- French Stewart - Jim / Jerry / Stephanie
- Davenia McFadden - Annette Johnson
- Mariel Hemingway - Ruth Saunders
- Derek Basco - Jimmy
- Randy Sklar - Ricky
- James Pickens Jr. - Cliff
- Molly Hagan - Sara
- Lin Shaye - Mrs. Cooper
- Kyla Pratt - Keisha
- James Wellington - Man #2
- John DiMaggio - Mr. Thalasinos
- Jon Wellner - Graduate #2
- Carlton Wilborn - Mr. Ellison
- Daran Norris - Man
- Connie Sawyer - Mrs. Yudelson
- Esther Scott - Marge
- Molly Cheek - Donna
- Jim Ward - Dr. Regozy
- Joe O'Connor - Mr. Engel
- Clayton Landey - Mr. Morello
- Mitzi McCall - Mrs. Gould
- Annie Wood - Theresa Campbell
- Dave Power - Jerry
- Tamara Taylor - Dana McCall
- Octavia Spencer - Ticket Woman
- John Fugelsang - Greg Jackson
- Roxanne Beckford - Francine
- Paul Connor - Tony
- Michael Bower - Patient
- Leon Russom - Fire Marshal
- Jessica Sara - Little Girl
- Jenica Bergere - Connie
- Amy Farrington - Judy
- Jon Polito - Leonard Nagle
- Jackie Debatin - Rita
- Mary-Pat Green - Denise
- Kathryn Joosten - Mrs. Goldsmith
- Leonard Nimoy - Professor Emmett Fowler
- Russ Woody - Mr. Pearson
- Rhea Perlman - Dr. Katherine Simmons
- Jenny Gago - Mrs. Cruz
- Taylor Nichols - Marty
- Jane Clayson Johnson - Self
- James Read - Dan
- Floyd Van Buskirk - Delivery Guy
- Nathan Davis - Milton Fowler
- Julie Caitlin Brown - Nicky
- David Graf - Lloyd Martin
- Jimmy Pardo - Mr. Ford
- Betty Garrett - Mrs. Firth
- Arturo Gil - Water Man
- Frank Novak - Myers
- John Harrington Bland - Nervous Patient
- Lauren Holly - Laura
- Wayne Alexander - Wholesome Man
- J.P. Manoux - Rusty
- Valerie Curtin - Ms. Russell
- Elya Baskin - Alexei
- Miriam Shor - Rosie, DMV Employee
- Shannon Welles - Mrs. Soloman
- Mary Mara - Beth
- Claire Yarlett - Ms. Alcott
- Ken Merckx - Waiter
- Marvin Kaplan - Mr. Gordon
- Logan O'Brien - Billy
- Denise Dowse - Janet Katz
- Kyle Massey - Kid
- Bruce A. Young - Officer Matlin
- Stephen Lee - Mr. Herrup
- T.J. Thyne - Mr. Messinger
- Bruce Gray - Mr. Fuller
- Dyllan Christopher - Sean
- Smith Cho - Victoria
- Bill Cosby - Hilton Lucas (uncredited)
- Chip Heller - Customer
- R. Martin Klein - Husband
- Zachary Isaiah Williams - Kid #1
- Julie Claire - Sandy
- Earl Billings - Mr. Kimsey
- Josh Blake - Danny Grillo
- Tim Lounibos - Radiologist
- Mary Steenburgen - Patient (uncredited)
- Jacob Smith - Jared
- Jason Sklar - Donnie
- Conchata Ferrell - Zora
- Heidi Swedberg - Mrs. Whitford
- Cleo King - Mrs. Davis
- Anne Pitoniak - Tillie
- Annie Abbott - Mrs. Vale
- Kenneth Choi - Kim Nam Kyu
- Kitty Swink - Helen Willakie
- Peter Siragusa - Mr. Marino
- Frank Roman - Mr. Danzetti
- Lauri Hendler - Mrs. Howarth
- Paul Bates - Mr. Garland
- Gregg Berger - Clerk
- John Rubinstein - Dickie
- Lauren Tuerk - Patient
- Lombardo Boyar - Hector
- Gilbert Gottfried - Alan
- Regis Philbin - Homeless Man
- Andy Milder - Clark
- Wade Williams - George
- Vasili Bogazianos - Dr. Axelrod
- Abigail Mavity - Abigail
- Darryl Theirse - Henry Millman
- Sean O'Bryan - Randy
- Matt Battaglia - Lester
- Ken Davitian - Cab Driver (uncredited)
- Richard Hatch - Self
- Lauri Johnson - Mrs. Sullivan
- Michael J. Pollard - Elliott
- Thom Gossom Jr. - Mr. Rainey
- Kevin James - Doug Heffernan (uncredited)
- Kara Zediker - Debbie
- John Astin - Richard Wilson
- Camille Saviola - Mrs. Corigliani
- Rainbow Borden - Gary Lowenhower
- Betty Murphy - Mrs. Katz
- Alice Krige - Dr. Sondra Rush
- Richard Gilliland - Frank
- Kathy Christopherson - Gina
- Judyann Elder - Judge Miriam Reinhold
- Danny Woodburn - Arnoldo
- Cody Arens - Boy
- Jason Kravits - Mr. Whitford
- David Chisum - Good Looking Guy
- Christopher Michael Moore - Mr. Bursky
- Kathleen Freeman - Edith / Evelyn
- Vivian Bang - Kim Soon Kon
- Kali Rocha - Kayla
- Scott Thompson Baker - Dr. Witlin
- Antonio Sabàto, Jr. - Linda's Boyfriend
- Loren Berman - Scott
- Joseph Fuqua - Tom
- James DuMont - Mr. Rigney
- Lindsay Price - Amanda
- Robert Joy - Tetzloff
- Charlie Stewart - Charlie
- Joe Nieves - Joe
- Sean Marquette - Jimmy
- Kenneth Mars - Melvin
- Ken Thorley - Patient #1
- Travis T. Flory - Kid
- Rachel Reenstra - Lana, Drug Rep
- Jolie Jenkins - Lisa
- Jesse D. Goins - Locksmith
- Jon Cryer - Roger
- Amy Spanger - Susan
- Dick Van Dyke - Fred Becker
- Tia Riebling - Pregnant Lady #2
- Yeardley Smith - Ruby
- Jaime Pressly - Grace
- Frances Fisher - Dr. Elizabeth Carson
- Jim Rash - Eddie Blatt
- John Mahoney - Father Joe D'Andrea
- George Wendt - Frank
- Henry Holden - Jeff
- Melba Englander - Nurse
- Gregory White - Monsignor
- Keith Szarabajka - Wayne
- Paul Dooley - Mr. Lerner
- Hal Holbrook - Mr. Humphries
- Dave Foley - Owen
- Nicollette Sheridan - Anna
- Orson Bean - Mr. Bennett
- Carol Ann Susi - Mrs. Marino
- LeVar Burton - Mr. Haller
- Sara Mornell - Anita
Elya Baskin interpreta a Alexei en la serie.
Bruce A. Young hace el papel de Officer Matlin.
Taylor Nichols interpreta a Marty en la serie.
Paul Bates hace el papel de Mr. Garland.
Conchata Ferrell interpreta a Zora en la serie.
Frances Fisher interpreta a Dr. Elizabeth Carson en la serie.
Mary Steenburgen hace el papel de Patient (uncredited).
John Mahoney hace el papel de Father Joe D'Andrea.
Jon Polito interpreta a Leonard Nagle en la serie.
Alice Krige hace el papel de Dr. Sondra Rush.
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