- French Stewart - Jim / Jerry / Stephanie
- Davenia McFadden - Annette Johnson
- Mariel Hemingway - Ruth Saunders
- Derek Basco - Jimmy
- Randy Sklar - Ricky
- James Pickens Jr. - Cliff
- Molly Hagan - Sara
- Lin Shaye - Mrs. Cooper
- Kyla Pratt - Keisha
- James Wellington - Man #2
- John DiMaggio - Mr. Thalasinos
- Jon Wellner - Graduate #2
- Carlton Wilborn - Mr. Ellison
- Daran Norris - Man
- Connie Sawyer - Mrs. Yudelson
- Esther Scott - Marge
- Molly Cheek - Donna
- Jim Ward - Dr. Regozy
- Joe O'Connor - Mr. Engel
- Clayton Landey - Mr. Morello
- Mitzi McCall - Mrs. Gould
- Annie Wood - Theresa Campbell
- Dave Power - Jerry
- Tamara Taylor - Dana McCall
- Octavia Spencer - Ticket Woman
- John Fugelsang - Greg Jackson
- Roxanne Beckford - Francine
- Paul Connor - Tony
- Michael Bower - Patient
- Leon Russom - Fire Marshal
- Jessica Sara - Little Girl
- Jenica Bergere - Connie
- Amy Farrington - Judy
- Jon Polito - Leonard Nagle
- Jackie Debatin - Rita
- Mary-Pat Green - Denise
- Kathryn Joosten - Mrs. Goldsmith
- Leonard Nimoy - Professor Emmett Fowler
- Russ Woody - Mr. Pearson
- Rhea Perlman - Dr. Katherine Simmons
- Jenny Gago - Mrs. Cruz
- Taylor Nichols - Marty
- Jane Clayson Johnson - Self
- James Read - Dan
- Floyd Van Buskirk - Delivery Guy
- Nathan Davis - Milton Fowler
- Julie Caitlin Brown - Nicky
- David Graf - Lloyd Martin
- Jimmy Pardo - Mr. Ford
- Betty Garrett - Mrs. Firth
- Arturo Gil - Water Man
- Frank Novak - Myers
- John Harrington Bland - Nervous Patient
- Lauren Holly - Laura
- Wayne Alexander - Wholesome Man
- J.P. Manoux - Rusty
- Valerie Curtin - Ms. Russell
- Elya Baskin - Alexei
- Miriam Shor - Rosie, DMV Employee
- Shannon Welles - Mrs. Soloman
- Mary Mara - Beth
- Claire Yarlett - Ms. Alcott
- Ken Merckx - Waiter
- Marvin Kaplan - Mr. Gordon
- Logan O'Brien - Billy
- Denise Dowse - Janet Katz
- Kyle Massey - Kid
- Bruce A. Young - Officer Matlin
- Stephen Lee - Mr. Herrup
- T.J. Thyne - Mr. Messinger
- Bruce Gray - Mr. Fuller
- Dyllan Christopher - Sean
- Smith Cho - Victoria
- Bill Cosby - Hilton Lucas (uncredited)
- Chip Heller - Customer
- R. Martin Klein - Husband
- Zachary Isaiah Williams - Kid #1
- Julie Claire - Sandy
- Earl Billings - Mr. Kimsey
- Josh Blake - Danny Grillo
- Tim Lounibos - Radiologist
- Mary Steenburgen - Patient (uncredited)
- Jacob Smith - Jared
- Jason Sklar - Donnie
- Conchata Ferrell - Zora
- Heidi Swedberg - Mrs. Whitford
- Cleo King - Mrs. Davis
- Anne Pitoniak - Tillie
- Annie Abbott - Mrs. Vale
- Kenneth Choi - Kim Nam Kyu
- Kitty Swink - Helen Willakie
- Peter Siragusa - Mr. Marino
- Frank Roman - Mr. Danzetti
- Lauri Hendler - Mrs. Howarth
- Paul Bates - Mr. Garland
- Gregg Berger - Clerk
- John Rubinstein - Dickie
- Lauren Tuerk - Patient
- Lombardo Boyar - Hector
- Gilbert Gottfried - Alan
- Regis Philbin - Homeless Man
- Andy Milder - Clark
- Wade Williams - George
- Vasili Bogazianos - Dr. Axelrod
- Abigail Mavity - Abigail
- Darryl Theirse - Henry Millman
- Sean O'Bryan - Randy
- Matt Battaglia - Lester
- Ken Davitian - Cab Driver (uncredited)
- Richard Hatch - Self
- Lauri Johnson - Mrs. Sullivan
- Michael J. Pollard - Elliott
- Thom Gossom Jr. - Mr. Rainey
- Kevin James - Doug Heffernan (uncredited)
- Kara Zediker - Debbie
- John Astin - Richard Wilson
- Camille Saviola - Mrs. Corigliani
- Rainbow Borden - Gary Lowenhower
- Betty Murphy - Mrs. Katz
- Alice Krige - Dr. Sondra Rush
- Richard Gilliland - Frank
- Kathy Christopherson - Gina
- Judyann Elder - Judge Miriam Reinhold
- Danny Woodburn - Arnoldo
- Cody Arens - Boy
- Jason Kravits - Mr. Whitford
- David Chisum - Good Looking Guy
- Christopher Michael Moore - Mr. Bursky
- Kathleen Freeman - Edith / Evelyn
- Vivian Bang - Kim Soon Kon
- Kali Rocha - Kayla
- Scott Thompson Baker - Dr. Witlin
- Antonio Sabàto, Jr. - Linda's Boyfriend
- Loren Berman - Scott
- Joseph Fuqua - Tom
- James DuMont - Mr. Rigney
- Lindsay Price - Amanda
- Robert Joy - Tetzloff
- Charlie Stewart - Charlie
- Joe Nieves - Joe
- Sean Marquette - Jimmy
- Kenneth Mars - Melvin
- Ken Thorley - Patient #1
- Travis T. Flory - Kid
- Rachel Reenstra - Lana, Drug Rep
- Jolie Jenkins - Lisa
- Jesse D. Goins - Locksmith
- Jon Cryer - Roger
- Amy Spanger - Susan
- Dick Van Dyke - Fred Becker
- Tia Riebling - Pregnant Lady #2
- Yeardley Smith - Ruby
- Jaime Pressly - Grace
- Frances Fisher - Dr. Elizabeth Carson
- Jim Rash - Eddie Blatt
- John Mahoney - Father Joe D'Andrea
- George Wendt - Frank
- Henry Holden - Jeff
- Melba Englander - Nurse
- Gregory White - Monsignor
- Keith Szarabajka - Wayne
- Paul Dooley - Mr. Lerner
- Hal Holbrook - Mr. Humphries
- Dave Foley - Owen
- Nicollette Sheridan - Anna
- Orson Bean - Mr. Bennett
- Carol Ann Susi - Mrs. Marino
- LeVar Burton - Mr. Haller
- Sara Mornell - Anita
Elya Baskin hace el papel de Alexei.
Bruce A. Young interpreta a Officer Matlin en la serie.
Taylor Nichols interpreta a Marty en la serie.
Paul Bates interpreta a Mr. Garland en la serie.
Conchata Ferrell hace el papel de Zora.
Frances Fisher hace el papel de Dr. Elizabeth Carson.
Mary Steenburgen hace el papel de Patient (uncredited).
John Mahoney interpreta a Father Joe D'Andrea en la serie.
Jon Polito hace el papel de Leonard Nagle.
Alice Krige hace el papel de Dr. Sondra Rush.
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