- Clayton Halsey - Announcer (voice)
- Phil Proctor - Announcer (voice)
- David Walsh - Narrator (voice)
- Tyler Crispen - Houseguest
- Tyler Crispen - Guest
- Erika Landin - Houseguest
- Erika Landin - Potential Houseguest
- Alison Irwin - Houseguest
- Alison Irwin - Potential Houseguest
- Janelle Pierzina - Houseguest
- Janelle Pierzina - Coach
- Janelle Pierzina - Guest
- Janelle Pierzina - Potential Houseguest
- Rachel Reilly - Houseguest
- Rachel Reilly - Guest
- Ariana Grande - Guest
- Amber Borzotra - Houseguest
- Paola Shea - Houseguest
- Kristen Bitting - Houseguest
- Da'Vonne Rogers - Houseguest
- Keesha Smith - Houseguest
- Jeff Schroeder - Houseguest
- Jeff Schroeder - Guest
- Cassi Colvin - Houseguest
- Shannon Dragoo - Houseguest
- Shannon Dragoo - Guest
- Hardy-Ames Hill - Houseguest
- Hardy-Ames Hill - Guest
- Lori Valenti - Houseguest
- Scott Long - Houseguest
- Will Wikle - Houseguest
- Will Kirby - Houseguest
- Will Kirby - Guest
- Will Kirby - Potential Houseguest
- Justin Giovinco - Houseguest
- Michelle Maradie - Houseguest
- Daniel Durston - Houseguest
- Billy Eichner - Guest
- Luke Macfarlane - Guest
- America Lopez - Houseguest
- Cory Wurtenberger - Houseguest
- Frankie Grande - Houseguest
- Frankie Grande - Guest
- Josh Duhamel - Guest
- Marcellas Reynolds - Houseguest
- Marcellas Reynolds - Guest
- Marcellas Reynolds - Potential Houseguest
- Bill 'Bunky' Miller - Houseguest
- Bill 'Bunky' Miller - Guest
- Bill 'Bunky' Miller - Potential Houseguest
- Derrick Levasseur - Houseguest
- Derrick Levasseur - Guest
- Cody Calafiore - Houseguest
- Cody Calafiore - Guest
- Enzo Palumbo - Houseguest
- Corey Brooks - Houseguest
- Natalie Negrotti - Houseguest
- Paulie Calafiore - Houseguest
- Howie Gordon - Houseguest
- Howie Gordon - Potential Houseguest
- Jozea Flores - Houseguest
- Ziggy Marley - Guest
- Julia Nolan - Houseguest
- Austin Matelson - Houseguest
- Meg Maley - Houseguest
- Diane Henry - Houseguest
- Diane Henry - Potential Houseguest
- Jace Agolli - Houseguest
- James Rhine - Houseguest
- James Rhine - Potential Houseguest
- Phil Keoghan - Guest
- Kathy Griffin - Guest
- Rob Gronkowski - Guest
- Britini D'Angelo - Houseguest
- Whitney Williams - Houseguest
- Jessie Godderz - Houseguest
- Jessie Godderz - Guest
- Will Mega - Houseguest
- Brittany Petros - Houseguest
- Monica Bailey - Houseguest
- Monica Bailey - Potential Houseguest
- Monica Bailey - Guest
- Eddie McGee - Houseguest
- Tonya Paoni - Houseguest
- Sheryl Crow - Guest
- Amanda Craig - Houseguest
- David Lane - Houseguest
- Jack Owens - Houseguest
- Jee Choe - Houseguest
- Robert Roman - Houseguest
- Jun Song - Houseguest
- Drew Daniel - Houseguest
- Dana Varela - Houseguest
- Dana Varela - Potential Houseguest
- Jen Johnson - Houseguest
- Sheila Kennedy - Houseguest
- Neil Garcia - Houseguest
- Steven Daigle - Houseguest
- Michelle Costa - Houseguest
- Braden Bacha - Houseguest
- Kara Monaco - Houseguest
- David Girton - Houseguest
- Nick Uhas - Houseguest
- Lisa Donahue - Houseguest
- Lisa Donahue - Potential Houseguest
- Mike "Boogie" Malin - Houseguest
- Mike "Boogie" Malin - Coach
- Mike "Boogie" Malin - Guest
- Mike "Boogie" Malin - Potential Houseguest
- Elissa Slater - Houseguest
- GinaMarie Zimmerman - Houseguest
- Analyse Talavera - Houseguest
- Tommy Bracco - Houseguest
- Bobby Moynihan - Guest
- Josh Martinez - Houseguest
- Josh Martinez - Guest
- Nathan Marlow - Houseguest
- Kaycee Clark - Houseguest
- Kaycee Clark - Guest
- Ben Platt - Guest
- Tom Green - Guest
- Bebe Rexha - Guest
- Tucker Des Lauriers - Houseguest
- Neil Patrick Harris - Guest
- Gabby Douglas - Guest
- McKayla Maroney - Guest
- Aly Raisman - Guest
- Kyla Ross - Guest
- Jordyn Wieber - Guest
- Jon Cryer - Guest
- Conchata Ferrell - Guest
- Marin Hinkle - Guest
- Angus T. Jones - Guest
- Melanie Lynskey - Guest
- Charlie Sheen - Guest
- Holland Taylor - Guest
- Brett Eldredge - Guest
- Jerry O'Connell - Host
Kathy Griffin hace el papel de Guest.
Julie Chen Moonves interpreta a Self - Host en la serie.
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