- Liberty Godshall - Nancy
- Madeleine Fisher - Jennifer Hunt / Felicia Norris
- William Conrad - Frank Cannon
- Janice Rule - Diane Stewart
- Darleen Carr - Julie Barton
- Victoria Shaw - Dorothy Carlyle
- William Shatner - Phil Carlyle / Fred Williams
- Corinne Camacho - Bonnie Lee
- Geraldine Brooks - Janet Enright
- Jerry Houser - Paul Thayer
- Andrew Parks - Charles Lomax
- Eric Braeden - Steven Kingston
- Jamie Smith-Jackson - Christie Sanders
- Richard Hatch - Eric Garvin
- Barbara Stuart - Winnie Harback
- Nancy Wickwire - Mrs. Sanders
- Michael Blodgett - Kirk
- Nico Minardos - Raul Felipe
- Jack Cassidy - Craig Woodridge
- Estelle Winwood - Aunt Anita
- Cathy Lee Crosby - Nancy Erdmore
- Anne Francis - Miriam Woodridge
- Jackie Coogan - Phil Rooney
- Heidi Vaughn - Gloria Vickers
- Paul Lambert - Earl Samson
- Roddy McDowall - Stanley Lambert
- Claude Akins - Eli Rile
- Neva Patterson - Bea Johnson
- Dabbs Greer - Andy Spake
- Bill Bixby - Alex Chandler
- Louise Troy - Hazel Turlock-Chandler
- Peter Haskell - Tony Neill
- Bert Freed - Det. Capt. Ben Wyatt
- Gary Owens - Gary Michaels
- Belinda Montgomery - Amy Partridge
- Christopher Stone - Eric Rome
- Patricia Smith - Ellen Cleveland
- Peggy McCay - Mrs. Benedict
- Tim O'Connor - Peter Harris
- Brooke Bundy - Miss Dorsey
- Ramon Bieri - Lt. Hager
- Gary Lockwood - Howard Lee
- Gary Lockwood - Mitch Mitchell
- James Luisi - Burt Logan
- James Luisi - Nick Gorman
- Susan Howard - Sandra Harris
- Wayne Rogers - Gil Atkens
- Stefanie Powers - Sharon Renford / Claire Atkens
- Bradford Dillman - Charles Kohlmeyer / Stanley Rickland
- Bradford Dillman - Terry McCormack
- Vincent Van Patten - Kevin Mills
- Margot Kidder - Lori Wright
- James Olson - Randall Stone
- Nina Foch - Eleanor DeRoche
- George Maharis - Warren Davis
- Albert Salmi - Vincent Buccola
- Lou Frizzell - Mr. Downey
- Lou Frizzell - John Flory
- Madlyn Rhue - Myra Stayley
- Carl Betz - Marshall Briggs
- Stephen Brooks - Victor Dayton
- Meg Foster - Doris Talbot
- Meg Foster - Glenda
- Robert Pine - Paul Colling
- Karen Machon - Kelly Barnes
- Reni Santoni - Tony Santos
- Reni Santoni - Chip Rawlins
- Leslie Nielsen - Edward Brendon
- Pippa Scott - Janice Harley
- Murray Hamilton - Clete Belford
- Richard Anderson - Frank Cassidy
- Laraine Stephens - Sheila Windsor
- Frank Marth - Seaver
- Don Porter - Jeremy Markham
- Jessica Walter - Brooke Leighton
- Bettye Ackerman - Margery Kinner
- Ed Nelson - Larry Kinner
- Meredith Baxter - Jenny Sutherland
- Christopher Connelly - Doug Wingate
- Mark Miller - Cal Medford
- Richard O'Brien - Sheriff
- Arlene Golonka - Nora Frazier
- Arlene Golonka - Sue Paige
- Ida Lupino - Kathy Revere
- Milton Selzer - Sam Benson
- Penny Fuller - Mary Dwayne
- Don Stroud - Chuck Summers
- Donna Baccala - Emily Kelso
- Barry Sullivan - Gordon McKenna
- Barry Sullivan - Jason Craig
- Daniel J. Travanti - Fred Bender
- Daniel J. Travanti - Lon Stevens
- Michael Burns - Brian Elder
- Marjoe Gortner - David Colton
- Jason Evers - Gil Turner
- Ross Martin - Maxwell Imry
- Scott Marlowe - Vincent Talbot
- Susan Oliver - Karen Macklin
- Jonathan Goldsmith - Mr. Smith
- Jonathan Goldsmith - Ed
- Jonathan Goldsmith - Mr. T
- Gilbert Roland - Juan DeVarga
- Cal Bellini - John Revez / Javier
- Joe Santos - Balazar
- David Wayne - Raymond Lennox / 'Steele'
- Sharon Acker - Laura Vaner
- Sharon Acker - Florence Armstrong
- Sharon Acker - Gail Bloom
- Eileen Heckart - Virginia Lennox / Steele
- Susan Clark - Karen Maybury / 'Leila Evanston'
- Patrick O'Neal - Charles Manly Wheeling
- Patrick O'Neal - Coleman Reeves
- John Vernon - Dr. Hank Danvers
- Joel Fabiani - Dr. David Bellman
- Patty McCormack - Angie McClaine
- Christine Belford - Eleanor Devers / Laura Tennace
- Christine Belford - Virginia Kirkland
- Mariette Hartley - Vanessa Stevenson / Kohlmeyer
- Andrew Duggan - Bill Sanderson
- George DiCenzo - Landau
- Robert Perault - Tony Torres
- Geoffrey Land - Deputy
- Andrew Prine - Shine Stanfield
- Andrew Prine - Jim Howard / Jim Hague
- Tony Colti - Mike Wolfe
- Tony Colti - Fred McAllen
- Tony Colti - Harry (Bartender)
- Robert Hogan - Stephen Triplett
- Robert Hogan - Reed Carpenter
- Robert Hogan - Lyle Casey
- Fritz Weaver - Jason Matthews
- Fritz Weaver - Laurence Sheffield
- A Martinez - Carlos Rojas / Tomas Aguilar / Tony Sierra
- Alberto Morin - Albert Allende
- Jamie Donnelly - Monica Gideon
- Jonathan Frakes - David Douglas
- Michael Lerner - Albert Krueger
- Connie Sawyer - Manager
- Lynn Hamilton - Laura Padget
- Laurence Luckinbill - Elliot Rexford / Lt. Damon Maxwell
- Char Fontane - Candy Harper
- Lloyd Gough - Felix Warner
- Glenn Corbett - Darryl Enders / Eddie Woods
- Glenn Corbett - Charlie Cort
- Mark Thomas - Corby Lyons / Ralph Miller / Murray
- Denver Pyle - Stayley Kircher
- Nick Nolte - Paul Barringer
- Barbara Stanger - Marilyn Barringer
- Roy Engel - Salesman
- Lloyd Bochner - Ray Greenwald
- Lloyd Bochner - John Stevens
- Mark Goddard - Tony Klinger
- Mark Goddard - Frank Halliday
- Mark Goddard - Vince Reeves
- Mark Goddard - Roger Clark
- Loni Anderson - Joanna Morgan
- Clu Gulager - Sheriff Mack Hollister
- Clu Gulager - Mark Landy
- Biff McGuire - Mason Barber
- Marj Dusay - Jennifer Allen / Rhodes
- Marj Dusay - Gail Anthony
- John Karlen - Johnny Alban
- Meshach Taylor - Parking Lot Attendant
- Kenneth Mars - William Tarkington IV
- Richard Bull - J.I. Fletcher
- Ben Piazza - Eugene Armstrong
- Diana Douglas - Alice Parks
- Bill Zuckert - Guard
- Bill Zuckert - Lew
- Lynne Marta - Katherine Wilson
- Lynne Marta - Sally
- Don Ross - Sawyer
- Jim McMullan - Major Scott
- Jim McMullan - Cliff Baxter
- Eileen Brennan - Anita Willson
- Marlyn Mason - Eve Garrison
- Marlyn Mason - Ginny Lind
- Arch Whiting - Deputy
- Annette O'Toole - Cas Carter
- Josh Taylor - Les Sayer
- Len Wayland - Ed Flynn
- Len Wayland - Tim Carter
- Len Wayland - Glen Wilcox
- Len Wayland - Frank at Scrap Yard
- Len Wayland - Joe Cooper
- Bob Harks - Sheriff (uncredited)
- Lynda Day George - Brina Douglas
- Lynda Day George - Ellie Briggs
- Dabney Coleman - Ted Sayers
- Dabney Coleman - George Clark
- Dabney Coleman - Brad Adamson
- Dabney Coleman - Paul Cleveland
- Charles Siebert - Gary Brock
- Denny Miller - Dixon
- Lori Lethin - Susan Cooper
- Linden Chiles - David Kingsley
- Linden Chiles - James Colin
- Linden Chiles - Ben Reston
- Linden Chiles - Rod Cursey
- Linden Chiles - Douglas Enright
- Barbara Perry - Mitzi
- Richard Evans - Buck
- Richard Evans - Deputy Jeremy Carter
- Richard Evans - Brother Love
- Mario Roccuzzo - Stacy Vernon
- Anne Helm - Helen Riley
- Joanne Linville - Mimi Nettleson Chiles
- Joanne Linville - Kay Rogers
- Art Hindle - Joe Bronson
- Macon McCalman - Ned Avery
- Carl Weathers - Jack Hopper
- Barbara Baldavin - Nurse Alison Claymore
- John McLiam - Dwight Hopkins
- Roger Perry - Russ Madden
- Roger Perry - John Evanston
- Roger Perry - Dan Carson
- Roger Perry - Don Hopkins
- Linda Kelsey - Cathy Lou Hopkins
- Jerry Ayres - Wayne Gibson
- Jack Ging - Dave Hendricks
- Jack Ging - Dr. Thomas Reston
- Jack Ging - Tom Powers
- Jack Ging - Wayne Houser
- Kenneth Tobey - Ron Hagarty
- Kenneth Tobey - Sheriff Tommy Allen
- Kenneth Tobey - Sheriff
- Katherine Justice - Liza Mills
- Katherine Justice - Suzanne Montaigne
- Katherine Justice - Shirley Jennings
- Katherine Justice - Libby Price
- Don Knight - Bertram Fisher
- Arthur Franz - Morgan Walding
- Monte Markham - Vince Barrett / Rick Hatfield
- Jamie Farr - Marty Paris
- Shirley Knight - Kay Lewiston
- Joshua Bryant - Dan Parker
- Markie Post - Linda Woods
- Robert Patten - Joe Beecher
- Robert Patten - Dr. Lincoln Bishop
- Curt Lowens - Dr. Myers
- Curt Lowens - Dr. Dryce
- David S. Cass Sr. - Jimmy Hickok
- Earl Boen - Eddie
- Don Dubbins - John Riley
- Don Dubbins - Sheriff Mason
- Don Dubbins - Frank Auburn
- Sherry Jackson - Erica Hughes
- Paul Picerni - Stan Toland
- Paul Picerni - Anthony Calvelli
- Susan Sullivan - Linda Gates
- Robert Webber - Gene Gates
- Paul Sorensen - Guard
- Paul Sorensen - Charlie Graham
- Phillip Pine - Dick Denfield
- Phillip Pine - Lyle Harrison
- Phillip Pine - Jay Randall
- Deborah Richter - Sally Marshall
- Doris Dowling - Miss Kelly
- Wayne Heffley - Carl Larkin
- Michael Tolan - Reed Calder
- Paul Fix - Alfred Sturmer
- Paul Fix - Amos Barringer
- Paul Fix - Jack Tattnal
- Rosemary Forsyth - Ruth Hanley
- Alex Henteloff - Bill Wayland
- Russell Thorson - Franklin
- Read Morgan - Red Edwards
- Read Morgan - Sheriff George
- Read Morgan - Skipper
- Read Morgan - Deputy Bailey
- Mills Watson - Frank Carter
- Elizabeth MacRae - Lucy Thornburgh
- Robert F. Simon - Mr. Strand
- Joseph Mell - Mr. Inball
- Joseph Mell - Veterinarian
- George Sawaya - Ted
- Conlan Carter - Roger Gosset
- Conlan Carter - Ed Chandler
- Jeff Donnell - Janet Gossett
- Robert Foxworth - Whit Brewer
- Tyne Daly - Madge Winston
- Vince Howard - Lt. Joe Taylor
- Vince Howard - Lt. Taylor
- Ina Balin - Laura Beecher
- Eve McVeagh - Millie / Maid
- Eve McVeagh - Woman walking dog (uncredited)
- Charles Cyphers - Brad Kirtz
- Charles Cyphers - Bill Garwood
- Charles Cyphers - Mike Hartney
- Charles Cyphers - Jimmy Dorset
- Ellen Geer - Mary Wiley
- William Lanteau - Mr. Turlock
- Paul Bryar - Joe Carter
- Paul Bryar - Cooley
- Paul Bryar - Mr. Jannett
- Paul Bryar - Ben Harlow
- Jerry Douglas - Ross Kemper
- Jerry Douglas - Lee Wallace
- Jacqueline Scott - Gwen Reynolds
- Barney Phillips - Harry Verby
- Robert Yuro - Eddie
- Michael V. Gazzo - Mr. Farinelli
- Richard Derr - Stuart Nettleson Jr.
- Richard Derr - Harry Doyle
- Richard Derr - Charlie Monahan
- Richard Derr - Mr. Garnett
- Richard Derr - Wayne Hogan
- Ed Flanders - 'Doc' Fred Tucker
- Gail Strickland - Susan Taylor
- Peter Brocco - Harry Hamlin
- Quinn K. Redeker - Jeffrey Allen McClaine
- Quinn K. Redeker - Vic Chambers
- Quinn K. Redeker - Vincent Lewiston
- Quinn K. Redeker - Ben Kingston
- Mark Pinter - Mark
- Arch Johnson - Sheriff Les Sprague
- Joe E. Tata - Little Angel
- Van Williams - Munson
- William Swan - Hotel Receptionist
- Arthur Tovey - Butler (uncredited)
- Dick Van Patten - Melvin Pearson
- Richard Eastham - Lawrence Adams
- Michael Caffey
- Ron Satlof
- Lawrence Dobkin
- Walter Grauman
- Virgil W. Vogel
- Russ Mayberry
- Robert C. Dennis
- William Keys
- Robert Sherman
- Dick Nelson
- Shirl Hendryx
- Larry Brody
- Frank Denson
Laurence Luckinbill interpreta a Elliot Rexford / Lt. Damon Maxwell en la serie.
George DiCenzo hace el papel de Landau.
Carl Weathers interpreta a Jack Hopper en la serie.
Jonathan Frakes interpreta a David Douglas en la serie.
Michael Lerner interpreta a Albert Krueger en la serie.
Nick Nolte interpreta a Paul Barringer en la serie.
Annette O'Toole interpreta a Cas Carter en la serie.
Claude Akins hace el papel de Eli Rile.
William Shatner hace el papel de Phil Carlyle / Fred Williams.
Eve McVeagh interpreta a Millie / Maid en la serie.
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