- Rachel Maddow - Rachel Maddow
- Requell Jodeah - BBC Reporter
- Bowen Zhang - Chinese Reporter
- Sasha Piltsin - GNC Operator
- Quynh Mi - SATCOM Operator
- Kris McRonney - INCO Operator
- Aidan Wang - SURGEON Operator
- Heather Decksheimer - Operator
- Ian Hawes - ESA Engineer
- Bruce Dawson - Hutch Fulton
- Bonnie Hay - Nurse
- Sonia Sunger - Newscaster
- Anastassia Krainik - Anna Popov
- Nadia Hatta - Mei Chen
- Alessandro Juliani - Dr. Lawrence Madigan
- Rhys Fleming - Annie
- Rocky Anderson - Texan
- Bernie Yao - Gordon
- Anantjot S Aneja - Rohit Arya
- Donald Sales - Jerry
- Ava Julien - Teacher
- Gabriela Reynoso - Marie Rodriguez
- Kamal Sidhu - Ram's Mother
- Gary Sanghera - Doctor
- Javier Lacroix - Priest
- Alona Tal - Miriam Weisberg
- Aiden Stoxx - Kwesi Weisberg-Abban - Young
- Sean Kuling - Scott
- Madeleine Kelders - Doctor
- Bobby Hernandez - Instructor
- Aliana Cerullo - 15-Year-Old Emma Green
- Clem Cheung - Lu's Father (Older)
- Irene Tsu - Lu's Mother (Older)
- Jessie Liang - Woman (Young Lu's Mother)
- Vincent Cheng - Doctor
- Sharmaine Yeoh - Chinese Translator
- Liza Cosier - Russian Translator
- Alex Vishniakoff - Roscosmos Sergei Sokolov
- Alex Vishniakoff - Roscosmos Head / Sergei Sokolov
- Alex Vishniakoff - Roscosmos Head Sergei Sokolov
- Michael Patrick Thornton - Dr. Fred Putney
- Ryan Mah - Dave
- Ryan Mah - Engineer #1
- Marion Eisman - Miriam Weisberg
- Jay Zhang - Zhang Yong
- John Murphy - Ryan Masters
- John Murphy - Ryan Master
- Martin Cummins - Jack Willmore
- Olena Medwid - Natalya Popov
- Adam Pateman - Adam
- Adam Pateman - Engineer #3
- Gabrielle Rose - Darlene Cole
- Jamie Nieto - Travis Parker
- Shevon Nieto - Veronica
- Grace Wang - CNSA Assistant
- Krista Magnusson - Engineer #5
- Krista Magnusson - NASA Engineer Krista Longhurst
- Brian Markinson - George Lane
- Diana Bang - Freddie
- Jessica Garcie - NASA Assistant
- Veena Sood - IRSO Head Meera Patel
- Lydia Campbell - Jane
- Lisa Chandler - Engineer #4
- Anthony Ingram - ESA Head Ted Salter
- Bethel Lee - Engineer #6
- Fiona Fu - CNSA Head / Li Jun
- Chris Jones
- Matt Reeves
- Rafi Crohn
- Andrew Hinderaker
- Adam Kassan
- Jeni Mulein
- Jessica Goldberg
Clem Cheung interpreta a Lu's Father (Older) en la serie.
Josh Charles interpreta a Matt Logan en la serie.
Hilary Swank interpreta a Emma Green en la serie.
Mark Ivanir hace el papel de Misha.
Ray Panthaki interpreta a Ram en la serie.
??? interpreta a Yu en la serie.
Ato Essandoh interpreta a Kwesi en la serie.
Talitha Bateman interpreta a Alexis Logan en la serie.
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