- Jack Ellis - Jim Fenner
- Eva Pope - Frances Myers
- Mandana Jones - Nikki Wade
- Joe Shaw - Dominic McAllister
- Nicola Stapleton - Janine Nebeski
- Linda Henry - Yvonne Atkins
- Simone Lahbib - Helen Stewart
- Isabelle Amyes - Barbara Hunt
- Sharon Duncan-Brewster - Crystal Gordon
- Paul Opacic - Mark Waddle
- Tracey Wilkinson - Di Barker
- Tracey Wilkinson - Di Fenner
- Alicya Eyo - Denny Blood
- Debra Stephenson - Shell Dockley
- Kim Oliver - Buki Lester
- Charlotte Lucas - Selena Geeson
- Claire King - Karen Betts
- Stephanie Beacham - Phyllida Oswyn
- Amanda Barrie - Beverley Tull
- Tristan Sturrock - Colin Hedges
- Liz May Brice - Pat Kerrigan
- James Gaddas - Neil Grayling
- Dannielle Brent - Natalie Buxton
- Rebecca Hazlewood - Arun Parmar
- Amanda Donohoe - Lou Stoke
- Angela Bruce - Mandy Goodhue
- Colin Salmon - Dr. Rowan Dunlop
- Sid Owen - Donny Kimber
- Penny Ryder - Nellie Snape
- Jan Francis - Catherine Earlham
- Annette Badland - Angela Robbins
- Wendi Peters - Pamela Jolly
- Zöe Lucker - Tanya Turner
- Gideon Turner - Robin Dunstan
- Neil Conrich - DI Thackeray
- Fern Britton - Fern Britton
- Phillip Schofield - Phillip Schofield
- Shola Adewusi - Fatima Ibrahim
- Joanne Froggatt - Rachel Hicks
- Lynn Farleigh - Mrs Williams
- Simon Williams - Oliver Lilley
- Susan Aderin - Ms Carter
- Vinny Dhillon - Clinic Nurse
- Sheila Ruskin - Mrs Dunstan
- Daryl Fishwick - Mrs Hicks
- Timmy Lang - Spencer Lindsay
- Jean Ainslie - Sister Jill
- Ian Flintoff - Vicar
- Jane Galloway - Mary
- Shelley Longworth - Ms Wall
- Luisa Bradshaw-White - Lorna Rose
- Oliver Fox - Sean Parr
- Andrew Frame - Officer Donegan
- Alastair Stewart - Newsreader
- Ruth Mitchell - Midwife
- Melanie Ramsay - Mel
- Matthew James Thomas - Tom Fenner
- Frederick Warder - DI Williamson
- Scott Charles - Martin Dawson
- Denise Black - Jessie Devlin
- Nicholas Barnes - Security Guard
- Sian Webber - Meg Richards
- Colin Heywood - Personal Trainer
- Julie Legrand - Rita Dockley
- Lara Cazalet - Zandra Plackett
- Rod Culbertson - John
- Alison Newman - Renee Williams
- Jason Hetherington - DS Sullivan
- Elizabeth Bradley - Mrs. Foster
- Alan McKenna - PO Latham
- Kim Taylforth - Marilyn Fenner
- Sally Watts - Betty Wheeler
- Helen Schlesinger - Tessa Spall
- Jane Lowe - Monica Lindsay
- Ian Dunn - Trevor
- Nick Burnell - Mr Meadows
- Martin Crewes - Guy Cullen
- Clare Lawrence-Moody - Amanda Hunt
- Dan Fredenburgh - Greg Hunt
- Tim Faraday - DS Hamilton
- Ivan Kaye - Charlie Atkins
- Tom Cotcher - Mr Jones
- John Rowe - Judge Shuttlewood
- Dione Inman - Clerk of Court
- Paula Bacon - Fiona
- Andrew Grainger - Chris Bisset
- David Crow - Gary
- Sarah Neville - Mrs Warner
- Maxwell Hutcheon - Mr Casey
- Sam Halpenny - DS Culver
- Rory MacGregor - PC Waterhouse
- Joanne Mitchell - Jude Longley
- Jane How - Lady Myddleton
- Roland Oliver - Simon Stubberfield
- Marlene Sidaway - Mrs. Barker
- Mark Pegg - PO MacFarlane
- Kate Steavenson-Payne - Charlotte Myddleton
- Joy Elias-Rilwan - Translator (voice)
- Helen Grace - Caroline Lewis
- Selva Rasalingam - DC Patel
- Lisa Turner - Gina Rossi
- Amanda Gordon - Dionne Clarke
- Michael Higgs - Dr. Thomas Waugh
- Kate O'Mara - Virginia O'Kane
- Maureen Beattie - Marion McLoughlin
- Victoria Pritchard - Trisha
- Danièle Lydon - Claire Walker
- David Henry - Gordon Alexander
- Bernard Gallagher - Judge Hardy
- Owen Oakeshott - DC O'Leary
- David Baukham - DI Reign
- David Baukham - Security Guard
- Graham Turner - Curtis
- David Cann - Francis Cowan
- Andrew Lancel - Barry Pearce
- Richard Dixon - Graham Hutton
- Patrick Cremin - DS Davidson
- Vanessa Earl - Nurse Kitt
- Rosemary Smith - Officer Lightfoot
- Sarah Hadland - Spike
- Martin Milman - Inspector Simms
- Matilda Thorpe - Inspector Shaw
- Pauline Whitaker - Nun
- Pauline Whitaker - Principal Officer
- Tom Keller - Vince Purvis
- Sarah Winman - Susan Franklin
- David Roper - Mr Adams
- Mike Dowling - Aidan Connor
- Nathan Constance - Josh Mitchell
- Adam Leese - Damien Morrison
- Jade Williams - Rhiannon Dawson
- Bill Wallis - Judge Bradshaw
- Elizabeth Rider - Ms Green
- Kellie Bright - Cassie Tyler
- Joplin Sibtain - Naj Khan Din
- Doyne Byrd - Businessman
- Jochum ten Haaf - Dutch Police Sergeant
- Gregory Floy - Mr Pugh
- Geoffrey Hutchings - Bobby Hollamby
- Frances Jeater - Mrs Derbyshire
- John O'Mahony - Duty Medical Officer
- Graham Kent - Stan Harvey
- Paul Brennen - Eric Bostock
- Andy Rashleigh - Doug McBain
- Alex King - Ritchie Atkins
- Timothy Davies - Vicar
- Ash Varrez - Doctor Khan
- Nicole Faraday - Snowball Merriman
- Don Gallagher - DI Armitage
- Maria Charles - Noreen Biggs
- Jamie Thomas King - Tony
- Steven Cree - Waiter
- Robert Hudson - PO McArthur
- Ruth Platt - Lucy Kerridge
- Eamon Geoghegan - DS Rivers
- Christopher Biggins - Christopher Biggins
- Michael Elwyn - Rev. Henry Mills
- Garfield Morgan - Clive Mills
- Nikki Amuka-Bird - Paula Miles
- Nikki Amuka-Bird - PO Miles
- Milo Twomey - Paul Knights
- Janine Wood - Forensics Officer
- David Fleeshman - DI Harwell
- Liam Noble - Officers' Club Barman
- Chrissie Cotterill - Sue Yates
- Meera Syal - Janan Hamad
- Gordon Peaston - PO Paddle
- Janice Acquah - Reporter
- Margaret Blakemore - Journalist
- Christopher Peacock - Reporter
- Stuart Organ - Duty Officer Smithson
- Gloria Onitiri - Marcia
- Steven Webb - David Saunders
- Steven Webb - David
- Lisa Bowerman - Doctor
- Geff Francis - Rick Revoir
- Paul Brightwell - DI Ackroyd
- Stephen Rahman Hughes - Stuart Jones
- Fiona Gillies - Rosalind Oxborough
- David Yelland - Gregory Hedley
- Richard Walker - Judge
- Holly Palmer - Milly Yates
- June Page - Mrs Welles
- Francis Magee - Rob Skelton
- Tim Frances - Sergeant Ledwell
- Don McCorkindale - Frank Twigg
- Carrie Davies - Registrar
- Jonathan Maitland - Reporter
- Frank McCusker - Miller
- Jude Akuwudike - Leroy
- Richard Mylan - Benjamin
- Christine Furness - Waitress
- Jonnie Hurn - Andy
- Dave Hill - Ron
- Claire-Louise Cordwell - Shop Assistan
- Mika Simmons - Blonde Detective
- Nicky Henson - Hugo
- Jaimi Barbakoff - Sales Assistant
- Francesca Fowler - Laura Canning
- Daniel Hill - Dr. Nelson
- Ashlie Walker - Emily Canning
- John Cater - Solicitor
- Hayley Angela Gilbert - Journalist
- Philip McGough - Dr. Nicholson
- Philip McGough - Dr Nicholson
- Colette O'Neil - Sister Thomas
- Peter Ellis - Father Kelly
- Malcolm Scates - Bob Webster
- Angela McHale - Nurse
- Paul Henry - Frank
- Joanna Brookes - Denise
- Ross O'Hennessy - Security Agent
- Romolo Bruni - Paco
- Robert Cambrinus - Sergei
- Rad Lazar - Mikhail
- Sudha Bhuchar - Magistrate
- David Gwillim - Mr. Fergus
- Terence Harvey - Derek
- Teddy Kempner - Jeweller
- Louis Waymouth - Bobby Darren Hollamby
- Ben Joiner - Spanish Barman
- Antony Gabriel - Prosecution Lawyer
- Patrick Pearson - Mr. Davis
- Karen Meagher - Magistrate
- Phillip Lester - Clive
- Elizabeth Banks - Journalist
- Aoife McMahon - Frankie
- Emma Jerrold - Colette
- Seeta Indrani - Consultant
- Alaistair Southey - Brendan
- Tony Slattery - DI Alan Hayes
- Clara Salaman - Pathologist
- Gaynor Howe - Christy Mackay
- Gaynor Howe - Christy
- Nicola Redmond - Miranda Miles
- Michael Fish - Michael Fish
- Candida Gubbins - Dr. Henderson
- Andrew Scarborough - Kevin Spiers
- Sandra De Sousa - Ashlee Wilcox
- Andrew Forbes - DI Barrow
- Ellie Haddington - Joy Masterton
- Bill Buckhurst - Jack
- Steve Swinscoe - Mr. Nebeski
- Quill Roberts - Lawyer
- Samuel Oatley - Ian Nebeski
- Laura Dos Santos - Emira Al Jahani
- Jon Carver - Sergeant Havers
- Rashid Karapiet - Imam
- Endy McKay - Sherie
- Helen Modern - Stella Gough
- Katie Amess - Cashier
- Gugu Mbatha-Raw - Fidelity
- Richard Syms - Humanist Officant
- Annette Bentley - Maggie
- Matthew Butler-Hart - Police Officer
- Murray Ewan - Mr. Fisk
- Cheryl Fergison - Latoya
- Abhin Galeya - Pete
- Peter Geddis - Ted
- Andrew Hilton - Judge Lloyd
- Joseph Steyne - Prisoner
- Celia Bannerman - Mrs. Fisk
- Eddie Osei - George
- Charlotte Eaton - Nurse Fitt
- Ben Cato - Gary
- David Lumsden - Lawyer
- Dickon Tolson - Steve
- Laura Rogers - Sheena Williams
Nicky Henson hace el papel de Hugo.
Victoria Alcock interpreta a Julie Saunders en la serie.
Kika Mirylees hace el papel de Julie Johnston.
Helen Fraser interpreta a Sylvia Hollamby en la serie.
Nicola Stapleton interpreta a Janine Nebeski en la serie.
Stephanie Beacham interpreta a Phyllida Oswyn en la serie.
Amanda Barrie hace el papel de Beverley Tull.
Liz May Brice interpreta a Pat Kerrigan en la serie.
Amanda Donohoe interpreta a Lou Stoke en la serie.
Angela Bruce interpreta a Mandy Goodhue en la serie.
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