- Stefanie Powers - Angie Ives
- Madlyn Rhue - Holly Allencamp
- Robert Webber - Jerry Brinkman
- John Brodie - Ritchie Mulligan
- Deacon Jones - Joe Fabian
- Tom Mack - Ed Wolinski
- Gene Washington - Clay Mills
- Conrad Janis - Video Technician
- Michael Lerner - Bartender
- Jock Mahoney - Albert Bates
- Curt Gowdy - Curt Gowdy
- Charlie Jones - Charlie Jones
- Marty Ingels - Marty Ingels
- Chuck Morrell - Hank Ives
- Anitra Ford - Susan
- Colby Chester - Corliss
- John Finnegan - Lt. Hallohan
- Russell Arms - Ambulance Attendant
- Peggy Walton-Walker - Dr. Judy Forrest
- Bart Burns - 1st Reporter
- Chris Forbes - Debbie
- Marvin Goux - Coach (uncredited)
- Joseph La Cava - Bartender (uncredited)
- Rod McGaughy - Coach (uncredited)
- Clark Ross - Library Patron (uncredited)
- Jeffrey Sayre - Reporter (uncredited)
- Joanna Pettet - Christine Verdon
- William Windom - Harry Wexler
- Herb Edelman - Joe Taddenhurst
- Bert Convy - Douglas Ruderman
- Percy Rodriguez - Faldor
- Peter Mark Richman - Andy Cole
- John Fiedler - Paddle
- Stafford Repp - Police Chief
- Warren Finnerty - Whitey
- Seamon Glass - Deke
- Owen Bush - Engineer (uncredited)
- Edward Coch Jr. - Railroad Worker (uncredited)
- James W. Gavin - Helicopter Pilot (uncredited)
- Stuart Nisbet - Lieutenant Keenan (uncredited)
- Edward C. Short - Hobo (uncredited)
- Broderick Crawford - Gilbert Deretzo
- Louise Sorel - Alicia Danato
- Gordon Pinsent - John Weymouth
- Jack MacGowran - Michele Lanier
- Victor Jory - Paul Andros
- Ned Romero - Chief Frank Mendoza
- Ahna Capri - Mme. Pompadour
- Peter Donat - Robert Morgan
- Peter Brocco - Cardinal Joinville
- Kermit Murdock - Archbishop
- Bob Harks - Party Guest (uncredited)
- Bob Harks - Security Guard (uncredited)
- Annette Charles - Cecelia Gomez
- Ruben Moreno - Colonel Perez
- Julio Medina - Padre Borda
- Pedro Regas - Enrico Rojas
- Adele Yoshioka - Receptionist
- Erica Hagen - Bikini Girl
- Paul Gleason - Border Guard
- Eumenio Blanco - Tourist (uncredited)
- Robert Buckingham - Party Guest (uncredited)
- Monty O'Grady - Commuter (uncredited)
- Byron Morrow - Commisioner Grant
- Byron Morrow - Max Benson
- Joe Pine - Party Guest (uncredited)
- Cosmo Sardo - Bartender (uncredited)
- Olan Soule - Desk Clerk (uncredited)
- Lada Edmund Jr. - Lila Porter
- Bruce Kirby - Collier
- Alan Fudge - Father Cass
- Alan Fudge - Logan Howard
- Al Bain - Pedestrian (uncredited)
- James Rosin - Las Vegas Bellhop (uncredited)
- Francisco Ortega - Padre Guillermo
- Anne Francis - Katherine Wells
- John Crawford - Owen Summers
- Harry Carey, Jr. - Dean Barrett
- Pamela Hensley - Mandy
- Penny Fuller - Gloria Hamilton
- Mike Farrell - Jason Trotter
- Penny Marshall - Receptionist
- George Brenlin - Davis
- Sabrina Scharf - Wyn
- Julie Rogers - Lois
- William Sylvester - Dr. Stahl
- Anne Baxter - Leslie Lyle
- Richard Jordan - Chris Bailey
- Jim Davis - Ed McKay
- Poupée Bocar - Wanda
- Gene Dynarski - Leo
- Gene Dynarski - Wheeler
- Nancy Olson - Louise Merrick
- Gretchen Corbett - Vicki Merrick
- Lynnette Mettey - Emily Parker
- Bruce Gordon - Maxwell Barker
- Phillip Pine - Ed Harvey
- Kathrine Baumann - Gloria
- Frank Maxwell - Higgins
- Walter Brooke - Walter Peterson
- Kathie Browne - Shirley Cole
- Lew Brown - Wilson
- Kai Hernandez - Sandra
- Gerald Peters - Davis
- Sharyn Wynters - Lorraine
- Don Knight - Isaac Porter
- Richard Gautier - Mario Fratelli
- Arlene Martel - Diana Maitland
- Hal Buckley - Sanborn
- Titos Vandis - Capt. Larkos
- Martin Kosleck - Bruno
- Susan Damante - Leona Sanborn
- Rudy Challenger - Lt. Trask
- Jeane Manson - Wilda Porter
- Hal Baylor - Foreman
- Sterling Hayden - Tony Fowler
- Victoria Principal - Brooke Collins
- Jack Kelly - Lou Wayne
- Patricia Quinn - Charlotte
- James Daris - Roy Gilbert
- Charles H. Gray - Capt. Roberts
- Carlos Romero - Sheriff Ortega
- Linden Chiles - Henry DeWitt
- Linden Chiles - Fennyman
- Richard Roat - Stan Price
- Paul Cavonis - Andy Hall
- Beverly Gill - Gina
- Laurence Haddon - Joe Daley
- Larry Ward - Len Malloy
- Don Hanmer - Charlie Tyson
- Byron Mabe - Walt Kinsdale
- Stella Stevens - Jill Hammond
- Joel Fabiani - Art Woodward
- David Doyle - Elliot
- David Wayne - Walter Tyson
- Ted Cassidy - Jerry Crawford
- Linda Evans - Cherry Saint-Saëns
- Andrew Prine - Tom Wardlow
- Dick Van Patten - Donald Morgan
- Robert Rothwell - Officer Lonigan
- Jessica Walter - Erica Osburn
- Andrew Duggan - Cap'n Jack Osburn
- William Schallert - Leo Osburn
- Gregory Sierra - Norman Esposito
- Liam Dunn - Hanrahan
- Gary Lockwood - Owen Russell
- Joe Maross - Lt. Nash
- Larry Pennell - Pete Biesecker
- Mark Russell - Gate Guard (uncredited)
- Ramon Bieri - John Hargroves
- Terry Wilson - Chuck Smith
- Brenda Vaccaro - Sharon Clark
- Kevin McCarthy - Allen Markham
- Pernell Roberts - Matthew Donniger
- Roger C. Carmel - Oliver Garson
- Janis Paige - Lydia
- Anthony Eustrel - Butler
- Cesar Romero - Marius Avantalu
- Eric Braeden - Paul Bolitho
- Sue Ane Langdon - Sybil Payson
- John Saxon - Harry Harland
- Paul Picerni - Det. Ed Winslow
- Dorrie Thomson - Felix's Young Woman
- Howie Horwitz
- George Eckstein
- Hal Mooney
Sterling Hayden interpreta a Tony Fowler en la serie.
Michael Lerner interpreta a Bartender en la serie.
Harry Carey, Jr. interpreta a Dean Barrett en la serie.
Bruce Kirby interpreta a Collier en la serie.
Gary Lockwood hace el papel de Owen Russell.
William Sylvester interpreta a Dr. Stahl en la serie.
George Peppard interpreta a Thomas Banacek en la serie.
George Murdock interpreta a Cavanaugh en la serie.
Ralph Manza interpreta a Jay Drury en la serie.
Murray Matheson hace el papel de Felix Mulholland.
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