- Daniel Eric Gold - Matt Hartley
- Judith Light - Claire Meade
- Becki Newton - Amanda Tanen
- Ashley Jensen - Christina McKinney
- Michael Urie - Marc St. James
- Arap Bethke - Antonio
- Carol Kane - Lena Korvinka
- Jamie-Lynn Sigler - Natalie
- Alexander Chaplin - Fabian
- Adriana Lima - Adriana Lima
- Nikki Blonsky - Teri
- Gene Simmons - Gene Simmons
- Caroline Aaron - Judge Biotch
- Barry Bostwick - Roger Adams
- Megan Hilty - Glinda
- Lorraine Toussaint - Yoga
- Thea Vidale - Cholli
- Rita Moreno - Aunt Mirta
- Sarah Jones - Natalie Whitman
- Kristin Chenoweth - Diane
- Nigel Barker - Nigel Barker
- Chris Williams - Wilhediva Hater Robert
- Julian De La Celle - Daniel Jr.
- Kathy Najimy - Dr. Frankel
- Hamish Linklater - Evan Grant
- Lindsay Lohan - Kimmie Keegan
- Christine Baranski - Victoria Hartley
- Patti LuPone - Mrs. Weiner
- Daniel Davis - Dr. Morgan Remus
- John Cho - Kenny
- Kavi Raz - Clerk
- Anthony Cistaro - Waiter
- Mo'Nique - L'Amanda
- Vera Wang - Vera Wang
- Hannah Marks - Taylor
- James Van Der Beek - Luke Carnes
- Illeana Douglas - Sheila
- Stephanie Faracy - Rosemary Tanen
- Betty White - Betty White
- Bianca Roe - Mode Girl
- Nicholas Gonzalez - Carlo Medina
- Rachel Roberts - Marla
- Katharine McPhee - Katharine McPhee
- Gina Gershon - Fabia
- Bonnie Dennison - Ava
- Dana Ivey - Roberta
- Heather Tom - Holly Wright
- Shari Albert - Casting Associate
- Billie Jean King - Billie Jean King
- Liz Smith - Liz Smith
- Mo Rocca - TV Host
- Jasmine Jessica Anthony - Antonells
- Rick Fox - Dwayne
- AnnaLynne McCord - Petra
- Jowharah Jones - Nico Slater
- Salma Hayek Pinault - Sofia Reyes
- Rib Hillis - Sven
- Lucy Liu - Grace Chin
- Rhys Coiro - Vincent Bianchi
- Mini Anden - Aerin
- Lilyan Chauvin - Yolanda
- Angélica Vale - Angelica
- Lynn Redgrave - Olivia Guillemette
- Fisher Stevens - Mr. Z
- Patricia Velásquez - Victoria Velez
- Kristen Johnston - Helen
- Frank Whaley - Mr. Sparks
- Katrina Bowden - Heather
- Rachel Maddow - Rachel Maddow
- Donna Murphy - Eve
- Gabrielle Union - Renee Slater
- Christian Hoff - D.A. Richard Blackman
- Octavia Spencer - Constance Grady
- Robert Desiderio - Mr. Gallico
- Christian Siriano - Christian Siriano
- Naomi Campbell - Naomi Campbell
- Jayma Mays - Charlie
- Dylan Baker - Bennett Wallis
- Bryan Batt - Spencer Cannon
- Grant Bowler - Connor Owens
- Adam Ferrara - Sammy
- Freddy Rodríguez - Gio Rossi
- Kevin Kilner - Dr. Mervin Farber
- Elisabeth Hasselbeck - Elisabeth Hasselbeck
- Bernadette Peters - Jodie Papadakis
- Marlo Thomas - Sandra Winthrop
- David Blue - Cliff St. Paul
- Eddie Cibrian - Coach Diaz
- Tim Gunn - Fashion TV Reporter
- Debi Mazar - Leah Feldman
- Darryl Stephens - Waiter
- Courtney Ford - M.W.
- Mykel Shannon Jenkins - Tavares
- Scottie Thompson - Photo Editor
- Justina Machado - Cousin Clara
- Judy Gold - Joan
- Christine Ebersole - Frances
- Tovah Feldshuh - Mrs. Varner
- Aubrey Dollar - Marisa
- Rich Sommer - Jimmy Wilson
- Kari Matchett - Dr. Wallace
- Robert Verdi - Robert Verdi
- Eliza Dushku - Cameron Ashlock
- Victoria Beckham - Victoria Beckham
- Victor Garber - Professor Barrett
- Kurt Fuller - Mr. Tanen
- Nina Garcia - Nina Garcia
- Nolan North - Male Anchor
- Stelio Savante - Steve
- Kevin Sussman - Walter
- Adam Rodriguez - Bobby Talercio
- Brooklyn Decker - Lexie
- Thomas Sadoski - Ryan the Caterer
- Ralph Macchio - Archie Rodriguez
- Brennan Brown - Miles Foster
- Luna Lauren Velez - Elena
- Paul McCrane - District Attorney Weitz
- Ashley Rickards - Sharra
- Derek Riddell - Stuart
- Ivana Miličević - Lena
- Jesse Tyler Ferguson - Gabe Farkus
- Greg Proops - TV Fashion Reporter
- Patrick Fabian - Fashion TV Anchor
- Bob Clendenin - Bruno Jacobs
- RuPaul - Rudolph
- Sarah Lafleur - Molly
- Aaron Tveit - Zachary Boule
- Chip Zien - Frank
- Nestor Serrano - Anthony Talercio
- Omarion - Omarion
- Bailey Chase - Becks Scott
- Leslie Jordan - Quincy Combs
- Liz Torres - Evelyn
- Charlie David - Scott (uncredited)
- Max Greenfield - Nick Pepper
- Kate Reinders - Ginger (uncredited)
- David Rasche - Calvin Hartley
- Louis Giambalvo - Dr. Squazzi
- Artemis Pebdani - Rita
- Teddy Sears - Hunter
- Brett Cullen - Ted LeBeau
- Lucy Davis - Fashion TV Anchor
- Michael Genet - Dr. Thompson
- Ryan McGinnis - Austin
- Brian Stokes Mitchell - Don Jones
- Rachel Dratch - Penny Meadows / Mindy Meadows
- Shad Moss - Bow Wow
- Andy Milder - Lawyer
- Christie Brinkley - Penelope Graybridge
- Daniel Gerroll - Lindsay Dunne
- Juliette Goglia - Hillary
- Jerry O'Connell - Joel
- Nadia Dajani - Denise Ludwig
- John Tartaglia - Paolo
- Lainie Kazan - Dina Talercio
- Annie Potts - Linda
- Rebecca Wisocky - Marsha Stein
- Cleo King - Anne Fraiser
- Mike Faiola - Mailroom Boy
- Alec Mapa - Suzuki St. Pierre
- Rob Bartlett - Security Guard
- Eden Espinosa - Elphaba
- Shakira - Shakira
- Antonio Sabàto, Jr. - Antonio Sabato Jr.
- Martha Stewart - Martha Stewart
- Matt Newton - Troy
- Allison McAtee - Friday Night
- Smith Cho - Megan
- Kevin Alejandro - Santos
- Wendy Benson-Landes - Veronica
- Lisa K. Wyatt - Janet, Copy Editor
- Sal Landi - Mr. Green
- Yaya DaCosta - Nico Slater
- Jill Latiano Howerton - Model
- Jill Latiano Howerton - Assistant #1
- Jill Latiano Howerton - Blonde
- Lupita Ferrer - Rich Latina
- Ninel Conde - Sexy woman - TV (uncredited)
- David Gere - Bartender (uncredited)
- Elizabeth McLaughlin - Lindsay
- Ava Gaudet - Gina Gambarro
- Stephanie Cannon - Bess
- Max Ehrich - Randy
- Lisa Howard - Dominatrix
- Cody Klop - Little Daniel
- Arloa Reston - Reporter #2
- Elizabeth Payne - Masked Lady
- Cicily Daniels - Zelda
- Christine Jones - Fey Sommers
- Scott Porter - Guy
- Kristen Schaal - Nancy
- Corinne Dekker - Nancy
- Michael Rose - Edgar
- Gilles Marini - Jean-Luc
- Eve Mauro - Assistant
- Andy Kreiss - Host
- Ash Christian - Jeff
- Teresa Huang - Reporter #1
- Ron Butler - Reporter #2
- Diane Cary - Bradford's Assistant
- Tina Benko - Collette
- Portia - Nurse
- Margot White - Mrs. Byron Wu
- Alessandro Mastrobuono - Physician's Assistant
- Suzy Kaye - Emily (uncredited)
- Teri Weinberg
- Silvio Horta
- Sheila R. Lawrence
- Salma Hayek Pinault
- James D. Parriott
- Alice West
Ralph Macchio interpreta a Archie Rodriguez en la serie.
Caroline Aaron interpreta a Judge Biotch en la serie.
Lucy Liu interpreta a Grace Chin en la serie.
Christine Ebersole hace el papel de Frances.
Jerry O'Connell interpreta a Joel en la serie.
America Ferrera interpreta a Betty Suarez en la serie.
Eric Mabius interpreta a Daniel Meade en la serie.
Vanessa Williams interpreta a Willhelmina Slater en la serie.
Tony Plana interpreta a Ignacio Suarez en la serie.
Mark Indelicato hace el papel de Justin Suarez.
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