - Maitre d'
- Caitlyn Knisely - Young Woman
- Julian De La Celle - Andre from Marseille
- Mindy Sterling - Pamela
- Emily Tarver - Lindsey
- B.J. Mitchell - Derrick
- Alfonso Colichon - Break Dancer
- Doug Simpson - Principal Matthews
- Thomas Archer - Tyler
- Walter Fauntleroy - Black Panther
- Bishop Don Magic Juan - Bishop Don Juan
- Ellen Karsten - Old Lady
- Nathaniel 'Nate' Scott - Stand-in
- Sabrina Sky - Sabrina, Dre's Secretary
- Jermaine Dupri - Jermaine Dupri
- Maury Povich - Maury Povich
- Cassidey Fralin - Young Zoey
- Jerry Minor - Lance
- Lindsay Price - Maisie
- Mara Marini - Shawn
- Michael Rapaport - Jay Simmons
- Elle Young - Sharon
- Aseem Batra - Naiya
- Bumper Robinson - Marcus Montgomery
- Judith Moreland - Angela Montgomery
- Bill Maher - Bill Maher
- Max Goudsmit - Catering Waiter
- David Axelrod - David Axelrod
- Mary J. Blige - Mirabelle
- Ana Cristina Cash - Jogging Girl
- Andria Kozica - Tracy
- David Fickas - Glen Kinnebrew
- Christopher Carroll - Winston
- Christopher Carroll - Online Lecturer
- Karl Warren - Fred Garner
- Taya Amerson - Dancer Girl
- Kent Faulcon - Principal Green
- Bruce Katzman - Mr. Scott
- Lisa Linke - Ms. Nixon
- Ava Kolker - Little Girl
- Brad Grunberg - Derrik Blaust
- Gary 'G. Thang' Johnson - Customer
- Brandon Johnson - Customer
- Alyssa Gabrielle Rodriguez - Visitor
- Hash Patel - Surgeon
- Barry Ford - Moaning Man
- Jim Garrity - Sponsor Executive
- Marc Evan Jackson - David Cooper
- Beth Lacke - Andrea Cooper
- Michael Colyar - Reverend Hubbard
- Shaan Sharma - Man
- Marin Miller - Secretary
- Nathan Anderson - Cousin Dante
- Kezii Curtis - Cousin Carl
- Peter Navy Tuiasosopo - Officer Tuiasosopo
- Jacob Melton - Kid
- Makenzie Moss - Trick-or-Treat Kid
- Barry Shabaka Henley - T Jackson
- Marcus T. Paulk - Scootie
- Barry Floyd - Mike
- Malik S. - Jigga
- Jason Weaver - Ta-Ta
- Isaac Stephen Montgomery - Oozi
- Steve Lewis - Gun Store Owner
- Faizon Love - Sha
- Tyra Banks - Gigi
- Brooklyn McLinn - Napoleon
- Elia Cantu - Wife
- Janie Haddad Tompkins - Wife
- Mary-Margaret Lewis - Wife
- Scott Michael Morgan - Husband
- Bill Lewis - Husband
- LaMonica Garrett - Davis
- Brittini London - Tanya
- Diamond White - Kiersten
- John Witherspoon - James Brown
- John Hartmann - Financial Advisor
- Laila Lockhart Kraner - Young Rainbow
- Toby Huss - Nelson
- Brittany Daniel - Blair
- Christina DeRosa - Nicole
- Mike Rock - Volleyball Player
- JR Reed - Mr. Sheffield
- Anthony Lapenna - Donnie Pacino
- Ruby Rose Turner - Cool Kid
- Don Lemon - Don Lemon
- Jonathan Ohye - Prosecuting Attorney
- Sayeed Shahidi - Adonis Culpepper
- Dayna Dooley - Neika
- Lang Yun - Old Asian Lady
- Jet Jurgensmeyer - Caleb
- Regina Hall - Vivian
- Amanda Christine - Young Diane
- Christine Corpuz - Technician
- Emma Shannon - Susie Kwest
- Phil Morris - Frank Duckworth
- Valarie Pettiford - Donna Duckworth
- Sarah Hudson - Kayla
- Mark Bloom - Alan Feinstein
- Nat Faxon - Joseph Everton
- Mike Park - Orderly
- Andy S. Allen - Minister
- Darnell J. Cates - Juvon
- Keraun Harris - Smoke
- Jasmine Hester - Cheryl
- Rhyan Schwartz - Coffee House Guy
- Chris Brew - Coach Jerry
- Malachi Ryan - Basketball Player
- Jim Rash - Cody
- Angela Sprinkle - Cast Member
- David Abrams - Man
- Salome Azizi - Doctor Aziz
- Mark Roman - HOA Member
- Chris Hansen - Chris Hansen
- Alison Whitney - White Woman
- David Beeler - HOA Member
- Dalton E. Gray - White Kid
- Markees Christmas - Eustace
- Ronnie Alvarez - Messenger
- Kevin Bielinski - Security Guard
- Shane Costa - Man
- William Cowart - Electrician
- Lorraine Toussaint - Almaviligerais
- Cole Gerdes - Tyler
- Caitlin Leahy - Kelly
- Lance Barber - Dr. Gabler
- Alec Mapa - Neil
- Ryan Meharry - Eric
- Elaine Welteroth - Elaine
- Isabel Chanel Freeman - Animal Kingdom Park Guest
- Isabella Goodwin - Theme Park Guest
- Christian Janner - Student
- Farris Turner - Park Guest
- Diane Farr - Rachel
- Floyd Van Buskirk - Patient
- Roger J. Timber - DJ
- Roger J. Timber - Band Leader
- Stephanie Arcila - Ms. Gomez
- Mary Kay Place - Dr. Barris
- Stephen O'Mahoney - Louis
- Jay Alan Christianson - Coal Miner
- Michael Wayne Foster - Viking
- Darrett Sanders - Eskimo
- Glenn Herman - Delivery Guy
- Gabrielle Elyse - Shelly
- Brian Michael Jones - Baker
- Bob Rumnock - Baker
- Sarah Cortez - Barista
- Patrick Babbitt - Barista
- Ron Funches - Ledarius
- Affion Crockett - T Will
- Chris Spencer - Ronnie
- Christian Benz Belnavis - Pastor
- David Kerns - Fast Food Guy
- Bill Fagerbakke - Tom Avery
- Kyle Red Silverstein - Seth
- Mark Atteberry - Prosecutor
- Stewart Skelton - Judge
- Michael Naughton - Public Defender
- Caroline Redekopp - Judge
- Amy Tolsky - Bernice (Juror)
- Rick Gifford - Juror
- Jeremy Lawson - Homeless Man
- Casey Wilson - Patrice
- Doris Day Bowman - Doris
- Jules Sylvester - Animal Trainer
- Christy Meyers - Hannah
- Chris Brown - Richard Youngsta
- Joe Gillette - Bellman
- Dan Gordon - Jared
- Dean Sharpe - Big Homie
- Briana Walden - Doting Girl
- Joseph Meissner - Policeman
- Boise Holmes - Mr. Caldwell
- Ahmad Rashād - Ahmad Rashad
- Rashida Jones - Santamonica
- Scarlet Spencer - Young Santamonica
- Chris Parnell - Dean Parker
- Matt Walsh - President Schock
- Jules Hartley - Serendipity
- Janzy Paraiso - Stacy
- Christina Veronica - Sketchy Student
- Biz Markie - Biz Markie
- Jessica Lorez - Jess
- Anday Tural - Joey
- Tyler Antoine Gordon - DeBarge
- Mallory Sparks - Miriam
- Brooke Burgstahler - Student
- Kristen O'Meara - Dr. Emily Drexler
- Michael Strassner - Gym Teacher
- Julanne Chidi Hill - Secretary
- Kimberly Dawn Guerrero - Saleswoman
- Janice LeAnn Brown - Young Bow
- Alessandra Scotto - Teacher
- Tyrin Turner - Big
- Nicholas Crovetti - Dylan
- Cameron Crovetti - Dylan
- Brian D. Johnson - Darrington
- Bechir Sylvain - Greg
- Rick Fox - Rick Fox
- Karole Foreman - Woman
- David Jahn - Man
- Raleigh Adams - Waiter
- Mike Ostroski - Mike
- Gus Lynch - Coffee Shop Attorney
- Angel Laketa Moore - Erica
- John Flanders - Patient
- Amy Hill - Nana Jean
- Kristen Rozanski - White Parent
- Bianca Lopez - Announcer
- Emily Berry - Kelly
- Cedric the Entertainer - Smokey
- P.L. Brown - Pops' Friend
- Jensen LeFlore - Reggie
- Bryce Charles - Crystal
- Jalyn Hall - 8-Year-Old Dre
- Ethan Michael Mora - Hunter
- Dan Sachoff - Brian
- Seth Vernon - Hollywood Hipster, Camper
- Lyliana Wray - Riley
- Dana Powell - Marla
- Seth Coltan - Custodian
- Mike Bash - Angry Passerby
- Suzy Nakamura - Dr. Ima
- Sarah Randall Hunt - Rebecca
- Drew Wicks - Gavin
- Anthony Nguyen - Soldier
- Cuete Yeska - Angel
- Jaidyn Triplett - Young Zoey
- KJ Smith - Linda
- Aaron D. Alexander - Security Officer
- Kiff VandenHeuvel - Officer Mike
- Travis Joe Dixon - Officer Todd
- Alfredo Tavares - Camper Parent
- Alfredo Tavares - Cliff
- Derek Graf - Officer
- Connor Falk - Cameron Carter
- Marissa Strickland - Parent
- Justin Claiborne - Kid
- Gina Hiraizumi - Tiffany
- Terryn Westbrook - Doris
- Clint Culp - Patient
- Kurt Fuller - Police Officer
- Ithamar Enriquez - Luis
- Christina Webber - Rosa Parks
- Amad Jackson - Darrell
- Joshua Hoover - Carl
- P.J. Byrne - Mr. Solomon
- Jessica Tuck - Dr. Cole
- Andrew Patrick Ralston - Greg
- Brian Maillard - Kevin
- Zylan Brooks - Iris
- Herbert Russell - Glenn
- Sophia Stephens - Jessica
- Nicholas Sean Johnny - Pablo
- Indira G. Wilson - Mrs. Keeley
- Leah Henoch - Lizzie
- Melody Melendez - Jessica
- Nancy Lenehan - Barbara Piermont
- Nicholas Cafero - Kirby
- Otoja Abit - Roland
- Kiva Jump - Anna Quinones
- Tom Beyer - Patient
- Lauren Plaxco - Trendy Mom
- David Alan Wallace - Dr. Collins
- Eric Nenninger - Ryan Simmons
- Michael Beasley - Al Kebble
- Terrence Terrell - Ben
- Randal Edwards - Matt
- Jeff Sanders - Football Referee
- Zaria - Sasha
- Andy Richter - Mr. Schatz
- Quavo - Quavious 'Quavo' Marshall
- Tyler Lofton - Isaiah
- Andre Darnell Myers - Rickey
- Reggie Hayes - Walter
- Nadia Quinn - Abby
- Jeff Corbett - Chip
- Bashir Salahuddin - Harold
- Diallo Riddle - Reggie
- Christine Horn - Shaline
- Garikayi Mutambirwa - Mr. Amukamura
- Tina Tena Ansah - Mrs. Amukamura
- Bodhi del Rosario - Cowboy
- Marcus Folmar - Justin
- David Bowe - Stranger
- Steve Hasley - Docent
- Austin Boyce - Waitress
- Sara Lukasiewicz - Jasmine
- Steven Williams - Phillip
- Maahra Hill - Cheryl
- Gregory A. Thompson - Bartender
- Danny Brown - Rochée
- Nomsa Mlambo - A'rese
- Tunisha Hubbard - Angie
- Iona Morris - Iona Morris-Jackson
- Heidi McGowen - Heidi G. McGowen
- Marlon Aquino - Waiter
- Erich Lane - Waiter
- Tiana Masaniai - Woman at Table
- Christopher Allen - Man at Table
- Chris Aquilino - Glen
- Dean Kamen - Dean Kamen
- William Ragsdale - Dr. Chubb
- John Anthony Wylliams - Terrance
- Dylan Summerall - Root Beer
- Shondalia White - Erica
- Jessica Leigh Gonzales - Stella
- Jake Elliott - Ricky
- Michael Eric Dyson - Self
- The Kid Mero - The Kid Mero (voice)
- Stacey Abrams - Stacey Abrams (voice)
- Kenya Barris - Mysterious Salesman (voice)
- Telvin Griffin - Nijeul Adams
- Camaron Engels - Jeremy
- Hilda Boulware - Cousin Loretta
- Del Hunter-White - Aunt Mickey
- Kash Abdulmalik - John John
- Henry Dittman - Wayne
- Maya Nalli - Cashier
- Lola Kelly - Shopper
- Jasmine Ashanti - Crystal
- Eric C. Lynch - Darren
- Felice Heather Monteith - Maxine
- Yassir Lester - Jamal
- Terrell Owens - Terrell Owens
- Nathaniel Logan McIntyre - Bradley
- Andrew Ableson - British Ad Man
- Kevin Symons - Carl
- Aaron Lazar - Andrew Collins
- Mark Meir - Jeffrey
- Leo A. Perry - 9-Year-Old Devante
- Reid Scott - Griffin
- Justin De Rosa - Umpire
- Nicole Pacent - Erica
- Stephen A. Smith - Stephen A. Smith
- Shakira Ja'nai Paye - Vanessa
- Stephanie Charles - Jasmine
- Jeanté Godlock - Asia
- William Sterling - Waiter
- A.J. Hudson - Kid
- Andrew Bachelor - Isaiah
- Jeanie Buss - Jeanie Buss
- Dwight Howard - Dwight Howard
- Magic Johnson - Magic Johnson
- Rajon Rondo - Rajon Rondo
- André B. Walker - Black CPS Officer
- Vivica A. Fox - Vivica A. Fox
- Babyface - Kenneth 'Babyface' Edmonds
- Isaiah Mustafa - Isaiah Mustafa
- Eileen Barnett - Marsha
- Kimrie Lewis - Destiny
- Phillip Wampler - Drew
- Jason Garcia Jr. - Aiden
- Siaki Sii - Owen
- Nikki Tuazon - Tina
- Dawn Joyal - Betty
- Shane Nickerson - Angry Passerby
- Gin Blanton - Graduation Party Guest
- Roy Williams Jr. - Edwin
- Frankie McNellis - Kid
- Duchess Dukes - Tiffany
- Cherish Monique Duke - Jade
- Marcus T. Thomas - Terrence
- Brian Robert Burns - Waiter
- Chadwick Hopson - Chuck
- Stephanie Einstein - Woman
- Mystie Smith - Waitress
- Noelle Bellinghausen - Nadine
- Kate Prendergast - Sue
- Mallian Butler - Ashley
- Abe Kim - James
- Simone Biles - Simone Biles
- Salvador Chacon - Jorge
- Tanya Wheelock - Disney's Animal Kingdom Guest (uncredited)
- Rell Battle - Christipher
- Kathryn Taylor Smith - Ronnie
- Rebecca Asher
- Ken Whittingham
- Melissa Kosar
- Victor Nelli Jr.
- Anthony Anderson
- Oz Scott
- Melanie Boysaw
- Owen Smith
- Vijal Patel
- Isaiah Lester
- Damilare Sonoiki
- Hale Rothstein
- E. Brian Dobbins
- Alexis Frank Koczara
- Helen Sugland
- Michael Petok
- Laurence Fishburne
- Corey Nickerson
Anthony Anderson interpreta a Andre Johnson en la serie.
Michael Rapaport interpreta a Jay Simmons en la serie.
Tracee Ellis Ross interpreta a Rainbow Johnson en la serie.
Laurence Fishburne hace el papel de Pops Johnson.
Beau Bridges interpreta a Paul en la serie.
Vivica A. Fox interpreta a Vivica A. Fox en la serie.
Danny Glover interpreta a Uncle Norman en la serie.
Marcus Scribner interpreta a Junior Johnson en la serie.
Marsai Martin interpreta a Diane Johnson en la serie.
Miles Brown interpreta a Jack Johnson en la serie.
Capítulo disponible en las siguientes plataformas:
