- Jeffrey Nordling - Gordon Klein
- Kathryn Newton - Abigail Carlson
- Meryl Streep - Mary Louise Wright
- Douglas Smith - Corey Brockfield
- Darby Camp - Chloe Mackenzie
- Chloe Coleman - Skye Carlson
- Cameron Crovetti - Josh Wright
- Nicholas Crovetti - Max Wright
- Crystal R. Fox - Elizabeth Howard
- Anil Kumar - Dr. Winslow
- Paull Walia - David Roberts
- Sarah Sokolovic - Tori Bachman
- Sarah Burns - Gabrielle
- P.J. Byrne - Principal Nippal
- P.J. Byrne - Principal Warren Nippal
- Joel Spence - Matt
- Sarah Baker - Thea Cunningham
- Parker Croft - Brent
- Merrin Dungey - Detective Adrienne Quinlan
- Kate Rene Gleason - Stacey
- Kimmy Shields - Kelly
- Jennifer Lafleur - Fiona
- Keisuke Hoashi - Dr. Leo Chang
- Carrie Wampler - Lori
- Sheena Peña - College Student (uncredited)
- Molly Hagan - Dr. Moriarty
- Ivy George - Amabella Klein
- Hong Chau - Jackie
- Joseph Cross - Tom
- Gia Carides - Melissa
- Kelen Coleman - Harper Stimson
- Santiago Cabrera - Joseph Bachman
- Virginia Kull - Emily Barnes
- Patrick St. Esprit - Mayor Bartley
- Stephen Graybill - Saxon Baker
- Larry Sullivan - Oren Berg
- Danielle Judovits - Puppeteer
- Kathreen Khavari - Samantha
- Richard Israel - Theatrical Coordinator
- Mark Adair-Rios - Coach Bob
- David Monahan - Bernard
- Robin Weigert - Dr. Amanda Reisman
- Larry Bates - Stu
- Chris Kauffmann - Puppeteer
- Ryan O'Connor - Puppeteer
- Sunday Rose Kidman-Urban - School Child
- Faith Margaret Kidman-Urban - School Child
- Denis O'Hare - Ira Farber
- Becky Ann Baker - Judge Marylin Cipriani
- Matthew Tinker
- Liane Moriarty
- Bruna Papandrea
- David E. Kelley
- Andrea Arnold
Mark Adair-Rios hace el papel de Coach Bob.
Nicole Kidman interpreta a Celeste Wright en la serie.
Reese Witherspoon hace el papel de Madeline Mackenzie.
Shailene Woodley interpreta a Jane Chapman en la serie.
Laura Dern hace el papel de Renata Klein.
Adam Scott hace el papel de Ed Mackenzie.
Alexander Skarsgård hace el papel de Perry Wright.
Zoë Kravitz interpreta a Bonnie Carlson en la serie.
James Tupper interpreta a Nathan Carlson en la serie.
Iain Armitage interpreta a Ziggy Chapman en la serie.
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