- Jeffrey Nordling - Gordon Klein
- Kathryn Newton - Abigail Carlson
- Meryl Streep - Mary Louise Wright
- Douglas Smith - Corey Brockfield
- Darby Camp - Chloe Mackenzie
- Chloe Coleman - Skye Carlson
- Cameron Crovetti - Josh Wright
- Nicholas Crovetti - Max Wright
- Crystal R. Fox - Elizabeth Howard
- Anil Kumar - Dr. Winslow
- Paull Walia - David Roberts
- Sarah Sokolovic - Tori Bachman
- Sarah Burns - Gabrielle
- P.J. Byrne - Principal Nippal
- P.J. Byrne - Principal Warren Nippal
- Joel Spence - Matt
- Sarah Baker - Thea Cunningham
- Parker Croft - Brent
- Merrin Dungey - Detective Adrienne Quinlan
- Kate Rene Gleason - Stacey
- Kimmy Shields - Kelly
- Jennifer Lafleur - Fiona
- Keisuke Hoashi - Dr. Leo Chang
- Carrie Wampler - Lori
- Sheena Peña - College Student (uncredited)
- Molly Hagan - Dr. Moriarty
- Ivy George - Amabella Klein
- Hong Chau - Jackie
- Joseph Cross - Tom
- Gia Carides - Melissa
- Kelen Coleman - Harper Stimson
- Santiago Cabrera - Joseph Bachman
- Virginia Kull - Emily Barnes
- Patrick St. Esprit - Mayor Bartley
- Stephen Graybill - Saxon Baker
- Larry Sullivan - Oren Berg
- Danielle Judovits - Puppeteer
- Kathreen Khavari - Samantha
- Richard Israel - Theatrical Coordinator
- Mark Adair-Rios - Coach Bob
- David Monahan - Bernard
- Robin Weigert - Dr. Amanda Reisman
- Larry Bates - Stu
- Chris Kauffmann - Puppeteer
- Ryan O'Connor - Puppeteer
- Sunday Rose Kidman-Urban - School Child
- Faith Margaret Kidman-Urban - School Child
- Denis O'Hare - Ira Farber
- Becky Ann Baker - Judge Marylin Cipriani
- Matthew Tinker
- Liane Moriarty
- Bruna Papandrea
- David E. Kelley
- Andrea Arnold
Mark Adair-Rios interpreta a Coach Bob en la serie.
Nicole Kidman interpreta a Celeste Wright en la serie.
Reese Witherspoon hace el papel de Madeline Mackenzie.
Shailene Woodley interpreta a Jane Chapman en la serie.
Laura Dern hace el papel de Renata Klein.
Adam Scott hace el papel de Ed Mackenzie.
Alexander Skarsgård interpreta a Perry Wright en la serie.
Zoë Kravitz interpreta a Bonnie Carlson en la serie.
James Tupper interpreta a Nathan Carlson en la serie.
Iain Armitage interpreta a Ziggy Chapman en la serie.
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