- Hector Elizondo - Harry
- Jane Seymour - Bette
- Ben Vereen - Peter
- Priscilla Lopez - Meredith
- Jim Beaver - Spencer
- Anna Maria Horsford - Mrs. Ludlum
- Briga Heelan - Samantha
- Eliza Shin - Nurse
- Tim Bagley - Minister
- Terryn Westbrook - Leslie
- Mason McCulley - Monty
- Amy Pietz - Sheila
- Rashawn Nadine Scott - Jenny
- Megan McNulty - Barb
- Bob Glouberman - Andy
- Phillip Brock - Uncle Larry
- Edith Fields - Mrs. Franco
- Ramon Hilario - Mr. Lopez
- Courtenay Taylor - Woman V.O.
- Anthony Montgomery - Kyle
- Chasty Ballesteros - Amber
- Rosa Salazar - Adriana
- Adam Chambers - Paul
- Melissa Tang - Megyn
- Stephen Saux - Anesthesiologist
- Deep Rai - Barista
- Patrick Cox - Larry
- Matt Malloy - Malcolm
- Emanuel Borria - Doctor
- Lex Medlin - Lewis
- Elad Ziv - Brandon
- Darren Dupree Washington - Man
- Debby Gerber - Waitress
- Debby Gerber - Jen
- Jessica Tuck - Dr. Goodson
- Lyn Alicia Henderson - Paula
- Donna Pieroni - Paul's Mom
- Ashley Bornancin - Carla (voice)
- Andy Mackenzie - Stewie
- Andy Mackenzie - Don
- David Chan - Waiter
- Eileen Fogarty - Dr. Maxwell
- Angel Laketa Moore - Security Agent
- Nikki SooHoo - Nurse
- Jessica Lundy - Charlene
- Merrick McCartha - Guy
- Bernie Kopell - Mr. Knudsen
- Mirabelle Lee - Bella
- Davida Williams - Nina
- Jessica Helmer - Jesse
- George Wyner - Bill
- Ernie Grunwald - Mr. Kafkaman
- Del Hunter-White - Diane
- Becky Wu - Mary
- Jon Huck - John
- Jason Kravits - Dr. Baskin
- Michelle Ortiz - Adriana
- Ian Reed Kesler - Tony
- Johnathan McClain - Mark
- Todd Robert Anderson - Stuart
- Alice Hunter - Camille
- Sara Amini - Hannah
- Jay Preston - Peanut Vendor
- Reggie De Leon - Ramon
- Eric Lopez - Fan
- Rico E. Anderson - Officer Nelson
- Katie Finneran - Natalie
- Vicki Jo Costanzo - Vicky
- Michael Wajacs - Stan
- Otmara Marrero - Amanda
- Rondi Reed - Irene
- Ryan Cartwright - Asher
- Craig Gellis - Eddie
- D.B. Sweeney - Bert
Annaleigh Ashford interpreta a Gina en la serie.
Thomas Middleditch hace el papel de Drew.
Kether Donohue hace el papel de Gabby.
Darryl Stephens interpreta a Gideon en la serie.
Linda Lavin hace el papel de Norma.
David Anthony Higgins interpreta a Jerry en la serie.
Hector Elizondo interpreta a Harry en la serie.
Jane Seymour interpreta a Bette en la serie.
Ben Vereen interpreta a Peter en la serie.
Priscilla Lopez interpreta a Meredith en la serie.
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